预约演示
更新于：2025-05-26
Amlodipine Besylate/Perindopril Arginine
苯磺酸氨氯地平/精氨酸培哚普利
更新于：2025-05-26
概要
基本信息
药物类型 小分子化药 |
别名 Acerycal、Amlodipine/perindopril、Bi-Prestarium + [19] |
作用方式 抑制剂、阻滞剂 |
作用机制 ACE抑制剂(血管紧张素转化酶抑制剂)、VDCCs阻滞剂(电压门控性钙通道复合体阻滞剂) |
治疗领域 |
非在研适应症- |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C25H46N6O7 |
InChIKeyRYCSJJXKEWBUTI-YDYAIEMNSA-N |
CAS号612548-45-5 |
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关联
52
项与 苯磺酸氨氯地平/精氨酸培哚普利 相关的临床试验CTR20250903
评估受试制剂培哚普利氨氯地平片（Ⅲ）（规格：10 mg:5 mg）与参比制剂开素达®（规格：10 mg:5 mg）在健康成年参与者餐后状态下的单中心、开放、随机、单剂量、交叉生物等效性研究
CTR20250233
评估受试制剂培哚普利氨氯地平片（Ⅲ）（规格：10 mg:5 mg）与参比制剂开素达®（规格：10 mg:5 mg）在健康成年参与者空腹状态下的单中心、开放、随机、单剂量、交叉生物等效性研究
CTR20243293
随机、开放、单剂量、两制剂、两序列、两周期、自身交叉对照设计，评价中国健康受试者在空腹及餐后状态下单次口服培哚普利氨氯地平片的生物等效性试验
100 项与 苯磺酸氨氯地平/精氨酸培哚普利 相关的临床结果
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100 项与 苯磺酸氨氯地平/精氨酸培哚普利 相关的转化医学
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100 项与 苯磺酸氨氯地平/精氨酸培哚普利 相关的专利（医药）
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998
项与 苯磺酸氨氯地平/精氨酸培哚普利 相关的文献（医药）2025-12-31Journal of the International Society of Sports Nutrition
Pre-sleep casein ingestion with probiotic strains improves anaerobic power and lower-body-specific strength and power performance in soccer players
Article
作者: Imanian, Babak ; Sadeghi, Reza ; Eftekhari, Fereshteh ; Koureshfard, Negar ; Hemmatinafar, Mohammad
BACKGROUND:
Probiotics comprise various strains that offer numerous health benefits. Researchers have recently focused on the relationship between probiotic consumption and improved gut microbiota function, enhanced digestion, increased nutrient absorption, and enhanced sports performance. Therefore, the present study investigated the effects of pre-sleep casein intake, coupled with probiotic strains, on soccer players' anaerobic power, lower-body-specific strength, and power performance.
METHODS:
A randomized, double-blinded, and placebo-controlled study was conducted with forty-four male soccer players (Age: 22.81 ± 2.76 years, Height: 177.90 ± 6.75 cm, Weight: 67.42 ± 8.44 kg). The participants underwent the isokinetic strength, Wall-squat, and running-based anaerobic sprint (RAST) tests initially; then, they were randomly divided into four groups: probiotics (PRO), casein (CAS), probiotics with casein (PRO+CAS), and placebo (PLA). The PRO groups were given one probiotic capsule (containing eight bacterial strains: Lactiplantibacillus plantarum BP06, Lacticaseibacillus casei BP07, Lactobacillus acidophilus BA05, Lactobacillus bulgaricus BD08, Bifidobacterium infantis BI04, Bifidobacterium longum BL03, Bifidobacterium breve BB02, and Streptococcus thermophilus BT01, with a total dose of 4.5 × 1011 CFU) during dinner, while the CAS groups consumed 20 grams of casein powder 45 minutes before bed. The PRO+CAS group was given one probiotic capsule during dinner and 20 grams of casein powder 45 minutes before bed. The participants in the PLA group were given one red capsule (containing 5 grams of starch) during dinner. All participants were instructed to take the supplements only on training days, three times a week for four weeks. Additionally, isokinetic strength parameters, including absolute peak torque (APT) and average rate of force development (AvRFD), were measured for the knee extensors (ext) and flexors (flx) muscles (concentric phase at angular velocities of 60°/s and 180°/s, using the dominant leg). One-way analysis of covariance (ANCOVA) or Quade tests with a significance level of p < 0.05 was used to analyze the collected data.
RESULT:
The current study's findings indicated that APT-180°/s (ext) significantly increased in CAS (p = 0.008) and PRO+CAS (p = 0.003) compared to PLA. Additionally, the AvRFD-180°/s (ext) increased significantly in the PRO compared to the PLA (p = 0.007). Also, the AvRFD-60°/s (flx) increased significantly in the PRO+CAS group compared to the PLA (p = 0.014), CAS (p = 0.001), and PRO (p = 0.007). Furthermore, the AvRFD-180°/s (flx) increased significantly in the PRO+CAS compared to the CAS (p = 0.010). Moreover, the RAST average power increased dramatically in PRO+CAS compared to PLA (p = 0.003) and CAS (p = 0.02). Additionally, the Wall-squat test demonstrated a significant increase in PRO+CAS compared to PLA (p = 0.001) and PRO (p = 0.001). However, there were no significant differences in the APT-60°/s (ext&flx), APT-180°/s (flx), and AvRFD-60°/s (ext) between groups (p > 0.05).
CONCLUSION:
The simultaneous consumption of casein and probiotics significantly improved anaerobic power, isokinetic strength, and lower-body muscular endurance in male soccer players. These enhancements were more pronounced than those observed with casein or probiotics alone, as supported by statistical significance and effect sizes. The findings suggest a synergistic benefit of combined supplementation for athletic performance.
2025-12-31Journal of the International Society of Sports Nutrition
Elite collegiate swimmers do not meet sport nutrition recommendations during heavy training: effects of sex and within-day nutrient timing
Article
作者: Williams, Nancy I. ; Lundstrom, Emily A. ; Khen, Keiona M. ; De Souza, Mary Jane
BACKGROUND:
Compared to the general population, athletes experience high energy expenditures requiring increased energy and macronutrient intakes to sustain training and optimize performance. While the International Olympic Committee (IOC) and International Society for Sports Nutrition (ISSN) have established recommendations for nutrient intakes, many athletes do not meet the recommended daily allowance (RDA) for the general population, and sport and sex-specific differences are not well documented. Exploration of within-day energy balance (WDEB) shows athletes may achieve energy balance by the end of the day but may present with poor WDEB. Data support that female athletes are at greater risk of nutrient deficiencies than their male counterparts, and it is unclear whether swimmers meet sport-specific nutrient intake and timing recommendations. Following our previous WDEB analysis, the purpose of this investigation was to assess dietary macronutrient intake as related to RDAs (USDA and IOC/ISSN), within-day macronutrient timing, and associated sex differences in swimmers.
METHODS:
In elite male and female swimmers (n = 25; 18-22 yr), we assessed energy intake (EI), total daily energy expenditure (TDEE), macronutrient intake (fat (FAT), protein (PRO), carbohydrate (CHO)) and timing during heavy training. Frequency analysis was utilized to determine the number of athletes meeting general and athlete-specific RDAs. Repeated-measures ANOVA was used to assess nutrient timing across sex groups.
RESULTS:
When compared to IOC/ISSN daily recommendations, only 6/25 swimmers met FAT intake, 7/25 met CHO intake, and 24/25 met PRO intake IOC/ISSN daily recommendations.Males had greater EI and TDEE compared to females (p < 0.05). PRO consumption (% of EI) was a larger percentage of total intake in male vs females (28 ± 5% vs 23 ± 3%; F = 2.996; p = 0.014). No swimmers met CHO recommendations (g⋅kg-1) pre- or during exercise for the first daily training session. 13/25 met pre-exercise CHO recommendations, while 6/25 and 11/25 met during and post-exercise CHO recommendations for the second training session. Repeated measures ANOVA revealed effects of sex and time on intake (g⋅kg LBM-1⋅hr-1) for FAT (Sex; F = 5.659, p = 0.26; time; F = 12.068, p = 0.006) and PRO (Sex; F = 6.719, p = 0.016; time; F = 13.177, p = 0.011). There was a significant sex*time interaction for CHO consumption (F = 6.520, p = 0.017).
CONCLUSION:
The results from this study demonstrate significant sex-differences, indicating that most swimmers meet athlete-specific recommendations for PRO, but not CHO or FAT intake. CHO timing for pre-, during, and post-exercise was met by only 52% swimmers. Results suggest that swimmers should prioritize CHO intake, emphasized around and during training bouts.
2025-12-01MOLECULAR BIOLOGY REPORTS
Novel role of GRK2 in isoprenaline-induced activation of Na+/H+ exchanger 3 independent of β2-adrenergic receptor signaling
Article
作者: Wen, Hong ; Lai, Xiaomei ; Li, Jianling ; Dai, Yongfa ; Huang, Jing
BACKGROUND:
The activation of Na+/H+ exchanger 3 (NHE3) by β2-adrenergic receptor (β2-AR) signaling is well-established. Our research indicates that isoprenaline (ISO) induces activation of NHE3 independent of β2AR signaling but through a different way that has not been elucidated before.
METHODS:
The activation of NHE3 in HK-2 cell lines was quantified using the fluorescence probe BCECF/AM. The expression levels of G protein-coupled receptor kinase 2 (GRK2) and its downstream effector, β-arrestin 1 (ARRB1), were assessed through Western blot analysis and immunohistochemical staining. ISO-induced β2-AR signaling was blocked by ICI 118,551, a β2-AR antagonist, in HK-2 cells.
RESULTS:
ISO treatment significantly enhanced NHE3 activity, which was reduced by 64.5% with a GRK2 inhibitor (GRK2-IN) and completely inhibited by propranolol (PRO), a non-selective β-adrenergic receptor blocker. Neither GRK2-IN nor PRO impacted NHE3 activity in the absence of ISO. Additionally, while GRK2 expression remained unchanged, ISO markedly decreased ARRB1 expression. This decrease was mitigated by 64.08% with GRK2-IN and entirely blocked by PRO. GRK2-IN and PRO alone did not significantly alter ARRB1 expression.
CONCLUSION:
Our study suggests that ISO triggers downstream GRK2/ARRB1 signaling to increase NHE3 activity independent of traditional β2AR signaling. Given the fundamental role of NHE3 in renal water-sodium reabsorption, these insights may contribute to new strategies for the prevention and treatment of hypertension.
100 项与 苯磺酸氨氯地平/精氨酸培哚普利 相关的药物交易
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外链
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 冠状动脉疾病 | 澳大利亚 | 2010-01-11 | |
| 高血压 | 澳大利亚 | 2010-01-11 |
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临床结果
临床结果
适应症
分期
评价
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N/A | - | 440 | Perindopril/Amlodipine (P/A) | 醖鹽觸膚窪壓膚餘鏇選(鹽繭顧襯遞壓衊壓艱範) = 艱鹽獵積糧廠願選蓋蓋 簾構夢鹹遞鬱觸餘窪顧 (鹹顧選糧醖鏇淵顧積範 ) | 积极 | 2022-06-01 | |
Perindopril/Amlodipine/Indapamide (P/A/I) | 醖鹽觸膚窪壓膚餘鏇選(鹽繭顧襯遞壓衊壓艱範) = 膚遞遞築築鹹願壓鏇鏇 簾構夢鹹遞鬱觸餘窪顧 (鹹顧選糧醖鏇淵顧積範 ) | ||||||
N/A | - | 450 | Perindopril/Amlodipine (Dual SPC arm) | 鑰淵艱網繭築鑰膚廠構(獵鹹願範獵積觸願鹹願) = 85% of patients experienced no adverse events, recorded ones were clinically irrelevant 構網齋膚鹹夢網積獵壓 (餘醖築衊淵繭範願鏇願 ) | 积极 | 2021-04-01 | |
Perindopril/Amlodipine/Indapamide (Triple SPC arm) | |||||||
N/A | - | 1,814 | Perindopril/Amlodipine 3.5/2.5 mg | 積鏇鹽鑰襯網範艱鏇夢(鏇窪膚構糧夢構糧顧夢) = 築鏇膚鹽齋鏇廠積糧膚 構遞廠遞夢廠觸獵襯繭 (醖鬱膚糧簾蓋淵顧製構 ) 更多 | 积极 | 2017-09-01 | |
鑰醖觸構夢築鑰鑰網構(窪壓築觸構壓膚憲網廠) = 膚構廠網選鑰顧鹹淵襯 獵衊獵壓蓋顧繭網鏇廠 (網鹹顧淵製鹽鬱築艱獵 ) 更多 | |||||||
N/A | 102 | 鹽醖築鹽築淵艱壓鑰淵(蓋網顧衊醖憲鑰積觸構) = 積鑰憲淵憲觸鬱鬱餘顧 鏇製鹹窪構廠壓構鹹齋 (願糧壓鹹獵鑰遞積糧餘 ) | - | 2016-12-07 | |||
N/A | 1,907 | 範製糧壓簾觸獵築繭窪(鹽簾構窪觸繭築鑰積蓋) = 築膚壓淵齋構襯構鏇製 繭壓鏇製廠築獵衊築觸 (蓋襯網遞艱壓鏇鏇積築 ) 更多 | 积极 | 2016-09-01 | |||
N/A | 262 | 窪窪選獵蓋鑰壓蓋鹹遞(襯膚繭積窪範簾蓋窪廠) = 製膚繭膚觸壓範鹹鬱築 憲膚築淵窪繭構淵夢範 (壓壓糧繭襯積襯壓衊壓, 8.9) 更多 | 积极 | 2016-09-01 | |||
窪窪選獵蓋鑰壓蓋鹹遞(襯膚繭積窪範簾蓋窪廠) = 顧醖簾顧遞築積簾簾廠 憲膚築淵窪繭構淵夢範 (壓壓糧繭襯積襯壓衊壓, 8.9) 更多 | |||||||
N/A | - | 459 | FDC perindopril arginine/amlodipine | 廠獵範衊廠願網鏇蓋衊(膚遞淵壓繭淵壓衊製遞) = 鹹繭網簾遞獵鹽選糧網 衊窪夢壓壓衊繭憲簾選 (積構繭壓襯壓積觸遞遞 ) | - | 2016-08-28 | |
Free combinations of lisinopril + amlodipine | 廠獵範衊廠願網鏇蓋衊(膚遞淵壓繭淵壓衊製遞) = 簾淵獵選憲鏇鹽艱簾襯 衊窪夢壓壓衊繭憲簾選 (積構繭壓襯壓積觸遞遞 ) | ||||||
临床3期 | 837 | (XOMA 985) | 襯鹹選壓願製獵餘窪鏇(選繭淵願壓積窪襯繭遞) = 衊鑰製淵糧願夢襯蓋齋 鹹鏇獵構構鹹觸鑰艱膚 (鑰遞獵廠醖構憲夢艱膚, 8.38) 更多 | - | 2015-08-25 | ||
(Amlodipine Besylate (AMLb)) | 襯鹹選壓願製獵餘窪鏇(選繭淵願壓積窪襯繭遞) = 膚繭餘網構艱製廠製壓 鹹鏇獵構構鹹觸鑰艱膚 (鑰遞獵廠醖構憲夢艱膚, 8.33) 更多 |
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