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17β-羟基类固醇脱氢酶(17β-HSDs)家族至少包含15个成员，负责催化多种类型雌激素和雄激素17-羟基和17-酮基之间的氧化还原，是性激素代谢的关键酶。由于17-羟基和17-酮基的转变会影响性激素与受体的结合活性，因此通过对性激素活性的调节，17β-HSDs广泛参与了性激素相关的生理功能调控。在一些性激素相关疾病中，部分178-HSDs家族蛋白也被认为有成为药物靶标的潜力。 17β-HSD1由HSD17B1基因表达，催化低活性雌激素雌酮(estrone/E1，17-酮基形式)还原为高活性的雌二醇(Estradio1/E2，17-羟基形式)。E2对ERa和ERB均有较强结合，其雌激素受体激活效应是E1的10倍。此外，17β-HSD1还可以化脱氢表雄酮(dehydroepiandrosterone，DHEA)还原为雄烯二醇(androstenediol)，但17β-HSD1对E1的亲和力更高。在人体中，17β-HSD1主要表达在卵巢、乳腺和胎盘等组织中。与17β-HSD1相反，17β-HSD2，将E2、雄烯二醇和睾酮分别氧化为E1、DHEA和4-雄烯(4androstene)。17β-HSD2广泛表达在子宫、胎盘、肝、胃肠道和泌尿系统里。17β-HSD2可以保护实体组织免受过量性激素的伤害。 子宫内膜异位症是指子宫内膜组织(腺体和间质)在子宫腔被覆内膜及子宫以外的部位出现、生长、浸润，反复出血，继而引发疼痛、不孕及结节或包块等。内异症是生育年龄妇女的多发病、常见病，通常具有雌激素依赖的特点。研究发现，内异组织中E2的表达量平均上调了2.7倍。在内异症病灶中，所有促进E2合成的还原酶家族上调，17β-HSD1上调最为明显，平均达559倍;而氧化酶HSD17β2下调。通过抑制17β-HSD1，可以显著下调内异症病灶中的E2水平。表明17β-HSD1/2的比例失调是内异症中E2上调的主要原因。此外，一些E2的依赖的乳腺癌、子宫内膜癌等癌种中，也发现17β-HSD1/2比例失调，例如Hsd17b1出现为基因扩增而出现Hsd1762杂合性缺失。因此，17β-HSD1抑制剂有望用于子宫内膜异位症和乳腺癌等适应症的临床治疗。关于这个病知乎上李鸿政写的《急诊见闻录：生命抢救倒计时》第8节有个故事描述。 目前临床在研的17β-HSD1抑制剂只有Forendo公司的Linustedastat，目前处于临床二期。 金赛的专利WO2025185710中模仿并未是Linustedastat，而是该公司包括核心专利CN107207561在内的其他系列专利，在该系列专利其定义肟的氧原子取代为氢或3个碳原子内的烷基，而金赛则是将其改为卤代烷机或环烷基，代表性化合物如下。

How the Relationship Between DHT and DHEA Shapes Men’s Health Understanding the relationship between DHT and DHEA helps patients see hormones not as isolated numbers, but as interconnected systems driving vitality and health.” — Chris Rue, FNP-C METAIRIE, LA, UNITED STATES, September 2, 2025 / EINPresswire.com / -- DHEA is often called the “mother hormone” because it serves as a precursor for many other hormones, including testosterone and estrogen. From testosterone, the enzyme 5-alpha-reductase creates DHT, one of the most potent and active androgens in the body. The relationship between DHT and DHEA is a perfect example of how hormones work together in a cascade. DHEA lays the foundation, while DHT delivers powerful effects on tissues such as muscles, bones, and the reproductive system. When either one falls out of balance, men may experience fatigue, low libido, mood changes, or muscle decline. At MOPE Clinic, providers assess both hormones as part of a full-spectrum hormone evaluation. By looking at the entire hormonal cascade, the clinic helps patients restore balance and improve their quality of life. What Is DHEA? Dehydroepiandrosterone (DHEA) is produced mainly in the adrenal glands. Levels peak in early adulthood and naturally decline with age, often falling sharply by the time men reach their 40s or 50s. Because DHEA converts into both testosterone and estrogen, a drop in DHEA can reduce downstream hormones, including DHT. Low DHEA has been associated with: Fatigue and poor stamina Decreased sexual desire Lower mood and irritability Weakened immune response Loss of muscle mass and strength Optimizing DHEA through lifestyle, supplementation, or medically guided therapy can help restore balance across the entire hormone network. What Is DHT? Dihydrotestosterone (DHT) is derived from testosterone and is often misunderstood. While it is best known for contributing to male pattern baldness, its role in men’s health extends far beyond hair. DHT strongly binds to androgen receptors, making it more potent than testosterone in some tissues. DHT contributes to: Pubertal development and sexual differentiation Libido and erectile function Muscle strength and bone density Fat distribution and metabolic health Confidence, focus, and mental drive Although too much DHT can contribute to prostate growth or hair thinning in genetically susceptible men, balanced levels are crucial for vitality and performance. Benefits of DHT and DHEA Balance for Hormone Optimization When DHEA and DHT are in balance, men experience improved health and well-being. The synergy between these two hormones supports: Sexual function – DHT enhances libido and sexual performance, while DHEA contributes to sexual desire and stamina. Physical strength – Together, they promote lean muscle growth, stronger bones, and faster recovery after exercise. Mental clarity – Balanced levels are linked with sharper focus, greater resilience, and better mood stability. Healthy metabolism – DHEA influences fat metabolism, and DHT encourages lean muscle retention, which boosts energy use. This combined impact highlights why the relationship between DHT and DHEA matters so much in hormone optimization. Addressing Hair and Prostate Concerns Understandably, many men worry about the effects of DHT on hair and prostate health. Genetics play a strong role in male pattern baldness, and while DHT contributes, it is not the sole cause. Similarly, prostate enlargement can be influenced by DHT, but lifestyle, genetics, and other hormones also matter. MOPE Clinic helps patients navigate these concerns by carefully monitoring hormone levels and tailoring treatment. The goal is to preserve the benefits of DHT while minimizing unwanted side effects. Treatments may include DHEA supplementation, testosterone therapy, lifestyle modifications, or advanced peptide therapies depending on the individual’s needs. Cognitive and Emotional Benefits Hormones impact the brain just as much as the body. DHEA supports resilience against stress, while DHT enhances confidence and mental clarity. Together, they improve overall well-being. Emerging research even suggests that healthy androgen balance may reduce the risk of neurodegenerative decline. Patients who restore optimal DHEA and DHT levels often report clearer thinking, stronger memory, and steadier moods. Lifestyle Practices That Support Hormonal Balance MOPE Clinic emphasizes that medical treatment works best alongside healthy lifestyle choices. Natural ways to support DHEA and DHT levels include: Resistance training – Builds muscle and boosts androgen activity. Proper sleep – Restorative sleep helps regulate adrenal and gonadal hormones. Stress management – Reduces cortisol’s negative impact on hormone production. Nutrient-dense diet – Provides essential fats and proteins for hormone synthesis. When lifestyle changes are not enough, medical interventions ensure safe and effective hormone optimization. MOPE Clinic’s Approach to Managing DHT and DHEA At MOPE Clinic, providers understand that every patient’s hormone profile is unique. Rather than using a one-size-fits-all approach, the clinic combines advanced lab testing with personalized treatment. By evaluating DHEA, testosterone, estradiol, cortisol, and DHT together, practitioners identify imbalances and design targeted plans. Ongoing monitoring ensures patients achieve long-term improvements in energy, body composition, libido, and mood. Why Education Is Key Misinformation about hormones often causes unnecessary fear. By educating patients, MOPE Clinic empowers them to make informed decisions. Understanding the relationship between DHT and DHEA helps patients see hormones not as isolated numbers, but as interconnected systems driving vitality and health. About MOPE Clinic MOPE Clinic, led by Chris Rue, FNP-C, specializes in hormone replacement therapy, weight management, and peptide optimization. Based in Metairie, Louisiana, MOPE Clinic delivers evidence-based, personalized care that restores balance and enhances overall wellness. For more information, visit https://mopeclinic.com or call 504-322-3888 to schedule a consultation. Chris Rue Metairie Optimal Performance Enhancement +1 504-265-5491 info@mopeclinic.com Visit us on social media: LinkedIn Facebook Legal Disclaimer: EIN Presswire provides this news content "as is" without warranty of any kind. We do not accept any responsibility or liability for the accuracy, content, images, videos, licenses, completeness, legality, or reliability of the information contained in this article. 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