San Diego-based Endeavor BioMedicines closed on a Series B financing worth $101 million.
“Endeavor BioMedicines is developing precision medicines targeting the genetic culprits of cancer and fibrosis,” said John Hood, co-founder, chief executive officer and chairman of Endeavor. “Researchers have investigated Hedgehog and ULK1 signaling pathways over the last decade, but now we have the understanding and capability to identify the patients who will benefit most from them. The capital raised from a committed, top-tier investor syndicate enables us to deliver the right drug to the right patients in order to get the best clinical outcome.”
As part of the financing deal, Andrew Lam with Ally and Monal Mehta with Avidity will join the board of directors, joining John Hood, Bernard Davitian of Omega Fund and Patrick Enright of Longitude. On September 22, 2021, Endeavor dosed the first patient in its Phase II study of taladegib for IDF. It is a randomized, placebo-controlled, multi-center trial designed to evaluate the efficacy and safety of the drug by itself in mild to moderate IPF. It is being run in the Asia-Pacific region and will enroll about 60 participants, 30 patients in each arm. The participants will receive either a placebo or taladegib as a daily oral dose for 12 weeks of treatment. After treatment, they will be followed for another six weeks. The primary endpoints include change from baseline in frequency and severity of adverse events and key vital sign measurements. Secondary measures include Forced Vital Capacity, FEV1 and other lung function measures. Depending on the study results, they hope to run a Phase II trial of the drug in combination with standard of care sometime this year.
The company officially launched in January 2021 with a $62 million Series A financing led by Omega Funds, Longitude Capital and Endeavor’s management. It was co-founded by Hood, who previously founded and acted as chief executive officer of Impact Biomedicines until Celgene acquired it in 2018. Miguel de los Rios is Endeavor’s co-founder and chief scientific officer; he previously was chief executive officer of Rift Biotherapeutics.