Secarna Pharmaceuticals Gmbh & Co.

DUBLIN--( BUSINESS WIRE )--The "CD39 Targeted Therapies Clinical Trials, Therapeutic Approaches & Market Opportunity Insight 2025" report has been added to ResearchAndMarkets.com's offering. CD39 targeting therapies are emerging as a promising strategy for modulating immune responses in a range of diseases. CD39 serves as a vital ectonucleotidase that influences the purinergic signaling pathway, thereby regulating the equilibrium between immune activation and suppression. By converting ATP into AMP, which is further transformed into adenosine by CD73, CD39 is instrumental in establishing an immunosuppressive microenvironment. This environment is particularly advantageous for tumors but also plays a role in chronic infections and autoimmune diseases. Inhibiting CD39 activity may restore immune functionality and enhance patient outcomes in these contexts. Report Highlights: First CD39 Targeted Therapy Approval Expected By 2029 CD39 Targeted Therapies In Clinical Trials: > 15 Therapies CD39 Inhibitors Clinical Trials Insight By Company, Country, Indication and Phase CD39 Targeted Therapy Research and Development Trends By Indication CD39 Targeted Therapies Proprietary Technologies Platforms By Company In the realm of oncology, the contribution of CD39 to immune suppression within the tumor microenvironment (TME) is well-established. Tumors frequently utilize the CD39-CD73-adenosine axis to evade immune surveillance, resulting in immune cell exhaustion and diminished anti-tumor responses. Elevated levels of CD39 on regulatory T cells (Tregs) and CD8+ T cells have been associated with unfavorable prognoses in various malignancies. By employing monoclonal antibodies that target CD39, such as IPH5201, it is possible to reactivate the immune system to more effectively combat tumor cells. IPH5201, which is being developed by Innate Pharma and AstraZeneca, is currently under investigation in conjunction with immune checkpoint inhibitors (ICIs) to enhance the immune response in patients with solid tumors. In addition to cancer, CD39-targeting therapies show considerable potential for addressing other diseases, particularly chronic viral infections, autoimmune disorders, and sepsis. In the context of chronic infections like HIV, tuberculosis, and Chagas disease, CD39 is implicated in immune exhaustion and suppression, which obstructs effective immune responses. By inhibiting CD39, there is a possibility of reversing immune dysfunction and improving the body's capacity to eliminate pathogens. In autoimmune disorders, where there is an overactivation of the immune system, the targeting of CD39 may aid in reestablishing equilibrium by enhancing the inhibitory function of regulatory T cells, which are vital for averting tissue damage. The therapeutic promise of targeting CD39 also encompasses sepsis, as CD39 expression on monocytes and macrophages is instrumental in regulating inflammation. In the context of sepsis, achieving a balanced immune response is crucial to mitigate tissue injury while effectively managing infection. By inhibiting the activity of CD39, therapeutic interventions could diminish excessive inflammation and restore immune homeostasis, presenting a novel strategy for addressing this critical condition. The clinical advancement of therapies aimed at CD39 is still in its nascent phase, with several candidates progressing through clinical trials, particularly in Phase 2. Among these, IPH5201 stands out as a leading candidate, demonstrating encouraging outcomes in both preclinical and early-phase clinical investigations. These antibodies are being assessed not only in oncology but also across a range of chronic conditions where CD39 plays a significant role in immune regulation. By focusing on CD39, these therapies seek to bolster immune responses in scenarios characterized by immune suppression or dysfunction. Looking forward, the potential uses of CD39-targeting therapies are extensive. The integration of anti-CD39 antibodies with other treatment modalities, such as immune checkpoint inhibitors or antiviral therapies, presents the opportunity for synergistic effects, thereby enhancing the immune response. Nonetheless, challenges persist, particularly concerning the context-dependent function of CD39 across various diseases and patient demographics. Achieving a precise balance between immune activation and suppression will be essential for the safe and effective implementation of these therapies. As clinical trials advance and additional data is collected, therapies targeting CD39 may emerge as a fundamental component of personalized medicine, effectively addressing various diseases through the precise and controlled modulation of immune responses. Key Topics Covered: Introduction To CD39 Targeting Therapies Role of CD39 & Emergence As Therapeutic Target Discovery of CD39 & Development Of Targeting Therapies CD39 Targeting Therapies Mechanism Of Action CD39 Inhibition CD39 Agonism Current CD39 Targeting Therapy Approaches Antibodies Nucleic Acid Therapeutics Small Molecule Inhibitors Global CD39 Targeted Therapies Clinical Trials Overview By Company By Indication By Country By Phase CD39 Targeted Therapies Clinical Trials Insight By Company, Country, Indication & Phase Research Preclinical Phase I Phase II Global CD39 Targeting Therapy Market Trends & Developments Current Market Outline Future Market Opportunities Role Of CD39 Targeting Therapies By Indication: Clinical Development & Collaborations Cancer Autoimmune & Inflammatory Diseases Cardiovascular Diseases Infections CD39 Targeted Therapies Technology Platforms OligoCreator & LNAplus Platforms - Secarna Pharmaceuticals Unnamed Platforms - Biotheus Unnamed Platform - Adimab OriAb Antibody Discovery Platform - Oricell Therapeutics TMAb Platform - Sensei Biotherapeutics Global CD39 Targeted Therapies Market Dynamics Market Drivers & Opportunities Market Challenges & Restraints Competitive Landscape Adimab Arcus Biosciences Biotheus BrightPath Biotherapeutics Elpiscience Biopharmaceuticals Innate Pharma Orega Biotech OriCell Therapeutics Secarna Pharmaceuticals Trishula Therapeutics For more information about this report visit https://www.researchandmarkets.com/r/pftdih About ResearchAndMarkets.com ResearchAndMarkets.com is the world's leading source for international market research reports and market data. 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Partnership expands spectrum of Secarna’s capabilities for the development of targeted ASOs beyond antibodies and sugar molecules New platform capabilities extend the reach of Secarna’s antisense approaches, potentially offering new treatment options for a wider range of diseases MARTINSRIED, Germany & OXFORD, England--(BUSINESS WIRE)-- Secarna Pharmaceuticals GmbH & Co. KG (Secarna), a leading independent European antisense drug discovery and development company, and Orbit Discovery Ltd. (Orbit), a leader in the discovery of therapeutic peptide hits, today announced that they have entered into a collaboration to discover and develop peptide-conjugated targeted antisense oligonucleotide (ASO) therapeutics. The collaboration will leverage Orbit’s expertise and bead-based peptide display engine for the identification, screening, and selection of cyclic peptides specific to a wide range of disease targets, to be paired with Secarna’s ASO molecules. The addition of cyclic peptides to Secarna’s proprietary ASO discovery and development platform will expand its therapeutic spectrum, positioning it to develop targeted antisense assets beyond modalities such as antibodies and sugar molecules, like GalNAc. “We are very pleased to embark on this collaboration with Orbit Discovery, as the team’s expertise in peptide discovery and development will further enhance our capabilities for the development of targeted antisense therapeutics”, said Konstantin Petropoulos, CBO of Secarna Pharmaceuticals. “We look forward to working with Orbit to expand both the therapeutic potential and universe of targeted ASO therapeutics with highly specific, potent, safe and convenient therapeutic options available for patients who urgently need them.” Orbit’s peptide discovery services enable the screening of large libraries of peptides through the combination of DNA-encoded libraries and bead-based presentation. The proprietary technology is uniquely equipped to address soluble targets and targets in situ, both on and in cells, allowing for faster discovery times of relevant peptide leads based on affinity screens and/or functional screens. The collaboration not only strengthens Secarna's ability to create targeted antisense therapeutics, paired to cyclic peptides, but will also extend the reach of antisense approaches, potentially offering new treatment options for a wider range of diseases. “Together with Secarna, we are excited to address the growing need for effective and highly specific targeted therapeutics, focused on enabling new options for the way innovative ASO therapies are delivered”, said Dr. Neil Butt, Chief Executive Officer, Orbit Discovery. “This collaboration is further validation of our expertise in the discovery of targeting peptide conjugates, and adds to our growing portfolio of partners that share our goal of delivering a generation of therapeutics with lower toxicity and better tissue specificity that will ultimately be safer and more effective for patients globally.”

DALLAS & MARTINSRIED, Germany--(BUSINESS WIRE)-- Celanese Corporation (NYSE: CE), a global specialty materials and chemical company, and Secarna Pharmaceuticals GmbH & Co. KG, a leading independent European antisense drug discovery and development company, today announced a research collaboration for the development of long-acting implants that deliver antisense oligonucleotides (ASOs). ASOs are synthetic molecules designed to target specific messenger RNA to prevent the production of proteins implicated in the progression of a wide range of diseases including cardiometabolic, central nervous system, oncological and rare diseases. Antisense therapy is an innovative, commercially-validated therapeutic approach, but often requires frequent administration or the delivery of large doses to achieve uptake at the intended site of action, ultimately causing a high treatment burden for patients. The Celanese VitalDose® Drug Delivery Platform and Secarna’s proprietary ASO Drug Discovery and Development Platform will be used to develop ASO-eluting implants, which have the potential to lessen the dosing frequency, minimize off-target immune responses and improve targeting to provide better patient outcomes for a range of indications. The VitalDose® Drug Delivery Platform provides reliable, controlled-release performance and has a long history of use in approved parenteral drug products in the United States and Europe. It can be tuned to deliver months to years of drug release and has demonstrated, stable ASO release over one year. “Collaborating with Secarna allows us to develop an innovative implant that has the potential to significantly change the way disease-modifying ASO therapies are administered,” said Cyonna Holmes, global business strategy leader for Ophthalmology and RNA at Celanese. “Our team is excited to use our unique Drug Delivery Platform and expertise to help address the growing need for patient-centric, targeted solutions for ASO therapies alongside Secarna.” Secarna’s proprietary ASO Drug Development and Discovery Platform enables the company to discover novel therapies for targets that are difficult to reach therapeutically with conventional approaches. With several high value and innovative programs, Secarna has validated its platform in various indications such as cardiometabolic, immune-oncology, fibrotic/inflammatory diseases and the central nervous system. “We are looking forward to partnering with Celanese to combine our industry-leading ASO platform with their VitalDose® drug delivery technology,” said Konstantin Petropoulos, CBO of Secarna Pharmaceuticals. “Together we see the potential to enhance the way our targeted ASO therapies are delivered which ultimately serves our shared goal: to make highly specific, potent, safe and convenient therapeutic options available for patients who urgently need them.” Scientists at the Celanese Development & Feasibility Lab will independently conduct portions of the planned research in a dedicated pharmaceutical facility. For more information on Celanese VitalDose® technology, visit . About Celanese Celanese is a global leader in chemistry, producing specialty material solutions used across most major industries and consumer applications. Our businesses use our chemistry, technology and commercial expertise to create value for our customers, employees and shareholders. We are committed to sustainability by responsibly managing the materials we create for their entire lifecycle and are growing our portfolio of sustainable products to meet increasing customer and societal demand. We strive to make a positive impact in our communities and foster inclusivity across our teams. Celanese is a Fortune 500 company that employs approximately 12,400 employees worldwide with 2023 net sales of $10.9 billion. About Secarna Pharmaceuticals GmbH & Co. KG Secarna Pharmaceuticals is the leading independent European next-generation antisense drug discovery and development company addressing high unmet medical needs in immuno-oncology and immunology, as well as viral, neurodegenerative and cardiometabolic diseases. Secarna’s mission is to maximize the performance and output of its proprietary antisense oligonucleotide discovery and development platform to generate highly specific, safe, and efficacious best-in-class antisense therapies. With over 20 discovery and development programs, including both proprietary pipeline projects and partnered programs, Secarna focuses on targets in indications where antisense-based approaches have clear potential benefits over other therapeutic modalities. .