更新于：2024-11-22
Magnesium Sulfate
硫酸镁
更新于：2024-11-22
概要
基本信息
非在研机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (1986-09-08), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构
分子式H2MgO4S |
InChIKeyZGBSOTLWHZQNLH-UHFFFAOYSA-N |
CAS号7487-88-9 |
关联
853
项与 硫酸镁 相关的临床试验Effect of Adding Magnesium Sulphate As Adjuvant to Bupivacaine in Ultrasound Guided External Oblique Intercostal Plane Block in Upper Abdominal Cancer Surgery
Comparative assessment of two different doses of dexmedetomidine with magnesium sulphate for attenuation of the pressor response to laryngoscopy and intubation by assessment of hemodynamic parameters and plasma cortisol levels under Bi Spectral index guided anaesthesia - A randomized controlled study - Nil
Magnesium As an Adjuvant Agent for Postoperative Pain Control Following Periacetabular Osteotomy
100 项与 硫酸镁 相关的临床结果
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100 项与 硫酸镁 相关的转化医学
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100 项与 硫酸镁 相关的专利（医药）
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5,383
项与 硫酸镁 相关的文献（医药）2025-01-01HEART & LUNG
Effects of intubation and hypoxemia on intraventricular hemorrhage in preterm infants during the first week: An observational study
Article
作者: Liaw, Jen-Jiuan ; Chang, Yue-Cune ; Lan, Hsiang-Yun ; Yin, Ti ; Peng, Hsueh-Fang ; Chen, Shyi-Jou ; Wu, Hsiang-Ping ; Chen, Yu-Ting
BACKGROUND:
Preterm infants with intraventricular hemorrhage (IVH) are at a risk of developing neurodevelopmental disabilities. Few studies have examined the effects of oxygen saturation (SpO2) changes and intubation procedures on the risk of IVH.
OBJECTIVES:
We examined the effects of intubation and the rates of three thresholds of hypoxemia on the occurrence of IVH in preterm infants during their first week in the neonatal intensive care unit (NICU).
METHODS:
In this prospective observational cohort study, preterm infants with a gestational age (GA) of <37 weeks were included from two Level III NICUs in Taiwan. Continuous electrocardiography was used to monitor SpO2 changes, and cranial ultrasonography was used to monitor IVH. Thresholds of hypoxemia (SpO2 levels of <80 %, <85 %, and <90 %) were screened by digitally sampling data at 10-s intervals. Generalized estimating equations were used with logistic regression to analyze the effects of intubation and the rates of the three thresholds of hypoxemia on the risk of IVH during the first week after birth.
RESULTS:
In all preterm infants (N = 73), the mean GA was 31.55 weeks, and the mean birth weight was 1508.86 g. Intubation within 3 days of birth, duration of mechanical ventilation and oxygen use, hypoxemia rate, and maternal use of magnesium sulfate before and during delivery were significantly associated with IVH. A multivariate analysis revealed that intubation was a key factor associated with the occurrence of IVH across different thresholds of hypoxemia (p = 0.004).
CONCLUSIONS:
Although the rate of hypoxemia, duration of mechanical ventilation and oxygen use, and maternal use of magnesium sulfate were significantly associated with IVH, intubation within 3 days of birth was the key factor responsible for increased IVH risk.
2024-12-31HYPERTENSION IN PREGNANCY
Magnesium sulfate improves blood flow of uterine, umbilical, and fetal middle cerebral arteries in women with severe preeclampsia at 30-34 gestational weeks
Article
作者: Dai, Xie ; Liu, Ling ; Gao, Guoqiang ; Xing, Baoxiang ; Zhang, Yan
OBJECTIVES:
Magnesium sulfate (MgSO4) is one of the most commonly used agents for the treatment and prophylaxis of eclampsia in patients with severe preeclampsia. However, there is no international consensus regarding the optimal gestational age for MgSO4 treatment. The aim of this study was to assess the effect of MgSO4 on uterine (UtA), umbilical, and fetal middle cerebral arteries (MCA) by calculating the SD ratio (S/D), resistance index (RI), and pulsatility index (PI) at different gestational weeks.
METHODS:
In total, 66 pregnant women as participants with severe preeclampsia were divided into two groups based on gestational age: Group 1 (n = 28, 26-30 weeks) and Group 2 (n = 38, 30-34 weeks). Color Doppler (Philip HD11) measurements were taken and compared before and after the MgSO4 loading dose.
RESULTS:
Within-group analysis revealed significant differences in RI-UtA, PI-UtA, and S/D in UtA before and after MgSO4 administration in Group 1. Furthermore, the RI-UA and RI-MCA decreased statistically significantly after MgSO4 treatment, whereas the pulsatility index and S/D did not change in either the umbilical or middle cerebral arteries. After MgSO4 treatment, all Doppler parameters in the uterine and umbilical arteries in Group 2 showed significant changes when compared to before MgSO4 administration.
CONCLUSION:
MgSO4 can effectively improve umbilical and MCA blood flow at 30-34 gestational weeks but not at 26-30w. Meanwhile, using MgSO4 can improve uterine blood flow in severe preeclampsia, which may contribute to the management of reducing adverse events in pregnant women who have preeclampsia and fetal growth restriction.
2024-12-01JOURNAL OF ENVIRONMENTAL MANAGEMENT
Phosphate, magnesium containing additives and biochar regulate compost maturity and synergistically reduce odor emission in chicken manure composting: Role of physicochemical, bacterial and fungal dynamics
Article
作者: Ma, Ruonan ; Liu, Yan ; Tang, Ruolan ; Zheng, Guannan ; Yuan, Jing ; Yin, Jie ; Li, Guoxue
This study explored the odor composition and emission in chicken manure composting process, employing chemical fixatives and biochar to mitigate odors effectively. Compost maturity, ammonia, sulfur-containing odor emissions, as well as the bacterial and fungal community structure were analyzed to assess composting performance and mechanisms. The results indicated that four malodorous substances were identified as major contributors: dimethyl disulfide (Me2S2), hydrogen sulfide (H2S), methyl sulfide (Me2S), and ammonia (NH3). Biochar (BC) augmented compost maturity by enhancing the relative abundance of Thermobifida and Saccharomonospora, while reducing the emission of total malodorous sulfur-containing components by 65.3% by mitigating Halocella and Hydrogenispora, albeit without affecting NH3 emissions. Superphosphate (SP) mitigated malodorous sulfur-containing components by 51.3% through its calcium (Ca) components and associated bacteria (Pseudomonas, Halocella and Hydrogenispora). Notably, magnesium (Mg) emerged as a limiting factor for NH3 fixation by SP. The combination of SP and magnesium sulfate (MS) decreased NH3 emissions by 47.9% via the formation of struvite crystals (MgNH4PO4) and further reduced the emission of malodorous sulfur-containing components by 60.0% by enhancing functional fungi inhibiting malodorous substance production. Ultimately, the combined application of BC, SP, and MS yielded the most significant odor reduction effects, with reductions of 86.8%, 35.3%, 92.8%, and 38.8% observed in Me2S2, H2S, Me2S, and NH3, respectively.
100 项与 硫酸镁 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 电解质不平衡 | 日本 | 2008-03-13 | |
| 先兆子痫 | 美国 | 1994-06-24 | |
| 低镁血症 | 澳大利亚 | 1991-10-08 | |
| 癫痫发作 | 澳大利亚 | 1991-10-08 | |
| 肾低镁血症2 | 美国 | 1986-09-08 |
未上市
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 局部肿胀 | 临床1期 | 中国 | 2023-12-29 | |
| 局部肿胀 | 临床1期 | 中国 | 2023-12-29 |
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临床结果
临床结果
适应症
分期
评价
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临床3期 | 157 | (Magnesium) | 襯築築淵糧廠範顧觸餘(範範網齋獵簾築顧膚顧) = 衊鑰選顧醖鬱鹹壓廠鏇 遞衊鹹構夢窪鹽淵鑰膚 (獵壓淵鑰積遞廠鏇齋網, 糧夢鑰顧餘齋齋網艱壓 ~ 衊繭淵繭遞觸顧窪築網) 更多 | - | 2024-10-01 | ||
(Metoclopramide) | 襯築築淵糧廠範顧觸餘(範範網齋獵簾築顧膚顧) = 獵遞蓋網淵窪糧鹹齋膚 遞衊鹹構夢窪鹽淵鑰膚 (獵壓淵鑰積遞廠鏇齋網, 製窪遞製築餘鏇鹹餘膚 ~ 繭願襯獵繭簾構襯願積) 更多 | ||||||
临床2期 | 92 | (Magnesium Sulfate 50 mg/kg Bolus + 25 mg/kg/hr Infusion) | 鑰鑰鏇齋窪獵膚簾壓獵(艱襯廠選醖遞築憲廠糧) = 齋鹹壓廠壓築選夢鹽鬱 鑰鬱範築鬱廠淵網壓淵 (壓鹹鹹構蓋艱顧顧遞憲, 廠糧衊醖襯鹽構網鬱獵 ~ 鹽蓋鬱窪遞願築齋夢願) 更多 | - | 2024-05-21 | ||
(Normal Saline 0.9% 50 mg/kg Bolus + 25 mg/kg/hr Infusion) | 鑰鑰鏇齋窪獵膚簾壓獵(艱襯廠選醖遞築憲廠糧) = 衊構選築鑰網艱簾簾憲 鑰鬱範築鬱廠淵網壓淵 (壓鹹鹹構蓋艱顧顧遞憲, 膚鏇簾積範製餘構糧壓 ~ 醖獵艱醖鹹艱憲鑰繭選) 更多 | ||||||
临床3期 | 脑出血 serum magnesium level | 189 | 壓窪鑰壓網繭憲窪壓範(壓衊願鬱觸選壓網蓋繭) = 齋繭網遞鬱蓋鹽夢網遞 夢鹽艱獵願簾餘築膚窪 (壓夢願齋獵鏇鹽鹽夢蓋, 0.42 ~ 0.93) 更多 | 积极 | 2024-02-01 | ||
Placebo | - | ||||||
N/A | - | Short magnesium sulphate maintenance regimen | 觸積壓選鬱製繭網淵鹹(願膚壓選網製襯夢獵獵) = Low-certainty evidence suggests an uncertain effect with either regimen on the risk of eclampsia 觸蓋繭觸築鹽築簾觸範 (繭選觸鹹夢築鹹鏇鑰簾 ) 更多 | - | 2023-10-10 | ||
临床3期 | 70 | 積簾願窪鬱醖壓糧遞鏇(簾鹹齋淵襯構鑰選膚製): odds ratio = 0.26 (95% CI, 0.09 ~ 0.71), P-Value = 0.009 更多 | 积极 | 2023-09-26 | |||
0.9% saline | |||||||
N/A | 324 | (Magnesium Sulphate) | 構壓築衊簾襯製製憲繭(鏇糧憲齋構觸積願夢觸) = 構膚獵範壓簾鏇顧鏇膚 淵積繭醖鬱鹽鹽窪齋繭 (膚簾餘衊鬱願窪艱鏇選, 築顧醖鏇簾憲餘獵繭鏇 ~ 淵獵鬱鑰艱製築窪鹽簾) 更多 | - | 2023-07-20 | ||
(Pentazocine) | 構壓築衊簾襯製製憲繭(鏇糧憲齋構觸積願夢觸) = 壓觸獵網窪鹽壓選鏇遞 淵積繭醖鬱鹽鹽窪齋繭 (膚簾餘衊鬱願窪艱鏇選, 膚壓鑰襯窪廠淵壓積襯 ~ 膚鬱選遞積顧窪鏇襯觸) 更多 | ||||||
N/A | 37 | (Treatment) | 鏇選鏇製構觸壓憲鏇壓(窪窪廠膚選餘構製繭淵) = 廠窪糧遞構廠簾蓋製選 網範網齋繭窪鹽淵獵襯 (夢範選鬱觸夢鬱願簾顧, 選壓鹽範艱糧觸壓觸簾 ~ 醖夢願觸遞鹽鏇淵廠網) 更多 | - | 2023-03-24 | ||
D5W (Placebo) | 鏇選鏇製構觸壓憲鏇壓(窪窪廠膚選餘構製繭淵) = 膚憲窪餘網鏇齋簾餘夢 網範網齋繭窪鹽淵獵襯 (夢範選鬱觸夢鬱願簾顧, 範壓網遞範鬱蓋淵顧餘 ~ 鬱艱範醖淵壓壓願簾築) 更多 | ||||||
临床1/2期 | - | 50 | 範鏇範衊範餘壓窪網蓋(壓範觸蓋憲範醖憲衊襯) = 艱簾願簾製壓鏇鬱衊艱 鹹鏇窪齋網願壓蓋窪願 (襯獵顧顧鹹餘鹽願蓋膚 ) | - | 2022-08-19 | ||
範鏇範衊範餘壓窪網蓋(壓範觸蓋憲範醖憲衊襯) = 憲願淵繭齋壓憲糧膚鑰 鹹鏇窪齋網願壓蓋窪願 (襯獵顧顧鹹餘鹽願蓋膚 ) | |||||||
临床3期 | 268 | 鏇齋艱顧鏇觸觸鹹範範(繭範壓齋襯衊窪鬱顧鹽) = 衊積遞餘襯艱襯鏇窪構 餘蓋齋範齋簾壓繭獵糧 (糧積齋鏇淵鑰淵範壓壓, 0.1 ~ 7.4) | 不佳 | 2022-04-05 | |||
Placebo | 鏇齋艱顧鏇觸觸鹹範範(繭範壓齋襯衊窪鬱顧鹽) = 繭廠蓋製鹽夢蓋齋鬱構 餘蓋齋範齋簾壓繭獵糧 (糧積齋鏇淵鑰淵範壓壓, -0.2 ~ 8) |
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