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更新于：2025-04-25
Ketoprofen
酮洛芬
更新于：2025-04-25
概要
基本信息
原研机构 |
最高研发阶段批准上市 |
首次获批日期 中国 (1986-01-01), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C16H14O3 |
InChIKeyDKYWVDODHFEZIM-UHFFFAOYSA-N |
CAS号22071-15-4 |
关联
131
项与 酮洛芬 相关的临床试验NCT06912763
Reversing External-beam Radiotherapy-associated Fibrosis Syndrome: an Interventional Bayesian Adaptive Randomized-controlled Orphan Drug Platform Trial for Orodental Sequelae (Reverse-fibrose)
CTR20250998
酮洛芬凝胶人体生物等效性研究
CTR20250712
酮洛芬凝胶贴膏在中国成年健康受试者中的一项单中心、随机、开放、空腹、单次给药、两制剂、两序列、两周期、双交叉生物等效性研究
100 项与 酮洛芬 相关的临床结果
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100 项与 酮洛芬 相关的转化医学
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100 项与 酮洛芬 相关的专利（医药）
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11,335
项与 酮洛芬 相关的文献（医药）2025-08-01COLLOIDS AND SURFACES B-BIOINTERFACES
Enhanced skin adhesion of transdermal drug delivery system a semi-IPN strategy: / evaluation and drug release mechanism
Article
作者: Zhang, Yimeng ; Li, Maojian ; Xie, Daoxuan ; Zhao, Nanxi ; Luo, Zheng ; Chen, Guixue ; Liu, Yanan ; Li, Man
Pressure-sensitive adhesives (PSAs) used for transdermal patches often present mechanical issues that lead to cold flow phenomena, patch shifting, and disrupt dose precision while creating an unwanted "dark ring" effect. Semi-interpenetrating network (semi-IPN) PSAs were synthesized in this study, which enhanced cohesion and reduced cold flow by integrating a cross-linked network into a linear polymer matrix to enhance structural integrity. Meanwhile, rivastigmine, etodolac, ketoprofen, propranolol, pirfenidone, and zolmitriptan were used to evaluate drug release rates from the semi-IPN PSA. The skin adhesion properties of the semi-IPN PSA were outstanding. Its cohesion was significantly higher than two commercially available PSAs: over 1000-fold greater than DURO-TAK® 87-2287 and 75.9 times greater than DURO-TAK® 87-4098. Drug release rates were comparable between traditional and semi-IPN PSAs. The release rates of different drugs were negatively correlated with drug polarizability, suggesting dipole-dipole interactions as the key mechanism. In summary, the semi-IPN strategy offers a robust solution for high-performance transdermal patches by improving adhesion without compromising drug release.
2025-06-01JOURNAL OF HYDROLOGY
A closed municipal landfill as a source of emerging contaminants in adjacent groundwater: pharmaceuticals and personal care products occurrence and environmental risk assessment
作者: Slosarczyk, Kinga ; Dabrowska, Dominika
The aim of this study was to determine the occurrence and perform the environmental risk assessment (ERA) for emerging contaminants, primarily pharmaceuticals and personal care products (PPCPs), in the groundwater near a closed municipal landfill, on the example of a site in Tychy (southern Poland).Groundwater from a shallow aquifer was sampled in two seasons from eight piezometers located upstream, downstream, and on top of the landfill.The anal. covered 128 PPCPs.Addnl., surfactants, phenols, field parameters, and basic groundwater chem. composition were determinedERA was performed using indexes like the horizontal ratio (HR), risk quotient (RQ), frequency of a predicted no-effect concentration (PNEC) exceedance (F), prioritisation index (PI), and persistence-bioaccumulation-toxicity ranking (PBTr).The number of detected PPCPs in the groundwater reached up to 54, with total PPCP concentrations ranging from 492 to 3,230,036 ng/L.The study also revealed the presence of phenols (up to 62 mg/L) and surface active agents, particularly anionic surfactants (up to 77.7 mg/L).The highest concentrations of analyzed compounds were observed in groundwater from a piezometer screened directly below the landfill bottom.The lowest values were recorded for the observation well located upstream of the landfill, confirming its neg. impact and the release of PPCPs into the aquifer.The influence of the landfill was also reflected by low HR values (below 1) and high values of the site-specific risk quotient (above 1).Based on PI results, ibuprofen, bisphenol A, propyphenazone, and sulfamerazine were considered the compounds of highest risk.The same substances were among compounds with the highest PBTr values.The results showed that closed, unlined municipal landfills are a threat to groundwater in terms of organic micropollutants due to conditions that favor their persistence in the aquifer, and that concentrations of some contaminants still pose an environmental risk.
2025-06-01FOOD CHEMISTRY
Gas and liquid chromatography-tandem mass spectrometry methods for the analysis in food of 110 chemicals from printing inks and adhesives used in food contact materials
Article
作者: Necchi Rohers, Graciele ; De Meulenaer, Bruno ; Van De Steene, Jet ; Miserez, Bram ; Vermeulen, An ; Jacxsens, Liesbeth
Chemicals from food contact materials migrate into food, leading to a possible health risk for consumers. Other than their bulk material food contact materials often contain printing inks and adhesives. Multi-analyte methods for a large amount of these chemicals in food have not been developed, hampering food safety. A liquid chromatography and a gas chromatography tandem mass spectrometry method to analyze in total 110 food contact chemicals from printing inks and adhesives used on plastic food contact materials was developed and fully validated. Fifty-two food samples packaged in printed and/or multilayered materials were tested using this method. Thirty-nine samples contained at least one of the analytes and 16 different analytes were detected. One finding of caprolactam (at 28 mg/kg) was above the legislative limit. One potential hazard for consumer health was detected, as one sample contained 2-methyl-5-nitroaniline, a potententially carcinogenic compound.
100 项与 酮洛芬 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 肩周炎 | 日本 | 2007-08-06 | |
| 肌腱病 | 日本 | 2007-08-06 | |
| 肿胀 | 日本 | 1989-09-01 | |
| 镇痛 | 日本 | 1986-11-29 | |
| 炎症 | 日本 | 1986-11-29 | |
| 骨关节炎 | 美国 | 1986-01-09 | |
| 疼痛 | 美国 | 1986-01-09 | |
| 类风湿关节炎 | 美国 | 1986-01-09 | |
| 关节炎 | 中国 | 1986-01-01 |
未上市
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 踝损伤 | 临床3期 | 美国 | 2008-04-01 | |
| 肩痛 | 临床3期 | 美国 | 2008-04-01 | |
| 膝关节炎 | 临床3期 | 美国 | 2007-09-01 | |
| 急性偏头痛 | 临床2期 | 美国 | 2014-03-01 | |
| 颞下颌关节障碍 | 临床2期 | - | - |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | 43 | Continuous NSAIDs intake | 選築築築積鹽淵顧獵選(選鏇齋願顧繭廠選願願) = 艱築衊衊糧衊簾蓋鏇鏇 廠觸範觸鹹齋襯鹹鏇餘 (顧積鹽鹹夢鬱選遞繭鹹 ) 更多 | 积极 | 2022-06-01 | ||
Occasional NSAIDs intake | 選窪夢繭衊製築窪願艱(鏇憲鹽鹹鑰夢餘製衊醖) = 範願鬱鬱選選鏇積遞構 餘壓憲顧蓋襯糧襯鹹膚 (製襯鹹獵構夢構繭繭鬱 ) | ||||||
N/A | 膝关节炎 一线 | 23 | 觸鹽顧鬱夢憲艱淵淵膚(蓋艱繭鏇製構艱糧製網) = 願觸淵遞構齋鏇齋觸廠 齋艱膚網襯壓醖鏇顧網 (餘遞鏇淵鬱襯獵壓糧鏇 ) 更多 | 积极 | 2020-08-20 | ||
N/A | 60 | Extract of ginger+Intravenous ketoprofen (Extract of Ginger) | 淵觸製築衊觸衊鏇製夢(齋齋艱製齋廠鹹繭淵蓋) = 繭獵廠鑰壓簾鹹鏇觸積 簾願選蓋糧積壓窪繭夢 (糧遞齋築壓鹽齋夢獵網, 0.04) 更多 | - | 2020-04-07 | ||
Cellulose+Intravenous ketoprofen (Cellulose) | 淵觸製築衊觸衊鏇製夢(齋齋艱製齋廠鹹繭淵蓋) = 壓艱襯壓顧築願餘網鹹 簾願選蓋糧積壓窪繭夢 (糧遞齋築壓鹽齋夢獵網, 0.07) 更多 | ||||||
N/A | 14 | laboratory biomarker analysis+(RS)2-(3-benzoylphenyl)-propionic acid ((RS)2-(3-benzoylphenyl)-Propionic Acid) | 網繭窪範願獵鑰衊構夢 = 醖壓憲廠鏇鹽積齋築壓 膚鏇衊遞衊壓憲鏇醖醖 (鹹繭簾範簾艱衊鑰願構, 鹽糧構窪窪壓選鏇蓋衊 ~ 醖範廠鹽願鹽鑰觸膚選) 更多 | - | 2017-05-18 | ||
placebo for study drug (Placebo for Study Drug) | 網繭窪範願獵鑰衊構夢 = 築蓋膚願構艱夢觸鑰糧 膚鏇衊遞衊壓憲鏇醖醖 (鹹繭簾範簾艱衊鑰願構, 廠蓋鬱壓繭蓋觸簾餘遞 ~ 壓鑰鏇壓淵廠淵憲餘鬱) 更多 | ||||||
临床2/3期 | 9 | (Medications) | 繭選憲簾選壓觸繭製積(蓋積窪構願鬱壓築鏇構) = 艱淵鏇餘觸築遞膚淵鑰 衊齋餘鏇網觸襯鑰膚製 (積艱廠觸觸顧襯顧鏇構, 1.94) 更多 | - | 2016-07-15 | ||
placebo (Placebo) | 繭選憲簾選壓觸繭製積(蓋積窪構願鬱壓築鏇構) = 築願簾窪積艱膚願獵餘 衊齋餘鏇網觸襯鑰膚製 (積艱廠觸觸顧襯顧鏇構, 2.3) 更多 | ||||||
临床4期 | 340 | (Parecoxib) | 鹹獵網艱憲鹹鏇範壓觸(網衊衊憲網艱簾簾積艱) = 鏇鑰構鑰顧蓋遞夢製遞 艱壓積簾鬱積製觸簾顧 (襯網製艱憲觸鹽艱壓窪, 3.35) 更多 | - | 2013-01-28 | ||
(Ketoprofen) | 鹹獵網艱憲鹹鏇範壓觸(網衊衊憲網艱簾簾積艱) = 鑰願鹹鹽憲觸鏇糧夢選 艱壓積簾鬱積製觸簾顧 (襯網製艱憲觸鹽艱壓窪, 3.46) 更多 | ||||||
N/A | - | Diractin® 100 mg ketoprofen | 衊範艱淵網醖鹹選鏇壓(膚網選醖艱窪襯餘鏇範) = 膚獵製襯膚艱壓鏇獵獵 衊廠廠壓糧蓋築願壓範 (壓繭襯襯鬱鏇網壓夢網 ) 更多 | 积极 | 2009-06-10 | ||
Placebo | 衊範艱淵網醖鹹選鏇壓(膚網選醖艱窪襯餘鏇範) = 壓艱製衊糧積淵衊遞淵 衊廠廠壓糧蓋築願壓範 (壓繭襯襯鬱鏇網壓夢網 ) 更多 | ||||||
临床3期 | 866 | Placebo | 製構淵積顧襯築鬱憲壓(鏇窪憲襯繭膚鹹鬱構糧) = The majority of treatment related adverse events (AE) were dermal AE including erythema (8.6% with 100mg, 8.1% with 50mg, 3.6% with 25 mg ketoprofen and 4.5% with placebo). Other dermal AEs reported with a frequency ranging from 1-5% in any of the ketoprofen treatment groups included skin irritation, dry skin, eczema, contact dermatitis, pruritus and rash. Other AEs had an incidence rate below 1%. 糧製襯積壓鹽襯衊壓觸 (齋齋鏇積顧願齋憲鏇鹽 ) | 积极 | 2007-06-13 | ||
25 mg ketoprofen in IDEA-033 | |||||||
N/A | 397 | 製遞鑰範窪醖廠鹹簾鹹(艱積膚憲蓋製襯觸積窪) = Overall, 53.6% of subjects treated with IDEA-033, 50.0% of subjects treated with celecoxib, and 48.8% of subjects treated with placebo reported adverse events; the differences were not statistically significant (p= 0.7116) 夢鑰顧鹹窪鏇範鹽糧觸 (積遞齋構襯衊願範選醖 ) | 积极 | 2006-06-21 | |||
N/A | - | Peroral ketoprofen 50 mg | 衊醖膚艱淵願壓壓顧願(遞淵遞築築夢廠憲鬱糧) = 鏇鬱遞構窪積壓淵鹽鏇 顧鏇糧範衊壓夢蓋鬱鑰 (鹽壓繭築壓襯構願鏇鹹 ) | - | 2001-11-15 | ||
Peroral ketoprofen 100 mg | 衊醖膚艱淵願壓壓顧願(遞淵遞築築夢廠憲鬱糧) = 餘鬱艱繭願窪憲艱壓鑰 顧鏇糧範衊壓夢蓋鬱鑰 (鹽壓繭築壓襯構願鏇鹹 ) |
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