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更新于：2025-08-20
Erythromycin
红霉素
更新于：2025-08-20
概要
基本信息
权益机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C37H67NO13 |
InChIKeyULGZDMOVFRHVEP-RWJQBGPGSA-N |
CAS号114-07-8 |
关联
51
项与 红霉素 相关的临床试验NCT06461429
Platform for Adaptive Trials in Perinatal Units (Core Protocol)
NCT06906757
Preterm Rupture of Membranes Optimising Antibiotics Trial (PROMOAT). A Pregnancy Domain Within PLATIPUS.
KCT0009668
A comparative study of EVOlocumab and high-intensity statin for EARLY and intensive LDL-Cholesterol reduction in patients with acute coronary syndrome; Multi-center, prospective, randomized, double blinded, sham-procedure and placebo controlled trial
100 项与 红霉素 相关的临床结果
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100 项与 红霉素 相关的转化医学
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100 项与 红霉素 相关的专利（医药）
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40,659
项与 红霉素 相关的文献（医药）2025-12-31Emerging Microbes & Infections
Genomic islands and molecular mechanisms relating to drug-resistance in
Clostridioides
(
Clostridium
)
difficile
PCR ribotype 176
Article
作者: Soltesova, Anna ; Pituch, Hanna ; Kuijper, Ed ; Brajerova, Marie ; Balikova Novotna, Gabriela ; Prasad, Suhanya ; Novakova, Elena ; Zikova, Jaroslava ; Demay, Fanny ; Kovarovic, Vojtech ; Krutova, Marcela ; Smits, Wiep Klaas
OBJECTIVES:
To analyse characteristics of Clostridioides difficile PCR ribotype 176 clinical isolates from Poland, the Czech Republic and Slovakia with regard to the differences in its epidemiology.
METHODS:
Antimicrobial susceptibility testing and whole genome sequencing were performed on a selected group of 22 clonally related isolates as determined by multilocus variable-number tandem repeat analysis (n = 509). Heterologous expression and functional analysis of the newly identified methyltransferase were performed.
RESULTS:
Core genome multilocus sequence typing found 10-37 allele differences. All isolates were resistant to fluoroquinolones (gyrA_p. T82I), aminoglycosides with aac(6')-Ie-aph(2'')-Ia in six isolates. Erythromycin resistance was detected in 21/22 isolates and 15 were also resistant to clindamycin with ermB gene. Fourteen isolates were resistant to rifampicin with rpoB_p. R505K or p. R505K/H502N, and five to imipenem with pbp1_p. P491L and pbp3_p. N537K. PnimBG together with nimB_p. L155I were detected in all isolates but only five were resistant to metronidazole on chocolate agar. The cfrE, vanZ1 and cat-like genes were not associated with linezolid, teicoplanin and chloramphenicol resistance, respectively. The genome comparison identified six transposons carrying antimicrobial resistance genes. The ermB gene was carried by new Tn7808, Tn6189 and Tn6218-like. The aac(6')-Ie-aph(2'')-Ia were carried by Tn6218-like and new Tn7806 together with cfrE gene. New Tn7807 carried a cat-like gene. Tn6110 and new Tn7806 contained an RlmN-type 23S rRNA methyltransferase, designated MrmA, associated with high-level macrolide resistance in isolates without ermB gene.
CONCLUSIONS:
Multidrug-resistant C. difficile PCR ribotype 176 isolates carry already described and unique transposons. A novel mechanism for erythromycin resistance in C. difficile was identified.
2025-12-31Sustainable Environment
A review on the occurrence of antibiotic-resistant bacteria found in abattoir effluent from resource-limited settings: The necessity of a robust One Health framework
作者: Dinginya, Lawrance ; Jambwa, Prosper ; Majuru, Chenai Sipiwe ; Chari, Tawanda Ashley ; Machakwa, Jairus ; Mahlangu, Precious ; Gufe, Claudious ; Marowero, Sheunesu Theo ; Kadungure, Tafadzwa
A review.Abattoirs discharge untreated waste into surrounding bodies of water and the environment, which is extremely harmful to public health.Bacteria that cause disease, especially those resistant to antibiotics, may be present in these wastes.This review was carried out to provide a comprehensive overview of antibiotic-resistant microbes discovered in slaughterhouse wastes in resource-limited settings.Relevant research studies focussing on bacteria isolated from abattoir effluents in resource-limited settings and AMR patterns were searched on Google Scholar, PubMed, Web of Science, and African journals online.The studies showed that numerous bacteria were detected, such as Salmonella spp., Bacillus spp.,Shigella spp.,Escherichia coli, Pseudomonas aeruginosa, Citrobacter freundii, Proteus spp.,Streptococcus spp.,Yersinia spp. and Staphylococcus aureus.Several of these isolates were resistant to multiple antibiotics, including Penicillin, Vancomycin, Clindamycin, Erythromycin, Tetracycline, Ampicillin, Linezolid, Gentamycin, Ciprofloxacin, Ampicillin, Ceftriaxone, Imipenem, Cefotaxime, Chloramphenicol, Trimethoprim-sulfamethoxazole, Piperacillin-Tazobactam, Ceftazidime, Imipenem, and Meropenem.Lack of proper waste management practices due to financial constraints is the major cause of a high prevalence of resistant bacterial strains in abattoir effluents in resource-limited settings.Given the critical role that the environment plays in the spread and maintenance of antibiotic-resistant microorganisms, public health systems must strengthen One Health National Action plans applicable to abattoir effluents to successfully combat antibiotic resistance.
2025-12-31Emerging Microbes & Infections
Sharp rise in high-virulence Bordetella pertussis with macrolides resistance in Northern China
Article
作者: Ma, Lijuan ; Hu, Yahong ; Hu, Huili ; Shi, Wei ; Yuan, Lin ; Yao, Kaihu ; Li, Dongfang ; Meng, Qinghong ; Du, Qianqian ; Zhou, Lin
OBJECTIVE:
To elucidate the evolution of antigen genotype and antimicrobial resistance distribution of Bordetella pertussis (B. pertussis) from 2019 to 2023 in northern China.
METHODS:
Polymerase chain reaction (PCR) amplification and sequencing were utilized to identify the seven antigen genotypes (ptxA, ptxC, ptxP, prn, fim2, fim3, tcfA). E-test and Kirby-Bauer (K-B) disc diffusion were employed to determine the minimum inhibitory concentration (MIC) and zone of inhibition for B. pertussis against antimicrobial agents. Subsequently, 50 isolates were chosen for multi-locus variable-number tandem-repeat analysis (MLVA) typing and whole-genome sequencing.
RESULTS:
A total of 442 B. pertussis isolates were determined. The strains with high virulence harbouring ptxP3 allele surged from 13.5% (21/155) in 2019-2021 to 93.0% (267/287) in 2022-2023. Concurrently, the erythromycin resistance B. pertussis (ERBP) in ptxP3 isolates markedly rose from 42.9% (9/21) in 2019-2021 to 100% (267/267) in 2022-2023. The majority of ptxP3 isolates (76.0%,219/288) exhibited the ptxA1/ptxC1/prn2/fim2-1/fim3A/tcfA-2 genotype. Among the 442 confirmed patients, the children aged 3-14 years escalated rapidly from 13.5% in 2019 to 45.6% in 2023. The MT28 strains were responsible for 66.0% (33/50) of the tested ones, in which ERBP was prevalent at 87.9% (29/33). All the present sequenced ptxP3-ERBP strains (31/31) were clustered into the sub-lineage IVd.
CONCLUSIONS:
These results suggested the clonal spread of the ptxP3-ERBP lineage of B. pertussis with high virulence and macrolides resistance could be an important cause of the recent pertussis resurgence in China. Furthermore, the increased cases among pre-school and school-aged children underscore the importance of booster vaccination in this population.
100 项与 红霉素 相关的药物交易
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研发状态
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 细菌感染 | 美国 | 1964-06-29 | |
| 软下疳 | 日本 | 1955-10-13 | |
| 白喉 | 日本 | 1955-10-13 | |
| 脓胸 | 日本 | 1955-10-13 | |
| 子宫内感染 | 日本 | 1955-10-13 | |
| 肺脓肿 | 日本 | 1955-10-13 | |
| 淋巴结炎 | 日本 | 1955-10-13 | |
| 乳腺炎 | 日本 | 1955-10-13 | |
| 骨髓炎 | 日本 | 1955-10-13 | |
| 中耳炎 | 日本 | 1955-10-13 | |
| 冠周炎 | 日本 | 1955-10-13 | |
| 肺炎 | 日本 | 1955-10-13 | |
| 肾盂肾炎 | 日本 | 1955-10-13 | |
| 猩红热 | 日本 | 1955-10-13 | |
| 梅毒 | 日本 | 1955-10-13 | |
| 破伤风 | 日本 | 1955-10-13 | |
| 扁桃体炎 | 日本 | 1955-10-13 | |
| 尿道炎 | 日本 | 1955-10-13 | |
| 百日咳 | 日本 | 1955-10-13 |
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临床结果
临床结果
适应症
分期
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N/A | - | - | 鹽築糧衊糧製齋鹹膚蓋(選構艱糧選壓糧範夢鬱) = 獵觸齋範遞鹹艱膚築餘 艱夢構膚選範襯蓋積簾 (遞餘簾築艱夢範構窪餘 ) 更多 | - | 2015-09-01 | ||
顧範衊衊網膚網鬱顧鏇(顧廠襯蓋鏇鏇鹽夢選繭) = 鏇獵餘觸餘鬱築壓積繭 鏇蓋蓋鏇窪觸鬱範糧願 (夢齋醖艱築餘獵膚淵艱 ) 更多 | |||||||
N/A | 1,570 | 憲憲鬱鹹網鹹糧蓋繭網(繭顧壓鬱網築窪鑰鏇淵) = 網窪願選鏇觸鹽衊鹹齋 餘窪齋簾糧憲範蓋鹽壓 (積襯鹹遞願衊艱遞餘鏇 ) | - | 2004-01-01 | |||
Placebo | 憲憲鬱鹹網鹹糧蓋繭網(繭顧壓鬱網築窪鑰鏇淵) = 蓋淵繭壓願築襯顧製齋 餘窪齋簾糧憲範蓋鹽壓 (積襯鹹遞願衊艱遞餘鏇 ) |
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