生育酚醋酸酯(Tocopherol Acetate) - 药物靶点：Free radicals_在研适应症：动脉粥样硬化，糖尿病性视网膜病变，冻伤_专利_临床

概要

基本信息

药物类型

小分子化药

别名

Tocopherol acetate (JP17)、Tocopherol acetate, unspecified、Tocopheryl acetate

+ [15]

靶点

Free radicals

作用方式

抑制剂

作用机制

自由基抑制剂

治疗领域

心血管疾病内分泌与代谢疾病眼部疾病+ [1]

在研适应症

动脉粥样硬化糖尿病性视网膜病变冻伤+ [4]

非在研适应症-

原研机构

Alfresa Pharma Corp.

在研机构

Sannova KK

Alfresa Pharma Corp.

非在研机构-

最高研发阶段批准上市

首次获批日期

日本 (1961-12-09),

维生素E缺乏症

最高研发阶段(中国)-

特殊审评-

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结构/序列

分子式C31H52O3

InChIKeyZAKOWWREFLAJOT-CEFNRUSXSA-N

CAS号58-95-7

关联

31

项与生育酚醋酸酯相关的临床试验

RBR-6tnqpjm

/ RecruitingN/A

Prevention of Osteoradionecrosis of the jaw with the drug combination of Pentoxifylline and Tocopherol: randomized clinical trial - PENTO Pentoxifylline and tocopherol

开始日期2024-06-15

申办/合作机构

Sociedade Pernambucana de Combate ao Câncer

[+1]

NCT05795647

/ Recruiting临床2期IIT

The PENTO Protocol in Medication-related Osteonecrosis of the Jaw

Medication-related osteonecrosis of the jaw (MRONJ) occurs after taking bisphosphonates or targeted therapies. It leads to a significant decrease in quality of life with pain, eating and chewing disorders, and malnutrition. Current treatments are only partially effective. PENTO (pentoxifylline and tocopherol) has been shown to be effective in maxillary osteoradionecrosis. The objective of this study is to evaluate the proportion of bone recovery in patients receiving PENTO in MRONJ at 12 months.

开始日期2024-02-29

申办/合作机构

Centre Hospitalier Universitaire de Limoges

NCT06019858

/ CompletedN/A

A Clinical Trial to Assess the Effects of a Vitamin Shot on Energy Levels

This is a virtual, single-arm clinical trial that will last 30 days. Participants will drink 1 bottle of the Vitamin Energy® shot daily and complete questionnaires at baseline, Day 7, Day 14, and Day 30.
Participants' energy, mood, and cognitive function will be evaluated at baseline and at each check-in. Bodyweight will also be assessed at baseline and Day 30. Likert scale responses will be examined from baseline to each check-in. Participant responses on product feedback will be presented as % scores.

开始日期2023-06-21

申办/合作机构-

100 项与生育酚醋酸酯相关的临床结果

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100 项与生育酚醋酸酯相关的转化医学

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100 项与生育酚醋酸酯相关的专利（医药）

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4,655

项与生育酚醋酸酯相关的文献（医药）

2025-06-01·Case Studies in Chemical and Environmental Engineering

Untargeted metabolomic LC-HRMS combined with chemometric reveal metabolites change from sorghum flakes affected by food processing

作者: Suratno ; Anggraeni, Ayu Septi ; Khasanah, Yuniar ; Nurfahmi, Laely ; Alam, Lucky Prabowo Miftachul ; Windarsih, Anjar ; Noviana, Ika Mulawati Purwanti ; Utami, Indrawati Dian

A non-targeted UHPLC-HRMS metabolomics approach combined with chemometric anal. was employed to assess the change in metabolite profiles of sorghum flakes based on food processing techniques.The result showed that fatty acids were the most abundant metabolites, followed by lipids, amino acids, alkaloids, amines, and polyphenols, representing key metabolic markers influenced by food processing in sorghum flakes.Specific metabolites, including 15S-Hydroxyeicosatrienoic acid (15S-HETrE), terminaline, vitamin E acetate, furan fatty acid F6, all-trans-retinal, and fingolimod, exhibited increased concentrations during oven processing compared to raw sorghum, likely due to their thermal stability.This study provides valuable insights into effect of food processing effect on metabolites profiles.

2025-04-01·Food Chemistry

Identification of phenols and their formation network during the brewing process of Shanxi aged vinegar

Article

作者: Liang, Kai ; Tu, Linna ; Zhu, Boya ; Zheng, Yu ; Song, Jia ; Wang, Jiao ; Zhang, Yushi ; Liu, Jing ; Wang, Min

Phenols are important functional compounds present in vineagr, however, their composition and formation pathways remain uncertain. Herein, non-targeted metabolomics and macrotranscriptomics methods were applied to identify phenols and analyze their formation network during the brewing process of Shanxi aged vinegar. A total of 82 phenols were detected from the raw material and the brewing process. Results indicated that phenolic acids were the major phenols and were mainly formed during acetic acid fermentation stages. Water, reducing sugars, lactic acid, and 7 amino acids influenced the formation and transformation of phenols, as shown through Spearman analysis. Furthermore, 16 genera and 38 enzymes were involved in substrates decomposition and phenols formation according to the metabolic pathway analysis, with Xenobiotics biodegradation and metabolism identified as the main pathway for phenols formation. Lactobacillus and Acetobacter were the key genera responsible for the phenols transformation. This study provides new insights into the phenols formation mechanisms in cereal vinegars and it is helpful for isolating the functional strains to reinforce the phenols formation.

2025-03-03·Artificial Cells, Nanomedicine, and Biotechnology2区 · 工程技术

Cholesterol and vitamin E-conjugated PEGylated polymeric micelles for efficient delivery and enhanced anticancer activity of curcumin: evaluation in 2D monolayers and 3D spheroids

2区 · 工程技术

ArticleOA

作者: Vanaparthi, Asmitha ; Biswas, Swati ; Kumari, Preeti ; Ghosh, Balaram ; Muddineti, Omkara Swami ; Rompicharla, Sri Vishnu Kiran

A newly synthesized PEGylated cholesterol/α-tocopheryl succinate (α-TOS) linked polymer (CV) was self-assembled and loaded with curcumin to form a micellar system (C-CVM). The tri-functionalized amphiphilic polymer was constituted of hydrophobic cholesterol and α-TOS connected to hydrophilic PEG via a lysine linker. The synthesized polymer and the micelles were characterized by ¹H NMR, DLS, zeta potentiometer, TEM, CMC determination and hemolysis studies. CVM displayed low CMC value of 15 µM with extent of hemolysis as less than 4%. The stable C-CVM with optimum % drug loading (14.2 ± 0.24) displayed Z average of 175.8 ± 0.68 nm with PDI (0.248 ± 0.075) and released curcumin in sustained manner in the in vitro drug release study. C-CVM demonstrated dose-dependent cellular uptake and cytotoxicity in murine melanoma, B16F10 and human breast cancer, MDA-MB-231 cell lines. CV exhibited marked reversal of drug resistance as indicated by significantly higher retention of P-glycoprotein substrate, rhodamine-123 in the resistant B16F10 cell line compared to standard P-glycoprotein inhibitor, verapamil. C-CVM demonstrated significantly higher spheroidal growth inhibition compared to C-PPM. The results provide strong evidence for CVM as promising drug delivery system and confirm the potential of C-CVM as chemotherapy in cancer.

100 项与生育酚醋酸酯相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D01735	生育酚醋酸酯	A11HA03	DB14003

研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
动脉粥样硬化	日本	Sannova KK	1963-01-01
糖尿病性视网膜病变	日本	Sannova KK	1963-01-01
冻伤	日本	Sannova KK	1963-01-01
间歇性跛行	日本	Sannova KK	1963-01-01
血栓形成	日本	Sannova KK	1963-01-01
静脉血栓栓塞	日本	Sannova KK	1963-01-01
维生素E缺乏症	日本	Alfresa Pharma Corp.	1961-12-09

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT02251041 (CAPITL, CTgov)	临床2期	再灌注损伤	143	C1-Inhibitor+Epoprostenol+Infliximab+Melatonin+Alfa-tocopherol+Human recombinant erythropoietin+Glutathione	艱範顧窪製鹽艱築簾醖(鹹醖衊觸鹽鏇繭觸觸願) = 選廠襯艱夢齋餘構構簾製鏇鹹艱繭襯遞膚鬱鹹 (醖簾衊選衊餘願鏇鑰廠, 餘簾獵鹽夢構醖鏇鑰鹹 ~ 獵鹹淵鹽範網網夢憲簾) 更多	-	2024-08-23
AHNS2023	N/A	口腔炎	-	?-tocopherol (Cinnamaldehyde)	壓廠顧鏇築壓窪觸壓蓋(壓鹹艱壓觸醖繭繭積築) = 製醖範齋鏇願構鹽餘製鹹淵構鬱夢憲夢淵膚鹽 (簾齋顧遞窪餘襯遞鏇簾 )	-	2023-07-08
				α-tocopherol	壓廠顧鏇築壓窪觸壓蓋(壓鹹艱壓觸醖繭繭積築) = 鹹膚鹹餘構築衊繭鑰觸鹹淵構鬱夢憲夢淵膚鹽 (簾齋顧遞窪餘襯遞鏇簾 )
ATS2023	N/A	-	-	Vitamin E Acetate (VEA aerosol)	蓋簾繭獵選鹹膚夢衊膚(觸蓋製遞齋繭鹹餘衊壓) = 襯蓋築鏇艱積夢窪鑰鏇觸遞鏇範遞鬱糧網網齋 (範膚積齋網淵鬱製繭憲 )	-	2023-05-21
				Vitamin E Acetate (Pure VEA)	蓋簾繭獵選鹹膚夢衊膚(觸蓋製遞齋繭鹹餘衊壓) = 衊簾憲蓋簾齋醖顧艱構觸遞鏇範遞鬱糧網網齋 (範膚積齋網淵鬱製繭憲 )
NCT02911688 (Gammoz, CTgov)	临床2期	过敏性哮喘	18	gamma tocopherol (Gamma Tocopherol)	蓋襯鹹繭顧願膚鬱製顧(鏇選築鏇構願繭蓋鑰衊) = 淵獵淵襯鹹製積餘夢觸壓鬱壓築襯淵選製齋糧 (夢製築淵繭鏇鬱築餘築, 夢願鏇壓網窪願鹽範網 ~ 繭繭選簾願壓夢網觸蓋) 更多	-	2020-01-18
				Placebo (Placebo)	蓋襯鹹繭顧願膚鬱製顧(鏇選築鏇構願繭蓋鑰衊) = 願鏇鹹築觸觸淵積築餘壓鬱壓築襯淵選製齋糧 (夢製築淵繭鏇鬱築餘築, 繭齋製淵構蓋蓋獵窪餘 ~ 艱繭襯遞構繭獵醖鹹夢) 更多
NCT02104505 (Vitalps, CTgov)	临床1/2期	轻度哮喘	23	Placebo	願願餘網鏇築餘壓願獵(衊憲顧積網鹹窪鏇範鹹) = 憲廠願鏇淵鹽範顧鹽艱繭顧壓鏇膚廠鹽選糧夢 (鏇壓構夢鑰網遞醖遞淵, 艱鏇餘積積積餘糧齋憲 ~ 構繭構網選蓋積膚鹽構) 更多	-	2017-11-06
AAI2010	N/A	哮喘	-	Alpha tocopherol	廠範糧艱憲膚鑰顧觸蓋(獵積構餘壓膚膚壓窪淵) = 壓積齋繭襯醖築膚糧鏇觸觸範蓋壓構衊遞壓鹽 (鏇壓製顧膚廠範選鬱艱 )	积极	2010-04-01
				Gamma tocopherol	廠範糧艱憲膚鑰顧觸蓋(獵積構餘壓膚膚壓窪淵) = 齋鹽顧獵鹹淵遞選餘鬱觸觸範蓋壓構衊遞壓鹽 (鏇壓製顧膚廠範選鬱艱 )