Gabapentin/B-complex(Gabapentin/B-complex) - 药物靶点：CACNA2D1 x CACNA2D2 x MUT_专利_临床

概要

基本信息

药物类型

化学药

别名

Gabapentin+vitamin B、Gavindo

靶点

CACNA2D1 x CACNA2D2 x MUT

作用方式

阻滞剂、刺激剂

作用机制

CACNA2D1阻滞剂(电压门控性钙通道α2/δ亚基-1阻滞剂)、CACNA2D2阻滞剂(电压门控性钙通道α2/δ亚基-2阻滞剂)、MUT刺激剂(甲基丙二酰辅酶A变位酶刺激剂)

+ [1]

治疗领域-

在研适应症-

非在研适应症-

原研机构

Merck KGaA

在研机构-

非在研机构

Merck KGaA

权益机构-

最高研发阶段无进展临床3期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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关联

2

项与 Gabapentin/B-complex 相关的临床试验

NCT01364298

/ Completed临床4期

Multicenter, Randomized, Open-label, Parallel Group, Phase IV Study to Compare the Efficacy and Safety of Gabapentin/B-complex Versus Pregabalin in the Management of Diabetic Peripheral Neuropathic Pain

This is a multicenter, randomized, open-label, parallel, Phase 4 clinical trial to compare efficacy and safety of gabapentin/B-complex versus pregabalin in diabetic peripheral neuropathy pain (DPNP) management.

开始日期2011-04-01

申办/合作机构

Merck KGaA

[+1]

NCT01263132

/ Completed临床3期

Neuropathic Pain Treatment Using F0434 vs. Gabapentin in Patients With Chronic Distal Diabetic Polyneuropathy: A Randomized, Controlled, Double-blind Study

This is a prospective, randomized, double blind, comparative, experimental controlled Phase 3 clinical trial to assess the efficacy, safety and superiority of F0343 (gabapentin combined with B vitamins) compared to gabapentin alone for treating neuropathic pain in subjects with chronic distal diabetic polyneuropathy.

开始日期2008-02-01

申办/合作机构

Merck KGaA

[+1]

100 项与 Gabapentin/B-complex 相关的临床结果

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100 项与 Gabapentin/B-complex 相关的转化医学

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100 项与 Gabapentin/B-complex 相关的专利（医药）

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1

项与 Gabapentin/B-complex 相关的文献（医药）

2012-03-01·World Journal of Microbiology and Biotechnology4区 · 工程技术

Genome shuffling improves thermotolerance and glutamic acid production of Corynebacteria glutamicum

4区 · 工程技术

Article

作者: Zhi-Hao Sun ; Ye Ni ; Qiao-Yan Du ; Miao Liu ; Pu Zheng ; Xiao-de Liu

Genome shuffling was used to improve the thermotolerance of L: -glutamic acid-producing strain Corynebacteria glutamicum. Five strains with subtle improvements in high temperature tolerance and productivity were selected by ultraviolet irradiation and diethyl sulfate mutagenesis. An improved strain (F343) was obtained by three rounds of genome shuffling of the five strains as mentioned above. The cell density of F343 was four times higher than that of ancestor strains after 24 h of cultivation at 44°C, and importantly, the yield of L: -glutamic acid was increased by 1.8-times comparing with that of the ancestor strain at 38°C in a 5-L fermentor. With glucose supplement and two-stage pH control, the L: -glutamate acid concentration of F343 reached 119 g/L after fermentation for 30 h. The genetic diversity between F343 and its ancestors was also evaluated by amplified fragment length polymorphism analysis. Results suggest that the phenotypes for both thermotolerance and L: -glutamic acid production in F343 were evolved.

100 项与 Gabapentin/B-complex 相关的药物交易

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研发状态

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT01364298 (CTgov)	临床4期	糖尿病周围神经性疼痛	353	Gabapentin/B-complex (Gabapentin/B-complex)	憲繭網願遞艱艱觸觸艱(餘範窪醖網鹹壓積醖鹽) = 鬱鹹糧鹽簾艱餘糧憲鑰願憲製壓夢選膚製齋範 (壓製齋願網齋願鹹衊壓, 鏇顧獵製壓繭鏇構鏇製 ~ 遞鬱製築齋網蓋憲衊壓) 更多	-	2014-02-06
				Pregabalin (Pregabalin)	憲繭網願遞艱艱觸觸艱(餘範窪醖網鹹壓積醖鹽) = 範鏇憲淵築鏇獵鬱鹹鬱願憲製壓夢選膚製齋範 (壓製齋願網齋願鹹衊壓, 餘窪製廠壓醖鹽鏇糧淵 ~ 窪製製襯蓋窪蓋壓夢積) 更多
NCT01364298 (EASD2012)	临床4期	糖尿病周围神经病变	323	Gabapentin/vitamins B1/B12 fixed combination (GVB)	(築網蓋醖獵鹹簾憲選襯) = For GVB group, 65/146 patients (44.52%) presented at least one adverse event. For pregaba group, figures were 76/145 and 52.41%, respectively. 餘餘簾膚觸鏇齋憲鑰衊 (觸鏇積構窪繭廠鹽鏇顧 ) 更多	积极	2012-10-04
				Pregabalin (pregaba)