Folate binding protein (FBP) is highly over-expressed in breast, ovarian and endometrial cancers and is the source of immunogenic peptides (E39) that can stimulate cytotoxic T lymphocytes (CTL) to recognize and destroy FBP-expressing cancer cells in the laboratory. The purpose of this study is to test whether a peptide-based vaccine consisting of the E39 peptide mixed with the FDA-approved immunoadjuvant granulocyte macrophage colony-stimulating factor (GM-CSF) is safe and effective at inducing an in vivo peptide-specific immune response. Furthermore, the investigators intend to determine the best dose of the vaccine to utilize to produce this immunity most efficiently. The investigators will determine whether immunity to FBP will prevent clinical recurrence. Additionally, the investigators will compare these results with results from a trial utilizing the E75 peptide (from the HER2/neu protein) in ovarian and endometrial cancer patients in preparation for studying a combination vaccine.

开始日期2012-04-01

申办/合作机构

San Antonio Military Medical Center

100 项与 E39+GM-CSF vaccine(The University of Texas MD Anderson Cancer Center) 相关的临床结果

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100 项与 E39+GM-CSF vaccine(The University of Texas MD Anderson Cancer Center) 相关的转化医学

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100 项与 E39+GM-CSF vaccine(The University of Texas MD Anderson Cancer Center) 相关的专利（医药）

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311

项与 E39+GM-CSF vaccine(The University of Texas MD Anderson Cancer Center) 相关的文献（医药）

2024-12-01·POULTRY SCIENCE

Fermented blueberry pomace supplementation improves egg quality, liver synthesis, and ovary antioxidant capacity of laying hens

Article

作者: Azad, Md. Abul Kalam ; Chen, Ting ; Azad, Md Abul Kalam ; Li, Zhihua ; Qin, Binghua ; Lan, Wei ; Kong, Xiangfeng ; Cui, Yadong ; Wang, Haoran

The present study aimed to investigate the effects of dietary fermented blueberry pomace (FBP) supplementation on production performance, egg quality and nutritional value, plasma biochemical parameters, follicle number, reproductive hormones, lipid metabolism, and antioxidant capacity of laying hens during the late laying period. A total of 320 (345-d-old) Yukou Jingfen No. 8 laying hens were randomly divided into 4 groups, with eight replicates per group and 10 hens per replicate. The birds were fed a basal diet (control group) and a basal diet supplemented with 0.25, 0.5, and 1.0% FBP. The trial lasted 56 d. The results showed that FBP (0.25-1.0%) supplementation increased the egg albumen height and Haugh unit compared with the control group on d 14, while 0.5 to 1.0% FBP increased the eggshell thickness compared with the 0.25% FBP group on d 28 of the trial (P < 0.05). The methionine content in egg white was higher (P < 0.05) in the 1.0% FBP group compared with the 0.25% FBP group. The CAT activity in the ovary was increased (P < 0.05) in the FBP groups compared with the control group, while plasma GSH-PX activity was higher (P < 0.05) in the 1.0% FBP group compared with the 0.25% FBP and 0.5% FBP groups. Dietary FBP supplementation up-regulated (P < 0.05) gene expressions related to lipid metabolism in the liver (ACC, FAS, SCD1, and SREBP1) and yolk precursor synthesis (ESR2 and VTG II). Moreover, CYP11A1 expression in the ovary was up-regulated (P < 0.05) in the FBP groups compared with the control group, as well as in the 0.25% FBP group compared with the 1.0% FBP group. In summary, dietary FBP supplementation improved egg quality and nutritional value, ovarian antioxidant capacity, and yolk precursor synthesis, while 1.0% FBP had better effects than 0.25 and 0.5% doses.

2024-11-01·JOURNAL OF BIOTECHNOLOGY

Engineering Escherichia coli for D-allulose biosynthesis from glycerol

Article

作者: Dong, Zhen-Xing ; Guo, Qiang ; Zheng, Ling-Jie ; Fan, Li-Hai ; Luo, Xuan ; Zheng, Hui-Dong

D-allulose, a naturally occurring monosaccharide, is present in small quantities in nature. It is considered a valuable low-calorie sweetener due to its low absorption in the digestive tract and zero energy for growth. Most of the recent efforts to produce D-allulose have focused on in vitro enzyme catalysis. However, microbial fermentation is emerging as a promising alternative that offers the advantage of combining enzyme manufacturing and product synthesis within a single bioreactor. Here, a novel approach was proposed for the efficient biosynthesis of D-allulose from glycerol using metabolically engineered Escherichia coli. FbaA, Fbp, AlsE, and A6PP were used to construct the D-allulose synthesis pathway. Subsequently, PfkA, PfkB, and Pgi were disrupted to block the entry of the intermediate fructose-6-phosphate (F6P) into the Embden-Meyerhof-Parnas (EMP) and pentose phosphate (PP) pathways. Additionally, GalE and FryA were inactivated to reduce D-allulose consumption by the cells. Finally, a fed-batch fermentation process was implemented to optimize the performance of the cell factory. As a result, the titer of D-allulose reached 7.02 g/L with a maximum yield of 0.287 g/g.

2024-10-01·Physiological Reports

Fructose‐1,6‐bisphosphate reverses hypotensive effect caused by L‐kynurenine in Wistar male rats

Article

作者: Fernandes, Renata Streck ; Nunes, Fernanda Bordignon ; Catarina, Anderson Velasque ; Ferreira, Luis Fernando ; Caceres, Rafael Andrade ; Costa, Bruna Pasqualotto ; Machado, Kleiton Lima De Godoy ; Rigatto, Katya ; Becker, Tiago ; Branchini, Gisele ; de Oliveira, Jarbas Rodrigues

Abstract:

Hypotension is one of the main characteristics of the systemic inflammation, basically caused by endothelial dysfunction. Studies have shown that the amino acid L‐kynurenine (KYN) causes vasodilation in mammals, leading to hypotensive shock. In hypotensive shock, when activated by the KYN, the voltage‐gated potassium channel encoded by the family KCNQ (Kv7) gene can cause vasodilation. Fructose‐1,6‐bisphosphate (FBP) it is being considered in studies an anti‐inflammatory, antioxidant, immunomodulator, and a modulator of some ion channels (Ca2+, Na+, and K+). We analyzed the effects of KYN and FBP on mean blood pressure (MBP), systolic and diastolic (DBP) blood pressure, and heart rate variability (HRV) in Wistar rats. Results demonstrated that the administration of KYN significant decreased MBP, DBP, and increased HRV. Importantly, the FBP treatment reversed the KYN effects on MBP, DBP, and HRV. Molecular Docking Simulations suggested that KYN and FBP present a very close estimated free energy of binding and the same position into structure of KCNQ4. Our results did demonstrate that FBP blunted the decrease in BP, provoked by KYN. Results raise new hypotheses for future and studies in the treatment of hypotension resulting from inflammation.

100 项与 E39+GM-CSF vaccine(The University of Texas MD Anderson Cancer Center) 相关的药物交易

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研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
乳腺癌	临床2期	美国	Anderson University	-
乳腺癌	临床2期	-	The University of Texas MD Anderson Cancer Center	-
乳腺癌	临床2期	-	The Henry M. Jackson Foundation	-
乳腺癌	临床2期	-	Galena Biopharma, Inc.	-
子宫内膜癌	临床2期	美国	SELLAS Life Sciences Group, Inc.	-
子宫内膜癌	临床2期	-	The University of Texas MD Anderson Cancer Center	-
子宫内膜癌	临床2期	-	The Henry M. Jackson Foundation	-
子宫内膜癌	临床2期	-	Galena Biopharma, Inc.	-
卵巢癌	临床2期	美国	SELLAS Life Sciences Group, Inc.	-
卵巢癌	临床2期	-	Galena Biopharma, Inc.	-

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


AACR2016	临床1期	卵巢癌	51	E39’	壓夢蓋簾顧鑰艱膚積鏇(襯糧觸鑰糧選網範鬱鬱) = 選獵積鹽範齋築鏇齋餘糧窪餘選製鑰鏇鬱醖鬱 (觸衊醖願壓窪鏇範鹽齋 )	积极	2016-07-15
				E39 + GM-CSF	壓夢蓋簾顧鑰艱膚積鏇(襯糧觸鑰糧選網範鬱鬱) = 製網窪蓋夢製鏇簾遞鑰糧窪餘選製鑰鏇鬱醖鬱 (觸衊醖願壓窪鏇範鹽齋 )
NCT01580696 (Phase I/IIa Trial of Folate Binding Protein Vaccine in Ovarian Cancer, SITC2014)	临床2期	卵巢癌 \| 子宫内膜癌辅助 HLA-A2-	47	Vaccine Group (VG)	膚憲餘簾鑰獵遞鏇製積(鹽願艱膚範鏇築網鏇鏇) = 憲築繭窪鹹積構鏇糧蓋夢廠醖壓憲衊遞積夢鑰 (鏇鑰廠餘顧憲獵廠餘築 ) 更多	积极	2014-11-06
				folate binding protein (FBP) adjuvant cancer vaccine (E39+GM-CSF) (Control Group (CG))	膚憲餘簾鑰獵遞鏇製積(鹽願艱膚範鏇築網鏇鏇) = 獵憲淵簾鹹壓範膚製構夢廠醖壓憲衊遞積夢鑰 (鏇鑰廠餘顧憲獵廠餘築 ) 更多
SITC2013	临床1期	卵巢癌 \| 子宫内膜癌辅助 HLA-A2-	25	E39 vaccine 100mcg	餘遞齋壓遞遞襯廠壓網(蓋構獵構艱醖鹽遞餘餘) = 醖齋膚築遞鹹蓋糧遞膚積餘鬱觸製膚艱襯襯鬱 (齋製鑰醖範廠糧窪襯鑰 ) 更多	积极	2013-11-07
				E39 vaccine 500mcg	餘遞齋壓遞遞襯廠壓網(蓋構獵構艱醖鹽遞餘餘) = 製鹽餘齋願鹽餘製壓窪積餘鬱觸製膚艱襯襯鬱 (齋製鑰醖範廠糧窪襯鑰 ) 更多