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更新于：2024-12-27

Permethrin

扑灭司林

更新于：2024-12-27

概要

基本信息

药物类型

小分子化药

别名

(3-Phenoxyphenyl)methyl (±)-cis,trans-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate、3-(2,2-Dichloroethenyl)-2,2-dimethylcyclopropane carboxylic acid, (3-phenoxyphenyl) methyl ester、Nedax

+ [7]

靶点

Nav1.1

作用机制

Nav1.1阻滞剂(I型钠通道蛋白α亚基阻滞剂)

治疗领域

感染皮肤和肌肉骨骼疾病

在研适应症

虱病

非在研适应症-

原研机构

GSK Plc

在研机构

Medtech Products, Inc.

非在研机构

GSK Plc

最高研发阶段批准上市

首次获批日期

美国 (1986-03-31),

虱病

最高研发阶段(中国)-

特殊审评-

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结构/序列

分子式C21H20Cl2O3

InChIKeyRLLPVAHGXHCWKJ-UHFFFAOYSA-N

CAS号52645-53-1

关联

项与扑灭司林相关的临床试验

CTRI/2024/11/076913

/ Not yet recruiting临床4期IIT

A Comparative study to evaluate Efficacy and Safety of Topical Permethrin versus Oral Ivermectin in patients with scabies at a tertiary care centre: A Randomised controlled study. - NIL

开始日期2024-11-30

申办/合作机构-

CTRI/2024/10/075991

/ Not yet recruitingN/A

A Randomized, Double-Blind, Multi-Center, Parallel Study to Evaluate the Bioequivalenceusing Clinical Endpoint of Permethrin Cream, 5 percentage of KLM Laboratories Pvt. Ltd., India toPermethrin Cream, 5 percentage of Padagis Israel Pharmaceuticals Ltd in Subjects with scabies. - nil

开始日期2024-11-18

申办/合作机构-

IRCT20110420006243N5

/ Recruiting临床3期IIT

Comparison effect of permethrin shampoo to permethrin shampoo with vinegar in the treatment of head lice in children aged 6-13 years

开始日期2024-09-22

申办/合作机构

Shahed University

100 项与扑灭司林相关的临床结果

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100 项与扑灭司林相关的转化医学

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100 项与扑灭司林相关的专利（医药）

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4,068

项与扑灭司林相关的文献（医药）

2025-02-01·NEUROPHARMACOLOGY

Neuroprotection by 4R-cembranoid against Gulf War Illness-related Chemicals is mediated by ERK, PI3K, and CaMKII pathways

Article

作者: Roche Lima, Abiel ; Ferchmin, Pedro A ; Alicia, Sorangely Vázquez ; Rivera-Moctezuma, Félix G. ; Vázquez Alicia, Sorangely ; Pérez, Dinely ; Rivera-Moctezuma, Félix G ; Sabeva, Nadezhda ; Tosado-Rodríguez, Eduardo L. ; Ferchmin, Pedro A. ; Marrero Valentín, José L ; Tosado-Rodríguez, Eduardo L ; Marrero Valentín, José L.

Gulf War Illness (GWI) has been consistently linked to exposure to pyridostigmine (PB), N,N-Diethyl-meta-toluamide (DEET), permethrin (PER), and traces of sarin. In this study, diisopropylfluorophosphate (DFP, sarin surrogate) and the GWI-related chemicals were found to reduce the number of functionally active neurons in rat hippocampal slices. These findings confirm a link between GWI neurotoxicants and N-Methyl-D-Aspartate (NMDA)-mediated excitotoxicity, which was successfully reversed by Edelfosine (a phospholipase Cβ (PLCβ3) inhibitor) and Flupirtine (a Kv7 channel agonist). To test whether 4R-cembranoid (4R), a nicotinic α7 acetylcholinesterase receptor (α7AChR) modulator known for its neuroprotective properties, can restore hippocampal neurons from glutamate-induced neurotoxicity, we exposed rat hippocampal slices with DFP for 10 min followed by 60 min treatment with 4R. We investigated the 4R mechanisms of neuroprotection after preincubation with LY294002, PD98059, and KN-62. The inhibition of the phosphatidylinositol 3-kinase (PI3K), mitogen-activated protein kinase (MEK1/2), and calcium/calmodulin-dependent protein kinase (CaMKII) abrogated the protective effect of 4R against DFP-induced neurotoxicity. In separate experiments, after incubation with DFP, followed by 4R for 1 h, cellular extracts were prepared for Western blotting of phospho-Akt, phospho-GSK3β, phosphorylated extracellular signal-regulated kinase (ERK)1/2, CaMKII and cAMP response element-binding protein (CREB). Our results show that DFP induces neuronal dysfunction by dephosphorylation, while 4R restores the phosphorylation of Akt, GSK3, ERK1/2, CREB, and CaMKII. Moreover, our proteomics analysis supported the notion that 4R activates additional signaling pathways related to enhancing neuronal signaling, synaptic plasticity, and apoptotic inhibition to promote cell survival against DFP, offering biomarkers for developing treatment against GWI.

2025-02-01·VETERINARY JOURNAL

Tremors in cats: 105 cases (2004–2023)

Article

作者: Liatis, T ; De Decker, S ; Bhatti, S F M

Although tremors are common neurological presentations, there is little known about their clinical features and underlying etiologies in cats. The aim of this study was to evaluate the clinical features, and underlying diagnoses in cats with tremors. We hypothesized that the results of this study would provide clinically useful information for clinicians when evaluating cats with tremors. This is a retrospective, single-center, study of cats with tremors between 2004-2023. Inclusion criteria included complete medical records, presence or report of tremor or twitch, and a final or presumptive diagnosis. One hundred five cats met the inclusion criteria. The most common diagnoses associated with tremors were degenerative encephalopathy (19/105; 18.1%), feline infectious peritonitis (FIP) (17/105; 16.2%), congenital portosystemic shunt (17/105; 16.2%), intoxication (16/105 15.2%) and polyneuropathy (8/105; 7.6%). Most common degenerative encephalopathies were suspected cerebellar cortical degeneration (7/19; 50%) and lysosomal storage diseases (7/19; 50%) and manifested intention head tremors. Intention head tremors were also seen in cats with FIP and thiamine deficiency encephalopathy. Portosystemic shunt tremors were of variable features, focal or generalised, intentional, nonintentional or both. The most common intoxication was permethrin ingestion and was most commonly associated with generalized tremors as the main presenting complaint. The most common type of tremor in cats with a polyneuropathy was a generalised tremor or limb tremor. Different tremor phenotypes occur and are associated with specific underlying diagnoses in cats. This information can aid clinicians on the best way to approach cats with a variety of tremor phenotypes.

2024-12-01·ENVIRONMENTAL RESEARCH

Characterization of pesticide exposures and their associations with asthma morbidity in a predominantly low-income urban pediatric cohort in Baltimore City

Article

作者: Meeker, John D. ; Quirós-Alcalá, Lesliam ; Matsui, Elizabeth C ; Matsui, Elizabeth C. ; Tore, Grant ; Peng, Roger D. ; Fandiño-Del-Rio, Magdalena ; Peng, Roger D ; Meeker, John D

BACKGROUND:

Pesticides may impact respiratory health, yet evidence of their impact on pediatric asthma morbidity is limited, particularly among urban children.

OBJECTIVE:

To characterize pesticide biomarker concentrations and evaluate their associations with pediatric asthma morbidity among predominantly low-income, Black children in Baltimore City, USA.

METHODS:

We measured urinary concentrations of 10 biomarkers for pyrethroid insecticides (cyfluthrin:4F-3PBA, permethrin:3PBA), organophosphate insecticides (chlorpyrifos:TCPY, malathion:MDA, parathion:PNP, diazinon:IMPY), and herbicides (glyphosate:AMPA, GPS; 2,4-dicholorphenoxyacetic acid:2,4-D; 2,4,5-tricholorphenoxyacetic acid:2,4,5-T) among 148 children (5-17 years) with established asthma. Urine samples and asthma morbidity measures (asthma symptoms, healthcare utilization, lung function and inflammation) were collected every three months for a year. Generalized estimating equations were used to examine associations between pesticide biomarker concentrations and asthma morbidity measures, controlling for age, sex, race, caregiver education, season, and environmental tobacco smoke. In sensitivity analyses, we assessed the robustness of our results after accounting for environmental co-exposures.

RESULTS:

Frequently detected (≥90% detection) pesticide biomarker concentrations (IMPY, 3PBA, PNP, TCPY, AMPA, GPS) varied considerably within children over the follow-up period (intraclass correlation coefficients: 0.1-0.2). Consistent positive significant associations were observed between the chlorpyrifos biomarker, TCPY, and asthma symptoms. Urinary concentrations of TCPY were associated with increased odds of coughing, wheezing, or chest tightness (adjusted Odds Ratio, aOR, TCPY:1.60, 95% Confidence Interval, CI:1.17-2.18). Urinary concentrations of TCPY were also associated with maximal symptom days (aOR:1.38, CI:1.02-1.86), exercise-related symptoms (aOR:1.63, CI:1.09-2.44), and hospitalizations for asthma (aOR:2.84, CI:1.08-7.43). We did not observe consistent evidence of associations between the pesticide exposures assessed and lung function or inflammation measures.

CONCLUSION:

Among predominantly Black children with asthma, we found evidence that chlorpyrifos is associated with asthma morbidity. Further research is needed to assess the contribution of pesticide exposures to pediatric respiratory health and characterize exposure sources among vulnerable populations to inform targeted interventions against potentially harmful pesticide exposures.

项与扑灭司林相关的新闻（医药）

2024-12-14

·drugs

Wintertime Is Prime Time for Head Lice: What Parents Need to Know

SATURDAY, Dec. 14, 2024 -- Head lice can be a wintertime headache for families and schools, but simple precautions can stop the spread of these pesky parasites. Every year, 6 million to 12 million children in the United States, ages 3 to 11, experience head lice infestations, according to the U.S. Centers for Disease Control and Prevention. Contrary to popular belief, these tiny insects don’t jump or fly, said Ali Wurster , a nurse practitioner with the Texas A&M Health Mobile Health Clinic. “They actually crawl,” Wurster explained in a university release. “A kid can be sitting in a classroom even a foot away from another child, and if their heads don't touch, the lice are not going to jump onto someone else.” While many believe individuals with dirty or unclean hair are more likely to attract lice, the reverse is true, Wurster said. The small, sesame seed-sized parasites prefer a clean scalp. They spread most commonly among school-aged children through shared items like hats, coats, brushes or dress-up clothes, which present prime modes of transfer for the parasites. To prevent head lice, avoid sharing hats, brushes or clothing. School staff should regularly sanitize common items. Wurster also recommended keeping heads apart during nap time to further deter spread. While not harmful, head lice can cause significant discomfort and should be mitigated as soon as possible both to ease symptoms and stymie further spread. If lice are found, treatment is straightforward. Over-the-counter and prescription topical creams such as Nix and Permethrin work effectively, Wurster said. After applying the treatment, remove lice eggs (nits) with a fine-toothed comb, seal them in a plastic bag and repeat treatment in seven days if needed. Wash clothing, bedding and other fabric items in hot water and dry on high heat. Non-washable items, like stuffed animals, should be sealed in a plastic bag for two weeks. The CDC no longer requires children with lice to be sent home immediately; they can finish the school day, begin treatment after school, and return the next day. Despite misconceptions, families and schools can quickly address and oftentimes prevent head lice with an accurate understanding of how the parasites spread and best practices for treatment. SOURCE: Texas A&M Health, news release, Dec. 9, 2024 Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.

2024-08-13

·drugs

Pesticide Exposure Tied to Increased Risk for Stillbirth

TUESDAY, Aug. 13, 2024 -- Pesticide exposures during preconception and the first trimester may be associated with stillbirth, according to a study published online July 16 in the American Journal of Epidemiology . Melissa A. Furlong, Ph.D., from the University of Arizona College of Public Health in Tucson, and colleagues linked Arizona pesticide use records (27 types) with birth certificates (2006 to 2020) to estimate associations between living within 500 m of any application site and stillbirth. The researchers found that during 90 days preconception, any exposures to pesticides were associated with stillbirth, including cyfluthrin (relative risk [RR], 1.97), zeta-cypermethrin (RR, 1.81), organophosphates as a class (RR, 1.60), malathion (RR, 2.02), carbaryl (RR, 6.39), and propamocarb hydrochloride (RR, 7.72). During the first trimester, fenpropathrin (RR, 4.36), permethrin (RR, 1.57), organophosphates as a class (RR, 1.50), acephate (RR, 2.31), and formetanate hydrochloride (RR, 7.22) were associated with stillbirth. "These findings underscore the importance of considering individual pesticides rather than just the overall pesticide class, as specific chemical compounds may pose unique risks," Furlong said in a statement. "It also highlights the potential for prepregnancy exposures to affect reproductive outcomes." One author disclosed ties to pesticide registrants unrelated to the research.

2023-12-27

·生物谷

Molecular Cell | 蒋辉实验室揭示线粒体自噬的感知和抑制因子PPTC7及其对线粒体数量的调控作用

线粒体自噬(mitophagy)是重要的线粒体质量及数量调控机制, 与发育、癌症、衰老和神经退行性病变等生理病理状况高度相关。现已知两类哺乳动物mitophagy通路：由PINK1-Parkin介导的泛素依赖途径，以及由BNIP3, NIX和FUNDC1等介导的受体依赖途径。然而，人们对mitophagy调控机制及其生理病理意义仍有待探索。突出的表现是，缺失已知mitophagy通路的小鼠(如Pink1-/-、Parkin-/-、Bnip3-/-等)表型微弱，与普遍认知的mitophagy重要性有明显差距。2023年12月26日，北京生命科学研究所/清华大学生物医学交叉研究院蒋辉实验室在Molecular Cell在线发表了题为"A mitophagy sensor PPTC7 controls BNIP3 and NIX degradation to regulate mitochondrial mass"的论文。该论文发现了一个感知并抑制mitophagy的因子PPTC7，阐明了PPTC7调控mitophagy的分子机制并揭示其对线粒体数量和代谢稳态的调控作用。作为监控mitophagy水平的关键因子，PPTC7感知mitophagy受体BNIP3和NIX的蛋白水平，进而起始BNIP3/NIX-PPTC7-SCFFBXL4完整复合物的组装，促进SCFFBXL4泛素化和降解BNIP3和NIX，从而抑制mitophagy。该通路对维持细胞线粒体数量、代谢平衡、和个体存活至关重要。01FBXL4介导的mitophagy调控与退行性疾病MTDPS13蒋辉实验室长期从事线粒体蛋白稳态调控机制研究，之前报道了一个线粒体外膜复合物UBXD8-VCP介导BNIP3降解，从而抑制mitophagy(链接：EMBO Reports | 蒋辉实验室揭示UBXD8调控凋亡和线粒体自噬的分子机制)。为进一步发掘mitophagy调控机制，研究生曹钰通过靶向线粒体的遗传筛选发现多个mitophagy抑制因子，其中包括FBXL4和PPTC7(链接：EMBO Journal | 蒋辉实验室揭示线粒体自噬调控及线粒体疾病新机制)。已知FBXL4突变导致致死性退行性疾病线粒体DNA耗竭综合征13(MTDPS13)1,2，但其机理未明。作者发现FBXL4定位于线粒体外膜，与Skp1和Cullin1组成SCFFBXL4 E3泛素连接酶。SCFFBXL4通过泛素化降解BNIP3和NIX来抑制mitophagy。而病人来源的FBXL4突变抑制SCFFBXL4组装，导致BNIP3和NIX蛋白积累和mitophagy过度激活。FBXL4突变患者表现出mtDNA耗竭、线粒体数量减少、酸中毒、神经和肌肉退行性病变等严重症状。与FBXL4突变病人类似，Fbxl4-/-小鼠表现出BNIP3和NIX蛋白积累、mitophagy失控、线粒体数量减少、代谢紊乱和围产期死亡等严重表型。更重要的是，在Fbxl4-/-小鼠中敲除Bnip3或Nix可以挽救线粒体数量、恢复代谢平衡并挽救小鼠寿命。这些结果表明过度mitophagy导致的线粒体数量减少是MTDPS13的致病原因并为治疗提供了思路。02PPTC7调控FBXL4介导的BNIP3和NIX降解鉴于BNIP3和NIX强大且危险的线粒体清除能力，细胞必须牢牢控制其水平，但细胞监控并调节BNIP3和NIX降解的分子机制仍不清楚。研究生孙雨秋研究另一个筛选发现的mitophagy抑制因子PPTC7。前人研究表明PPTC7是定位于线粒体基质的磷酸酶。但令人诧异的是，与敲除FBXL4类似，敲除PPTC7同样导致BNIP3和NIX的积累和过度mitophagy；Pptc7-/-小鼠表现出mitophagy失控、线粒体数量减少和围产期死亡的表型，且该表型可以被Nix敲除所挽救(图1)。此外，PPTC7过表达可促进内源BNIP3和NIX被FBXL4降解，而FBXL4过表达则没有效果，提示PPTC7作为上游限速因子调控FBXL4介导的BNIP3和NIX降解。但是，线粒体基质蛋白PPTC7如何调控线粒体外膜上的蛋白降解？图1PPTC7缺失过度激活BNIP3和NIX依赖的mitophagy，造成线粒体数量减少和小鼠死亡。A,Pptc7 -KO升高小鼠肝脏中mitophagy受体BNIP3和NIX的蛋白水平(红框)并导致其他线粒体蛋白减少(蓝框)。B,小鼠生存曲线。03PPTC7前体通过与BNIP3/NIX直接互作，滞留在线粒体外膜通常情况下，线粒体基质蛋白的前体形式(precursor)在N端定位序列(targeting sequence)的引导下进入线粒体，并在线粒体基质切除定位序列，完成成熟过程。作者发现在野生型细胞里，PPTC7以成熟形式(mature form,切除了定位序列)存在于线粒体基质，而在FBXL4-KO细胞里，PPTC7同时具有定位于线粒体基质的成熟形式和定位于线粒体外膜的前体形式。进一步分析表明，FBXL4-KO细胞中积累的BNIP3和NIX导致PPTC7前体出现在线粒体外膜;在野生型细胞中直接过表达BNIP3或NIX也可诱导PPTC7前体出现在线粒体外膜定位。通过体外重组蛋白实验，作者发现BNIP3和NIX与PPTC7直接互作，并使用交联质谱分析了NIX-PPTC7的互作区域。在截去NIX与PPTC7的直接互作区域后，NIX无法诱导PPTC7前体的外膜定位，表明BNIP3和NIX通过与PPTC7的直接互作，将PPTC7前体定位于线粒体外膜。04弱化的PPTC7定位序列帮助PPTC7在线粒体外膜滞留有意思的是，作者发现与经典线粒体基质定位序列相比，PPTC7的定位序列长度短且引导能力差，推测该特征削弱了PPTC7前体进入线粒体基质的能力，有利于PPTC7前体被外膜BNIP3/NIX滞留。因此，研究者将PPTC7的定位序列替换成经典序列，发现它使PPTC7全部进入线粒体基质，无法被滞留在外膜，失去调节BNIP3和NIX降解的能力。05外膜PPTC7起始组装BNIP3/NIX-PPTC7-SCFFBXL4复合物那么外膜PPTC7如何促进SCFFBXL4介导的BNIP3和NIX降解呢？作者发现除与BNIP3/NIX直接互作之外，PPTC7还与SCFFBXL4复合物中的Cullin1直接互作。作者表达纯化了NIX，PPTC7，FBXL4,Cullin1-Rbx1和Skp1的重组蛋白，发现只有在所有蛋白都存在的情况下，这些蛋白才能组装成完整的NIX-PPTC7-SCFFBXL4复合物，缺少NIX，PPTC7，FBXL4任何一个组分都导致复合物散架。以上结果提供了一个mitophagy的负反馈调控模型:积累在线粒体外膜的mitophagy受体BNIP3和NIX与PPTC7前体直接互作，将其滞留在外膜，起始BNIP3/NIX-PPTC7-SCFFBXL4复合物的组装，从而泛素化和降解BNIP3和NIX，防止mitophagy过度激活(图2)。06禁食情况下，肝脏诱导PPTC7来抑制mitophagy和维持代谢稳态一个重要的问题是在负反馈调控mitophagy之外，PPTC7是否还会响应生理信号？鉴于PPTC7过表达能促进BNIP3和NIX降解，作者重点研究了生理信号对PPTC7表达的调节，发现禁食不改变骨骼肌PPTC7的表达，但在肝脏强烈诱导PPTC7。与之相对应，禁食强烈诱导骨骼肌mitophagy，但不改变肝脏mitophagy水平，作者推测肝脏mitophagy受到PPTC7上调的压制。因此，作者在小鼠肝脏敲除PPTC7，发现禁食导致缺失PPTC7的肝脏丢失大量线粒体。禁食情况下，肝脏负有重要使命-通过糖异生(gluconeogenesis)维持血糖水平。而糖异生需要线粒体提供两个重要支持：ATP和丙酮酸羧化酶(pyruvate carboxylase)。作者发现，敲除肝脏PPTC7导致禁食状态下肝脏ATP缺乏，糖异生受阻，造成严重的低血糖。因此，禁食情况下，肝脏特异上调PPTC7以压制mitophagy，从而维持线粒体数量和代谢稳态(图2)。图2 PPTC7调控mitophagy的工作模型。1. mitophagy的负反馈稳态调控。正常情况下，PPTC7表达后进入线粒体基质行使正常功能。当mitophagy受体BNIP3和NIX积累时，BNIP3/NIX将PPTC7前体滞留于外膜，起始BNIP3/NIX-PPTC7-SCFFBXL4复合物组装，从而降解BNIP3和NIX，防止mitophagy过度激活和线粒体丢失。2. 在禁食情况下，肝脏上调PPTC7以压制mitophagy，从而维持肝脏能量供应和糖异生通路活力，维持血糖水平。综上，该工作报道了一个感知和抑制mitophagy的PPTC7-SCFFBXL4通路。PPTC7作为关键调控因子，能够整合稳态维持和生理信号来调控mitophagy水平，以此维持线粒体数量和细胞代谢稳态。该通路的发现显著增进了我们对mitophagy与线粒体数量控制(mitochondrial mass control)的理解。禁食情况下，肝脏和骨骼肌对mitophagy的差异化调节及其功能研究也丰富了我们对生理情况下组织特异性mitophagy调控的认知。清华大学生物医学交叉研究院博士生孙雨秋为论文第一作者，蒋辉博士为通讯作者。该论文其他作者包括蒋辉课题组的曹钰和万华云，董梦秋实验室的阿达莱提买买提明和董梦秋博士，代谢组学中心的马燕博士和曹杨，蛋白质组中心的陈涉博士和李琳，遗传筛选中心的李祺博士和吴重阳，刘清华实验室的王濛。该研究由科技部、北京市政府和清华大学共同资助，在北京生命科学研究所完成。论文链接：https://www-cell-com.libproxy1.nus.edu.sg/molecular-cell/fulltext/S1097-2765(23)01014-6本文仅用于学术分享，转载请注明出处。若有侵权，请联系微信：bioonSir 删除或修改！

临床1期蛋白降解靶向嵌合体引进/卖出

100 项与扑灭司林相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D05443	扑灭司林	P03AC04	DB04930

研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
虱病	美国	GSK Plc	1986-03-31

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临床结果

适应症

分期

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


WCD2023	N/A	疥疮	-	5% permethrin cream	壓廠鹽選壓觸夢製獵齋(積齋製齋鏇觸鏇範獵觸) = 淵觸窪鏇築衊範壓糧積繭壓壓壓鹹鹽鬱襯鹹構 (網糧積簾鑰範醖簾觸鏇 )	积极	2023-07-03
IRCT2017100936672N1 (Pubmed \| Rev Recent Clin Trials)	早期临床1期	头虱	121	Ozonated Olive Oil Topical Lotion	衊糧積鬱憲獵觸製築觸(艱繭觸築選繭觸製鹽膚) = 願願齋網艱鬱膚襯遞範遞簾選壓顧夢繭糧製夢 (壓鬱餘蓋積簾鏇餘膚鹹 )	积极	2022-02-01
NCT02978508 (CTgov)	临床3期	疥疮	140	Permethrin Cream, 5% (Permethrin Cream, 5%)	選齋壓糧鬱鑰鹹鏇選醖(艱願膚鬱齋餘鏇繭壓醖) = 築壓鏇繭積鏇鹹顧餘範鬱壓糧窪顧醖壓積簾鏇 (憲廠襯襯糧顧餘願繭衊, 積願鹹構憲鹽鬱餘築鏇 ~ 夢鹹衊鏇顧網鏇顧觸艱) 更多	-	2020-09-02
				Elimite (Elimite)	選齋壓糧鬱鑰鹹鏇選醖(艱願膚鬱齋餘鏇繭壓醖) = 夢築壓糧鹹憲糧鏇顧遞鬱壓糧窪顧醖壓積簾鏇 (憲廠襯襯糧顧餘願繭衊, 觸襯衊齋壓築憲夢鹹構 ~ 憲範網糧鏇網鹽築齋鹽) 更多
NCT02775617 (AIM-Skin, CTgov)	临床4期	雅司病 \| 脓疱疮 \| 疥疮	1,291	Ivermectin+Azithromycin+Permethrin (Parallel Treatment)	獵鬱積衊簾構繭齋鹽艱(構夢糧製鹹衊壓醖襯壓) = 觸壓壓壓糧壓醖顧醖憲壓簾遞簾製築餘艱蓋膚 (遞選餘簾遞構遞願願鹹, 膚網鬱鹹構鹹鹹夢築窪 ~ 糧膚憲選鑰襯遞襯齋築) 更多	-	2019-09-13
				Ivermectin+Azithromycin+Permethrin (Sequential Treatment)	獵鬱積衊簾構繭齋鹽艱(構夢糧製鹹衊壓醖襯壓) = 蓋構鹹簾製艱餘製餘製壓簾遞簾製築餘艱蓋膚 (遞選餘簾遞構遞願願鹹, 範繭壓廠網鬱衊艱鹽淵 ~ 製齋顧積觸鏇淵觸餘築) 更多
NCT03236168 (CTgov)	临床3期	疥疮	118	Ivermectin+Malathion Shampoo 0.5%+Permethrin 5%	廠獵鑰糧鏇衊顧襯窪觸(鏇蓋衊鹹積鑰積獵夢壓) = 夢鏇鹽鏇築淵艱築衊簾鹹選網憲鑰構窪選網鏇 (繭衊齋蓋襯獵築糧鑰選, 壓製製膚遞艱醖選齋構 ~ 膚糧鹹淵壓鹹獵築艱選) 更多	-	2019-06-14
NCT03178942 (CTgov)	临床3期	疥疮	254	Elimite™ Cream (permethrin) 5% (Reference: Elimite™ Cream)	構繭製膚壓壓鏇鏇範淵(選觸簾鬱願範築網壓構) = 願壓夢廠壓膚鏇鬱構夢憲積鹹齋遞願蓋壓鑰壓 (鏇製範構夢蓋構範壓範, 選衊繭糧鏇獵網醖憲選 ~ 顧繭選範憲夢衊遞顧蓋) 更多	-	2019-03-14
				Permethrin Cream, 5% (Test: Permethrin Cream, 5%)	構繭製膚壓壓鏇鏇範淵(選觸簾鬱願範築網壓構) = 醖醖憲選鬱餘鹹窪憲遞憲積鹹齋遞願蓋壓鑰壓 (鏇製範構夢蓋構範壓範, 齋積構觸網鑰鬱願願築 ~ 構醖衊夢願選衊齋獵築) 更多
ISRCTN88144046 (Pubmed)	N/A	头虱	90	4% dimeticone liquid gel	製遞選糧鏇築鬱衊鬱衊(獵齋鏇願願鏇顧襯積選) = 鹹衊鏇憲範壓糧網顧繭淵艱廠簾窪夢壓醖鹽簾 (構鑰餘廠積衊窪鹽艱鑰 )	积极	2013-04-01
				1% permethrin creme rinse	製遞選糧鏇築鬱衊鬱衊(獵齋鏇願願鏇顧襯積選) = 壓築鬱鏇鹹壓網糧糧遞淵艱廠簾窪夢壓醖鹽簾 (構鑰餘廠積衊窪鹽艱鑰 )