更新于：2024-06-20
Mivacurium Chloride
米库氯铵
更新于：2024-06-20
概要
基本信息
药物类型 化学药 |
别名 Mivacurium chloride (USAN/INN)、BW-B1090U、Mivacron + [1] |
作用机制 Nicotinic receptors拮抗剂(烟碱受体拮抗剂) |
治疗领域 |
在研适应症 |
非在研适应症 |
原研机构 |
非在研机构 |
最高研发阶段批准上市 |
首次获批日期 美国 (1992-01-22), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构
分子式C58H80ClN2O14 |
InChIKeyKFWHZSUNFAPZPW-FBIVYNMFSA-M |
CAS号106861-44-3 |
关联
16
项与 米库氯铵 相关的临床试验Effect of mivacurium on tonsillar adenoidectomy in pediatric patients
Evaluation of Effectiveness of Two Different Doses of Mivacurium in Modified Rapid Sequence Intubation for Emergency Surgery ,Prospective Randomized Double Blind Study
Comparison of continuous infusion of two doses of mivacurium during laryngeal microsurgery under general anesthesia:a prospective, randomized, controlled, double-blind clinical trial
100 项与 米库氯铵 相关的临床结果
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100 项与 米库氯铵 相关的转化医学
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100 项与 米库氯铵 相关的专利（医药）
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709
项与 米库氯铵 相关的文献（医药）2023-12-06Evidence-based complementary and alternative medicine : eCAM
Retracted: Comparative Analysis of the Anesthesia Effect of Cisatracurium Besylate and Mivacurium Chloride Otolaryngology Surgery
作者: And Alternative Medicine, Evidence-Based Complementary
[This retracts the article DOI: 10.1155/2022/6192409.].
2023-12-01Biochemical pharmacology
Drug and pro-drug substrates and pseudo-substrates of human butyrylcholinesterase
Review
作者: Lockridge, Oksana ; Shaihutdinova, Zukhra ; Masson, Patrick
Butyrylcholinesterase (BChE) is present in plasma and numerous cells and organs. Its physiological function(s) is(are) still unclear. However, this enzyme is of pharmacological and toxicological importance. It displays a broad specificity and is capable of hydrolyzing a wide range of substrates with turnovers differing by several orders of magnitude. Nowaday, these substrates include more than two dozen carboxyl-ester drugs, numerous acetylated prodrugs, and transition state analogues of acetylcholine. In addition, BChE displays a promiscuous hydrolytic activity toward amide bonds of arylacylamides, and slowly hydrolyzes carbamyl- and phosphoryl-esters. Certain pseudo-substrates like carbamates and organophosphates are major drugs of potential medical interest. The existence of a large genetic poly-allelism, affecting the catalytic properties of BChE is at the origin of clinical complications in the use of certain drugs catabolized by BChE. The number of drugs and prodrugs hydrolyzed by BChE is expected to increase in the future. However, very few quantitative data (Km, kcat) are available for most marketed drugs, and except for myorelaxants like succinylcholine and mivacurium, the impact of BChE genetic mutations on catalytic parameters has not been evaluated for most of these drugs.
2023-10-11Journal of clinical medicine
Spontaneous Ventilation Combined with Double-Lumen Tube Intubation during Thoracic Surgery: A New Anesthesiologic Method Based on 141 Cases over Three Years.
Article
作者: Furak, Jozsef ; Szabo, Zsolt ; Matuz, Maria ; Farkas, Attila ; Fabo, Csongor ; Paroczai, Dora ; Oszlanyi, Adam ; Szarvas, Matyas ; Lantos, Judit
BACKGROUND:
Non-intubated thoracic surgery has not achieved widespread acceptance despite its potential to improve postoperative outcomes. To ensure airway safety, our institute has developed a technique combining spontaneous ventilation with double-lumen tube intubation (SVI). This study aimed to verify the feasibility and limitations of this SVI technique.
METHODS:
For the SVI method, anesthesia induction involves fentanyl and propofol target-controlled infusion, with mivacurium administration. Bispectral index monitoring was used to ensure the optimal depth of anesthesia. Short-term muscle relaxation facilitated double-lumen tube intubation and early surgical steps. Chest opening preceded local infiltration, followed by a vagal nerve blockade to prevent the cough reflex and a paravertebral blockade for pain relief. Subsequently, the muscle relaxant was ceased. The patient underwent spontaneous breathing without coughing during surgical manipulation.
RESULTS:
Between 10 March 2020 and 28 October 2022, 141 SVI surgeries were performed. Spontaneous respiration with positive end-expiratory pressure was sufficient in 65.96% (93/141) of cases, whereas 31.21% (44/141) required pressure support ventilation. Only 2.84% (4/141) of cases reversed to conventional anesthetic management, owing to technical or surgical difficulties. Results of the 141 cases: The mean maximal carbon dioxide pressure was 59.01 (34.4-92.9) mmHg, and the mean lowest oxygen saturation was 93.96% (81-100%). The mean one-lung, mechanical and spontaneous one-lung ventilation time was 74.88 (20-140), 17.55 (0-115) and 57.73 (0-130) min, respectively.
CONCLUSIONS:
Spontaneous ventilation with double-lumen tube intubation is safe and feasible for thoracic surgery. The mechanical one-lung ventilation time was reduced by 76.5%, and the rate of anesthetic conversion to relaxation was low (2.8%).
100 项与 米库氯铵 相关的药物交易
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研发状态
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 妊娠剧吐 | 中国 | 2005-08-11 | |
| 麻醉 | 美国 | 1992-01-22 |
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临床结果
临床结果
适应症
分期
评价
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临床4期 | 24 | (Moderate/Normal Surgical Block) | 憲選憲製製糧艱壓糧艱(齋鑰淵願窪憲選醖壓蓋) = 顧憲壓衊齋鹹壓餘簾艱 遞艱齋憲鑰糧範艱衊構 (鹽醖衊窪壓鬱憲蓋繭鬱, 淵構獵憲範糧糧簾餘獵 ~ 構繭憲糧築糧醖齋選鹹) 更多 | - | 2016-10-17 | ||
(Deep Surgical Block) | 憲選憲製製糧艱壓糧艱(齋鑰淵願窪憲選醖壓蓋) = 齋餘蓋壓艱積積鑰積網 遞艱齋憲鑰糧範艱衊構 (鹽醖衊窪壓鬱憲蓋繭鬱, 蓋齋願膚獵積觸糧衊襯 ~ 築膚製餘網築壓網鑰鹽) 更多 | ||||||
N/A | - | - | Mivacurium 50 microg/kg | 襯網構壓廠觸遞鏇淵顧(窪鑰遞糧醖糧遞顧糧鬱) = 積齋鬱網築壓鹽鏇鬱窪 夢膚鬱遞糧壓窪衊築夢 (膚簾糧襯淵膚膚範築鑰, 82 ~ 127) 更多 | - | 2001-12-01 | |
Mivacurium 100 microg/kg | 襯網構壓廠觸遞鏇淵顧(窪鑰遞糧醖糧遞顧糧鬱) = 窪襯積糧醖膚憲構構餘 夢膚鬱遞糧壓窪衊築夢 (膚簾糧襯淵膚膚範築鑰, 51 ~ 82) 更多 |
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