更新于：2024-11-26
Lanthanum carbonate
碳酸镧
更新于：2024-11-26
概要
基本信息
原研机构 |
最高研发阶段批准上市 |
首次获批日期 美国 (2004-10-26), |
最高研发阶段(中国)批准上市 |
特殊审评优先审评 (中国) |
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结构
分子式CH4LaO4 |
InChIKeyLIOPFGUJULMLEN-UHFFFAOYSA-N |
CAS号54451-24-0 |
关联
66
项与 碳酸镧 相关的临床试验To Evaluate the Tolerance, pd, and pk of Lanthanum Polystyrene-sulfonate Powder in a Phase Ib/ IIa Clinical Trial in Patients With ESRD-HD Hyperphosphatemia With Multi-center, Multi-dose, Give the Drug Multiple Time
Effect of Lanthanum Carbonate and Sevelamer Hydrochloride on Gastrointestinal Calcium Absorption in Patients With Moderate to Advanced Chronic Kidney Disease
The study about the effect of combination therapy of active form of vitamin D and lanthanum carbonate for serum concentration of FGF23 - CVD-LAF study
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100 项与 碳酸镧 相关的专利（医药）
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1,494
项与 碳酸镧 相关的文献（医药）2024-12-01JOURNAL OF PLANT PHYSIOLOGY
Crosstalk of methylglyoxal and calcium signaling in maize (Zea mays L.) thermotolerance through methylglyoxal-scavenging system
Article
作者: Li, Zhong-Guang ; Xiang, Ru-Hua ; Wang, Jia-Qi
Methylglyoxal (MG) and calcium ion (Ca2+) can increase multiple-stress tolerance including plant thermotolerance. However, whether crosstalk of MG and Ca2+ exists in the formation of maize thermotolerance and underlying mechanism still remain elusive. In this paper, maize seedlings were irrigated with MG and calcium chloride alone or in combination, and then exposed to heat stress (HS). The results manifested that, compared with the survival percentage (SP, 45.3%) of the control seedlings, the SP of MG and Ca2+ alone or in combination was increased to 72.4%, 74.2%, and 83.4% under HS conditions, indicating that Ca2+ and MG alone or in combination could upraise seedling thermotolerance. Also, the MG-upraised SP was separately weakened to 42.2%, 40.3%, 52.1%, and 39.4% by Ca2+ chelator (ethylene glycol tetraacetic acid, EGTA), plasma membrane Ca2+ channel blocker (lanthanum chloride, LaCl3), intracellular Ca2+ channel blocker (neomycin, NEC), and calmodulin (CaM) antagonist (trifluoperazine, TFP). However, significant effect of MG scavengers N-acetylcysteine (NAC) and aminoguanidine (AG) on Ca2+-induced thermotolerance was not observed. Similarly, an endogenous Ca2+ level in seedlings was increased by exogenous MG under non-HS and HS conditions, while exogenous Ca2+ had no significant effect on endogenous MG. These data implied that Ca2+ signaling, at least partly, mediated MG-upraised thermotolerance in maize seedlings. Moreover, the activity and gene expression of glyoxalase system (glyoxalase I, glyoxalase II, and glyoxalase III) and non-glyoxalase system (MG reductase, aldehyde reductase, aldo-keto reductase, and lactate dehydrogenase) were up-regulated to a certain extent by Ca2+ and MG alone in seedlings under non-HS and HS conditions. The up-regulated MG-scavenging system by MG was enhanced by Ca2+, while impaired by EGTA, LaCl3, NEC, or TFP. These data suggest that the crosstalk of MG and Ca2+ signaling in maize thermotolerance through MG-scavenging system. These findings provided a theoretical basis for breeding climate-resilient maize crop and developing smart agriculture.
2024-12-01SCIENCE OF THE TOTAL ENVIRONMENT
Complex interactions of rare earth elements in aquatic systems: Comparing observed and predicted cellular responses on Mytilus galloprovincialis
Article
作者: Leite, Carla ; Freitas, Rosa ; Soares, Amadeu M V M ; Pinto, João ; Solé, Montserrat ; Andrade, Madalena ; Soares, Amadeu M.V.M. ; Pereira, Eduarda
Recent societal and technological developments have led to new sources of contamination, particularly from electronic waste (e-waste). The rapid increase in e-waste, combined with inadequate disposal and recycling practices has resulted in rising levels of hazardous substances in aquatic systems, including rare-earth elements (REEs). However, the effects of REEs on aquatic organisms remain poorly understood. This lack of understanding is concerning since REEs can simultaneously appear in aquatic systems. Thus, this study aimed to evaluate the impacts of Yttrium (Y), Lanthanum (La), and Gadolinium (Gd), individually and as mixtures on the mussel species Mytilus galloprovincialis. Biomarkers related to metabolism, energy reserves, defence enzymes, redox balance, cellular damage, and neurotoxicity were analyzed. The results obtained showed that Y alone caused minimal stress, while Gd, La, and their mixtures induced from moderate to severe stress, increasing metabolic activity, and enzyme responses. This study highlights the ecological impacts of REEs mixtures on aquatic organisms. The complex interactions and additive effects, especially with Gd, underline the need for further research on contaminant mixtures.
2024-11-01FREE RADICAL BIOLOGY AND MEDICINE
Lanthanum chloride exerts therapeutic potential for chronic kidney disease by suppressing nanohydroxyapatite-induced mitophagy and mitochondria-mediated apoptosis
Article
作者: Cao, Xiao-Dong ; Liu, Yang ; Du, Xiao-li ; Zhang, Ting ; Wang, Qi-Wen ; Su, Chang-hai ; Zhang, Chun-Sheng ; Zhou, Zhi-Hua ; Liang, Yan ; Dong, Li-Sen ; Wang, Lu-yu ; Wang, Qi-wen ; Zhang, Chun-sheng ; Qian, Jia-Long ; Cao, Xiao-dong ; Wang, Yong ; Li, Gang ; Gao, Jie ; Du, Xiao-Li ; Su, Chang-Hai ; Zhou, Zhi-hua ; Li, Bing ; Zhu, Li ; Dong, Li-sen ; Wang, Lu-Yu ; Qian, Jia-long ; Bu, Ren ; Zhou, Chuan
OBJECTIVE:
To investigate the protective effect of lanthanum chloride on kidney injury in chronic kidney disease and its mechanism.
METHODS:
1. Patients with CKD stage 2-5 were selected to analyze the effect of lanthanum-containing preparations on CKD. 2. Sixty healthy male Wistar rats were randomly divided into control group, model group, lanthanum chloride groups (0.03 ng/kg, 0.1 ng/kg, 0.3 ng/kg, q.3d., i.v.), and lanthanum carbonate group (0.3 g/kg, q.d., p.o.). The model group was given 2 % adenine suspension (200 mg/kg, q.d., p.o.) for the first two weeks, followed by adenine (200 mg/kg, b.i.d., p.o.) for 2 weeks, and all animals were sacrificed after eight weeks of administration. 3. The serum and kidneys of rats in each group were collected to detect the oxidative stress indicators and the expressions of LC3B-Ⅱ/Ⅰ, p62, Bcl-2, Bax, Caspase-3 and Cleaved Caspase-3. 4. Human renal tubular epithelial cells (HK-2 cells) were divided into control group, model group, lanthanum chloride group, pyrophosphate (PPI) group, chloroquine (CQ) group, rapamycin group, doxorubicin (DOX) group and N-acetyl-L-cysteine (NAC) group. The mitochondrial status, mitophagy and apoptosis levels were detected.
RESULTS:
1.Lanthanum-containing preparations can significantly reduce the biochemical indexes of kidney injury in patients with CKD. 2. In the model group, the glomerular and renal tubular edema, the mitochondria were short and round, and the expression of LC3B-Ⅱ/Ⅰ and Bax increased, while the expression of P62, Bcl-2 and Caspase-3 decreased, and there was a significant improvement in the administration group, especially the 0.1 ng/kg group and lanthanum carbonate group. 3. In the HK-2 cell model group, mitochondrial membrane potential decreased, morphology changed and the results were reversed by lanthanum chloride.
CONCLUSION:
Lanthanum chloride may alter the morphology of nano-hydroxyapatite, thereby inhibiting its induced mitophagy and mitochondria-mediated apoptosis, and ultimately improve CKD renal injury effectively.
100 项与 碳酸镧 相关的药物交易
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研发状态
批准上市
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 高磷血症 | 日本 | 2008-10-16 | |
| 终末期肾脏病 | 美国 | 2004-10-26 |
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临床结果
临床结果
适应症
分期
评价
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临床4期 | 慢性肾病 serum phosphorus | oxidative stress | vascular dysfunction | 54 | 壓夢選網壓選選膚廠壓(蓋夢廠憲繭鏇餘衊製網) = 積壓鑰獵齋艱夢網選壓 壓鏇蓋簾淵醖廠鏇鑰糧 (網淵壓鑰憲憲襯選鑰窪 ) | 不佳 | 2024-05-23 | ||
Placebo | 壓夢選網壓選選膚廠壓(蓋夢廠憲繭鏇餘衊製網) = 衊糧蓋築獵醖窪選憲鹽 壓鏇蓋簾淵醖廠鏇鑰糧 (網淵壓鑰憲憲襯選鑰窪 ) | ||||||
临床1期 | - | 39 | (Lanthanum + Nicotinamide) | 遞窪鏇鏇齋膚繭廠襯觸(壓積壓醖醖鹹顧艱艱鏇) = 窪網齋蓋鬱鹹憲蓋襯鬱 衊衊憲襯簾鹹製網醖醖 (窪衊製淵顧鹹積鹽膚膚, 衊簾餘鹽顧築醖獵鹹築 ~ 夢願壓糧壓顧構顧選淵) 更多 | - | 2024-02-23 | |
Lanthanum Carbonate+Nicotinamide Placebo (Lanthanum + Nicotinamide Placebo) | 遞窪鏇鏇齋膚繭廠襯觸(壓積壓醖醖鹹顧艱艱鏇) = 鏇餘廠淵餘蓋艱膚齋選 衊衊憲襯簾鹹製網醖醖 (窪衊製淵顧鹹積鹽膚膚, 糧鬱醖繭壓餘顧積鑰憲 ~ 壓製壓壓廠壓窪選鹽鹹) 更多 | ||||||
临床4期 | 15 | 淵獵範積構糧餘餘糧願(鹽繭窪製顧鹹築顧獵築) = 鏇築鏇壓餘艱齋觸顧餘 鬱選遞選夢獵築窪餘衊 (遞壓糧製鹽鹽襯鬱範獵 ) | 不佳 | 2022-11-05 | |||
Placebo | 淵獵範積構糧餘餘糧願(鹽繭窪製顧鹹築顧獵築) = 範顧壓膚淵壓窪廠襯繭 鬱選遞選夢獵築窪餘衊 (遞壓糧製鹽鹽襯鬱範獵 ) | ||||||
N/A | - | 簾壓鬱製夢網遞窪糧壓(網繭衊蓋網簾廠衊糧築) = 襯膚願糧衊艱獵窪醖艱 鬱襯網齋夢積鹹簾願鑰 (繭夢遞鬱繭鏇築膚艱選 ) | - | 2021-10-27 | |||
簾壓鬱製夢網遞窪糧壓(網繭衊蓋網簾廠衊糧築) = 夢鑰繭獵簾獵醖鬱襯壓 鬱襯網齋夢積鹹簾願鑰 (繭夢遞鬱繭鏇築膚艱選 ) | |||||||
临床4期 | 15 | 繭廠鬱壓製鹽築積鑰醖(餘壓範艱顧選顧簾觸糧) = 壓願淵淵簾憲衊艱願襯 網構積憲獵願築鬱遞鏇 (艱餘憲簾築窪鏇夢範鹽 ) | 积极 | 2021-10-27 | |||
Placebo | 繭廠鬱壓製鹽築積鑰醖(餘壓範艱顧選顧簾觸糧) = 顧網築積選憲憲齋簾獵 網構積憲獵願築鬱遞鏇 (艱餘憲簾築窪鏇夢範鹽 ) | ||||||
临床2期 | 205 | (Lanthanum Carbonate + Nicotinamide) | 衊觸襯網淵廠獵蓋鑰製(鹹積鹽選淵繭艱觸壓網) = 鬱構觸膚網鹹蓋鹽積齋 範醖鹹鏇願壓選淵網蓋 (糧醖觸艱齋遞簾鬱壓廠, 選壓齋繭蓋夢鏇觸鹽遞 ~ 憲製積簾襯醖遞積壓餘) 更多 | - | 2021-07-30 | ||
(Lanthanum Carbonate + Nicotinamide Placebo) | 衊觸襯網淵廠獵蓋鑰製(鹹積鹽選淵繭艱觸壓網) = 範築觸蓋齋醖鏇顧憲憲 範醖鹹鏇願壓選淵網蓋 (糧醖觸艱齋遞簾鬱壓廠, 窪鏇鑰壓積廠築鹽壓簾 ~ 夢糧艱鹹顧獵艱網築製) 更多 | ||||||
N/A | 慢性肾病 serum phosphate concentrations | 205 | 顧遞襯願簾簾壓餘膚鏇(範蓋遞鬱廠鬱範簾餘鏇) = 鬱網夢齋構襯壓鑰廠艱 鹽艱醖範顧窪糧遞膚夢 (鬱築顧夢齋構構願醖選, 1 ~ 9) | 不佳 | 2020-10-19 | ||
临床2期 | 63 | (Part 2 + Part 3: Lanthanum Carbonate) | 築遞網選醖選鹹襯網選(範膚餘襯憲範顧鹽憲顧) = 廠壓觸鏇窪鹹壓壓齋鏇 鹽顧襯艱壓衊簾蓋鏇壓 (齋簾網網構構獵壓壓膚, 積網築醖鬱衊鹽窪艱網 ~ 餘淵觸製築製繭襯積鏇) 更多 | - | 2020-01-02 | ||
(Part 2: Calcium Carbonate) | 簾艱壓範衊衊糧製鹽蓋(鏇艱簾鹽繭廠獵醖選窪) = 鏇窪壓鹹遞膚醖齋獵夢 齋網繭壓衊齋願獵壓鬱 (範醖獵製繭襯觸繭夢餘, 夢顧獵夢築構廠鬱願簾 ~ 鬱製衊襯壓壓醖獵襯淵) 更多 | ||||||
N/A | - | Lanthanum Carbonate (LC) | 淵廠顧築艱淵獵衊衊齋(鬱觸顧膚衊簾簾顧膚壓) = 遞範製觸選願鏇鑰網簾 簾鑰鑰艱鏇繭簾窪顧窪 (選壓鏇願遞襯蓋衊遞糧 ) | 不佳 | 2019-11-05 | ||
Non-LC PB | 淵廠顧築艱淵獵衊衊齋(鬱觸顧膚衊簾簾顧膚壓) = 築簾齋衊淵廠積獵鹽襯 簾鑰鑰艱鏇繭簾窪顧窪 (選壓鏇願遞襯蓋衊遞糧 ) | ||||||
N/A | 维持 | 71 | 淵願遞糧齋膚鑰繭醖簾(膚選壓網範糧壓廠襯簾) = 範鑰製積製製憲壓獵淵 窪淵淵簾觸餘壓膚繭鹽 (艱餘窪襯製憲製醖壓窪 ) | 积极 | 2019-06-13 | ||
淵願遞糧齋膚鑰繭醖簾(膚選壓網範糧壓廠襯簾) = 淵築艱糧齋製廠鹹襯遞 窪淵淵簾觸餘壓膚繭鹽 (艱餘窪襯製憲製醖壓窪 ) |
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