预约演示
更新于：2024-12-25
Phenylephrine Hydrochloride/Tropicamide
盐酸去氧肾上腺素/托品卡胺
更新于：2024-12-25
概要
基本信息
药物类型 小分子化药 |
别名 MicroStat、Mydcombi、Mydrin-PG + [13] |
作用机制 ADRA1激动剂(肾上腺素能受体α-1家族激动剂)、mAChRs拮抗剂(毒蕈碱型乙酰胆碱受体家族拮抗剂) |
非在研适应症- |
原研机构 |
非在研机构- |
最高研发阶段批准上市 |
首次获批日期 日本 (1962-05-12), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C17H20N2O2 |
InChIKeyBGDKAVGWHJFAGW-UHFFFAOYSA-N |
CAS号1508-75-4 |
查看全部结构式(2)
关联
9
项与 盐酸去氧肾上腺素/托品卡胺 相关的临床试验NCT06366217
Efficacy of the MydCombi on Pupillary Dilation in Pediatric and Adult Patients
NCT06217796
A Single-Center, Open Label, Phase 4 Study of the Safety and Efficacy of Fixed Combination Phenylephrine 2.5%-Tropicamide 1% Ophthalmic Solution (Mydcombi®) Administered With the Mydcombi Dispenser for Pupil Dilation (THE MIST-2.1 STUDY)
NCT06288321
Randomized Controlled Trial Comparing the Efficacy and Safety of Mydriatic Microdrops Over Standard Dose Mydriatics for Pupil Dilation in Retinopathy of Prematurity Examination
100 项与 盐酸去氧肾上腺素/托品卡胺 相关的临床结果
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100 项与 盐酸去氧肾上腺素/托品卡胺 相关的转化医学
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100 项与 盐酸去氧肾上腺素/托品卡胺 相关的专利（医药）
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22
项与 盐酸去氧肾上腺素/托品卡胺 相关的文献（医药）2022-12-09Medicine
Lens subluxation after use of a percussion massage gun: A case report
Article
作者: Fan, Wei ; Mu, Jiancheng
Rationale::
To report the first case of lens dislocation and secondary acute angle-closure glaucoma (AACG) following use of a percussion massage gun (PMG) around the eye.
Patient concerns::
A 69-year-old Chinese man had been using a PMG around his right eye for 2 months in order to relieve headache. After eye pain and blurred vision for 5 days, he went to the ophthalmological emergency department. His best-corrected visual acuity at distance was counting fingers.
Diagnosis::
The patient was diagnosed with lens subluxation, secondary AACG and pterygium in the right eye. Cataracts were diagnosed in both eyes.
Interventions::
The patient underwent phacoemulsification and anterior vitrectomy. After surgery, the patient was given eye drops containing tobramycin, dexamethasone, 0.1% bromfenac sodium hydrate ophthalmic solution and Mydrin-P for 1 month.
Outcomes::
At 3-month follow-up, uncorrected visual acuity in the right eye was counting fingers. The outcome of optometry in the right eye was +11.50 DS/−0.50 DC * 110°, with corrected-distance visual acuity of 4/20. IOP was 20.7 mm Hg in the right eye and 15.7 mm Hg in the left. Endothelium in the right cornea showed endothelial damage. Nevertheless, the patient reported no right eye pain anymore, and he indicated that he was satisfied with his situation.
Lessons::
Caregivers, sports professionals and the general public should be aware of the dangers of PMGs and the need to use them appropriately and safely, for example during self-massage and rehabilitation therapy. In particular, we recommend not using PMGs above the neck, which should be clearly indicated in instruction manuals.
2021-12-01BMC ophthalmology4区 · 医学
A randomized clinical trial using cyclopentolate and tropicamide to compare cycloplegic refraction in Chinese young adults with dark irises
4区 · 医学
ArticleOA
作者: Zhao, Liqiong ; Liu, Zhuzhu ; Wang, Biying ; Wei, Ruihua ; Zhang, Hongmei ; Du, Bei ; Jin, Na ; Pei, Ruxia ; Rong, Hua ; Pang, Yi
Abstract:
Background:
To evaluate the necessity of cycloplegia for epidemiological studies of refraction in Chinese young adults (aged 17–22 years) with dark irises, and to compare the cycloplegic effects of 1% cyclopentolate and 0.5% tropicamide in them.
Methods:
A total of 300 young adults (108 males and 192 females) aged 17 to 22 years (mean 19.03 ± 1.01) were recruited from Tianjin Medical University from November 2019 to January 2020. Participants were randomly divided into two groups. In the cyclopentolate group, two drops of 1% cyclopentolate eye drop were administrated (one drop every 5 min), followed by autorefraction and subjective refraction 30 to 45 min later. In the tropicamide group, four drops of 1% Mydrin P (Tropicamide 0.5%, phenylephrine HCl 0.5%) eye drop were given (one drop every 5 min), followed by autorefraction and subjective refraction 20 to 30 min later. The participants and the examiners were masked to the medication. Distance visual acuity, intraocular pressure (IOP), non-cycloplegic and cycloplegic autorefraction (Topcon KR-800, Topcon Co. Tokyo, Japan), non-cycloplegic and cycloplegic subjective refraction and ocular biometry (Lenstar LS-900) were performed.
Results:
The values of spherical equivalent (SE) and sphere component were significantly different before and after cycloplegia in the cyclopentolate group and the tropicamide group (p < 0.05). The mean difference between noncycloplegic and cycloplegic autorefraction SE was 0.39 D (±0.66 D) in the cyclopentolate group and 0.39 D (±0.34 D) in the tropicamide group. There was no significant difference in the change of SE and sphere component after cycloplegia between the cyclopentolate group and the tropicamide group (p > 0.05). In each group, no significant difference was found between autorefraction and subjective refraction after cycloplegia (p > 0.05). We also found that more positive or less negative cycloplegic refraction was associated with the higher difference in SE in each group.
Conclusions:
Cycloplegic refractions were generally more positive or less negative than non-cycloplegic refractions. It is necessary to perform cycloplegia for Chinese young adults with dark irises to obtain accurate refractive errors. We suggest that cycloplegic autorefraction using tropicamide may be considered as a reliable method for epidemiological studies of refraction in Chinese young adults with dark irises.
Trial registration:
The study was registered on September 7, 2019 (Registration number: ChiCTR1900025774).
2021-07-01Japanese journal of ophthalmology3区 · 医学
Difference of refractive status before and after cycloplegic refraction: the Lhasa Childhood Eye Study
3区 · 医学
Article
作者: Meng, Zhaojun ; Li, Lei ; Su, Han ; Dai, Wei ; Fu, Jing ; Yao, Yao ; Sun, Yunyun ; Chen, Weiwei
PURPOSE:
To compare the differences between cycloplegic and noncycloplegic refraction as well as associated factors in grade one students of primary schools, and explore the effectiveness of noncycloplegic refraction for refractive error screening.
STUDY DESIGN:
Cross-sectional study.
METHODS:
A school-based study of 1856 students was conducted in Lhasa, Tibetan Plateau, China. Cycloplegia was achieved with two drops of 1% cyclopentolate and 1 drop of Mydrin P at a 5-min interval. Autorefraction was performed under both cycloplegic and noncycloplegic conditions. Bland-Altman analysis, receiver operating characteristic curve analysis, univariate and multiple linear regression models were used for analysis.
RESULTS:
Of the 1856 children enrolled, 1830 (98.60%) completed all procedures. The average age was 6.83 ± 0.46 years. 965 (52.73%) children were boys and 1737 (94.92%) were Tibetan. Overall, there was a significant difference between cycloplegic and noncycloplegic SE of 0.90 ± 0.76D (P < 0.001). However, the intra-class coefficient correlation (ICC) for cylinder between these two methods was high (ICC = 0.941, 95% CI, 0.935-0.946). Larger differences between cycloplegic and noncycloplegic SE were associated with hyperopic RE and higher cylindrical value (P < 0.001). The prevalence of myopia, emmetropia and hyperopia with and without cycloplegia was (3.93% vs 14.59%), (9.95% vs 45.8%) and (86.21% vs 39.56%), respectively. Myopia, emmetropia and hyperopia based on noncycloplegic refraction was defined as SE ≤ - 0.625D, - 0.625 < SE ≤ 0D, and SE > 0D, respectively.
CONCLUSIONS:
Lack of cycloplegia leads to underestimation of hyperopia, with overestimation of myopia and emmetropia. Larger hyperopic refraction exhibited greater difference between cycloplegic and noncycloplegic refraction.
100 项与 盐酸去氧肾上腺素/托品卡胺 相关的药物交易
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外链
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| - | - | - |
研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 睫状肌麻痹 | 日本 | 1990-03-08 | |
| 瞳孔散大 | 日本 | 1962-05-12 |
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临床结果
临床结果
适应症
分期
评价
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临床4期 | 29 | Mydcombi 8µL | 鹹壓壓鬱構夢鹹網選憲(積製築廠餘蓋夢網遞壓) = 獵醖壓夢醖廠網遞衊糧 獵廠蓋壓艱襯壓鹹窪範 (製鬱獵製壓獵憲製膚鹽 ) 更多 | 积极 | 2024-04-25 | ||
临床4期 | 30 | 網蓋簾構築鏇壓網襯鑰(衊簾餘選構糧餘鬱構簾) = 齋觸襯糧鬱壓夢遞鑰憲 鏇網壓鹹鑰繭繭襯繭選 (淵願衊餘襯艱範遞構夢, 構遞構範壓繭選艱衊憲 ~ 夢觸衊糧夢餘積壓窪鏇) 更多 | - | 2024-04-18 | |||
MIST-1 (FDA) 人工标引  | 临床3期 | 372 | 積窪網製遞艱衊繭艱憲(醖鑰鹹憲顧淵餘繭網觸) = 網遞鬱糧構築醖憲構艱 繭願觸夢糧構齋願醖繭 (窪鹽鹹積顧齋窪襯築鹹, 0.07) 更多 | 积极 | 2023-05-05 | ||
積窪網製遞艱衊繭艱憲(醖鑰鹹憲顧淵餘繭網觸) = 糧獵構鏇淵餘壓壓選鑰 繭願觸夢糧構齋願醖繭 (窪鹽鹹積顧齋窪襯築鹹, 0.06) 更多 | |||||||
MIST-2 (FDA) 人工标引 | 临床3期 | 276 | 膚鹽鹹餘膚憲蓋蓋鬱積(夢觸願壓鑰網夢繭艱網) = 憲積鬱鹹齋夢壓選衊衊 構艱廠繭衊蓋淵鬱築醖 (願網顧蓋選築夢衊夢獵, 0.07) | 积极 | 2023-05-05 | ||
Placebo | 膚鹽鹹餘膚憲蓋蓋鬱積(夢觸願壓鑰網夢繭艱網) = 觸襯繭鏇壓範衊繭鹹鹽 構艱廠繭衊蓋淵鬱築醖 (願網顧蓋選築夢衊夢獵, 0.04) |
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