The purpose of this study is to evaluate the investigational drug, tipifarnib (a pill taken by mouth), in combination with the Food and Drug Administration (FDA) approved drug, naxitimab, administered intravenously (IV; a liquid that continuously goes into your body through a tube that has been placed during a surgery into one of your veins). Naxitamab is FDA approved for pediatric patients 1 year of age and older and adult patients with relapsed or refractory high-risk neuroblastoma in the bone or bone marrow who have demonstrated a partial response, minor response, or stable disease to prior therapy, it may not be approved in the type of disease used in this study.
The goals of this part of the study are:
* Test the safety and tolerability of tipifarnib in combination with naxitimab in patients with cancer
* To determine the activity of study treatments chosen based on:
* How each subject responds to the study treatment
* How long a subject lives without their disease returning/progressing

开始日期2024-11-01

申办/合作机构

Hershey Medical Center

NCT06528496 / Recruiting临床2期IIT

N10: Reduced Therapy for High-Risk Neuroblastoma

The purpose of this study is to find out whether N10 chemotherapy is a safe and effective treatment for children with high-risk neuroblastoma.

开始日期2024-07-22

申办/合作机构

Memorial Sloan Kettering Cancer Center

NCT06574698 / RecruitingN/AIIT

Adding Of Naxitamb In Induction Therapy For High Risk Neuroblastoma: A Prospective, Single-Arm Clinical Study

To explore the efficacy of adding anti-GD2 immunotherapy (Naxitamab) at the stage of induction chemotherapy for newly diagnosed high risk neuroblastoma patients. To investigate wether anding Naxitamab in the induction phase will improve the response rate at the end of induction therapy and further improve the overall survival rate.

开始日期2024-05-06

申办/合作机构

广州市妇女儿童医疗中心

100 项与那昔妥单抗相关的临床结果

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100 项与那昔妥单抗相关的转化医学

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100 项与那昔妥单抗相关的专利（医药）

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155

项与那昔妥单抗相关的文献（医药）

2024-11-01·Cancer Genomics & Proteomics

GD2 in Breast Cancer: A Potential Biomarker and Therapeutic Target

Review

作者: Mokbel, Kefah ; MOKBEL, KEFAH

Expression of disialoganglioside GD2 in normal tissues is primarily limited to the central nervous system, peripheral sensory nerve fibers, dermal melanocytes, lymphocytes, and mesenchymal stem cells. Its widespread overexpression in various cancer types allows it to be classified as a tumor-associated antigen with potential diagnostic and therapeutic implications. This article reviews the synthesis pathways of GD2 and its role in cancer cell adhesion, proliferation, and metastasis with a focus on breast cancer. GD2 appears to be overexpressed on the outer membrane of most breast cancer cells and breast cancer stem cells (BCSCs) and is closely linked to epithelial-mesenchymal transition (EMT). GD3 synthase (GD3S) is considered to be the rate-determining step in GD2 synthesis. Clinical studies indicate that GD2 expression is increased in 35-70% of breast cancer samples, with higher levels in triple-negative breast cancer (TNBC). This overexpression correlates with more aggressive tumor features and worse prognosis. Therapeutic targeting of GD2 with monoclonal antibodies (moABs) like dinutuximab and naxitamab has demonstrated anti-cancer activity in preclinical cancer models and human clinical trials against high-risk neuroblastoma reducing tumor growth and enhancing survival. GD2-specific chimeric antigen receptor (CAR) T-cell therapy and GD3S inhibition present other promising therapeutic strategies to improve clinical outcomes. Furthermore, GD2-targeted vaccines are currently being investigated in cancer therapy. This narrative review article underscores the critical role of GD2 in breast cancer pathogenesis and highlights the promising therapeutic opportunities it offers. It advocates for the initiation of clinical trials to further explore the potential of GD2-targeted treatment in combination with standard breast cancer therapies.

2024-10-01·JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY

Omalizumab for Treatment of Anti-GD2 Antibody-related Urticaria

Article

作者: Lentini-Rivera, Angela ; Lin, Yichih ; Kasper, Christine ; Shrager, Leslie ; Markova, Alina ; Andre Jones, Latisha ; Modak, Shakeel ; Lacouture, Mario ; Durney, Christina ; D’Andrea, Linda ; Glincher, Rachel

Outcomes for high-risk neuroblastoma have improved with the addition of antidisialoganglioside (GD2) antibody-mediated immunotherapy to multimodality therapy. Urticaria is an expected side effect of anti-GD2 immunotherapy. Rarely, despite maximal use of antihistamines and H2 receptor antagonists, refractory urticaria can result in impaired quality of life, and delays or discontinuation of immunotherapy. The anti-IgE monoclonal antibody, omalizumab, is approved for the treatment of asthma and chronic spontaneous urticaria. We successfully managed grade 3, naxitamab-related urticaria refractory to standard management in 2 patients using omalizumab, allowing for continued anti-GD2 immunotherapy. Omalizumab did not impact antitumor activity or immunogenicity of naxitamab.

2024-05-01·Anti-cancer agents in medicinal chemistry

An Expedition on Synthetic Methodology of FDA-approved Anticancer Drugs (2018-2021)

Review

作者: Gupta, Ghanshyam Das ; Jain, Ankit ; Vishakha, S ; Navneesh, N ; Verma, Sant Kumar ; Patel, Preeti ; Kurmi, Balak Das

Abstract::

New drugs being established in the market every year produce specified structures for selective biological targeting. With medicinal insights into molecular recognition, these begot molecules open new rooms for designing potential new drug molecules. In this review, we report the compilation and analysis of a total of 56 drugs including 33 organic small molecules (Mobocertinib, Infigratinib, Sotorasib, Trilaciclib, Umbralisib, Tepotinib, Relugolix, Pralsetinib, Decitabine, Ripretinib, Selpercatinib, Capmatinib, Pemigatinib, Tucatinib, Selumetinib, Tazemetostat, Avapritinib, Zanubrutinib, Entrectinib, Pexidartinib, Darolutamide, Selinexor, Alpelisib, Erdafitinib, Gilteritinib, Larotrectinib, Glasdegib, Lorlatinib, Talazoparib, Dacomitinib, Duvelisib, Ivosidenib, Apalutamide), 6 metal complexes (Edotreotide Gallium Ga-68, fluoroestradiol F-18, Cu 64 dotatate, Gallium 68 PSMA-11, Piflufolastat F-18, 177Lu (lutetium)), 16 macromolecules as monoclonal antibody conjugates (Brentuximabvedotin, Amivantamab-vmjw, Loncastuximabtesirine, Dostarlimab, Margetuximab, Naxitamab, Belantamabmafodotin, Tafasitamab, Inebilizumab, SacituzumabGovitecan, Isatuximab, Trastuzumab, Enfortumabvedotin, Polatuzumab, Cemiplimab, Mogamulizumab) and 1 peptide enzyme (Erwiniachrysanthemi-derived asparaginase) approved by the U.S. FDA between 2018 to 2021. These drugs act as anticancer agents against various cancer types, especially non-small cell lung, lymphoma, breast, prostate, multiple myeloma, neuroendocrine tumor, cervical, bladder, cholangiocarcinoma, myeloid leukemia, gastrointestinal, neuroblastoma, thyroid, epithelioid and cutaneous squamous cell carcinoma. The review comprises the key structural features, approval times, target selectivity, mechanisms of action, therapeutic indication, formulations, and possible synthetic approaches of these approved drugs. These crucial details will benefit the scientific community for futuristic new developments in this arena.

144

项与那昔妥单抗相关的新闻（医药）

2024-10-25

·BioSpace

Y-mAbs Announces Third Quarter 2024 Conference Call and Webcast

NEW YORK, Oct. 25, 2024 (GLOBE NEWSWIRE) -- Y-mAbs Therapeutics, Inc. (the “Company” or “Y-mAbs”) (Nasdaq: YMAB), a commercial-stage biopharmaceutical company focused on the development and commercialization of novel radioimmunotherapy and antibody-based therapeutic products for the treatment of cancer, today announced it will report third quarter 2024 financial and operating results before the market open on Friday, November 8, 2024. The Company will hold a conference call and webcast to discuss these results at 8:00 a.m. ET. Conference call and webcast details: Investors (domestic): Investors (international): (877) 407-0792 (201) 689-8263 To access a live webcast of the update, please use this link . About Y-mAbs Y-mAbs is a commercial-stage biopharmaceutical company focused on the development and commercialization of novel, radioimmunotherapy and antibody-based therapeutic cancer products. The Company’s technologies include its investigational Self-Assembly DisAssembly (“SADA”) Pretargeted Radioimmunotherapy Platform (“PRIT”) and bispecific antibodies generated using the Y-BiClone platform. The Company’s broad and advanced product pipeline includes the anti-GD2 therapy DANYELZA® (naxitamab-gqgk), the first FDA-approved treatment for patients with relapsed or refractory high-risk neuroblastoma in the bone or bone marrow after a partial response, minor response, or stable disease to prior therapy. Forward-Looking Statements Statements in this press release about future expectations, plans and prospects, as well as any other statements regarding matters that are not historical facts, may constitute “forward-looking statements” within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. Such statements include, but are not limited to, statements about our business model, including financial outlook for 2024 and beyond, including estimated operating expenses, cash burn and DANYELZA product revenue and sufficiency of cash resources and related assumptions; implied and express statements regarding the future of the Company’s business, including with respect to expansion and its goals; the Company’s plans and strategies, development, commercialization and product distribution plans; expectations with respect to the Company’s products and product candidates, including potential territory and label expansion of DANYELZA and the potential market opportunity related thereto and potential benefits thereof, and the potential of the SADA PRIT Technology and potential benefits and applications thereof; the Company’s mission of delivering better and safer therapies to patients; expectations relating to key anticipated development milestones, including potential expansion and advancement of commercialization and development efforts, including potential indications, applications and geographies, and the timing thereof; expectations with respect to current and future clinical and pre-clinical studies and the Company’s research and development programs, including with respect to timing and results; expectations related to the timing of the initiation and completion of regulatory submissions; additional product candidates and technologies; expectations regarding collaborations or strategic partnerships and the potential benefits thereof; expectations related to the use of cash and cash equivalents, and the need for, timing and amount of any future financing transaction; expectations with respect to the Company’s future financial performance; and other statements that are not historical facts. Words such as ‘‘anticipate,’’ ‘‘believe,’’ “contemplate,” ‘‘continue,’’ ‘‘could,’’ ‘‘estimate,’’ ‘‘expect,’’ “hope,” ‘‘intend,’’ ‘‘may,’’ ‘‘might,’’ ‘‘plan,’’ ‘‘potential,’’ ‘‘predict,’’ ‘‘project,’’ ‘‘should,’’ ‘‘target,’’ “will,” ‘‘would’,’ “guidance,” “goal,” “objective,” and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Our product candidates and related technologies are novel approaches to cancer treatment that present significant challenges. Actual results may differ materially from those indicated by such forward-looking statements as a result of various factors, including but not limited to: risks associated with the Company’s financial condition and need for additional capital; the risks that actual results of the Company’s restructuring plan and revised business plan will not be as expected; risks associated with the Company’s development work; cost and success of the Company’s product development activities and clinical trials; the risks of delay in the timing of the Company’s regulatory submissions or failure to receive approval of its drug candidates; the risks related to commercializing any approved pharmaceutical product including the rate and degree of market acceptance of product candidates; development of sales and marketing capabilities and risks associated with failure to obtain sufficient reimbursement for products; the risks related to the Company’s dependence on third parties including for conduct of clinical testing and product manufacture; the Company’s ability to enter into partnerships; the risks related to government regulation; risks related to market approval, risks associated with protection of the Company’s intellectual property rights; risks related to employee matters and managing growth; risks related to the Company’s common stock, risks associated with macroeconomic conditions, including the conflict between Russia and Ukraine and sanctions related thereto, the state of war between Israel and Hamas and the related risk of a larger regional conflict, inflation, increased interest rates, uncertain global credit and capital markets and disruptions in banking systems; and other risks and uncertainties affecting the Company including those described in the “Risk Factors” section included in the Company’s Quarterly Report on Form 10-Q for the quarter ended March 31, 2024, in the Company’s Quarterly Report on Form 10-Q for the quarter ended June 30, 2024, and future filings and reports by the Company. Any forward-looking statements contained in this press release speak only as of the date hereof, and the Company undertakes no obligation to update any forward-looking statement, whether as a result of new information, future events or otherwise. DANYELZA® and Y-mAbs® are registered trademarks of Y-mAbs Therapeutics, Inc. Investor Contact: Courtney Dugan VP, Head of Investor Relations cdu@ymabs.com

免疫疗法上市批准财报

2024-10-01

·GlobeNewswire-Health Care

Y-mAbs to Participate in Upcoming Investor Conferences in October

NEW YORK, Oct. 01, 2024 (GLOBE NEWSWIRE) -- Y-mAbs Therapeutics, Inc. (the “Company” or “Y-mAbs”) (Nasdaq: YMAB), a commercial-stage biopharmaceutical company focused on the development and commercialization of novel radioimmunotherapy and antibody-based therapeutic products for the treatment of cancer, today announced that its management team will participate in the following upcoming investor conferences: Oppenheimer Targeted Radiopharmaceutical Therapies in Oncology SummitDate: Tuesday, October 8, 2024Time: 9:30 a.m. ETLocation: New York, NYPanel: “The Next Wave of TRTs – Targets, Targeting Technologies and Isotopes” BMO Oncology SummitDate: Tuesday, October 8, 2024Time: 3:00 p.m. ETLocation: New York, NYFireside chat: “Shifting the Antibody Paradigm” About Y-mAbsY-mAbs is a commercial-stage biopharmaceutical company focused on the development and commercialization of novel, radioimmunotherapy and antibody-based therapeutic cancer products. The Company’s technologies include its investigational Self-Assembly DisAssembly (“SADA”) Pretargeted Radioimmunotherapy Platform (“PRIT”) and bispecific antibodies generated using the Y-BiClone platform. The Company’s broad and advanced product pipeline includes the anti-GD2 therapy DANYELZA® (naxitamab-gqgk), the first FDA-approved treatment for patients with relapsed or refractory high-risk neuroblastoma in the bone or bone marrow after a partial response, minor response, or stable disease to prior therapy. Forward-Looking StatementsStatements in this press release about future expectations, plans and prospects, as well as any other statements regarding matters that are not historical facts, may constitute “forward-looking statements” within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. Such statements include, but are not limited to, statements about our business model, including financial outlook for 2024 and beyond, including estimated operating expenses, cash burn and DANYELZA product revenue and sufficiency of cash resources and related assumptions; implied and express statements regarding the future of the Company’s business, expectations related to the use of cash and cash equivalents, and the need for, timing and amount of any future financing transaction; expectations with respect to the Company’s future financial performance; and other statements that are not historical facts. Words such as ‘‘anticipate,’’ ‘‘believe,’’ “contemplate,” ‘‘continue,’’ ‘‘could,’’ ‘‘estimate,’’ ‘‘expect,’’ “hope,” ‘‘intend,’’ ‘‘may,’’ ‘‘might,’’ ‘‘plan,’’ ‘‘potential,’’ ‘‘predict,’’ ‘‘project,’’ ‘‘should,’’ ‘‘target,’’ “will,” ‘‘would’,’ “guidance,” “goal,” “objective,” and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Our product candidates and related technologies are novel approaches to cancer treatment that present significant challenges. Actual results may differ materially from those indicated by such forward-looking statements as a result of various factors, including but not limited to: risks associated with the Company’s financial condition and need for additional capital; the risks that actual results of the Company’s restructuring plan and revised business plan will not be as expected; risks associated with the Company’s development work; cost and success of the Company’s product development activities and clinical trials; the risks of delay in the timing of the Company’s regulatory submissions or failure to receive approval of its drug candidates; the risks related to commercializing any approved pharmaceutical product including the rate and degree of market acceptance of product candidates; All statements are subject to the risks described in the "Risk Factors" section included in the Company’s Annual Report on Form 10-K for the fiscal year ended December 31, 2023, the Company’s Quarterly Report on Form 10-Q for the quarterly period ended March 31, 2024, the Company’s Quarterly Report on Form 10-Q for the quarterly period ended June 30, 2024, and future filings and reports by the Company. Any forward-looking statements contained in this press release speak only as of the date hereof, and the Company undertakes no obligation to update any forward-looking statement, whether as a result of new information, future events or otherwise. DANYELZA® and Y-mAbs® are registered trademarks of Y-mAbs Therapeutics, Inc. Investor Contact:Courtney DuganVP, Head of Investor Relationscdu@ymabs.com

免疫疗法上市批准

2024-09-09

·GlobeNewswire-Health Care

Y-mAbs Presents Neuroblastoma Research on Naxitamab and SADA PRIT Technology Platform at AACR Special Conference on Advances in Pediatric Cancer Research

Sept. 06, 2024 -- Y-mAbs Therapeutics, Inc. (the “Company” or “Y-mAbs”) (Nasdaq: YMAB), a commercial-stage biopharmaceutical company focused on the development and commercialization of novel radioimmunotherapy and antibody-based therapeutic products for the treatment of cancer, today announced new clinical and preclinical data from studies evaluating naxitamab and GD2-SADA, respectively, in neuroblastoma. The results are summarized in poster presentations scheduled to be presented September 6 – 7, 2024, at the American Academy of Cancer Research (“AACR”) Special Conference in the Advances in Pediatric Cancer Research in Toronto, Canada. Naxitamab maintains disease control in patients with refractory/relapsed high-risk neuroblastoma: A poster titled “Disease control in patients treated with naxitamab for refractory/relapsed high-risk neuroblastoma” (poster #B055) will be presented on September 7, 2024, during poster session B. This study analyzed the disease control rate with a 12-week minimum of stable disease from the start of naxitamab treatment, based on data from a prespecified interim analysis of Trial 201 (NCT03363373). Patients with refractory/relapsed high-risk neuroblastoma and residual disease in the bone and/or bone marrow who were treated with naxitamab in combination with granulocyte-macrophage colony-stimulating factor (“GM-CSF”) achieved a disease control rate of 63%, with the results suggesting consistent disease control irrespective of baseline Curie score. “Naxitamab’s ability to maintain disease control provides an important measure for those who are most at risk for disease progression,” said Vignesh Rajah, MBBS, DCH, MRCP (UK), Chief Medical Officer. “The results reflect our deep commitment to advancing the science and therapeutic management of neuroblastoma.” High-affinity binding of GD2-SADA to Tb-DOTA: A poster titled “GD2-SADA, a bispecific fusion protein that forms self-assembling and disassembling (“SADA”), GD2-avid tetramers with high affinity for chelated radiolanthanides” (poster # A075) will be presented today, September 6, 2024, during poster session A. The study demonstrated tight binding interactions between GD2-SADA and DOTA-chelated terbium, a metal in the same lanthanide family as lutetium with multiple medical isotopes of potential benefit in diagnosis and therapy. Building on previous in vitro findings, the study also characterized the self-assembly and disassembly of GD2-SADA, a dynamic equilibrium that permits high avidity binding of non-radiolabeled GD2-SADA tetramers to GD2-expressing tumors and the renal clearance of disassembled monomers during the first step of pre-targeted radiotherapy (“PRIT”). In a preclinical model of neuroblastoma, also presented in the poster, the chelated radioisotope is administered during the second step of PRIT and binds to GD2-SADA on tumor cells, delivering cytotoxic radiation with minimal off-target exposure. The results have informed ongoing PK/PD modeling and the initial dosing in Trial 1001 (NCT05130255), a first-in-human Phase 1 trial of GD2-SADA PRIT with 177Lu-DOTA in adolescent and adult patients with GD2-positive solid tumors, and with Trial 1002 planned for pediatric patients with high-risk neuroblastoma. “The data highlight the importance of continued innovation in the treatment of high-risk neuroblastoma, an aggressive and relentless tumor, and the most common extracranial solid tumor in children,” said Dr Rajah. “We remain committed to unlocking the full potential of naxitamab and our novel SADA PRIT technology platform in our mission of improving the lives of patients.” Researchers at Memorial Sloan Kettering Cancer Center (“MSK”) developed DANYELZA® (naxitamab-gqgk), which is exclusively licensed by MSK to Y-mAbs. MSK has institutional financial interests in the compound and Y-mAbs. Researchers at MSK, including Dr. Nai-Kong Cheung, developed the SADA technology for radioimmunotherapy, which is exclusively licensed by MSK to Y-mAbs. Dr. Cheung has intellectual property rights and interests in technology, and as a result of this licensing arrangement, MSK has institutional financial interests in the technology. DANYELZA® (naxitamab-gqgk) is indicated, in combination with granulocyte-macrophage colony-stimulating factor ("GM-CSF"), for the treatment of pediatric patients 1 year of age and older and adult patients with relapsed or refractory high-risk neuroblastoma in the bone or bone marrow who have demonstrated a partial response, minor response, or stable disease to prior therapy. This indication was approved under accelerated approval based on overall response rate and duration of response. Continued approval for this indication may be contingent upon verification and description of clinical benefits in a confirmatory trial. DANYELZA® includes a Boxed Warning for serious infusion-related reactions, such as cardiac arrest and anaphylaxis, and neurotoxicity, such as severe neuropathic pain and transverse myelitis. See full Prescribing Information for complete Boxed Warning and other important safety information. GD2-SADA is a bispecific fusion protein that tightly binds to the glycolipid GD2 and Lutetium 177 (Lu 177)-DOTA, a chelated or “caged” radionuclide. In the first step of pre-targeted radiotherapy, non-radiolabeled GD2-SADA tetramers are infused and bind to GD2-expressing solid tumors, while unbound GD2-SADA protein disassembles into low molecular weight monomers that are removed by the kidney. The second infusion delivers the “radioactive payload,” which binds directly to GD2-SADA on tumor cells for localized irradiation. GD2-SADA PRIT with Lutetium 177-DOTA is currently being investigated in adults and adolescents in Trial 1001 (NCT05130255). Y-mAbs is a commercial-stage biopharmaceutical company focused on the development and commercialization of novel, radioimmunotherapy and antibody-based therapeutic cancer products. The Company’s technologies include its investigational Self-Assembly DisAssembly (“SADA”) Pretargeted Radioimmunotherapy Platform (“PRIT”) and bispecific antibodies generated using the Y-BiClone platform. The Company’s broad and advanced product pipeline includes the anti-GD2 therapy DANYELZA® (naxitamab-gqgk), the first FDA-approved treatment for patients with relapsed or refractory high-risk neuroblastoma in the bone or bone marrow after a partial response, minor response, or stable disease to prior therapy. The content above comes from the network. if any infringement, please contact us to modify.

临床结果免疫疗法引进/卖出AACR会议上市批准

100 项与那昔妥单抗相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D11416	-	L01XC	DB15965

研发状态

批准上市

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
高风险神经母细胞瘤	美国	Y-mAbs Therapeutics, Inc.	2020-11-25

未上市

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
复发性骨肉瘤	临床2期	美国	Memorial Sloan Kettering Cancer Center	2015-07-01
复发性骨肉瘤	临床2期	美国	Y-mAbs Therapeutics, Inc.	2015-07-01
神经母细胞瘤	临床2期	美国	Memorial Sloan Kettering Cancer Center	2003-07-01
GD2阳性胶质瘤	临床1期	美国	Y-mAbs Therapeutics, Inc.	2011-08-15
GD2阳性胶质瘤	临床1期	美国	Memorial Sloan Kettering Cancer Center	2011-08-15
小细胞肺癌	临床前	-	Memorial Sloan Kettering Cancer Center	-

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT03363373 (Trial 201, ASCO2024)	临床2期	高风险神经母细胞瘤 GD2	74	Naxitamab plus GM-CSF	淵壓衊窪簾遞顧構製簾(醖鏇範鏇淵艱糧範艱淵) = 遞艱網衊簾齋簾廠膚醖鬱簾鏇選糧簾簾築製艱 (築築廠憲繭壓夢蓋蓋繭 )	积极	2024-05-24
NCT03363373 (Trial 201, ASCO2024)	临床2期	高风险神经母细胞瘤 GD2 monoclonal antibodies	74	Naxitamab plus GM-CSF	獵憲鏇襯顧膚壓膚遞遞(遞鏇範積窪獵廠構餘憲) = 選襯衊簾獵淵顧觸網範餘鏇簾窪夢艱簾鬱構壓 (憲網網艱衊壓鬱鹽簾衊 ) 更多	积极	2024-05-24
Literature 人工标引	N/A	高风险神经母细胞瘤	34	naxitamab+irinotecan+temozolomide+sargramostim	鑰餘積願願範壓製衊衊(糧憲衊窪齋範襯構顧夢) = 願鹹鹹夢鬱壓壓遞襯壓鹽齋衊廠遞膚繭糧鹹築 (憲遞衊窪憲獵選觸構鬱 ) 更多	积极	2023-10-03
Literature 人工标引	N/A	高风险神经母细胞瘤	34	naxitamab+irinotecan+temozolomide+sargramostim (early treatment)	鑰餘積願願範壓製衊衊(糧憲衊窪齋範襯構顧夢) = 蓋齋範構廠築襯構夢遞鹽齋衊廠遞膚繭糧鹹築 (憲遞衊窪憲獵選觸構鬱 ) 更多	积极	2023-10-03
NCT03363373 (ESMO_IO2022) 人工标引	临床2期	高风险神经母细胞瘤	74	Naxitamab 3mg/kg+GM-CSF	鏇簾簾鏇選膚鹹鹹壓鬱(鹽憲積餘構壓構範膚淵) = hypotension (58%) and pain (54%) 鹹鹽鹹簾鹹簾鏇鹹醖淵 (鏇簾鬱鑰膚製選簾衊餘 )	积极	2022-12-08
NCT03363373 (ASCO2022) 人工标引	临床2期	高风险神经母细胞瘤	48	GM-CSF+Naxitamab	淵構積製遞淵遞蓋齋網(積築鹹夢鬱糧齋獵蓋遞) = 蓋夢鬱簾窪鹽餘顧築積願淵築餘廠淵窪夢膚鬱 (艱齋網網鏇選廠窪襯鏇 ) 更多	积极	2022-06-02
NCT00072358 (CTgov)	临床2期	神经母细胞瘤	291	anti-GD2 murine IgG3 monoclonal antibody 3F8	廠築鏇網夢鏇窪廠觸窪(繭願繭夢觸鏇積選遞膚) = 襯鬱構網膚願範遞觸網選鹽鑰鏇襯壓遞糧窪淵 (齋觸願膚築襯齋築壓顧, 鹹蓋鹹壓蓋觸觸夢獵鏇 ~ 鬱窪壓範蓋膚壓選構積) 更多	-	2022-05-16
NCT03363373 (Trial 201, ESMO2021)	临床2期	高风险神经母细胞瘤	48	Naxitamab	衊壓願遞願鑰鏇衊壓願(積製顧積願獵壓觸簾鹹) = Anti-drug antibody formation was observed in 10/46 (22%) patients assessed 遞網鏇範簾夢窪遞構憲 (鑰淵觸構醖壓鏇鏇網繭 ) 更多	-	2021-09-17
NCT03363373 (Trial 201, ASCO2021)	临床2期	高风险神经母细胞瘤	22	Naxitamab	鑰齋鹽選積衊顧醖憲範(壓醖觸積淵醖鏇觸鏇選) = 鹽簾繭觸顧築鹽製鬱積範齋獵襯網觸齋壓範願 (鏇壓餘網餘網製鹹繭構 )	-	2021-05-28
ASCO2021	N/A	高风险神经母细胞瘤巩固	73	Naxitamab and GM-CSF	艱糧衊鏇網選鑰膚襯衊(願齋網鏇鏇糧築齋遞壓) = 2 蓋鹹膚鹹襯願構積餘鹽 (糧鹽構製獵糧廠遞範醖 ) 更多	积极	2021-05-28
NCT03363373 (ASCO2020)	临床2期	高风险神经母细胞瘤	24	Naxitamab	鑰獵餘願築鹹選餘範艱(選鹽蓋繭顧鏇遞餘夢膚) = 6 treatment-related SAEs were reported in 5 patients (anaphylactic reaction, pyrexia, and respiratory depression) 簾憲夢繭膚觸膚觸鑰構 (觸淵鏇糧窪餘遞構糧構 )	积极	2020-05-25