醋酸钙/碳酸镁(Calcium Acetate/Magnesium Carbonate) - 药物靶点：Phosphates_在研适应症：高磷血症_专利_临床

概要

基本信息

药物类型

小分子化药

别名

OsvaRen、Rephoren

靶点

Phosphates

作用机制

Phosphates 调节剂(磷酸盐调节剂)

治疗领域

在研适应症

非在研适应症

原研机构

在研机构

Fresenius Medical Care Zion LLC

Fresenius Kabi AG

非在研机构

Fresenius Medical Care Deutschland GmbH

最高研发阶段批准上市

首次获批日期

德国 (2006-07-01),

高磷血症

最高研发阶段(中国)-

特殊审评-

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结构

分子式C6H12CaMg2O10

InChIKeyBAWGBFZDYGEMLQ-UHFFFAOYSA-N

CAS号1173882-48-8

关联

2

项与醋酸钙/碳酸镁相关的临床试验

NCT02027662 / Completed临床2/3期

Study to Investigate Efficacy and Safety Equivalence of OsvaRen® Tablets and OsvaRen® Granules

Phosphate binders are crucial to the control of elevated phosphate levels in patients with chronic kidney disease. With the new formulation of granules the pill burden of patients is sought to be reduced.
This study is about efficacy and safety of the new drug formulation and compares it to the "old" formulation which are film-coated tablets.

开始日期2014-01-01

申办/合作机构

Fresenius Medical Care Deutschland GmbH

EUCTR2012-004178-24-DE / Not yet recruitingN/A

Study to investigate the therapeutic equivalence of OsvaRen® tablets and OsvaRen® granules - OsvaRen NEW

开始日期2013-12-27

申办/合作机构

Fresenius Medical Care Deutschland GmbH

100 项与醋酸钙/碳酸镁相关的临床结果

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100 项与醋酸钙/碳酸镁相关的转化医学

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100 项与醋酸钙/碳酸镁相关的专利（医药）

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6

项与醋酸钙/碳酸镁相关的文献（医药）

2021-03-01·Waste Management1区 · 环境科学与生态学

Dried sludge reburning blended with calcium magnesium acetate addition in a fluidized bed combustor

1区 · 环境科学与生态学

Article

作者: Li, Zhi ; Zhang, Li-Hui ; Yang, Shou-Meng ; Duan, Feng

The combustion and pollutant emission characteristics of the dried sludge in a fluidized bed combustor (FBC) were studied. The sludge reburning technology was employed for the first time in FBC. A scheme for using the dried sludge reburning blended with calcium magnesium acetate (CMA) to reduce pollutants simultaneously was also proposed, and the effect of the CMA addition was investigated. Results showed that fluidized bed reburning technology can be used to effectively treat the sewage sludge with lower calorific values. As the secondary fuel mass percentage increases, the unburned carbon content in fly ash and the CO emission increase, resulting in lower combustion efficiency. However, the de-NO ratio increases from 37.1% to 53.7%, and the de-SO₂ ratio only increased from 1.6% to 7.6% as the secondary fuel mass percentage increase from 10% of 25%. For dried sludge blended with CMA, the minimum emissions of SO₂ and NO significantly decrease to 254 mg/Nm³ and 70.9 mg/Nm³ at Ca/S ratio of 2, respectively. Results of main gaseous pollutant emissions from the sludge combustion in an FBC using different pollutant removal methods were compared under well-defined conditions. Fuel reburning blended with CMA addition has the smallest SO₂ and NO emissions.

2015-12-01·Bioresource Technology1区 · 工程技术

Effect of calcium magnesium acetate on the forming property and fractal dimension of sludge pore structure during combustion

1区 · 工程技术

Article

作者: Feng Duan ; Yaji Huang ; Lihui Zhang ; Chiensong Chyang

The changes in pore structure characteristics of sewage sludge particles under effect of calcium magnesium acetate (CMA) during combustion were investigated, the samples were characterized by N2 isothermal absorption method, and the data were used to analyze the fractal properties of the obtained samples. Results show that reaction time and the mole ratio of calcium to sulfur (Ca/S ratio) have notable impact on the pore structure and morphology of solid sample. The Brunauer-Emmett-Teller (BET) specific surface area (SBET) of sample increases with Ca/S ratio, while significant decreases with reaction time. The fractal dimension D has the similar trend with that of SBET, indicating that the surface roughness of sludge increases under the effect of CMA adding, resulting in improved the sludge combustion and the desulfurization process.

2014-07-01·Kidney International1区 · 医学

Does mild hypermagnesemia increase risk of PTH oversuppression?

1区 · 医学

Letter

作者: Rodriguez, Mariano ; de Francisco, Ángel L M

To the Editor: We read with great interest the article by Sakaguchi et al.¹ on a cohort study of 142,555 hemodialysis patients investigating the relationship of serum magnesium (Mg) with mortality risk as well as the comment by Courivaud and Davenport.² The authors observed a J-shaped association of Mg serum levels and mortality.They argue that the increasing risk of cardiovascular disease-associated mortality in the highest Mg sextile might be attributable to some extent to parathyroid hormone (PTH) oversuppression.Courivaud and Davenport² therefore advise caution, as oversuppressing PTH by mild hypermagnesemia may lead to adynamic bone disease.Recently, we could demonstrate in vitro that PTH suppression by Mg is mainly observed when moderately low calcium (Ca) concentrations are present.³ Mean Ca levels of the Japanese patients were 9.3±0.9 mg/dL, and hence well in the normal range.Further, clin. data of the CALcium acetate MAGnesium carbonate (CALMAG) study and its post hoc evaluation⁴ revealed that mean serum Mg levels of 3.11 mg/dL (1.279 mmol/l) in the CaAc/MgCO₃ group were not paralleled by changes of PTH and/or bone turnover markers.The serum Mg levels found in that study were equivalent to the levels at the lower end of the highest sextile in the Japanese cohort.Even though we fully agree with the authors that prospective studies on Mg supplementation for investigating its influence on bone are highly needed to fully answer this question, we feel that a general relationship of increased serum Mg levels and adynamic bone disease is not supported by existing studies.

100 项与醋酸钙/碳酸镁相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	-	V03AE04	-

研发状态

批准上市

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
高磷血症	德国	Fresenius Kabi AG	2006-07-01

未上市

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
慢性肾病	临床3期	德国	Fresenius Medical Care Deutschland GmbH	2014-01-01
高磷血症	临床3期	德国	Fresenius Medical Care Deutschland GmbH	2014-01-01

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


SP643 (ERA2015)	N/A	慢性肾病	72	Sevelamer Carbonate	(夢鑰夢觸願餘範餘壓鏇) = 網膚網蓋襯鬱膚膚鬱壓鹹壓夢窪淵觸窪蓋獵鏇 (淵網構鬱構獵窪鏇膚鹹 )	积极	2015-05-21
				Lanthanum Carbonate	(夢鑰夢觸願餘範餘壓鏇) = 餘鏇憲襯簾構膚顧製廠鹹壓夢窪淵觸窪蓋獵鏇 (淵網構鬱構獵窪鏇膚鹹 )