Poloxamers, commonly known as Pluronics, are a special family of synthetic tri-block copolymers
with a core structure made of hydrophobic poly (propylene oxide) chains sandwiched by
two hydrophilic poly (ethylene oxide) chains. It is possible to modify the mechanical, bioactive, and
microstructural characteristics of Pluronics to simulate the behavior of different types of tissues. Additionally,
they are auspicious drug carriers with the capacity to increase therapeutic agent availability
and to design nano-drug formulations for various ailments. The nanoformulation composed of
Pluronics is more susceptible to cancer cells due to their amphiphilic nature and feature of selfassembling
into micelles. Today's expanding poloxamer research is creating new hopes that increase
the possibility of new remedies for a brand-new nanomedicine age treatment. This article provides a
concise overview of the classification, grading, and attributes of drug delivery systems (DDSs) as
well as the potential for Pluronics to create micro and nanocarriers. We subsequently discuss its utility
in drug delivery for cancer, gene therapy, anti-infective therapy, antioxidants, anti-diabetic drugs,
anti-HIV, Alzheimer's disease, and antimicrobial drugs. This review also highlighted several patented
formulations that contain various grades of Pluronics in one or more different ways. The recent findings
in fundamental research in the field properly demonstrate the strong interest in these novel
pharmaceutical strategies.