预约演示
更新于：2025-02-07
Aceclofenac
醋氯芬酸
更新于：2025-02-07
概要
基本信息
原研机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C16H13Cl2NO4 |
InChIKeyMNIPYSSQXLZQLJ-UHFFFAOYSA-N |
CAS号89796-99-6 |
关联
40
项与 醋氯芬酸 相关的临床试验CTRI/2024/11/077314
A post approval observational study to assess the impaCt Of fixed dose coMbination of Trypsin: Chymotrypsin+ Aceclofenac + Paracetamol In Outpatient SEttings of India (COMPOSE I) - Compose I
CTRI/2024/11/077228
A Comparative Evaluation of The Effect of Low-Level LASER Therapy, LASER-Activated Irrigation and Preoperative Aceclofenac on Post Endodontic Pain After Single Visit Root Canal Treatment - A Randomized Controlled Trial. - NIL
CTR20243256
醋氯芬酸片（100mg）在中国健康受试者中空腹和餐后给药条件下随机、开放、单剂量、两序列、两周期、双交叉生物等效性试验
100 项与 醋氯芬酸 相关的临床结果
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100 项与 醋氯芬酸 相关的转化医学
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100 项与 醋氯芬酸 相关的专利（医药）
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2,014
项与 醋氯芬酸 相关的文献（医药）2025-02-01JOURNAL OF MOLECULAR STRUCTURE
Drug-amino acid interaction: Molecular dynamics in aqueous medium using time domain reflectometry
作者: Alwaleedy, Suad ; Narwade, Pallavi ; Kumbharkhane, Ashok C. ; Karale, Ravikant R. ; Al-Hamdani, Saeed Mohammed ; Kamble, Savita ; Sarode, Arvind V.
Present work reports dielec. response of the non-steroidal anti-inflammatory drug (NSAID) aceclofenac in aqueous valine solutions at various concentrations and temperatures (278.15 K-298.15 K) in the frequency range of 0.01 GHz to 30 GHz using Time-domain reflectometry (TDR) technique.The frequency dependent complex dielec. permittivity has been analyzed by Harviliak-Negami equation.Debye model is used for the description of complex dielec. permittivity spectra ε*(ν).The structural and dynamical properties of water has been investigated at different concentrations of valine and aceclofenac using dielec. as well as thermodn. parameters that includes static dielec. constant (ε0), relaxation time (τ0), Kirkwood correlation factor (g), free energy of activation (ΔF), entropy of activation (ΔS), and enthalpy of activation (ΔH).Towards the measured low temperature and high concentrations of Valine and Aceclofenac (ACF), static dielec. constant (ε0) was found to be increasing.This could be due to increased effective dipole-dipole parallel alignment and can be confirmed by the increasing values of correlation factor (g > 1).The dipole-dipole interaction between Drug-Amino acid resulted in increased dielec. relaxation time (τ0) of system due to increased steric hindrance for the rotation of dipoles.The free energy of activation was found to be in the range of 2.22 and 2.58 Kcal mol-1.The entropy is more neg. at high concentration suggesting more ordered structure.The slope of log (Tτ0) vs. 1000/T gives the value of enthalpy (ΔH).
2025-01-02Expert Opinion On Drug Safety
Risk of drug-induced delirium in older patients- a pharmacovigilance study of FDA adverse event reporting system database
Article
作者: Li, Jiayu ; Zhou, Ying ; Jia, Boying ; Zhou, Shuang ; Wan, Liyan ; Cui, Yimin
BACKGROUND:
Drug-induced delirium is known risk factors associated with increased morbidity and mortality in older patients. The objective was to evaluate the risk of drug-related delirium in older patients based on the FDA Adverse Event Reporting System (FAERS).
RESEARCH DESIGN AND METHODS:
Delirium reports in older patients (age ≥65) extracted from the FAERS database using Open Vigil 2.1. The reported odds ratio and the proportional reported ratio were calculated to detect the adverse reaction signal of delirium. Combined with published evidence, suspected drugs were categorized as known, possible, or new potential delirium-risk-increasing drugs.
RESULTS:
Of the 130,885 reports (including 28,850 delirium events and 1,857 drugs) analyzed for this study, 314 positive signal drugs were detected. Positive signal drugs are mainly concentrated on the drug of nervous system, cardiovascular system , alimentary tract and metabolism and anti-infectives for systemic use. Of the positive signal drugs, 26.11% (82/314) were known delirium-risk increasing drugs, 44.90% (141/314) were possible and 28.98% (91/314) were new potential.
CONCLUSION:
Drug-induced delirium risk is prevalent in older patients, according to the FAERS. The risk level of drug-induced delirium should be taken into account to optimize drug therapy in clinical practice.
2024-12-16Journal of biomolecular structure & dynamics
Water dynamics on the structural properties of some NSAID’s with leucine in the picosecond region using time domain spectroscopy
Article
作者: Alwaleedy, Suad ; Karale, Ravikant R. ; Kabara, Komal B. ; Kumbharkhane, Ashok C. ; Sarode, Arvind V. ; Kamble, Savita ; Al-Hamdani, Saeed
Concentration-dependent dielectric response for non-steroidal anti-inflammatory drugs (NSAIDs): Aceclofenac (ACF) and Diclofenac (DCF) in the aqueous leucine solution have been reported at different concentrations and temperatures (298.15 K to 283.15 K). The time domain reflectometry technique in the frequency region of 1 GHz to 30 GHz was used for the present study. Complex permittivity (ε*), static dielectric constant (ε), dielectric relaxation time (τ), dipole moment (μ) and Kirkwood correlation factor (g) have been calculated and discussed in terms of the molecular interaction of water and the used drugs. To give more insights into the structural dynamics of drug-induced amino acids, the study includes molar enthalpy of activation (ΔH), entropy of activation (ΔS), and free energy of activation (ΔF). The overall study concludes that the drug (DCF) having a potent inhibitor of cyclooxygenase found a higher static dielectric constant (ε0) than that of the drug (ACF) having more carbon (C), hydrogen (H), and oxygen (O) in the chain, which is more efficient in controlling pain.Communicated by Ramaswamy H. Sarma.
100 项与 醋氯芬酸 相关的药物交易
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研发状态
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 平滑肌瘤 | 欧盟 | 2018-08-27 | |
| 平滑肌瘤 | 冰岛 | 2018-08-27 | |
| 平滑肌瘤 | 列支敦士登 | 2018-08-27 | |
| 平滑肌瘤 | 挪威 | 2018-08-27 | |
| 风湿性疾病 | 西班牙 | - | 1993-05-19 |
| 强直性脊柱炎 | - | - | 1992-01-01 |
| 骨关节炎 | - | - | 1992-01-01 |
| 类风湿关节炎 | - | - | 1992-01-01 |
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临床结果
临床结果
适应症
分期
评价
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N/A | 120 | Aceclofenac 100 mg twice a day | 窪願構憲窪壓製築範選(遞憲鏇蓋鏇獵艱衊積願) = Adverse events of therapy were mild and not require discontinuation of therapy 蓋夢築艱顧觸願夢構觸 (窪憲繭憲醖觸襯鹽淵構 ) | 积极 | 2020-08-20 | ||
N/A | - | NSAIDs | 艱鹽獵範壓鬱積鑰壓窪(鏇鏇膚鏇構膚鏇網範製) = 餘簾鹽製膚壓簾觸蓋醖 遞製鹽繭遞憲願蓋構窪 (憲獵遞鑰蓋網糧憲範築, 1.7 ~ 3.1) | - | 2015-06-10 | ||
临床4期 | 143 | 壓願範襯鹹構蓋遞淵衊(選獵窪蓋襯餘窪齋齋鹽) = 鏇餘憲願選淵願窪網壓 繭糧窪齋鑰衊鑰製鑰夢 (衊鬱構願憲構鏇壓範膚, 鏇鹹構窪築廠選鏇壓鏇 ~ 齋鑰選製簾糧獵顧鬱夢) 更多 | - | 2013-06-24 | |||
N/A | 200 | 構築範鏇積觸廠網鏇積(憲糧齋觸憲醖憲膚鏇淵) = Adverse effects were noted in 3% of Aceclofenac treated OA patients and in 12% subjects treated with Diclofenac 遞糧網憲顧艱製壓鹹願 (鏇糧鏇顧廠廠鹹衊窪觸 ) | - | 2012-06-06 | |||
N/A | - | 鑰築願襯顧構窪夢蓋觸(顧顧製遞衊憲膚衊鹹鹽) = 餘鏇選鑰壓鏇簾願夢製 獵遞繭衊鏇積糧淵網憲 (範齋淵窪構製鑰壓製憲 ) 更多 | 积极 | 2002-06-12 |
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