Petrelintide

Company announcement – No. 2 / 2025 Zealand Pharma Announces Financial Results for the Full Year 2024 A transformational year with significant clinical advancement across differentiated obesity pipeline, while building the foundation for accelerated growth in the years to come Positive results with long-acting amylin analog petrelintide in 16-week Phase 1b trial and advancement into large, comprehensive Phase 2b trial in people with overweight or obesity Positive topline results with GLP-1/GLP-2 receptor dual agonist dapiglutide in 13-week Phase 1b trial and expansion of trial to investigate higher doses over a longer treatment period Positive results with glucagon/GLP-1 receptor dual agonist survodutide in Boehringer Ingelheim Phase 2 trial in MASH and advancement into largest Phase 3 MASH program with an incretin-based therapy DKK 8.5 billion (USD 1.2 billion) secured through two equity raises enabling significant investments in R&D pipeline and organizational capabilities Copenhagen, Denmark, February 20, 2025 - Zealand Pharma A/S (Nasdaq: ZEAL) (CVR-no. 20045078), a biotechnology company focused on the discovery and development of innovative peptide-based medicines, today announced financial results for the year ended December 31, 2024 and provided a corporate update. Driving innovation in obesity with differentiated mid- to late-stage pipeline “2024 was a transformational year for Zealand Pharma with positive data across our mid- to late-stage obesity pipeline and significant capital raised to further invest in our pipeline and the organization, preparing the company for the next phase of growth,” said Adam Steensberg, President and Chief Executive Officer at Zealand Pharma. “From this very solid foundation, both financially and organizationally, we expect accelerated momentum in 2025 with important clinical advancement of our obesity programs.” Key financial results for FY 2024 DKK millionFY 2024FY 2023Revenue62.7342.8Net operating expenses1-1,327.0-895.9Net operating result-1,272.2-572.2Net financial items188.8-136.6Cash position29,022.01,633.1 Notes:1. Net operating expenses consist of R&D, S&M, G&A and other operating items.2. Cash position includes cash, cash equivalents and marketable securities. Financial guidance for 2025 The strong cash position enables Zealand Pharma to significantly accelerate its investments in the company’s wholly-owned obesity programs, which in 2025 will include three large Phase 2b trials. Net operating expenses expected in 2025 are mostly driven by research and development. Development costs primarily relate to the clinical advancement of the wholly-owned obesity programs, including Phase 2b trials, CMC activities related to API and Drug Product, as well as Phase 3 preparations. Research costs are mainly driven by enhanced investments in next-generation peptide therapeutics focused on obesity and inflammation. DKK million 2025 Guidance2024 ActualRevenue anticipated from existing and new license and partnership agreementsNo guidance62.7Net operating expenses32,000 – 2,5001,327.0 Notes:3. Financial guidance based on foreign exchange rates as of February 19, 2025. Highlights of the year and key events anticipated in 2025 Obesity – advancing the differentiated pipeline Petrelintide, a long-acting amylin analog. Zealand Pharma reported positive results from the 16-week Phase 1b trial with petrelintide and presented the data at the Obesity Society Annual Meeting (ObesityWeek). In December 2024, the company subsequently initiated ZUPREME-1, a large, comprehensive Phase 2b trial in people with overweight or obesity and anticipates completion of participant enrolment in the first half of 2025. The company also expects to expand the development program of petrelintide by initiating ZUPREME-2, a Phase 2b trial in people with overweight or obesity and type 2 diabetes in the first half of 2025. Dapiglutide, a first-in-class GLP-1/GLP-2 receptor dual agonist. Zealand Pharma reported positive topline results from the 13-week Phase 1b trial with dapiglutide, providing support for advancing this candidate into a large Phase 2b trial in people with overweight or obesity, which is planned for initiation in the first half of 2025. The company also expanded the Phase 1b trial to evaluate higher doses of dapiglutide over a longer treatment period, with topline results from this part of the trial expected in the first half of 2025. Survodutide, a glucagon/GLP-1 receptor dual agonist. Boehringer Ingelheim reported positive results from the Phase 2 trial with survodutide in MASH, presented the data at the European Association for the Study of the Liver (EASL), and received a Breakthrough Therapy Designation from the U.S. FDA. Boehringer Ingelheim subsequently initiated two large registrational Phase 3 trials with survodutide in people with MASH; LIVERAGE™ in people with moderate or advanced liver fibrosis (stages 2 or 3) and LIVERAGE™-Cirrhosis in people with compensated cirrhosis (fibrosis stage 4). In 2024, Boehringer Ingelheim also completed participant enrolment for SYNCHRONIZE™-1 and SYNCHRONIZE™-2, the Phase 3 clinical trials of survodutide in people with overweight or obesity without and with type 2 diabetes, respectively. Rare diseases – long-term commitment to patients with CHI and SBS Dasiglucagon in congenital hyperinsulinism (CHI). Zealand Pharma is prepared to resubmit the New Drug Application (NDA) for three weeks of dosing to the U.S. FDA contingent on the third-party manufacturing facility receiving an inspection classification upgrade. Subsequently, Zealand Pharma also expects to submit the required and detailed analyses from existing continuous glucose monitoring datasets to support the use of dasiglucagon beyond three weeks. Glepaglutide in short bowel syndrome (SBS). In December 2024, Zealand Pharma received a Complete Response Letter (CRL) for the NDA for glepaglutide, a long-acting GLP-2 analog under development for the treatment of adults with SBS with intestinal failure. In 2025, the company expects to initiate a single placebo-controlled Phase 3 trial (EASE-5) to provide further confirmatory evidence for a regulatory submission in the U.S. and to support regulatory submissions for glepaglutide in geographies outside the U.S. and the EU. In parallel, Zealand Pharma anticipates proceeding with current plans to submit a Marketing Authorization Application to support EU approval. Chronic inflammation – progressing the pipeline ZP9830, Kv1.3 ion channel blocker. Zealand Pharma initiated the first-in-human clinical trial with ZP9830, a Kv.1.3 ion channel blocker in late 2024 and anticipates completing this trial in 2025. The company believes this candidate holds potential to treat a broad range of cell-mediated autoimmune diseases. Sustainability – building a sustainable organization In 2024, Zealand Pharma launched a refined sustainability strategy and developed a Climate Change Transition Plan, outlining activities and targets for climate change mitigation. The company will further accelerate its sustainability efforts in 2025, with key focus areas including the expected submission of the Climate Change Transition Plan to the Science Based Targets Initiative and continued preparations for the EU’s Corporate Sustainability Reporting Directive. Zealand Pharma achieved notable organizational growth in 2024 with a 30% increase in the number of employees compared to 2023. Yet, the company maintained its high employee engagement score of 8.8/10 and decreased the employee turnover rate from 10.3% in 2023 to 7.3% in 2024. Conference call today at 2 PM CET / 8 AM ET Zealand Pharma’s management will host a conference call today February 20 at 2:00 PM CET / 8:00 AM ET to present results for the full year 2024 followed by a Q&A session. Participating in the call will be Chief Executive Officer, Adam Steensberg; Chief Financial Officer, Henriette Wennicke; Chief Medical Officer, David Kendall; and Chief Commercial Officer, Eric Cox. The conference call will be conducted in English. The live listen-only audio webcast of the call and accompanying slide presentation will be accessible at https://edge.media-server.com/mmc/p/96nk8pep. To receive telephone dial-in information and a unique personal access PIN, please register at https://register.vevent.com/register/BI735075144114493ead489441f1d0740f. Participants are advised to register for the call or webcast approximately 10 minutes before the start. A recording of the event will be available following the call on the Investor section of Zealand Pharma’s website at https://www.zealandpharma.com/investors/events-presentations/. About Zealand Pharma Zealand Pharma A/S (Nasdaq: ZEAL) is a biotechnology company focused on the discovery and development of peptide-based medicines. More than 10 drug candidates invented by Zealand Pharma have advanced into clinical development, of which two have reached the market and three candidates are in late-stage development. The company has development partnerships with a number of pharma companies as well as commercial partnerships for its marketed products. Zealand Pharma was founded in 1998 and is headquartered in Copenhagen, Denmark, with a presence in the U.S. For more information about Zealand Pharma’s business and activities, please visit www.zealandpharma.com. Forward looking statements This company announcement contains “forward-looking statements”, as that term is defined in the Private Securities Litigation Reform Act of 1995 in the United States, as amended, even though no longer listed in the United States this is used as a definition to provide Zealand Pharma’s expectations or forecasts of future events regarding the research, development, and commercialization of pharmaceutical products, the timing of the company’s clinical trials and the reporting of data therefrom. These forward-looking statements may be identified by words such as “aim,” “anticipate,” “believe,” “could,” “estimate,” “expect,” “forecast,” “goal,” “intend,” “may,” “plan,” “possible,” “potential,” “will,” “would”, and other words and terms of similar meaning. You should not place undue reliance on these statements, or the scientific data presented. The reader is cautioned not to rely on these forward-looking statements. Such forward-looking statements are subject to risks, uncertainties and inaccurate assumptions, which may cause actual results to differ materially from expectations set forth herein and may cause any or all of such forward-looking statements to be incorrect, and which include, but are not limited to, unexpected costs or delays in clinical trials and other development activities due to adverse safety events or otherwise; unexpected concerns that may arise from additional data, analysis or results obtained during clinical trials; our ability to successfully market both new and existing products; changes in reimbursement rules and governmental laws and related interpretation thereof; government-mandated or market-driven price decreases for our products; introduction of competing products; production problems; unexpected growth in costs and expenses; our ability to effect the strategic reorganization of our businesses in the manner planned; failure to protect and enforce our data, intellectual property and other proprietary rights and uncertainties relating to intellectual property claims and challenges; regulatory authorities may require additional information or further studies, or may reject, fail to approve or may delay approval of our drug candidates or expansion of product labelling; failure to obtain regulatory approvals in other jurisdictions; exposure to product liability and other claims; interest rate and currency exchange rate fluctuations; unexpected contract breaches or terminations; inflationary pressures on the global economy; and political uncertainty, including due to the ongoing military conflict in Ukraine. If any or all of such forward-looking statements prove to be incorrect, our actual results could differ materially and adversely from those anticipated or implied by such statements. The foregoing sets forth many, but not all, of the factors that could cause actual results to differ from our expectations in any forward-looking statement. All such forward-looking statements speak only as of the date of this press release/company announcement and are based on information available to Zealand Pharma as of the date of this release/announcement. We do not undertake to update any of these forward-looking statements to reflect events or circumstances that occur after the date hereof. Information concerning pharmaceuticals (including compounds under development) contained within this material is not intended as advertising or medical advice. Contacts Anna Krassowska, PhD (Investors and Media)Vice President, Investor Relations & Corporate CommunicationsZealand PharmaEmail: akrassowska@zealandpharma.com Adam Lange (Investors)Investor Relations OfficerZealand PharmaEmail: alange@zealandpharma.com Neshat Anis Ahmadi (Investors)Investor Relations ManagerZealand PharmaEmail: neahmadi@zealandpharma.com Attachment Zealand Pharma 2024 Annual Report

诺和诺德2024：司美格鲁肽大卖292.96亿美元，惜败K药 2025年2月5日，诺和诺德公布了2024年度财报，全年营收2904亿丹麦克朗（约 421.49 亿美元），其中最具看点的就是“司美格鲁肽系列能否超越K药，登顶新药王”，结果是惜败。 具体而言，司美格鲁肽系列包括降糖注射版Ozempic、降糖口服版Rybelsus以及减重版Wegovy，三款产品销售额分别为1203.42 亿丹麦克朗（174.66 亿美元）、233.01 亿丹麦克朗（ 33.82 亿美元）以及582.06亿丹麦克朗（84.48 亿美元），总计销售额达到292.96亿美元，占到了诺和诺德总营收的约69.5%。 其中，Wegovy的增幅高达87%，不难看2025年司美格鲁肽登顶新药王几乎就是板上钉钉的事。结合去年12月份，诺和诺德宣布成功收购CDMO巨头Catalent，GLP-1产品的产能不足问题有望于今年得到缓解。 此外，作为诺和诺德老字号的胰岛素类产品，全年营收也达两位数增长（17%），具体包括依柯胰岛素、德谷胰岛、德谷胰岛素+利拉鲁肽（Xultophy）以及地特胰岛素的营收驱动。 目前，减重领域是当之无愧的红海，MNC、Biotech无不争相涌入，靶点更是百花齐放，GLP-1受体激动剂、GIP受体激动剂、MC4R激动剂、胰淀粉样多肽、胃饥饿素等等百花齐放。作为单靶点的司美格鲁肽无疑成为众玩家挑战的对象，其中礼来于去年12月宣布旗下Zepbound头对头Wegovy，前者减重效果高出后者47%。 作为反击，诺和诺德有高剂量Wegovy与CagriSema两张底牌，但临床数据均未达市场预期，索性其皮下注射amycretin在早期研究中报阳，以此有望直接“对标”礼来Zepbound或Retatrutide。推荐阅读：36周减重22%！又一重磅GLP-1产品公布临床结果，2025年还有哪些减重产品值得期待？ 最后，据知名行业媒体endpoints news统计，2025年，除了amycretin，Metsera的MET-097i、Zealand的Petrelintide等多款减重明星产品都将公布最新临床进展，值得关注。 GSK2024：肿瘤管线同比增长98%，2025年5款产品有望上市 2025年2月5日，GSK公布2024年业绩，全年营收313.76亿英镑（约401.27亿美元），同比增长7%。GSK业务分为特药、疫苗以及普药三大板块，其中疫苗板块2024年呈下降趋势（-4%），普药板块小幅度增加（6%），特药板块全年营收118.10亿英镑（约151.05 亿美元），增幅达两位数（19%）。 具体而言，特药板块中HIV药物仍为营收支柱，包括多替拉韦产品组合共计共收入70.89亿英镑，同比增长13%。其次就是肿瘤产品的翻倍增长，同比增长98%至14.10亿英镑。莫洛昔尼与PD-1单抗Jemperli2024年销售额涨幅均超过100%，全年营收分别为3.53 亿英镑和4.67亿英镑。其次，PARP抑制剂尼拉帕利实现17%的同比增长，全年销售额为5.93亿英镑。 2025年，GSK预计有5款产品有望获得监管机构批准，具体包括：多发性骨髓瘤药物Blenrep（BCMA ADC ）、哮喘药物Depemokimab（长效IL-5抗体）、COPD新药Nucala（IL-5抗体）、20多年来首个用于治疗尿路感染的新型口服抗生素Gepotidacin以及五价脑膜炎球菌疫苗MenABCWY。 默沙东2024：K药大卖294.82亿美元，暂停供应中国HPV疫苗 2025年2月4日，默沙东公布了2024年财报。第四季度全球销售额达156亿美元，全年总营收达641.68亿美元，同比增长了7%，净利润大幅提升，达到了171.17亿美元。 具体产品方面，K药表现依旧亮眼，全年销售额达294.82亿美元，同比增长18%，占全年总额的45.94%。值得一提的是，历史上很少有一款药能像K药这般，上市十年依旧保持每年近20%的稳步增长，其背后核心是默沙东倾尽全力拓展K药的临床适应症。通过ClinialTrial检索，K药的注册数超过1400项，规模之大，绝无仅有。 然而未来五年，K药、西格列汀/二甲双胍、来特莫韦等重磅产品均将面临专利悬崖，如何选择接棒产品对默沙东而言至关重要。根据近两年的BD交易金额浅析，默沙东共计338亿美元牵手科伦博泰与第一三共，重金押入ADC领域可见仍将重心放在肿瘤学领域。 此外，本次财报中默沙东另一大核心营收支柱HPV疫苗Gardasil营收不及预期，同比下降3%。默沙东宣布将暂停向中国供应Gardasil，预计将持续至少到今年年中。作为代理商的智飞生物采购压力大幅减轻，这一暂停有助于减少过剩库存。因此，默沙东2025年业绩展望下调，预计今年销售额将在641亿美元至656亿美元之间。受此消息影响，默沙东当日股价盘后大跌9.07%，报90.74美元/股。 辉瑞2024：ADC产品营收超32亿美元，终止开发B7-H4 ADC 2025年2月4日，辉瑞也公布了2024年财报，全年营收636.27亿美元，同比增长7%，剔除COVID相关产品后，收入同比增长12%（高于预期的9-11%）。 具体产品方面，口服抗凝药阿哌沙班（Eliquis）仍为辉瑞核心收入支柱，2024年全年销售额达73.66亿美元，同比增长10%；首款同时获批急性治疗和预防的CGRP靶向药物Nurtec ODT/Vydura快速放量，全年销售额为12.63亿美元，同比增长36%；唯一获批的ATTR-CM口服疗法Vyndaqel/Vyndamax以及RSV疫苗ABRYSVO收入变现强劲，值得关注。 令人意外的是，两款COVID产品Paxlovid和Comirnaty仍为辉瑞带来了110.69亿美元的产品营收，较去年的124.99亿美元，降低幅度尚在预期之内。此外，辉瑞借助COVID红利斥430亿美元巨资收购Seagen之后，也逐渐得到回报。其中，旗下四款ADC产品Padcev（Nectin-4）、Adcetris（CD30）、Tukysa（HER2）以及Tivdak（TF）分别营收15.88亿美元、10.89亿美元、4.80亿美元以及1.31亿美元，合计32.88亿美元。 此外，值得一提的是，辉瑞宣布披露了关于ADC候选产品12亿美元的无形资产减值，其中包括终止开发B7-H4 ADC药物B7H4V，该产品为收购Seagen所得，以及一款HER2 ADC药物Disitamab vedotin，Seagen拥有其亚洲以外独家权益，原研为荣昌生物。 艾伯维2024：自免新药接棒昔日“药王” 2025年1月31日，艾伯维公布2024年业绩，全年营收563.34亿美元，同比增长3.7%。其中自免领域营收达266.82亿美元，占总营收的47.36%。其中昔日药王修美乐全年销售额达89.93亿美元，同比下滑37.6%；IL-23单抗Skyrizi（利生奇珠单抗）全年营收117.18亿美元，同比增长50.9%；JAK1抑制剂Rinvoq（乌帕替尼）全年营收59.71亿美元，同比增长50.4%。虽修美乐面对专利悬崖，商业化逐渐呈现疲态，但利生奇珠单抗与乌帕替尼强势接棒，去年上述三款产品均均进入免疫赛道产品销量前十。 近年来，艾伯维通过一系列的license-in交易和收购，不断扩大其在自免市场的覆盖范围。仅2024年，艾伯维先后与OSE Immunotherapeutics、Parvus Therapeutics、明济生物达成了自免产品开发合作，并相继收购了Landos Biopharma、Celsius Therapeutics以及Nimble Therapeutics三家Biotech，披露总交易金额超30亿美元。 诺华2024：沙库巴曲缬沙坦大卖78亿美元，终止一项终止CD40抗体临床试验 2025年1月31日，诺华公布2024年业绩，全年营收503.17亿美元，同比增长12%，两位数的增长幅度，在一众MNC中当属前列。其原因在于诺华聚焦的四大治疗领域心血管-肾脏-代谢、免疫、神经科学和肿瘤均达成了两位数增长。 具体产品而言，心衰药物Entresto（沙库巴曲缬沙坦）、银屑病治疗药物Cosentyx（司库奇尤单抗）以及多发性硬化症药物Kesimpta营收占据前三甲，销售额分别为78.22亿美元、61.41亿美元以及32.24亿美元。 其中，沙库巴曲缬沙坦作为十年老药，专利到期，诺华为防止仿制药进入美国市场，与仿制药企MSN Pharma进行法律博弈近3年，今年1月美国联邦巡回上诉法院暂时禁止 MSN Pharma 将其 Entresto 仿制药商业化，诺华利用法律武器小胜一筹。其次，Entresto进入了美国第一轮医保谈判名单，如果2026年能顺利执行，该药也将面临大幅（53%）降价。 除了上述主要营收产品，胆固醇药物Leqvio成为诺华增长最快的产品，销售额飙升114%，达7.54亿美元。此外，诺华还在财报中披露，将终止CD40抗体iscalimab在干燥综合征方面的开发，认为其在风险获益评估中不具备竞争力。此前，赛诺菲的CD40L抗体frexalimab也在干燥综合征上折戟，目前诺华仍有一款靶向BAFF-R的单克隆抗体Ianalumab在进行干燥综合征的临床试验。 罗氏2024：Vabysmo冲击眼科药王，连砍十条管线或将彻底放弃TIGIT？ 2025年1月30日，罗氏公布2024年财报。全年总营收604.95亿瑞士法郎（约664亿美元）同比增长7%，净收入91.87亿瑞士法郎（约101亿美元），同比下降19%。 具体产品方面，眼科用药Vabysmo（法瑞西单抗）成为罗氏2024年主要增长动力，该药物全年销售额达38.64亿瑞士法郎（约42.43亿美元），同比增长68%，得益于此，罗氏眼科领域增长幅度最高，达44%。此外，乳腺癌药物Phesgo（曲妥珠单抗+帕妥珠单抗皮下制剂）的销售额达到了17.40亿瑞士法郎（约19.82亿美元），同比增长62%。 值得一提的是，在本次财报中罗氏一口气终止了十个临床试验，其中围绕TIGIT单抗tiragolumab就砍了4个，包括两项II期研究（转移性头颈部鳞状细胞癌+非小细胞肺癌）以及两项三期研究（PDL1高表达非小细胞肺癌+食管鳞状细胞癌）。推荐阅读：罗氏砍掉十条管线？彻底放弃TIGIT？ 去年，罗氏tiragolumab两次折戟非小细胞肺癌，默沙东Vibostolimab同样在黑色素瘤、非小细胞肺癌等治疗领域接连受挫，后者于去年12月宣布正式退出。无独有偶，此前已有BMS于诺华相继退货TIGIT产品。随着MNC的陆续退场，曾经顶流的TIGIT靶点，疑云密布。尽管如此，罗氏并未彻底放弃TIGIT产品，目前仍有五项III期临床研究正在进行，涵盖NSCLC、食管癌和肝癌等领域。 赛诺菲2024：Dupixent大卖131亿欧元， 2025年1月30日，赛诺菲公布2024年业绩，营收410.81亿欧元（约445.61亿美元，同比增长11.3%。 具体产品而言，Dupixent（度普利尤单抗）无疑是最亮眼的，全年营收130.72亿欧元（约141.79亿美元），同比增长23.1%，成为继修美乐之后新晋自免药王。去年，度普利尤单抗在欧美中三地斩获慢阻肺病（COPD）适应症，直击百亿蓝海市场，截止日前度普利尤单抗已取得了12个适应症。 此外，赛诺菲还有9款新上市药企快速放量，销售额总计达45亿欧元，其中RSV抗体Beyfortus上市两年就买入重磅炸弹之列，全年营收16.86亿欧元（约18.29亿美元），同比增长214.4%。 值得一提的是，赛诺菲在公布2024年财报的同时，也宣布启动50亿欧元的股票回购计划。即从大股东欧莱雅手中回购约2.3%赛诺菲股份，售价为每股101.5欧元，交易总额达到30亿欧元（约合31.1亿美元），以此抵消剥离消费者保健业务（Opella）所带来的影响。 封面图来源：123rf DeepSeek | 点评康方生物依沃西等10款2025年有望获批的潜在First-In-Class药物 2025-02-04 DeepSeek预测：2035-2040年间，首位华人跨国药企CEO有望诞生 2025-02-03 用火热的DeepSeek帮助设计1期临床试验方案。您对结果满意吗？ 2025-02-02 版权声明/免责声明 本文为汇编文章。 本文仅作信息交流之目的，不提供任何商用、医用、投资用建议。 文中图片、视频、字体、音乐等素材或为药时代购买的授权正版作品，或来自微信公共图片库，或取自公司官网/网络，部分素材根据CC0协议使用，版权归拥有者，药时代尽力注明来源。 如有任何问题，请与我们联系。 衷心感谢! 药时代官方网站:www.drugtimes.cn 联系方式: 电话:13651980212 微信:27674131 邮箱:contact@drugtimes.cn 点击，查看更多精彩!