Delving into the Latest Updates on 安徽省药物研究所 with Synapse

概览

疾病领域	数量

感染	2

排名前五的药物类型	数量

中药	4

关联

4

项与安徽省药物研究所相关的药物

Chaiqin Lidan Granules

柴芩利胆颗粒

靶点-

作用机制-

在研机构

安徽省药物研究所

原研机构

安徽省药物研究所

在研适应症

慢性胆囊炎

非在研适应症-

最高研发阶段临床2期

首次获批国家/地区-

首次获批日期-

Qinbei Zhike Granules

芩贝止咳颗粒

靶点-

作用机制-

在研机构

安徽省药物研究所

原研机构

安徽省药物研究所

在研适应症

急性支气管炎

非在研适应症-

最高研发阶段临床2期

首次获批国家/地区-

首次获批日期-

Chaiqin Xiaoer Qingre Suppository

柴芩小儿清热栓

靶点-

作用机制-

在研机构

深圳市北科联药业科技有限公司 [+1]

原研机构-

在研适应症

急性上呼吸道感染 [+1]

非在研适应症-

最高研发阶段临床2期

首次获批国家/地区-

首次获批日期-

4

项与安徽省药物研究所相关的临床试验

CTR20132866 / Recruiting临床2期

治疗小儿急性上呼吸道感染（感冒风热证）发热有效性和安全性的安慰剂对照、多中心Ⅱa期临床研究。

1.探索柴芩小儿清热栓治疗小儿急性上呼吸道感染（感冒风热证）发热的退热作用； 2.观察柴芩小儿清热栓临床应用的安全性

开始日期2014-12-16

申办/合作机构

深圳市北科联药业科技有限公司

[+1]

CTR20131520 / Recruiting临床2期

耳闭清颗粒治疗急性分泌性中耳炎（风热袭耳证）有效性和安全性的随机、双盲、剂量平行对照、多中心临床试验

初步评价耳闭清颗粒治疗急性分泌性中耳炎（风热袭耳证）的有效性与安全性，同时进行剂量探索，为Ⅲ期临床试验提供依据。

开始日期2012-03-16

申办/合作机构

安徽九鼎医药科技有限公司

[+1]

CTR20180796 / Recruiting临床2期IIT

以安慰剂为对照评价芩贝止咳颗粒治疗急性气管-支气管炎（痰热证）临床研究

1）对芩贝止咳颗粒治疗急性气管-支气管炎（痰热证）进行剂量探索； 2）初步评价芩贝止咳颗粒治疗急性气管-支气管炎（痰热证）的有效性和安全性。

开始日期2008-05-08

申办/合作机构

安徽省药物研究所

100 项与安徽省药物研究所相关的临床结果

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0 项与安徽省药物研究所相关的专利（医药）

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55

项与安徽省药物研究所相关的文献（医药）

2015-09-01·Molecular Medicine Reports4区 · 医学

NADPH oxidase-derived production of reactive oxygen species is involved in learning and memory impairments in 16-month-old female rats

4区 · 医学

Article

作者: Wu, Wangyang ; Huang, Dake ; Kan, Hongwei ; Liang, Yan ; Yin, Yanyan ; Wang, Chunyan ; Hu, Wen ; Wang, Yuchan ; Li, Weizu

Women undergoing the natural menopause can experience progressive cognitive dysfunction, particularly in the form of memory impairment. However, the mechanisms underlying memory impairments in the menopause remain to be elucidated. There is increasing evidence that oxidative damage caused by excessive reactive oxygen species (ROS) production may correlate with age‑associated cognitive impairment. The nicotinamide adenosine dinucleotide phosphate oxidase (NOX) family is important in the generation of ROS in the brain. It has been hypothesized that the accumulation of ROS, derived from NOX, may be involved in menopause‑associated learning and memory impairments. The present study investigated whether NOX‑derived ROS generation affected the learning and memory ability in 3‑month and 16‑month‑old female rats. The results of a morris water maze assessment revealed that there were significant learning and memory impairments in the 16‑month‑old female rats. Furthermore, the activity of superoxide dismutase (SOD), level of malondialdehyde (MDA), production of ROS and expression levels of NOX2, p47phox, Ras‑related C3 botulinum toxin substrate 1 (RAC1) and protein kinase C α (PKCα) were investigated in the cortex and hippocampus of 3‑month and 16‑month old female rats. The results demonstrated that the activity of SOD was significantly decreased, whereas the levels of MDA, production of ROS and expression levels of NOX2, p47phox, RAC1 and PKCα were significantly increased in the 16‑month old female rats. These results suggested that NOX‑mediated oxidative stress may be important in menopause‑associated learning and memory impairments.

2014-05-01·Pharmacology Biochemistry and Behavior4区 · 心理学

Protective effects of ginsenoside Rg1 on chronic restraint stress induced learning and memory impairments in male mice

4区 · 心理学

Article

作者: Yin, Yanyan ; Wu, Wangyang ; Li, Weiping ; Wang, Yuchan ; Hu, Wen ; Kan, Hongwei ; Li, Weizu ; Wang, Mingming

Alzheimer's disease (AD) is one of the major neurological diseases of the elderly. Chronic stress, which can induce atrophy and functional impairments in several key brain areas such as the frontal cortex and hippocampus, plays an important role in the generation and progression of AD. Currently, there are no effective drug treatment options for preventing chronic stress induced learning and memory impairments and neuronal damage. Ginsenoside Rg1 (Rg1) is a steroidal saponin abundantly contained in ginseng. This study explored the neuroprotective effects of Rg1 on chronic restraint stress (CRS) induced learning and memory impairments in a mouse model. Our results showed that Rg1 (5mg/kg) significantly protected against learning and memory impairments induced by CRS in a Morris water maze. Besides, Rg1 (2, 5mg/kg) was able to decrease ROS generation and attenuate the neuronal oxidative damage in the frontal cortex and hippocampus CA1 in mice. Additionally, the inhibition of NOX2, p47phox and RAC1 expression is also involved in the action mechanisms of Rg1 in this experimental model. This study provided an experimental basis for the clinical application of Rg1 in chronic stress induced neuronal oxidative damage.

2013-01-25·Neural regeneration research2区 · 医学

Buyang Huanwu Decoction fraction protects against cerebral ischemia/reperfusion injury by attenuating the inflammatory response and cellular apoptosis.

2区 · 医学

ArticleOA

作者: Jin, Yulian ; Wu, Changqing ; Huang, Dake ; Dong, Liuyi ; Shao, Xu ; Wang, Chunyan ; Li, Sheng ; Qin, Jiang

Buyang Huanwu Decoction fraction extracted from Buyang Huanwu Decoction contains saponins of Astragalus, total paeony glycoside and safflower flavones. The aim of this study was to demonstrate the neuroprotective effect and mechanism of Buyang Huanwu Decoction fraction on ischemic injury both in vivo and in vitro. In vivo experiments showed that 50-200 mg/kg Buyang Huanwu Decoction fraction reduced infarct volume and pathological injury in ischemia/reperfusion rats, markedly inhibited expression of nuclear factor-κB and tumor necrosis factor-α and promoted nestin protein expression in brain tissue. Buyang Huanwu Decoction fraction (200 mg/kg) exhibited significant effects, which were similar to those of 100 mg/kg Ginkgo biloba extract. In vitro experimental results demonstrated that 10-100 mg/L Buyang Huanwu Decoction fraction significantly improved cell viability, decreased the release of lactate dehydrogenase and malondialdehyde levels, and inhibited the rate of apoptosis in HT22 cells following oxygen-glucose deprivation. Buyang Huanwu Decoction fraction (100 mg/L) exhibited significant effects, which were similar to those of 100 mg/L Ginkgo biloba extract. These findings suggest that Buyang Huanwu Decoction fraction may represent a novel, protective strategy against cerebral ischemia/reperfusion injury in rats and oxygen-glucose deprivation-induced damage in HT22 cells in vitro by attenuating the inflammatory response and cellular apoptosis.

100 项与安徽省药物研究所相关的药物交易

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100 项与安徽省药物研究所相关的转化医学

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管线布局中药物为当前组织机构及其子机构作为药物机构进行统计，早期临床1期并入临床1期，临床1/2期并入临床2期，临床2/3期并入临床3期

临床2期

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当前项目

药物(靶点)	适应症	全球最高研发状态

柴芩利胆颗粒	慢性胆囊炎更多	临床2期
柴芩小儿清热栓	发热更多	临床2期
芩贝止咳颗粒	急性支气管炎更多	临床2期
耳闭清颗粒	急性渗出性中耳炎更多	临床2期