A review. Approx. 30%-40% of all new chem. compounds engineered through a drug discovery program exhibit poor aqueous solubility, which presents a major challenge to modern drug delivery system. To overcome such issues, formulation scientists have developed certain novel drug delivery systems (NDDS), for example, solid lipid nanoparticles (SLN), fast-dissolving tablets (FDT), etc. It is clear that SEDDSs have provided potential avenue for the oral delivery of poorly soluble drugs, as it exert avoidance, or partial avoidance, of the slow dissolution process, which limits the bioavailability of hydrophobic drugs.