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更新于：2025-07-19
Dexpanthenol
右泛醇
更新于：2025-07-19
概要
基本信息
原研机构 |
在研机构 |
最高研发阶段批准上市 |
首次获批日期 日本 (1959-03-20), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C9H19NO4 |
InChIKeySNPLKNRPJHDVJA-ZETCQYMHSA-N |
CAS号81-13-0 |
关联
33
项与 右泛醇 相关的临床试验NCT06822608
Evaluation of a Fixed Combination of Dexpanthenol and Hyaluronic Acid Preservative-free Eye Drops on Corneal Epithelialization After Trans Epithelial PRK: a Prospective, Contralateral, Randomized, Double-blind, Placebo-controlled Trial
IRCT20240809062706N2
The effect of topical dexpanthenol cream on the prevention of striae in primigravida women: A double-blind randomized controlled trial
IRCT20220516054879N6
A comparative study of the effects of Hypericum Perforatum and Dexpanthenol topical cream on the healing process of scar caused by neck surgeries
100 项与 右泛醇 相关的临床结果
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100 项与 右泛醇 相关的转化医学
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100 项与 右泛醇 相关的专利（医药）
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1,246
项与 右泛醇 相关的文献（医药）2025-12-01MOLECULAR BIOLOGY REPORTS
The pantothenic acid derivative dexpanthenol ameliorated doxorubicin-induced neurotoxicity via regulating AKT/CREB/BDNF and AKT/NRF2 signaling pathways
Article
作者: Savran, Mehtap ; Ozmen, Ozlem ; Imeci, Orhan ; Asci, Halil ; Unlu, Melike Dogan
BACKGROUND:
Doxorubicin (Dox)-induced neurotoxicity is a well-documented side effect of chemotherapy. Dexpanthenol (Dex), an analog of vitamin B5, has shown protective properties. This study aimed to explore the molecular mechanisms by which Dex mitigates Dox-induced neurotoxicity, particularly through the protein kinase B (AKT)/cyclic AMP-response element-binding protein (CREB)/brain-derived neurotrophic factor (BDNF) pathway and nuclear factor erythroid 2-related factor 2 (NRF2) signaling.
METHODS AND RESULTS:
The experiment was conducted using four groups: control, Dex, Dox, and Dox + Dex, comprising a total of 32 female Wistar Albino rats. After two weeks of treatment, the rats were euthanized, and brain and cerebellum tissues were collected for analysis. Biochemical analysis was performed spectrophotometrically to assess oxidative stress parameters, while histological and immunostaining analyses focused on nuclear factor kappa B (NF-κB) and inducible nitric oxide synthase (iNOS) immunoexpressions. Genetic analysis of AKT, CREB, BDNF, and NRF2 gene expressions was conducted using real-time polymerase chain reaction. Histopathological evaluation of the Dox group revealed hyperemia, microhemorrhage, neuronal damage, and neuronophagia. Additionally, an increase in caspase-3, tumor necrosis factor-alpha, NF-κB, and iNOS immunoexpressions were observed, along with elevated total oxidant status and oxidative stress index. A decrease in AKT, CREB, BDNF, and NRF2 gene expressions accompanied these changes. Dex treatment significantly reversed these pathological findings, effectively protecting the brain from Dox-induced neuronal damage.
CONCLUSION:
In conclusion, Dex may provide neuroprotection in female rats with Dox-induced neurotoxicity by activating the CREB/BDNF pathway and reducing oxidative stress through AKT-mediated NRF2 synthesis. Further detailed studies exploring additional pathways are required to incorporate Dex into cancer treatment protocols and minimize side effects.
2025-10-01COMPUTERS & CHEMICAL ENGINEERING
Caffeine, riboflavin and curcumin amended clays for PFAS binding
作者: Wang, Meichen ; Xenophontos, Xenophon ; Lilly, Kendall ; Oladele, Johnson O. ; Martinez, Laura ; Phillips, Timothy D. ; Tamamis, Phanourios
Per- and polyfluoroalkyl substances (PFAS) are usually found in mixtures with other toxic compoundsTherefore, the study and design of broad acting sorbents, such as clays, is an attractive sorption solutionWe previously demonstrated that clays amended with choline and carnitine could enhance PFAS sorption properties.Here, we used computations to screen from a pool of chem. compounds, which are either supplements or generally recognized as safe, and identified particular supplements that can be amended to clay and potentially improve its sorbing capacity for PFAS in acidic conditions.Simulations were initially used as a tool to identify promising amendments to the clay, while subsequently, simulations evaluated which selected amendments could potentially bind PFAS.Our results showed that caffeine-, riboflavin- and curcumin-amended clays can, in particular instances, enhance the binding of different PFAS compared to parent clays.Experiments investigated the sorption properties of the designed systems.Notably, caffeine-amended clay significantly enhanced GenX binding when compared to parent clay, with its binding capacity being increased from 0.15 mol/kg to 1.17 mol/kg.Caffeine-amended clay also enhanced binding for PFOS by 125%, compared to the parent clay, and for PFOA to a lesser extent.Addnl., riboflavin-amended clay enhanced binding for GenX, PFOA and PFOS by 120%, 23%, and 70%, resp., compared to the parent clay.Our studies provide atomistic details into their mechanisms of action.Both the novel computational library of chem. compound-amended clays and the approach utilized, combining computations and experiments, could enhance the future design of novel amended clays for other toxins.
2025-10-01COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
Effects of re-enter water on antioxidant, immune, intestinal flora and metabolome of Chinese mitten crab (Eriocheir sinensis) after high temperature air exposure
Article
作者: Wang, Shihui ; Luo, Liang ; Yang, Yuhong ; Zhao, Zhigang ; Li, Zhiqiang ; Guo, Kun ; Deng, Xiangyi ; Zhang, Rui
Both air exposure stress and heat stress can cause stress responses of Eriocheir sinensis and affect its normal life activities. The objective of this research was to investigate the impact of re-enter water treatment on immunoenzyme activity, immune-related gene expression, hemolymph parameters, intestinal microbiota composition, and metabolomic profiles in Eriocheir sinensis after being subjected to high-temperature air exposure. The findings indicated that the re-enter water effectively mitigated the negative impacts of high-temperature air exposure on both antioxidant and immune capacities. Following treatment with high-temperature air, levels of acid phosphatase (ACP), alkaline phosphatase (AKP), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) were significantly elevated compared to their baseline values (P < 0.05), followed by a decline as re-enter water started with recovery to baseline levels detected at 24 h after re-enter water. Additionally, the levels of heat shock proteins HSP90 and HSP70 exhibited a notable rise after being subjected to high-temperature air. Nevertheless, after 24 h of soaking treatment, these levels reverted to values similar to those recorded initially. However, after re-enter water treatment, the changes in intestinal microbial composition and metabolic level caused by high temperature air exposure were not effectively improved. The analysis of intestinal microbiota revealed that the relative abundance of Bacteroidetes in the recovery group was significantly lower compared to the initial group, whereas the relative abundances of Proteobacteria and Firmicutes were found to be higher than those in the initial group. Concurrently, metabolomics analysis indicated a significant increase in palmitic acid metabolism levels within the high-temperature air group (P < 0.05), while glycine content showed a notable decrease (P < 0.05), and the metabolic changes caused by high temperature air exposure was still not fully recovered after re-enter water.
100 项与 右泛醇 相关的药物交易
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研发状态
批准上市
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 泛酸缺乏症 | 日本 | 1959-03-20 | |
| 维生素B缺乏症 | 中国 | - | - |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 糖尿病足 | 临床3期 | 埃及 | 2011-07-01 | |
| 皮疹 | 临床3期 | 荷兰 | 2010-09-01 | |
| 肿瘤 | 临床3期 | 荷兰 | 2010-09-01 | |
| 烧伤 | 临床2期 | 法国 | 2007-09-01 | |
| 红斑 | 临床2期 | 法国 | 2007-09-01 | |
| 皮肤异常 | 临床2期 | 法国 | 2007-08-01 | |
| 干眼综合征 | 临床1期 | 墨西哥 | 2017-10-04 | |
| 瘙痒 | 临床1期 | 德国 | 2009-04-01 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床1期 | 24 | (PRO-167) | 遞鏇鏇膚範鏇廠壓鹽積(齋遞簾積簾觸壓窪夢觸) = 夢願築積膚鑰願蓋獵壓 鹽壓積蓋願醖淵製觸淵 (鏇觸簾憲淵憲憲繭糧廠, 112.5) 更多 | - | 2019-07-19 | ||
(Corneregel®) | 遞鏇鏇膚範鏇廠壓鹽積(齋遞簾積簾觸壓窪夢觸) = 積選餘構夢夢淵窪憲鬱 鹽壓積蓋願醖淵製觸淵 (鏇觸簾憲淵憲憲繭糧廠, 127.2) 更多 | ||||||
N/A | - | 16 | 壓製鹽憲遞廠膚觸繭鹽(蓋鏇膚範鏇淵網遞鏇繭) = 膚繭鬱憲製淵範艱壓願 顧餘選獵膚網鏇鹹簾簾 (糧廠餘糧廠構齋憲鏇繭, 13.72) | 积极 | 2009-04-01 | ||
壓製鹽憲遞廠膚觸繭鹽(蓋鏇膚範鏇淵網遞鏇繭) = 繭夢醖積網顧窪齋願襯 顧餘選獵膚網鏇鹹簾簾 (糧廠餘糧廠構齋憲鏇繭, 23.94) |
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