Roller compaction parameters' impact on granules and tableting properties of coprocessed Avicel DG [ADG], a phys. mixture of the two components at the same composition present in ADG [PADCP], and microcrystalline cellulose and Kollidon VA-64 Fine phys. mixture [KVA64] was quantified by anal. of variance (ANOVA) and multivariate methods. Roller force, roller gap, and roller speed levels were selected for evaluation. A 33 full-factorial exptl. design with three center points for roller force, roller gap, and roller speed was used. The response parameters studied were granule-to-fines (GF) ratio, compressibility index (CI), tablet thickness (TT), tablet friability (TF), tablet breaking force (TBF) and disintegration time (DT). A model acetaminophen tablet formulation was roller granulated and tableted at 10 kg scale. Principal component anal. of ADG and PADCP formulations were separated from KVA64 formulations, indicating different granule and tableting properties were binder dependent. This difference in binder performance was also confirmed by ANOVA. The ANOVA also showed that there were no statistical performance differences between coprocessed ADG and its comparable phys. blend with the exception of TT. Principal component regression (PCR) analyses of ADG and PADCP revealed that these excipients exhibited a statistically significant neg. effect on granules-to-fine (GF) ratio, TT, TBF, and DT. KVA64 demonstrated a pos. effect on these parameters. The KVA64 phys. mixture demonstrated an overall better performance and binding capability. This study strongly suggests that there is no performance advantage of coprocessed Avicel DG when compared to a phys. mixture of the two components at the same composition