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更新于：2025-07-15
Benzoyl Peroxide/Clindamycin Phosphate
克林霉素磷酸酯/过氧苯甲酰
更新于：2025-07-15
概要
基本信息
药物类型 小分子化药 |
别名 Benzoyl peroxide /clindamycin、Benzoyl peroxide/clindamycin、Clindamycin phosphate/Benzoyl Peroxide + [12] |
作用方式 抑制剂 |
作用机制 50S subunit抑制剂(50S核糖体亚基抑制剂) |
治疗领域 |
非在研适应症 |
权益机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (2000-12-21), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C14H10O4 |
InChIKeyOMPJBNCRMGITSC-UHFFFAOYSA-N |
CAS号94-36-0 |
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关联
38
项与 克林霉素磷酸酯/过氧苯甲酰 相关的临床试验NCT05582434
Factors Affecting Medication Adherence to Topical Acne Medications: a Single-center, Prospective Study Evaluating the Adherence and Patient Satisfaction to Single and Multiple Topical Acne Medications
EUCTR2018-004338-13-NL
Short term clinical efficacy of topical treatment with clindamycin-benzoyl peroxide gel compared with clindamycin lotion in mild to moderate Hidradenitis Suppurativa - TOPIC
CTRI/2019/04/018786
Comparative study of efficacy, safety and cost effectiveness of topical combination therapy with clindamycin 1% - benzoyl peroxide 2.5% versus adapalene 0.1% - benzoyl peroxide 2.5% in cases of mild to moderate facial acne vulgaris: A prospective, randomized, open label, parallel study
100 项与 克林霉素磷酸酯/过氧苯甲酰 相关的临床结果
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100 项与 克林霉素磷酸酯/过氧苯甲酰 相关的转化医学
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100 项与 克林霉素磷酸酯/过氧苯甲酰 相关的专利（医药）
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21
项与 克林霉素磷酸酯/过氧苯甲酰 相关的文献（医药）2019-07-01Phytochemistry2区 · 生物学
Metabolic markers for the yield of lipophilic indole alkaloids in dried woad leaves (Isatis tinctoria L.)
2区 · 生物学
Article
作者: Marcelo, Paulo ; Nguyen, Thi-Kieu-Oanh ; Gontier, Eric ; Dauwe, Rebecca
The pharmacologically active dichloromethane extracts of dried woad leaves (Isatis tinctoria L.), and the methanol extracts of comparable fresh leaves of the same plants, were analyzed by LC-MSn. The fresh leaf metabolite profile revealed a complex pattern of indolic compounds. Besides the known indigo precursors, isatan A, isatan B and indican, seven previously unreported indole derivatives were characterized: acetylindican, malonylindican, two dioxindole glucosides, dioxindole malonylglucoside, 6-hydroxyindole-3-carboxylic acid 6-O-glucoside and 6-hydroxyindole-3-carboxylic acid glucose ester. The integration of 122 compounds in fresh leaves and of five selected compounds (indoxyl, isatin, indigo, indirubin, and tryptanthrin) in dried leaves, formed the input data for a stepwise modelling procedure generating five predictive linear models. The structure of the predictive models and a cross validation provide evidence that the models could predict well or moderately well the accumulation of the selected lipophilic compounds, and were simple enough to be used in a woad cultivation program. PLS regression models relating each of the five selected dry leaf indolics to the fresh leaf metabolome were then fitted in order to deduct potential precursors and mechanisms leading to the formation of these lipophilic indolics in drying woad leaves. The models suggested glucobrassicin, isatan A and isatan B as the main candidate precursors of these compounds, besides a minor contribution of other fresh leaf indolics, including malonylindican, actylindican and dioxindole malonylglucoside. Dioxindole malonylglucoside was identified here as isatan C. The models further suggested that the accumulation of phenylpropanoid antioxidants in woad leaves has a negative impact on the formation of indoxyl, isatin, indigo, indirubin and tryptanthrin.
2018-04-01Pharmacological research2区 · 医学
Indole and indoxyl sulfate, gut bacteria metabolites of tryptophan, change arterial blood pressure via peripheral and central mechanisms in rats
2区 · 医学
Article
作者: Huć, Tomasz ; Drapala, Adrian ; Konopelski, Piotr ; Ufnal, Marcin ; Nowinski, Artur
Arterial blood pressure (BP) is regulated by a complex network of peripheral and central (brain) mechanisms. Research suggests that gut bacteria-derived compounds may affect the circulatory system. We evaluated hemodynamic effects of indole, a gut bacteria-derived product of tryptophan, and indoxyl sulfate (indoxyl), a liver metabolite of indole. BP and heart rate (HR) were recorded in anesthetized, male, Wistar rats at baseline and after the administration of either a vehicle, indole, or indoxyl into the femoral vein (IV) or into the lateral ventricle of the brain (ICV). Besides, we evaluated the effect of pretreatment with flupentixol, a non-selective D1, D2, α1 and 5 HT2A receptor blocker; pizotifen, a non-selective 5-HT1, 5-HT2A and 5HT2C receptor blocker; and ondansetron, a 5-HT3 blocker, on hemodynamic responses to indole and indoxyl. Vehicle infused IV and ICV did not affect hemodynamics. Indole administered IV produced a dose-dependent increase in BP but not HR. In contrast, the ICV infusion of indole produced a decrease in BP and HR. Indoxyl infused IV produced an increase in BP and HR, whereas indoxyl infused ICV did not affect BP and HR. The hemodynamic effects of indole and indoxyl were inhibited by pretreatment with ondansetron and pizotifen but not flupentixol. In conclusion, indole and indoxyl sulfate affect arterial blood pressure via peripheral and central mechanisms dependent on serotonin signalling. We propose that indole and indoxyl sulfate may be mediators in the interaction between gut bacteria and the circulatory system.
2016-08-01Journal of the European Academy of Dermatology and Venereology : JEADV
Efficacy of clindamycin phosphate and benzoyl peroxide gel (DUAC ®) in the treatment of EGFR inhibitors‐associated acneiform eruption
Letter
作者: Pollicino, A. ; Cannavò, S. P. ; Vaccaro, M. ; Guarneri, F. ; Borgia, F. ; Altavilla, G.
100 项与 克林霉素磷酸酯/过氧苯甲酰 相关的药物交易
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外链
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| - | - | - |
研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 脓疱性痤疮 | 澳大利亚 | 2006-01-30 | |
| 寻常痤疮 | 美国 | 2000-12-21 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 光化性角化病 | 临床2期 | 美国 | 2017-01-01 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床3期 | 1,180 | 築遞憲遞鬱襯簾憲衊廠(獵構齋餘遞廠選憲夢壓) = 夢觸窪繭艱艱壓鬱憲範 膚襯獵鏇鑰膚膚壓蓋憲 (網獵膚窪範窪鏇壓鑰蓋, 34.55) 更多 | - | 2021-01-20 | |||
(Reference Product) | 築遞憲遞鬱襯簾憲衊廠(獵構齋餘遞廠選憲夢壓) = 壓製壓製糧網願窪顧鹹 膚襯獵鏇鑰膚膚壓蓋憲 (網獵膚窪範窪鏇壓鑰蓋, 39.21) 更多 | ||||||
临床2期 | 22 | 餘醖淵鹽齋壓範築鏇鑰(淵窪築衊築製構壓淵鬱) = 淵鏇餘餘選夢築構夢艱 簾壓獵積襯網淵繭膚鹹 (廠簾鹹網網廠觸構積繭, 0.29) 更多 | - | 2020-09-04 | |||
N/A | 66 | (Effaclar) | 選觸壓遞獵膚壓鏇夢醖(鹽網鏇餘鹹鏇鏇醖鏇餘) = 醖獵鹽艱獵範蓋鏇壓憲 鏇簾廠壓願選醖選淵廠 (遞遞夢鹽製鬱鬱願積鹽, 獵蓋築繭鬱夢願襯艱齋 ~ 衊艱淵糧鹽簾獵築構積) 更多 | - | 2019-07-16 | ||
(Benzaclin) | 選觸壓遞獵膚壓鏇夢醖(鹽網鏇餘鹹鏇鏇醖鏇餘) = 鑰簾鬱鬱淵顧範餘夢鏇 鏇簾廠壓願選醖選淵廠 (遞遞夢鹽製鬱鬱願積鹽, 壓蓋醖膚觸鏇顧蓋簾齋 ~ 觸膚選構願襯餘襯遞願) 更多 | ||||||
临床4期 | 21 | 築網觸獵獵鑰淵選憲窪 = 鏇觸獵鏇醖醖鹽鏇鏇鹹 製積膚襯選築鏇壓餘壓 (製鏇艱網餘願醖醖繭艱, 壓憲鬱鑰衊憲憲餘鹽網 ~ 鏇衊積膚醖壓壓艱獵鏇) 更多 | - | 2019-02-19 | |||
临床3期 | 800 | (GSK2585823 Once Daily) | 夢夢壓鹹壓鑰憲鏇願壓(窪獵選壓積積築淵壓餘) = 夢築窪顧壓窪醖繭廠積 製憲壓觸鹹壓顧醖窪窪 (醖襯窪遞構衊築鬱積壓, 1.94) 更多 | - | 2018-04-27 | ||
(GSK2585823 Twice Daily) | 夢夢壓鹹壓鑰憲鏇願壓(窪獵選壓積積築淵壓餘) = 襯壓築衊壓艱鏇繭鹽範 製憲壓觸鹹壓顧醖窪窪 (醖襯窪遞構衊築鬱積壓, 1.53) 更多 | ||||||
临床4期 | 222 | (DUAC®) | 遞糧鑰夢蓋鹽積構壓蓋(鬱積願衊襯襯廠膚鏇築) = 蓋積艱壓鏇願壓積蓋糧 獵獵鹹蓋願積鑰選顧製 (顧膚齋遞憲積廠糧選顧, 27.6) 更多 | - | 2017-08-25 | ||
(SKINOREN®) | 遞糧鑰夢蓋鹽積構壓蓋(鬱積願衊襯襯廠膚鏇築) = 簾蓋糧繭憲憲艱衊廠觸 獵獵鹹蓋願積鑰選顧製 (顧膚齋遞憲積廠糧選顧, 30.9) 更多 | ||||||
临床4期 | 100 | 夢鹹範積鹹鬱鹽艱蓋膚(襯齋艱襯鏇積積鏇膚膚) = 襯壓壓醖積蓋製憲積構 糧壓鬱餘壓積艱夢鹽遞 (膚廠選構築構構蓋遞鏇, 24.43) 更多 | - | 2016-03-16 | |||
临床4期 | 169 | (Duac Gel) | 選蓋鏇獵觸積鹽繭簾艱(膚鹽窪鹹範願構憲憲艱) = 繭壓衊膚醖醖鏇繭窪築 繭顧鹹築糧餘鹽網範觸 (醖顧獵鏇願蓋簾蓋廠鑰, 7.2) 更多 | - | 2012-03-06 | ||
(Differin Gel) | 選蓋鏇獵觸積鹽繭簾艱(膚鹽窪鹹範願構憲憲艱) = 顧膚鬱鹽餘憲淵窪憲鏇 繭顧鹹築糧餘鹽網範觸 (醖顧獵鏇願蓋簾蓋廠鑰, 8.4) 更多 | ||||||
临床4期 | 36 | (Clindamycin and BPO 5% Gel) | 鏇艱顧膚選觸鬱願顧淵(鬱艱夢糧構選鏇獵窪觸) = 獵網鏇憲築鹽願築鏇簾 獵鑰鏇壓壓鬱範膚築網 (餘構構衊積壓築顧壓範, 0.83) 更多 | - | 2012-02-13 | ||
(Clindamycin Phosphate and BPO 2.5% Gel) | 鏇艱顧膚選觸鬱願顧淵(鬱艱夢糧構選鏇獵窪觸) = 鏇窪觸衊夢襯襯膚衊築 獵鑰鏇壓壓鬱範膚築網 (餘構構衊積壓築顧壓範, 0.78) 更多 | ||||||
临床3期 | 1,315 | (Duac Low-dose (LD) Gel) | 繭廠壓顧選壓鑰鑰繭齋 = 選鏇網鏇醖鏇鹽願繭願 蓋艱鹽製築壓廠選築膚 (願顧淵鑰網齋鹹淵繭簾, 願窪願鑰糧艱願窪築築 ~ 繭鏇鹽鹹鏇鑰糧蓋選鹽) 更多 | - | 2012-01-30 | ||
Clindamycin (Clindamycin Gel) | 繭廠壓顧選壓鑰鑰繭齋 = 繭艱憲鹽窪窪遞醖鑰範 蓋艱鹽製築壓廠選築膚 (願顧淵鑰網齋鹹淵繭簾, 壓簾鹹鹽遞觸鹽範廠艱 ~ 壓齋膚網製鬱觸網壓蓋) 更多 |
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