主要目的：采用正葡萄糖钳夹技术，在中国健康男性受试者中比较甘李药业股份有限公司生产的重组甘精胰岛素注射液（3ml：900单位/支）（受试制剂，T）与赛诺菲安万特制药有限公司甘精胰岛素注射液（来优时®TOUJEO，参比制剂，R）的药代动力学（PK）和药效动力学（PD）的生物等效性。次要目的：评价甘精胰岛素注射液在中国健康男性受试者中的安全性。

开始日期2021-10-13

申办/合作机构

甘李药业股份有限公司

NCT04236895

/ Completed临床1期

A Glucose Clamp Trial Investigating the Biosimilarity of Gan & Lee Insulin Glargine Injection (Insulin Glargine 100 U/mL) With US and EU Lantus® Comparator Products in Patients With Type 1 Diabetes Mellitus

Primary objectives:
To demonstrate biosimilarity with regard to the total and maximum pharmacokinetic exposure during one dosing interval (AUC ins. 0-24h, Cins.
max) of Gan & Lee Insulin Glargine with Lantus® (US RLD / EU RP) in subjects with type 1 diabetes
To demonstrate biosimilarity with regard to the total and maximum pharmacodynamic response during one dosing interval (AUC GIR.0-24h, GIR max) of Gan & Lee Insulin Glargine with Lantus® (US RLD / EU RP) in subjects with type 1 diabetes
Secondary objectives:
To compare the pharmacokinetic and pharmacodynamic properties of Gan & Lee Insulin Glargine and of Lantus® (US RLD / EU RP)
To assess the safety and tolerability of Gan & Lee Insulin Glargine and of Lantus® (US RLD / EU RP)

开始日期2018-07-10

申办/合作机构

甘李药业股份有限公司

NCT03371082

/ Completed临床3期

An Open Label, Randomized, Multicenter, Phase 3 Study to Compare the Immunogenicity, Efficacy and Safety of Gan & Lee Pharmaceuticals Insulin Glargine Injection to Lantus in Adult Subjects With Type 1 Diabetes Mellitus.

Primary Objective:
•To evaluate equivalence of Gan & Lee Insulin Glargine Injection and Lantus® in terms of immunogenicity
Secondary Objective:
Immunogenicity:
• To evaluate the percentage of subjects with negative anti-insulin antibodies (AIAs) at baseline who develop confirmed positive AIA up to Week 26, the percentage of baseline in AIA titers between treatment groups, the percentage of subjects with confirmed positive AIA who develop any anti-insulin neutralizing antibodies up to visit Week 26, and percentage of subjects who develop confirmed positive AIA up to visit Week 26 of Gan & Lee Insulin Glargine Injection in comparison with that of Lantus®.
Safety:
•To evaluate the safety of Gan & Lee Insulin Glargine Injection in comparison with that of Lantus®.
Efficacy:
•To evaluate the efficacy of Gan & Lee Insulin Glargine Injection in comparison with that of Lantus®.

开始日期2017-10-31

申办/合作机构

甘李药业股份有限公司

100 项与重组甘精胰岛素 (甘李药业) 相关的临床结果

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100 项与重组甘精胰岛素 (甘李药业) 相关的专利（医药）

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项与重组甘精胰岛素 (甘李药业) 相关的文献（医药）

2024-06-01·Diabetes, obesity & metabolism

Immunogenicity, efficacy, and safety of biosimilar insulin glargine (Gan & Lee glargine) compared with originator insulin glargine (Lantus®) in patients with type 2 diabetes after 26 weeks' treatment: A randomized open label study

Article

作者: Fitz‐Patrick, David ; Hart, Terence ; Tidman, Raymond ; Nakhle, Samer ; Puente, Orlando ; Arora, Samir ; Rendell, Marc ; Maheshwari, Hiralal ; Warren, Mark ; Denham, Douglas ; Christofides, Elena A. ; Young, Douglas ; Chadha, Anurekha ; Reed, John ; Norwood, Paul ; Johnson, Kimball A. ; Huffman, David ; Lillestol, Michael ; Soufer, Joseph ; Sugimoto, Danny ; Rizzardi, Barbara ; Bays, Harold

Abstract:

Aim:

To evaluate the equivalence of immunogenicity, safety and efficacy of Gan & Lee (GL) Glargine (Basalin®; Gan & Lee Pharmaceutical) with that of the reference product (Lantus®) in adult participants with type 2 diabetes mellitus.

Methods:

This was a phase 3, multicenter, open‐label, equivalence trial conducted across 57 sites. In total, 567 participants with type 2 diabetes mellitus were randomized in a 1:1 ratio to undergo treatment with either GL Glargine or Lantus® for 26 weeks. The primary endpoint was the proportion of participants in each treatment arm who manifested treatment‐induced anti‐insulin antibodies (AIA). Secondary endpoints included efficacy and safety metrics, changes in glycated haemoglobin levels, and a comparative assessment of adverse events. Results were analysed using an equivalence test comparing the limits of the 90% confidence interval (CI) for treatment‐induced AIA development to the prespecified margins.

Results:

The percentages of participants positive for treatment‐induced glycated haemoglobin by week 26 were similar between the GL Glargine (19.2%) and Lantus® (21.3%) treatment groups, with a treatment difference of −2.1 percentage points and a 90% CI (−7.6%, 3.5%) (predefined similarity margins: −10.7%, 10.7%). The difference in glycated haemoglobin was −0.08% (90% CI, −0.23, 0.06). The overall percentage of participants with any treatment‐emergent adverse events was similar between the GL Glargine (80.1%) and Lantus® (81.6%) treatment groups.

Conclusions:

GL Glargine was similar to Lantus® in terms of immunogenicity, efficacy, and safety, based on the current study.

2023-12-01·Diabetes, obesity & metabolism

Pharmacokinetic and pharmacodynamic bioequivalence of Gan & Lee insulin analogues aspart (rapilin®), lispro (prandilin®) and glargine (basalin®) with EU‐ und US‐sourced reference insulins

Article

作者: Lu, Jia ; Zijlstra, Eric ; Li, Longling ; Chen, Wei ; Heise, Tim ; Plum-Mörschel, Leona ; Xie, Tian ; Gan, Zhongru ; Andersen, Grit ; Hao, Chunyue ; He, Anshun

Abstract:

Aim:

For the successful approval and clinical prescription of insulin biosimilars, it is essential to show pharmacokinetic (PK) and pharmacodynamic (PD) bioequivalence to the respective reference products sourced from the European Union and the United States.

Methods:

Three phase 1, randomized, double‐blind, three‐period crossover trials compared single doses of the proposed biosimilar insulin analogues aspart (GL‐Asp, n = 36), lispro (GL‐Lis, n = 38) and glargine (GL‐Gla, n = 113), all manufactured by Gan & Lee pharmaceuticals, to the respective EU‐ and US‐reference products in healthy male participants (GL‐Asp and GL‐Lis) or people with type 1 diabetes (GL‐Gla). Study participants received 0.2 U/kg (aspart and lispro) or 0.5 U/kg (glargine) of each treatment under automated euglycaemic clamp conditions. The clamp duration was 12 h (aspart and lispro) or 30 h (glargine). Primary PK endpoints were the total area under the PK curves (AUCins.total) and maximum insulin concentrations (Cins.max). Primary PD endpoints were the total area under the glucose infusion rate curve (AUCGIR.total) and maximum glucose infusion rate (GIRmax).

Results:

Bioequivalence to both EU‐ and US‐reference products were shown for all three GL insulins. Least squares mean ratios for the primary PK/PD endpoints were close to 100%, and both 90% and 95% confidence intervals were within 80%–125% in all three studies. There were no noticeable differences in the safety profiles between test and reference insulins, and no serious adverse events were reported for the GL insulins.

Conclusion:

GL‐Asp, GL‐Lis and GL‐Gla are bioequivalent to their EU‐ and US‐reference products.

2019-05-01·Advances in therapy3区 · 医学

A Propensity Score Matched Comparison of Brand and Biosimilar Basal Insulin in Non-Critical Hospitalized Patients with Type 2 Diabetes Mellitus

3区 · 医学

Article

作者: Jiang, Jikang ; Zhang, Lei ; Gao, Weiguo ; Dong, Yanhu ; Hu, Xia ; Dong, Chao

INTRODUCTION:

Comparisons between brand and biosimilar basal insulin in hospitalized patients are lacking. We aimed to compare the efficacy and safety of brand insulin glargine vs. biosimilar insulin glargine in non-critical hospitalized patients with type 2 diabetes mellitus (T2DM).

METHODS:

This retrospective study was conducted using the electronic medical records of 194,006 patients at the Qingdao Endocrine and Diabetes Hospital between January 2006 and December 2017. A total of 476 patients diagnosed with T2DM, hospitalized, and treated with subcutaneous insulin glargine were included. After propensity score matching (1:3), patients who received biosimilar insulin glargine (Basalin) (n = 34) were compared to a matched group of patients who received brand insulin glargine (Lantus) (n = 101). Outcome measures were changes in fasting blood glucose (FBG), the incidence of hypoglycemia, and insulin dose.

RESULTS:

Compared to patients who received Basalin, patients who received Lantus achieved more reduction in FBG during insulin treatment (- 1.24 mmol/L vs. - 2.20 mmol/L; p = 0.04) and had a lower mean FBG at the end of treatment (8.20 mmol/L vs. 7.26 mmol/L; p = 0.12). Patients in Basalin and Lantus groups had a comparable mean daily dose of basal insulin at initiation (0.19 vs. 0.18 IU/kg; p = 0.30) and end of treatment (0.21 vs. 0.21 IU/kg; p = 0.99), and a similar duration of basal insulin treatment (16.4 vs. 15.3 days; p = 0.74). Hypoglycemia was infrequent in both Basalin and Lantus treatment (one vs. four patients, respectively; p = 1.00) and no severe hypoglycemic events were reported.

CONCLUSION:

In a non-critical hospital setting, subcutaneous treatment with Lantus brought significant FBG improvement without increased hypoglycemic risk.

项与重组甘精胰岛素 (甘李药业) 相关的新闻（医药）

2025-03-11

·PipelineReview

Gan & Lee Pharmaceuticals Announced First Participant Dosed in the US Phase 2 Clinical Study of Bofanglutide (GZR18) Injection for Overweight or Obesity

BEIJING, China and BRIDGEWATER, NJ, USA I March 10, 2025 I Gan & Lee Pharmaceuticals (Gan & Lee, Shanghai Stock Exchange: 603087) announced that the first participant has been successfully dosed in a Phase 2 clinical trial of bofanglutide (research code: GZR18) injection, a bi-weekly glucagon-like peptide-1 receptor agonist (GLP-1 RA) independently developed by Gan & Lee, in the US participants with overweight or obesity. Notably, bofanglutide is the first GLP-1 receptor mono-agonist to undergo a head-to-head comparison with tirzepatide for evaluating the efficacy in body weight management globally. This Phase 2 clinical trial (ClinicalTrials.gov registration number: NCT06737042) was designed to evaluate the efficacy and safety of bofanglutide injection in US adults with overweight or obesity. The study plans to enroll 285 subjects, who will be randomized to receive either 24 mg, 36 mg, or 48 mg of bofanglutide bi-weekly, 15 mg of tirzepatide once-weekly, or placebo. The primary endpoint is the percentage change in body weight from baseline at the end of the treatment. Previously, a Phase 1 study (NCT06548997) of bofanglutide injection demonstrated good safety and tolerability in US subjects, along with promising glucose-lowering and weight-loss potential [1] . The initiation of head-to-head clinical study for bofanglutide versus tirzepatide, marking a new phase in Gan & Lee’s GLP-1 innovation. This milestone underscores the company’s ambition to challenge the leading GLP-1 therapy in the global market for weight management, aiming to provide a better treatment option for patients with overweight or obesity worldwide. Reference: [1].Liu Y, Chen W, He X, He A, Zhao L, Xie T, Li Y, Zhao J, Hunt A, Shi A, Gan ZR. The safety, tolerability, pharmacokinetics and pharmacodynamics of GZR18 in healthy American and Chinese adult subjects. Diabetes Obes Metab. 2025 Mar 3. doi: 10.1111/dom.16285. Epub ahead of print. PMID: 40028667. About Bofanglutide (GZR18) Bofanglutide (R&D Code: GZR18) injection, developed by Gan & Lee Pharmaceuticals, is a bi-weekly GLP-1 receptor agonist (RA) indicated for glycemic control in adults with type 2 diabetes and body weight management in overweight/obese individuals. As the potential first bi-weekly GLP-1 RA in the world, early clinical trials have demonstrated its efficacy in weight reduction comparable to or superior to marketed counterparts, with a safety and tolerability profile consistent with the established class of GLP-1 RAs, and significant reductions in both blood glucose levels and body weight. About Gan & Lee Gan & Lee Pharmaceuticals developed the first Chinese domestic insulin analog. Currently, Gan & Lee has six core insulin products, including five insulin analog varieties: long-acting glargine injection (Basalin), fast-acting lispro injection (Prandilin ® ™), fast-acting aspart injection (Rapilin), mixed protamine zinc lispro injection (25R) (Prandilin ® ™25), aspart 30 injection (Rapilin30), and one human insulin injection – mixed protamine human insulin injection (30R) (Similin30). The company has two approved medical devices in China, namely reusable insulin injection pen (GanleePen), and disposable pen needle (GanleeFine) ® . In China’s 2024 National Insulin-Specific Centralized Procurement, Gan & Lee Pharmaceuticals ranked first among all selected companies in terms of procurement demand for insulin analogs. The company is also making strides in international markets, with the disposable pen needle (GanleeFine) approved by the US Food and Drug Administration (FDA) in 2020 and received GMP inspection approval from the European Medicines Agency (EMA) in 2024. These achievements significantly boost Gan & Lee’s competitiveness in both international and domestic markets ® . In the future, Gan & Lee will strive for comprehensive coverage in diabetes treatment. Moving forward with its mission to become a world-class pharmaceutical company, Gan & Lee will also actively develop new chemical entities and biological drugs, focusing on treatments for metabolic diseases, cardiovascular diseases, and other therapeutic areas. SOURCE: Gan & Lee Pharmaceuticals

临床1期临床2期上市批准

2025-03-01

·医药投资部落

国产胰岛素龙头的十年一梦

2015年3月，通化东宝股价最高摸到8.84元/股。 2025年3月，通化东宝最新收盘价格为7.45元/股。在胰岛素这个号称长坡厚雪的赛道上，作为国产龙头企业的通化东宝，十年的时间恍如黄粱一梦。 2024年1月，通化东宝披露2024年业绩预告显示，公司预计2024年年度实现归属净利润约为4052.77万元，同比减少约96.53%。公开数据显示，这将是通化东宝自2007年以来最差的业绩。胰岛素集采是造成通化东宝净利大幅下滑的重要原因之一。通化东宝表示，2024年新一轮胰岛素集采在全国各省市开始陆续落地实施，公司各胰岛素产品中标价格均有不同程度下降，导致销售收入下滑。同时，由于新一轮胰岛素集采落地带来公司产品价格下调的普遍预期，公司商业客户对库存进行控制与调整，对公司发货造成一定影响，因此销售收入同比下滑。与集采如影随形的，是同行之间的激烈竞争。 2024年2月26日，通化东宝发布2024年业绩预告更正公告：经财务部门再次测算，预计2024年实现归属于上市公司股东的净利润约为1164.21万元，同比减少约99%。业绩预告更正的主要原因，是通化东宝与同行甘李药业之间的官司。 2021年1月，甘李药业起诉通化东宝生产销售的“长舒霖”甘精胰岛素，侵害其“长秀霖”商标权，并构成不正当竞争。根据最终判决，通化东宝应赔偿甘李药业经济损失6000万元。导致通化东宝2024年业绩大亏的，还有终止的研发管线。 2024年7月11日，通化东宝发布公告称，经审慎考量，公司决定终止可溶性甘精赖脯双胰岛素注射液研发项目（以下简称“THDB0207注射液”）临床研究开发工作。可溶性甘精赖脯双胰岛素注射液，是一种创新的胰岛素制剂，它结合了长效的甘精胰岛素和速效的赖脯胰岛素，与预混胰岛素相比，甘精赖脯双胰岛素能够强化空腹血糖控制，并减少“肩效应”引发的低血糖风险。在6年前的2018年4月26日，通化东宝公司与法国SA ADOCIA公司签订许可协议，通化东宝有偿获得BioChaperone® Combo（胰岛素基础餐时组合）在所有大中华地区，以及马来西亚、新加坡等国家和地区的独家开发、生产并商业化权利。 2022年5月，通化东宝先后启动了CT046、CT047、CT048三项I期临床试验，研究主要目的在于评估THDB0207注射液的临床药理学特征。 2023年10月，通化东宝收到上述三项关键I期临床试验的总结报告，研究结果显示达到主要终点目标。 2024年二季度，在I期临床试验的基础上，综合多位中国权威临床专家的意见，得出需要补充开展II期临床试验的结论。主要原因是，基于THDB0207注射液I期临床试验的数据，在中国最新临床实践下，有必要继续探索该产品的临床价值，其中对夜间低血糖特征的充分考察尤为重要。但是这个时候，通化东宝的这款产品，已经完全不占市场先机。目前，在国内已上市的与THDB0207注射液类似的双胰岛素注射液，有诺和诺德公司于2019年5月获批上市的德谷门冬双胰岛素。此外，还有大批在研管线：吉林惠升的德谷门冬双胰岛素生物类似药于2023年已经报产，联邦制药、东阳光、重庆宸安、中美华东这4家公司的德谷门冬双胰岛素生物类似药已于2022年至2024年期间进入III期临床试验阶段，其研发进度都大幅领先于通化东宝的THDB0207注射液。在这种不利局面下，通化东宝做出了终止研发的决策。通化东宝项目研发资本化金额6455.82万元全额计提资产减值准备，同时对2018年已经支付给SA ADOCIA公司与该项目相关的预付商业化权利款金额2.54亿元确认为损失。上述两项会计处理，将减少公司2024年年度净利润2.70亿元。应该说，2024年的通化东宝，运气实在有点差。但是好转的迹象也正在显露。一方面，在最新一轮胰岛素集采中，公司胰岛素产品尽管价格有所下降，但全部胰岛素产品均成功以A/A1类中标，除基础签约量外，还获得了约1,000万支分配量，并在医院准入方面实现巨大的提升和突破。另外一方面，公司的出海战略正在取得成绩。 2024全年，通化东宝的海外业务大幅增长，预计实现收入超亿元，同比接近翻倍。通化东宝的人胰岛素注射液上市许可申请已获得EMA正式受理；同时公司与健友股份已就门冬、甘精、赖脯3款胰岛素达成战略合作，共同进军美国胰岛素市场，目前相关临床试验正在稳步推进中。此外，在创新药领域，公司进展也不小。 2月25日，通化东宝宣布完成了注射用THDBH120的一项I期临床试验，并获得临床试验总结报告，试验达到主要终点目标。注射用THDBH120是通化东宝重点在研的胰高血糖素样肽-1 (GLP-1) 受体和葡萄糖促胰岛素分泌多肽 (GIP) 受体双靶点激动剂，属于一类创新药，有望成为更长效的治疗糖尿病和肥胖的重磅药物。医药研究报告分享营收集与分享全市场主流医药研究报告每天仅需0.8元畅享超过2000篇存量精选医药研究报告每年新增额外500篇

财报IPO专利侵权临床1期

2024-11-15

·求实药社

甘李药业公布口服GLP-1 RA GZR18片I期临床试验数据

来源：多肽圈 2024年11月12日，甘李药业股份有限公司（以下简称：甘李药业，股票代码：603087.SH）宣布公司自主研发的口服胰高血糖素样肽-1受体激动剂（GLP-1 RA）GZR18片在中国健康受试者中的I期临床试验取得积极结果。该I期临床试验（CTR20240663）是一项随机、开放的首次人体研究，共计招募92名受试者，旨在评估GZR18片在中国成年健康受试者中的相对生物利用度、药代动力学、药效学、安全性、耐受性和评估进食时间对GZR18片药代动力学、药效学、安全性、耐受性的影响。本研究中，GZR18片总体安全性和耐受性良好，最常见的不良事件为胃肠道反应，符合GLP-1类药物的安全性特征。药代动力学研究显示，GZR18片吸收良好，支持每天一次口服给药。GZR18片在健康受试者中单次和多次给药后，药代动力学与药效学参数均呈剂量反应关系。此外，受试者接受每日口服一次目标剂量为60 mg的GZR18片治疗2周后，平均体重相对基线降低4.16%；且停药1周后，受试者体重持续减轻0.51%，较基线平均降幅达4.67%。观察至停药后21天，受试者的体重和BMI均未回升到基线值。关于GZR18 甘李药业研发的GZR18是一种长效GLP-1 RA，通过葡萄糖浓度依赖性机制发挥作用，增强胰岛素分泌，有效降低血糖水平。GZR18有注射液和口服两种给药方式，GZR18注射液是一种基于脂肪酸酰化设计的GLP-1RA，与人源GLP-1分子的同源性高达94% ，拟用于成人患者的2型糖尿病以及肥胖/超重患者的体重管理，目前在中国开展II期临床试验，也已完成首例受试者给药。GZR18片采用了小分子吸收促进剂SNAC（N-[8-（2-羟基苯甲酰基）氨基]辛酸盐）可逆性结合技术，在保证安全和有效性的前提下，一方面能有效解决口服多肽类GLP-1 RA生物利用度低、效果欠佳等问题，另一方面能提高患者的依从性，适应症为2型糖尿病，目前已完成I期临床试验。关于GLP-1RA GLP-1RA主要是通过激活胰岛 β 细胞上的 GLP-1 受体刺激胰岛 β 细胞分泌胰岛素及抑制胰岛 α 细胞分泌胰高糖素、抑制食欲、延缓胃排空等多重机制发挥降糖作用。根据药代动力学的特点，GLP-1RA可分为短效、长效和超长效制剂。关于甘李药业甘李药业股份有限公司（简称：甘李药业，股票代码：603087.SH）作为中国第一家掌握产业化生产重组胰岛素类似物技术的高科技生物制药企业，具备完整胰岛素研发管线。目前，公司拥有六款核心胰岛素产品，包括五个胰岛素类似物品种：长效甘精胰岛素注射液（长秀霖®）、速效赖脯胰岛素注射液（速秀霖®）、门冬胰岛素注射液（锐秀霖®）、预混精蛋白锌重组赖脯胰岛素混合注射液（25R）（速秀霖® 25）、门冬胰岛素30注射液（锐秀霖® 30）；以及人胰岛素品种：预混精蛋白人胰岛素混合注射液（30R）（普秀霖®30），产品覆盖长效、速效、预混三个胰岛素功能细分市场。同时，公司产品覆盖相关医疗器械，包括可重复使用的胰岛素注射笔（秀霖笔®）和一次性注射笔用针头（秀霖针®）。免责声明：文章内容仅供参考，不构成投资建议。投资者据此操作，风险自担, 关于对文中陈述、观点判断保持中立，不对所包含内容的准确性、可靠性或完整性提供任何明示或暗示的保证。请读者仅作参考，并请自行承担全部责任。本公众号发布的各类文章重在分享，如有侵权请联系我们，我们将会删除。联系我们 ABC 2025 展位火热预定中！扫码立即咨询电话：13816031174 （同微信）赞助形式包括但不仅限于演讲席位、会场展位、会刊彩页、晚宴赞助、会议用品宣传等。点击此处“阅读全文”咨询更多精彩

临床1期临床2期临床结果

100 项与重组甘精胰岛素 (甘李药业) 相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	-	A10AE04	-

研发状态

批准上市

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
糖尿病	中国	甘李药业股份有限公司	2005-05-10

未上市

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
2型糖尿病	临床3期	美国	甘李药业股份有限公司	2017-10-31
1型糖尿病	临床1期	德国	甘李药业股份有限公司	2018-07-10

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT03371082 (GLITTER1, CTgov)	临床3期	1型糖尿病	576	Gan & Lee Insulin Glargine Injection (Gan & Lee Insulin Glargine Injection)	廠鏇鑰鹽襯繭窪餘衊餘(鹽艱糧齋窪範窪衊憲衊) = 鹹鑰膚鹹願蓋遞窪艱鏇範壓齋壓遞製蓋遞獵糧 (窪繭醖壓淵衊醖顧構構, 88.88) 更多	-	2024-05-14
NCT03371082 (GLITTER1, CTgov)	临床3期	1型糖尿病	576	Lantus® (Lantus®)	廠鏇鑰鹽襯繭窪餘衊餘(鹽艱糧齋窪範窪衊憲衊) = 觸淵願夢醖築築製壓窪範壓齋壓遞製蓋遞獵糧 (窪繭醖壓淵衊醖顧構構, 332.90) 更多	-	2024-05-14
NCT03371082 (EASD2023)	临床3期	1型糖尿病	576	GL Glargine Injection	顧築廠構簾製鬱願鏇淵(範獵衊艱簾蓋願鑰範選) = similar rates of TEAEs reported in both groups (90.2% vs. 92.4%) 繭齋壓網壓齋鹹醖壓積 (鹽膚蓋餘鹽衊願鹹築範 ) 更多	积极	2023-10-05
NCT03371108 (EASD2023)	临床3期	2型糖尿病	567	GL Glargine Injection	鏇艱製膚積憲淵繭壓繭(製艱夢範鬱憲廠壓淵鬱) = 膚築壓夢醖獵艱醖繭廠廠鹽顧蓋憲壓蓋鏇齋艱 (簾簾鹹範鹹蓋壓選簾艱, -0.13 ~ 0.26)	积极	2023-10-05
NCT03371108 (GLITTER 2, CTgov)	临床3期	2型糖尿病	567	Gan & Lee Insulin Glargine Injection (Gan & Lee Insulin Glargine Injection)	壓鹽壓鏇鹽淵遞齋醖艱 = 蓋繭簾醖鏇網鏇鏇蓋選蓋構淵襯醖觸選鹹鬱構 (餘顧夢獵選鬱糧獵願構, 窪淵艱構膚繭鏇鬱壓壓 ~ 獵齋窪積鹽糧簾鏇糧築) 更多	-	2022-03-23
NCT03371108 (GLITTER 2, CTgov)	临床3期	2型糖尿病	567	Lantus® (Lantus®)	壓鹽壓鏇鹽淵遞齋醖艱 = 選衊遞淵簾廠顧襯廠窪蓋構淵襯醖觸選鹹鬱構 (餘顧夢獵選鬱糧獵願構, 蓋窪鏇膚鏇憲壓繭獵壓 ~ 餘夢簾窪遞製鏇鏇窪鹹) 更多	-	2022-03-23