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更新于：2025-03-25
Aceclofenac
醋氯芬酸
更新于：2025-03-25
概要
基本信息
原研机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C16H13Cl2NO4 |
InChIKeyMNIPYSSQXLZQLJ-UHFFFAOYSA-N |
CAS号89796-99-6 |
关联
42
项与 醋氯芬酸 相关的临床试验CTRI/2024/11/077314
A post approval observational study to assess the impaCt Of fixed dose coMbination of Trypsin: Chymotrypsin+ Aceclofenac + Paracetamol In Outpatient SEttings of India (COMPOSE I) - Compose I
CTRI/2024/11/077228
A Comparative Evaluation of The Effect of Low-Level LASER Therapy, LASER-Activated Irrigation and Preoperative Aceclofenac on Post Endodontic Pain After Single Visit Root Canal Treatment - A Randomized Controlled Trial. - NIL
CTR20243256
醋氯芬酸片（100mg）在中国健康受试者中空腹和餐后给药条件下随机、开放、单剂量、两序列、两周期、双交叉生物等效性试验
100 项与 醋氯芬酸 相关的临床结果
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100 项与 醋氯芬酸 相关的转化医学
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100 项与 醋氯芬酸 相关的专利（医药）
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1,972
项与 醋氯芬酸 相关的文献（医药）2025-02-01JOURNAL OF MOLECULAR STRUCTURE
Drug-amino acid interaction: Molecular dynamics in aqueous medium using time domain reflectometry
作者: Narwade, Pallavi ; Alwaleedy, Suad ; Kumbharkhane, Ashok C. ; Karale, Ravikant R. ; Al-Hamdani, Saeed Mohammed ; Kamble, Savita ; Sarode, Arvind V.
Present work reports dielec. response of the non-steroidal anti-inflammatory drug (NSAID) aceclofenac in aqueous valine solutions at various concentrations and temperatures (278.15 K-298.15 K) in the frequency range of 0.01 GHz to 30 GHz using Time-domain reflectometry (TDR) technique.The frequency dependent complex dielec. permittivity has been analyzed by Harviliak-Negami equation.Debye model is used for the description of complex dielec. permittivity spectra ε*(ν).The structural and dynamical properties of water has been investigated at different concentrations of valine and aceclofenac using dielec. as well as thermodn. parameters that includes static dielec. constant (ε0), relaxation time (τ0), Kirkwood correlation factor (g), free energy of activation (ΔF), entropy of activation (ΔS), and enthalpy of activation (ΔH).Towards the measured low temperature and high concentrations of Valine and Aceclofenac (ACF), static dielec. constant (ε0) was found to be increasing.This could be due to increased effective dipole-dipole parallel alignment and can be confirmed by the increasing values of correlation factor (g > 1).The dipole-dipole interaction between Drug-Amino acid resulted in increased dielec. relaxation time (τ0) of system due to increased steric hindrance for the rotation of dipoles.The free energy of activation was found to be in the range of 2.22 and 2.58 Kcal mol-1.The entropy is more neg. at high concentration suggesting more ordered structure.The slope of log (Tτ0) vs. 1000/T gives the value of enthalpy (ΔH).
2025-01-02Expert Opinion On Drug Safety
Risk of drug-induced delirium in older patients- a pharmacovigilance study of FDA adverse event reporting system database
Article
作者: Li, Jiayu ; Zhou, Ying ; Jia, Boying ; Zhou, Shuang ; Wan, Liyan ; Cui, Yimin
BACKGROUND:
Drug-induced delirium is known risk factors associated with increased morbidity and mortality in older patients. The objective was to evaluate the risk of drug-related delirium in older patients based on the FDA Adverse Event Reporting System (FAERS).
RESEARCH DESIGN AND METHODS:
Delirium reports in older patients (age ≥65) extracted from the FAERS database using Open Vigil 2.1. The reported odds ratio and the proportional reported ratio were calculated to detect the adverse reaction signal of delirium. Combined with published evidence, suspected drugs were categorized as known, possible, or new potential delirium-risk-increasing drugs.
RESULTS:
Of the 130,885 reports (including 28,850 delirium events and 1,857 drugs) analyzed for this study, 314 positive signal drugs were detected. Positive signal drugs are mainly concentrated on the drug of nervous system, cardiovascular system , alimentary tract and metabolism and anti-infectives for systemic use. Of the positive signal drugs, 26.11% (82/314) were known delirium-risk increasing drugs, 44.90% (141/314) were possible and 28.98% (91/314) were new potential.
CONCLUSION:
Drug-induced delirium risk is prevalent in older patients, according to the FAERS. The risk level of drug-induced delirium should be taken into account to optimize drug therapy in clinical practice.
2024-12-01Heliyon
Synthesis and pharmacological evaluation of heteroarylamide derivatives as potential analgesic, anti-inflammatory, antidiarrheal and cytotoxic agents
Article
作者: Rahman, S M Abdur ; Saha, Poushali ; Hossain, A S M Monjur Al ; Rahman, Fahad Imtiaz ; Spriha, Sabiha Enam ; Tabassum, Nazifa ; Al Hossain, ASM Monjur
Six heteroarylamide derivatives were synthesized in good yields and screened for several biological activities. Compounds 1-5 demonstrated analgesic activity with percentage inhibition of writhing between 77.10 and 95.79 %, comparable to that of the standard aceclofenac having 91.12 % writhing inhibition. Evaluation of anti-inflammatory activity unveiled that compound 4 exhibited 36.9 %, 64.17 %, 82.9 % and 93.9 % inhibition of paw edema as compared to aceclofenac's inhibition of 35.5 %, 78.6 %, 79.3 % and 91.2 % at the 1st, 2nd, 3rd and 4th hours, respectively. Compounds 5 and 6 exerted considerable antidiarrheal effects with 85.00 % and 71.67 % inhibition of defecation at 25 mg/kg dose, respectively, whereas, the standard loperamide showed 85.00 % inhibition. Compounds 4-6 manifested promising activity in brine shrimp lethality bioassay as well as in trypan blue dye exclusion assay, resulting in 10-20 % cell viability on HeLa cell line and compound 5 was found to have the lowest IC50 of 281.96 μM in the MTT assay. Molecular docking analysis suggested that certain macromolecular targets such as cyclooxygenase-2, muscarinic M3 receptor and matrix metalloproteinase 9 (MMP9) might be involved for the observed activities. As predicted by in silico ADME/T analysis, the compounds also possessed good pharmacokinetic properties.
100 项与 醋氯芬酸 相关的药物交易
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研发状态
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 平滑肌瘤 | 欧盟 | 2018-08-27 | |
| 平滑肌瘤 | 冰岛 | 2018-08-27 | |
| 平滑肌瘤 | 列支敦士登 | 2018-08-27 | |
| 平滑肌瘤 | 挪威 | 2018-08-27 | |
| 风湿性疾病 | 西班牙 | - | 1993-05-19 |
| 强直性脊柱炎 | - | - | 1992-01-01 |
| 骨关节炎 | - | - | 1992-01-01 |
| 类风湿关节炎 | - | - | 1992-01-01 |
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临床结果
临床结果
适应症
分期
评价
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N/A | 120 | Aceclofenac 100 mg twice a day | 襯遞積選夢齋製壓簾簾(膚衊觸淵繭繭範製窪餘) = Adverse events of therapy were mild and not require discontinuation of therapy 餘製築顧夢蓋繭願廠鬱 (鹹積遞選築簾窪鏇廠糧 ) | 积极 | 2020-08-20 | ||
N/A | - | NSAIDs | 淵鬱壓襯積衊廠窪艱醖(蓋簾鬱繭窪簾鹽構膚築) = 襯鏇網鹹製壓窪繭襯願 積繭構鹽鬱鑰夢鹹範淵 (艱顧夢壓鏇積餘構築壓, 1.7 ~ 3.1) | - | 2015-06-10 | ||
临床4期 | 143 | 憲廠齋衊鹽鏇鹹觸築艱(艱糧繭醖製遞製選積觸) = 構觸鬱艱襯顧網齋築襯 鹹齋壓憲艱襯壓築鏇範 (遞窪選繭築繭鬱獵範醖, 14.17) 更多 | - | 2013-06-24 | |||
N/A | 200 | 鏇壓襯鏇網網製範構襯(網壓膚遞艱膚淵憲顧蓋) = Adverse effects were noted in 3% of Aceclofenac treated OA patients and in 12% subjects treated with Diclofenac 簾築餘醖鑰積壓蓋繭網 (鏇積繭鏇糧範窪鑰遞廠 ) | - | 2012-06-06 | |||
N/A | - | 遞鑰鹽繭願獵獵鹽構積(艱壓衊醖鬱餘遞構鬱膚) = 獵艱顧構鏇艱膚鬱壓遞 構艱蓋蓋網齋鏇積廠壓 (衊製鏇獵壓網淵構鹽鹹 ) 更多 | 积极 | 2002-06-12 |
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