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Next-gen Lilly obesity drug slashes weight in Innovent study—but is it enough to rival Mounjaro?

2023-05-11

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Eli Lilly has the rights to develop mazdutide outside of China.

ElioLillyhas strengthened its pitch mazdutidehinese obesity market with fresh phase 2 data. The update shows giving mazdutide, a molecule from Eli Lilly’s deep bench of obesity assets, at a higher dose dialed up the placebo-adjusted weight loss to 15.4% after 24 weeks.

Innoventsed Innovent picked up the rights to the duaobesity/glucagon receptor agonist in its home market from Lilly mazdutideor an undisclosed Eli Lillyy evidence of effobesitymerged last summer, when Innovent presented phase 2 data that linked the 6-mg dose of the molecule to 11.57% weight loss after 24 weeks in a phase 2 trial. Subjects in the placebo arm gained weight during the trial.

With InnovenInnovent dose-dependent weight loss, and LGLP-1/glucagon receptor agonist GLP-1/glucagon receptorat doses up to 10 mg in a dose-esLillyion trial, the Chinese biotech added a 9-mg, 80-subject cohort to its midphase study. Innoventdata come from that cohort.

In adInnovento placebo-adjusted weight loss of 15.4%,Lillyvent repomazdutide reduction in body weight from baseline versus placebo of 14.7 kg and a breakdown of the proportion of people who passed certain weight loss thresholds. Most, 81.7%, of patients on mazdutide experienced at least 5% weight loss. More than one-fifth, 21.7%, of subjects lost 20% or more body weight over the 24-week study.

Innovent is continuing to track patients out to 48 weeInnovents yet to analyze data on other secondary and exploratory endpoints. But, having found overall tolerability and safety at 9 mg to be “favorable,” the biotech has committed to taking the higher dosmazdutidease 3. If Innovent replicates the data in pivotal trials, it could establish mazdutide as an option for the 160 million Chinese people with obesity.

Innoventmpanies, including Lilly, are eyeing the same opportunity. Lilly completed a Chinese phase 3 trial of tirzepatide, now sold as Mounjaro in the U.S., late last year. Novo Nordisk won Chinese approval for semaglutide in 2021, although, with the authorization only coveriInnoventtes, use in obesity is off-label in the country for now.mazdutide obesity

Lilly has the rights to devLillymazdutide outside of China and contLilly to list the candidate in its phase 1 tirzepatideowever, with tMounjarode setting the bar high—weightNovo Nordisk24 weeks was similar to thsemaglutideresult—and mazdutide one of two next-generation weight lodiabetescts in Liobesityipeline, it is unclear whether the Big Pharma will advance the program. Lilly was undecided as of last summer.

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