A HPLC method for the determination of mazindol in tablets is described. The optimum conditions were as follows: ZORBAX CN column (4.6 mm × 25 cm); MeOH-0.01 mol/L dibasic ammonium phosphate buffer (8:2) as mobile phase and UV-254 detection. The proposed method is simple and rapid without the need of any preliminary separation The results obtained are satisfactory both with respect to recovery and precision.