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The paper introduced a method for determining 4 phenolic acid derivatives (danshensu, protocatechualdehyde, salvianolic acid B, and salvianolic acid A) from Danshen injection by HPLC.The method is simple and accurate, and can be used for quality control of Danshen injections.

Zhongguo Zhongyiyao Keji

Pharmacological effects of motherwort (Leonurus japonicus)

作者: Zhang, Jian-bing ; Wang, Mu-lan ; He, Jiang-min ; Pan, Ying-feng ; Ding, Jie

A review.This paper reviewed the pharmacol. effects of motherwort (Leonurus japonicus), including the effects on uterus and hemorheol., anti-inflammatory and analgesic effects, diuretic effect, and the effect on immune system.

Scientific Reports3区 · 综合性期刊

De novo assembly and annotation of the Zhe-Maidong (Ophiopogon japonicus (L.f.) Ker-Gawl) transcriptome in different growth stages

3区 · 综合性期刊

ArticleOA

作者: Wang, Tingzhang ; Wu, Rongrong ; Wang, Ying ; Chen, Huan ; Liu, Huijun ; Ying, Xuhui

AbstractZhe-Maidong (Ophiopogon japonicus (L.f.) Ker-Gawl) is a traditional medicinal herb in the family Liliaceae that has significant pharmacological effects on immunity and cardiovascular disease. In this study, three different growth stages of Zhe-Maidong were investigated using RNA-seq, and a total of 16.4 Gb of raw data was obtained. After filtering and assembling, 96,738 unigenes with an average length of 605.3 bp were ultimately generated. A total of 77,300 unigenes were annotated using information from five databases, including the NT, NR, SwissProt, Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) databases. Additionally, the mechanisms of flavonoid, saponin and polysaccharide biosynthesis and of accumulation at different stages of tuber development were also characterized. From the first to third years, the contents of flavonoids, saponins and polysaccharides all increased, whereas the expression levels of related genes decreased in the flavonoid and saponin pathways and first increased and then decreased in the polysaccharide pathway. The results of this study provide the most comprehensive expressed sequence resource for Zhe-Maidong and will expand the available O. japonicus gene library and facilitate further genome-wide research and analyses of this species.

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100 项与 Chia Tai Qingchunbao Pharmaceutical Co., Ltd. 相关的转化医学

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