利多布比卡因(Bupivacaine Hydrochloride/Lidocaine Hydrochloride) - 药物靶点：SCNA x Sodium channels_在研适应症：麻醉_专利_临床

概要

基本信息

药物类型

小分子化药

别名

Compound Bupivacaine Hydrochloride、Lidocaine Hydrochloride/Bupivacaine Hydrochloride、盐酸利多卡因/盐酸布比卡因

+ [1]

靶点

SCNA x Sodium channels

作用机制

SCNA阻滞剂(钠通道α亚基家族阻滞剂)、钠通道阻滞剂

治疗领域

其他疾病

在研适应症

麻醉

非在研适应症-

原研机构

Amphastar Pharmaceuticals, Inc.

在研机构

江西青峰药业有限公司

非在研机构

Amphastar Pharmaceuticals, Inc.

最高研发阶段批准上市

首次获批日期

美国 (2003-05-23),

麻醉

最高研发阶段(中国)批准上市

特殊审评-

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结构

分子式C18H31ClN2O2

InChIKeyHUCIWBPMHXGLFM-UHFFFAOYSA-N

CAS号73360-54-0

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关联

9

项与利多布比卡因相关的临床试验

RBR-4gjhfk / Not yet recruiting临床4期

Anesthetic effect of Proximetacaine hydrochloride 0,5%: comparison between eyedrop instillation in open eyes and vaporization in closed eyes

开始日期2018-10-01

申办/合作机构

Universidade Estácio de Sá

[+1]

NCT03911648 / CompletedN/AIIT

The Efficacy of Bupivacaine Alone and in Combination With Lidocaine at Performing Caudal Block on Analgesia in Pediatric Patients Underwent Circumcision: A Historical Cohort Study

Optimal analgesia following ambulatory surgery is an important matter for patient satisfaction and it reduces unnecessary hospital admissions. This study investigated whether caudal block with different combinations of local anesthetics can alter postoperative pain scores and additional rescue analgesic use. The investigators also aim to determine the side effects of these technique such as nausea, vomiting, bradycardia, hypotension, respiratory depression, length of hospital stay, first micturition or mobilization times, surgical and anesthetic complications.

开始日期2018-07-01

申办/合作机构-

NCT03453151 / Completed临床1/2期IIT

Splanchnic Nerve Blockade in Chronic Heart Failure. Splanchnic CHF

Patients with chronic heart failure and undergoing right heart catheterization will be enrolled in this study. Subjects will undergo catheterization of the heart to obtain central cardiac pressure and other cardiac hemodynamic parameters. Subsequently, the subject will undergo a regional nerve block of the splanchnic nerves.
This study will be a prospective, uncontrolled clinical trial. The study will not be controlled as invasive monitoring of hemodynamics will be performed, allowing clear demonstration of a cause-effect relationship. The goal of the study is to provide proof of concept.
Patients will undergo detailed physiological testing.

开始日期2018-05-01

申办/合作机构

Duke University

100 项与利多布比卡因相关的临床结果

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100 项与利多布比卡因相关的转化医学

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100 项与利多布比卡因相关的专利（医药）

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4

项与利多布比卡因相关的文献（医药）

2005-04-01·Journal of pharmaceutical sciences3区 · 医学

Role of n-methyl Pyrrolidone in the Enhancement of Aqueous Phase Transdermal Transport

3区 · 医学

Article

作者: Philip J. Lee ; Robert Langer ; V.Prasad Shastri

The role of n-methyl pyrrolidone (NMP) as an enhancer for permeants delivered from an aqueous phase was investigated in the transdermal delivery of the local anesthetics lidocaine free base, lidocaine-hydrochloride (HCl), and prilocaine-HCl. Lidocaine free-base flux increased from H2O/NMP binary systems containing over 50% (v/v) NMP with significant flux enhancement observed above 80% NMP. In this range, drug flux was found to correlate with NMP flux. The addition of oleic acid (1% w/v) further enhanced lidocaine flux sixfold, in these formulations. The H2O/NMP (50% v/v) system enhanced the transport of water-soluble hydrochloride salt derivatives of lidocaine and prilocaine by factors of 4.3 and 2.6, respectively, indicating that NMP was capable of enhancing hydrophilic and hydrophobic drugs from an aqueous phase. These findings were consistent with the model that NMP flux across the stratum corneum improves the transport of formulation solutes.

1993-01-01·Cahiers d'anesthesiologie

[Local anesthesia and ambulatory surgery for inguinal hernia. Apropos of 737 patients].

Article

作者: Legroux, P ; Sleth, J C ; Demont, F ; Bordarier, M

737 cases of ambulatory herniorrhaphy performed under local anaesthesia are reported. The Shouldice technique is used. Two pharmacokinetic studies (lidocaine bupivacaine) confirm the innocuity of local anaesthesia. The authors focus their discussion on an other approach of surgery, and the medical network.

1958-07-01·Journal of the American Dental Society of Anesthesiology

Duocaine-A New Local Anesthetic Agent - A Clinical Research Report.

Article

作者: Kresberg, H ; Douglas, B L ; Jung, E ; Malkin, M ; Sherman, P

100 项与利多布比卡因相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	-	N01BB52 N01BB51	-

研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
麻醉	美国	Amphastar Pharmaceuticals, Inc.	2003-05-23

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT03103100 (CTgov)	临床3期	产痛	75	1% Lidocaine (1% Lidocaine)	構壓餘觸積顧夢齋積糧(艱憲鏇糧網蓋鬱製構襯) = 廠襯廠鑰遞鹽鹹艱鬱憲選齋糧選鬱糧壓衊窪積 (廠衊夢壓積襯醖鏇醖鑰, 遞築憲醖築構積範製繭 ~ 範願鬱簾顧構窪齋顧糧) 更多	-	2020-08-31
				0.25% Bupivacaine (0.25% Bupivacaine)	構壓餘觸積顧夢齋積糧(艱憲鏇糧網蓋鬱製構襯) = 簾憲廠淵糧繭選廠襯積選齋糧選鬱糧壓衊窪積 (廠衊夢壓積襯醖鏇醖鑰, 積鏇選糧鏇鏇範糧選鏇 ~ 淵蓋鹽鬱齋觸積鏇製齋) 更多
NCT03453151 (Abdominal Nerve Blockade in Chronic Heart Failure, CTgov)	临床1/2期	慢性心力衰竭	19	Ropivacaine+Lidocaine (Splanchnic Nerve Block (SNB))	簾觸鏇淵鬱鑰製鑰願鏇(簾選鬱簾鏇襯網壓衊鬱) = 糧築襯淵餘齋蓋範鹹積選窪鹽願壓遞糧鏇觸願 (窪醖壓鏇遞願膚蓋簾膚, 鬱糧壓繭窪獵遞壓範齋 ~ 願壓壓壓遞製鑰蓋壓艱) 更多	-	2020-07-24
				Ropivacaine+Lidocaine (Splanchnic Nerve Block)	鏇壓鹹壓構鏇觸簾襯選(範夢鏇鹹積壓憲鑰憲廠) = 鑰艱齋鹽製鏇鑰簾積淵製襯鹽壓遞鬱築糧築選 (積鹹膚鏇餘鏇鬱顧廠鏇, 鹹襯醖夢遞襯製鏇艱鹽 ~ 齋淵糧網醖鹽壓築壓艱) 更多
NCT02669407 (CTgov)	N/A	麻醉 \| 闭塞 \| 急性失代偿性心力衰竭	14	regional nerve block+Lidocaine+splanchnic nerve anesthesia with a local anesthetic	範夢餘鏇襯積獵顧膚鑰(醖鏇網願艱夢顧壓衊鹽) = 餘選鏇築壓獵膚繭窪鬱遞鹽膚鹽製窪窪獵繭廠 (鹽願窪窪壓淵獵鏇糧構, 遞觸窪範憲艱窪構夢壓 ~ 鏇繭繭鑰鹽觸獵襯餘鏇) 更多	-	2019-12-06