Delving into the Latest Updates on 西华大学 with Synapse

概览

排名前五的药物类型	数量

小分子化药	2

排名前五的靶点	数量

SIRT5(NAD依赖性脱乙酰酶sirtuin-5)	2

关联

2

项与西华大学相关的药物

Compound 58(Xihua University)

Compound 58(西华大学)

靶点

SIRT5

作用机制

SIRT5抑制剂

在研机构

西华大学

原研机构

西华大学

在研适应症

急性肾损伤

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

XHU-58

靶点

SIRT5

作用机制

SIRT5抑制剂

在研机构

西华大学

原研机构

西华大学

在研适应症

急性肾损伤

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

100 项与西华大学相关的临床结果

登录后查看更多信息

0 项与西华大学相关的专利（医药）

登录后查看更多信息

11,036

项与西华大学相关的文献（医药）

2025-05-31·ACM Computing Surveys

Trustworthy AI-based Performance Diagnosis Systems for Cloud Applications: A Review

作者: Zhao, Zhiming ; Xin, Ruyue ; Wang, Jingye ; Chen, Peng

Performance diagnosis systems are defined as detecting abnormal performance phenomena and play a crucial role in cloud applications. An effective performance diagnosis system is often developed based on artificial intelligence (AI) approaches, which can be summarized into a general framework from data to models. However, the AI-based framework has potential hazards that could degrade the user experience and trust. For example, a lack of data privacy may compromise the security of AI models, and low robustness can be hard to apply in complex cloud environments. Therefore, defining the requirements for building a trustworthy AI-based performance diagnosis system has become essential. This article systematically reviews trustworthiness requirements in AI-based performance diagnosis systems. We first introduce trustworthiness requirements and extract six key requirements from a technical perspective, including data privacy, fairness, robustness, explainability, efficiency, and human intervention. We then unify these requirements into a general performance diagnosis framework, ranging from data collection to model development. Next, we comprehensively provide related works for each component and concrete actions to improve trustworthiness in the framework. Finally, we identify possible research directions and challenges for the future development of trustworthy AI-based performance diagnosis systems.

2025-05-01·Food Hydrocolloids

Impact of interfacial rigidity on the rheological properties of high internal phase Pickering emulsions stabilized by casein, walnut protein isolate, and their complexes

作者: Zhou, Zheng ; Xu, Yanfei ; Jiang, Rui

This study investigated the effect of interfacial rigidity on the tunable rheol. properties of high internal phase Pickering emulsions (HIPPEs).To produce protein samples with varying degrees of flexibility, walnut protein isolate (WPI) was complexed with casein (CA) through a pH shifting method and further crosslinked with genipin.CA/WPI and genipin-crosslinked CA/WPI (G-CA/WPI) nanocomplexes exhibited significantly decreased particle sizes (lower than 150 nm), increased β-sheet content, and enhanced rigidity.While CA/WPI and G-CA/WPI demonstrated appropriate wettability (close to 90°), their interfacial tensions were relatively higher than that of CA by 2.5-5 mN/m.Notably, the quartz crystal microbalance (QCM) study revealed that the oil-water interface adsorbed with CA/WPI and G-CA/WPI exhibited significantly greater interfacial rigidity (low dissipation shifts <1.2 x 10^-6) than those adsorbed with CA, WPI, or their mixture (M-CA/WPI).The HIPPEs stabilized by 2% CA/WPI and G-CA/WPI exhibited comparable oil droplet sizes to those stabilized by CA or M-CA/WPI, yet they demonstrated significantly enhanced storage modulus by 1.5-5-fold and increased critical stresses by up to 25-fold, indicating their improved viscoelastic properties.Lissajous-Bowditch curves further confirmed that the HIPPEs fabricated with CA/WPI and G-CA/WPI were more resistant to deformation.These findings underscore the pivotal role of protein particle rigidity in the rheol. properties of stabilized HIPPEs, guiding the design of novel HIPPEs with tailored applications.

2025-04-01·Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

Raman spectroscopic fingerprinting for the identification and quantitative analysis of sports doping β − agonists based on gold nanopolyhedra

Article

作者: Zhang, Yahui ; Tan, Rui ; Zeng, Xuanjiang ; Wang, Chuanfeng ; Li, Ting ; Luo, Xiaojun ; Lin, Ruxi ; Chen, Liping

Beta - stimulant, that is, β - adrenergic stimulant, also known as β - agonists, is bioactive catecholamine compounds naturally produced in animals' adrenal medulla glands that induce relaxation in asthmatic airway smooth muscles upon inhalation while also temporarily boosting athletic alertness and alleviating fatigue. However, their potential for dependency poses health risks including unnoticed exacerbation leading to severe illness or fatality prompting their inclusion on WADA's prohibited substances list. Surface - enhanced Raman spectroscopy (SERS) offers a rapid, sensitive, and label - free means for identifying characteristic peaks associated with β - agonist compounds. In our investigation, the utilization of seed - mediated synthesis technique facilitated production of gold polyhedral substrates serving as highly sensitive biosensors for detecting β - agonist presence. The unique geometry of these particles generates enhanced SERS signals due to their multiple corners, resulting low detection limits (9.33 × 10^-7, 6.28 × 10^-7, and 6.19 × 10^-7 g·mL^-1 for salbutamol, clenbuterol and higenamine respectively), with promising prospects for improving overall sensitivity in β - agonists detection.

100 项与西华大学相关的药物交易

登录后查看更多信息

100 项与西华大学相关的转化医学

登录后查看更多信息