更新于：2024-11-15
Blonanserin
布南色林
更新于：2024-11-15
概要
基本信息
药物类型 小分子化药 |
别名 Blonanserin (JAN/INN)、LONASEN Tape、AD 5423 + [4] |
作用机制 5-HT2A receptor拮抗剂(5-羟色胺2A受体拮抗剂)、D2 receptor拮抗剂(多巴胺D2受体拮抗剂) |
治疗领域 |
在研适应症 |
非在研适应症- |
最高研发阶段批准上市 |
首次获批日期 日本 (2008-01-25), |
最高研发阶段(中国)批准上市 |
特殊审评优先审评 (中国) |
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结构
分子式C23H30FN3 |
InChIKeyXVGOZDAJGBALKS-UHFFFAOYSA-N |
CAS号132810-10-7 |
关联
56
项与 布南色林 相关的临床试验浙江金华康恩贝生物制药有限公司生产的布南色林片与持证商为Sumitomo Dainippon Pharma Co.，Ltd的布南色林片（规格：4 mg，商品名：洛珊®）在中国健康受试者中进行的单中心、随机、开放、两制剂、单次给药、两序列、四周期、完全重复交叉设计空腹/餐后状态下的生物等效性研究。
Comparative effectiveness and tolerability of Amisulpride versus Blonanserin augmentation to Clozapine in Treatment Resistant Schizophrenia - nil
布南色林片（规格：4mg）在中国健康受试者中餐后给药条件下随机、开放、单剂量、两序列、交叉生物等效性试验
100 项与 布南色林 相关的临床结果
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100 项与 布南色林 相关的转化医学
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100 项与 布南色林 相关的专利（医药）
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175
项与 布南色林 相关的文献（医药）2024-12-01SCHIZOPHRENIA RESEARCH
Efficacy and tolerability of blonanserin in schizophrenia: A systematic review and meta-analysis of randomized controlled trials
Article
作者: Dong, Shimeng ; Schneider-Thoma, Johannes ; Wu, Hui ; Yanagimoto, Hiroko ; Lin, Xiao ; Tian, Jing ; Leucht, Stefan ; Nomura, Nobuyuki ; Qin, Mengchang ; Siafis, Spyridon
BACKGROUND:
Blonanserin is approved for treating schizophrenia in Japan, South Korea, India, and China. We aimed to synthesize the efficacy and tolerability of blonanserin compared to other antipsychotics.
METHODS:
A systematic review and pairwise meta-analysis were conducted using the Cochrane Schizophrenia Group's study-based trial register until January 24, 2024. We included open and blinded randomized controlled trials (RCTs) involving schizophrenia patients, with studies lasting at least 3 weeks. Primary outcomes focused on overall schizophrenia symptoms using rating scales and relapse rates. Secondary outcomes included symptom subtypes, treatment response, dropout rates, quality of life, and side effects, analyzed using standardized mean difference (SMD), mean difference (MD), and risk ratio (RR) with 95 % confidence intervals (CIs). The review protocol was published in Open Science Framework (https://osf.io/e7jfa/).
RESULTS:
Fourteen acute-phase studies with 2697 participants compared blonanserin to olanzapine, haloperidol, risperidone, paliperidone, aripiprazole, amisulpride, and placebo. Blonanserin showed greater efficacy than placebo (SMD = -0.47, 95 % CI: -0.66 to -0.27) and similar efficacy to other antipsychotics in reducing schizophrenia overall symptoms. No data on the number of participants who experienced relapse with blonanserin was available in the single maintenance-phase study. There were also no clear differences between antipsychotics in most secondary efficacy outcomes, but blonanserin produced less prolactin and weight increase but more akathisia and tremor than risperidone, and less prolactin increase, anticholinergic and extrapyramidal side-effects than haloperidol.
CONCLUSION:
Our study suggests that differences in efficacy between blonanserin and other antipsychotics are small and that blonanserin has a different tolerability profile than haloperidol and risperidone.
2024-12-01INTERNATIONAL JOURNAL OF PHARMACEUTICS
Preparation and release pattern study of long-term controlled release Blonanserin microspheres
Article
作者: Lin, Guimei ; Zhou, Jiamin ; Li, Lian ; Qiu, Shengnan ; Wan, Xiaoyu ; Liu, Yingying ; Li, Yaqi ; Zhang, Yankun ; Zang, Hengchang ; Li, Zengmei ; Shi, Yanbin ; Fu, Xianglei ; Chen, Xiangqin
To prepare a PLGA microsphere loaded with the antipsychotic Blonanserin without release leg period and released in a near-zero model for long time, in this study, 15 kDa and 75 kDa PLGA were chosen to be mixed with different ratios, and Blonanserin microspheres (Bn-MS) without significant differences in the particle size, drug loading capacity, and encapsulation rate were prepared by microfluidics. The release kinetic model was fitted to the release behavior by monitoring the changes in particle size and morphology during the Bn-MS release to investigate microspheres' in vitro release pattern. The results showed that the addition of appropriate ratios of mixed molecular weights to Bn-MS could eliminate the release hysteresis period. When the ratio of 15 kDa and 75 kDa was 1:9 (F3), the Bn-MS had a low burst release rate, moderate release rate, no release hysteresis period, a long release period of up to 35 days, and a stable release pattern close to the zero level. The results of the release mechanism study indicated that the hybrid PLGA improved the release behavior of the microspheres by adjusting the dissolution degradation rate of Bn-MS, which in turn affected the release mechanism of the microspheres.
2024-10-18BMC Psychiatry
A case report of adolescent lactation due to the drug blonanserin.
Article
作者: Wang, Chongze ; Yi, Zhenghui ; Lv, Qinyu ; Tang, Peiyuan ; Hong, Wu
BACKGROUND:
Second-generation antipsychotic drugs are increasingly used to treat depressive disorders with psychotic symptoms. In addition to effectively managing psychotic symptoms, second-generation antipsychotics can also result in adverse drug reactions in patients, which should not be underestimated.
CASE PRESENTATION:
We report the case of 14 years old unmarried female patient with depression. At first, she started with moping and gradually developed into self-injury and whispering. After antidepressant treatment combined with the second-generation antipsychotic drug blonanserin, the patient's psychotic and depressive symptoms improved significantly, while the patient developed lactation, which stopped after the medication was changed.
CONCLUSIONS:
Although Blonanserin's clinical trials have reported rare adverse reactions like elevated prolactin levels and even lactation, caution is still needed in clinical application of the drug. This case is expected to improve psychiatrists' choice of antidepressant therapy in combination with antipsychotic drugs.
100 项与 布南色林 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 精神分裂症 | 日本 | 2008-01-25 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床3期 | 580 | DSP-5423P Placebo (DSP-5423P Placebo) | 願夢壓夢膚觸選積簾齋(鑰範艱鏇獵憲獵製憲網) = 網艱製獵鑰繭衊鬱襯襯 壓衊艱築齋鏇築選鹹醖 (鬱蓋遞醖齋鬱鹽製鏇憲, 膚夢網醖夢願簾齋糧夢 ~ 網鹹繭鏇鹹襯齋獵製餘) 更多 | - | 2020-12-23 | ||
(DSP-5423P 40mg) | 願夢壓夢膚觸選積簾齋(鑰範艱鏇獵憲獵製憲網) = 鏇鹽築範襯簾鏇憲網鹹 壓衊艱築齋鏇築選鹹醖 (鬱蓋遞醖齋鬱鹽製鏇憲, 鏇淵艱糧鹽膚鏇顧壓鑰 ~ 壓衊願願顧齋廠築襯襯) 更多 | ||||||
临床3期 | 200 | (DSP-5423P (Cohort 1)) | 憲遞遞艱製廠衊窪範範(獵餘鑰窪膚鹹遞夢艱鹽) = 夢簾顧襯獵製鹹鬱獵淵 膚襯觸鹽襯觸襯鏇餘鹽 (襯蓋壓鏇廠糧壓襯願鹹, 觸網鑰憲艱襯窪齋顧獵 ~ 膚觸淵淵衊鹹選鏇齋夢) 更多 | - | 2020-11-19 | ||
(DSP-5423P (Cohort 2)) | 憲遞遞艱製廠衊窪範範(獵餘鑰窪膚鹹遞夢艱鹽) = 願淵衊蓋餘鏇蓋繭繭繭 膚襯觸鹽襯觸襯鏇餘鹽 (襯蓋壓鏇廠糧壓襯願鹹, 憲餘憲艱餘製醖築獵遞 ~ 齋夢願醖齋糧壓繭鹹夢) 更多 | ||||||
临床3期 | 267 | (Blonanserin) | 繭鹽簾範網鑰顧鹹壓蓋(網鑰壓淵觸獵獵膚廠獵) = 糧選簾淵製顧願鬱憲襯 鏇廠壓淵觸醖齋淵淵網 (餘網製簾顧鹽艱鑰憲築, 顧範鬱簾夢獵築憲衊廠 ~ 獵淵鹹鹽鹽艱膚餘製窪) 更多 | - | 2018-11-26 | ||
(Risperidone) | 繭鹽簾範網鑰顧鹹壓蓋(網鑰壓淵觸獵獵膚廠獵) = 獵鹹顧餘齋憲衊鹹選遞 鏇廠壓淵觸醖齋淵淵網 (餘網製簾顧鹽艱鑰憲築, 築構簾築齋鹽壓蓋鏇壓 ~ 積鏇願顧鹹夢鑰獵鹽範) 更多 |
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