Basic fibroblast growth factor(Kyoto University)(Basic fibroblast growth factor(Kyoto University))

概要

基本信息

药物类型

生长因子

别名

靶点

bFGF

作用方式

调节剂

作用机制

bFGF调节剂(成纤维细胞生长因子2调节剂)

治疗领域

心血管疾病

在研适应症-

非在研适应症

外周动脉疾病

原研机构

Kyoto University

在研机构-

非在研机构

Kyoto University

权益机构-

最高研发阶段无进展临床1期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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关联

3

项与 Basic fibroblast growth factor(Kyoto University) 相关的临床试验

JPRN-jRCTs061220098

/ Recruiting临床2期IIT

Evaluation of the regeneration facilitating effects of facial nerve decompression using basic fibroblast growth factor for severe facial paralysis

开始日期2023-02-20

申办/合作机构

The Japan Wool Textile Co., Ltd.

JPRN-UMIN000013629

/ CompletedN/AIIT

Injection laryngoplasty using basic fibroblast growth factor for the treatment of deficient glottal closure - Injection laryngoplasty using basic fibroblast growth factor for the treatment of deficient glottal closure

开始日期2013-04-01

申办/合作机构-

JPRN-jRCT1092220038

/ Completed临床1/2期IIT

Trials in chronic skin ulcers using new collagen substitutes incorporating basic fibroblast growth factor

开始日期2010-05-10

申办/合作机构

Kyoto University Hospital

100 项与 Basic fibroblast growth factor(Kyoto University) 相关的临床结果

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100 项与 Basic fibroblast growth factor(Kyoto University) 相关的转化医学

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100 项与 Basic fibroblast growth factor(Kyoto University) 相关的专利（医药）

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406

项与 Basic fibroblast growth factor(Kyoto University) 相关的文献（医药）

2025-06-01·Molecular Metabolism

Sex-dependent effects of FGF21 on HPA axis regulation and adrenal regeneration after Cushing syndrome in mice

Article

作者: Capó, Júlia ; Vidal, Oscar ; Casals, Gregori ; Díaz-Catalán, Daniela ; Mora, Mireia ; Enseñat, Joaquim ; Rodrigo-Calvo, Maria Teresa ; Vega-Beyhart, Arturo ; Hanzu, Felicia ; Squarcia, Mattia

BACKGROUNDCushing's syndrome (CS) results from prolonged exposure to excessive glucocorticoids (GCs), leading to metabolic disturbances and adrenal insufficiency (AI). Fibroblast growth factor 21 (FGF21) has shown promise as a potential therapeutic target for metabolic disorders. This study explores the effects of FGF21 on adrenal gland function in a mouse model of AI following chronic hypercortisolism and investigates sex-dependent differences in the hypothalamic-pituitary-adrenal (HPA) axis response.METHODSWe employed a mouse model of AI after chronic corticosterone (CORT) treatment. The effects of recombinant human FGF21 (hFGF21) administration on adrenal function were evaluated in AI mice. Male and female wild-type (WT) and FGF21-overexpressing transgenic (Tg) mice were subjected to 5 weeks of CORT treatment, reaching CS phenotype, followed by immediate analysis or a 10-week recovery period. Metabolic parameters, HPA axis function, and adrenal gland morphology and gene expression were assessed.RESULTSProlonged CORT exposure resulted in metabolic disturbances and HPA axis dysregulation. hFGF21 treatment increased CORT and ACTH secretion in AI mice. FGF21 overexpression influenced glucose homeostasis and insulin regulation during CORT treatment and recovery, with sex-specific effects. Tissue-specific regulation of Klb expression was observed across the HPA axis, with distinct patterns between males and females. Tg mice displayed altered adrenal progenitor cell activation and steroidogenic gene expression. Sex-specific differences were observed in adrenal capsule remodeling and gene expression patterns during recovery.CONCLUSIONSThis study reveals the complex interplay between FGF21 signaling and GC-induced metabolic and endocrine changes, suggesting a potential sex-specific role of FGF21 in metabolic regulation and HPA axis recovery following after CS.

2025-02-19·Nano Letters

Photothermal Conjugated Polymer Microneedle with Biofilm Elimination and Angiogenesis for Diabetic Wound Healing

Article

作者: Li, Hao ; Wang, Zijuan ; Xing, Chengfen ; Shao, Qi ; Zhang, Ran ; Xiao, Jian ; Qu, Shuyi ; Li, Boying ; Li, Wentai ; Li, Jie ; Nie, Chenyao ; Zhang, Xin

Diabetic wounds are highly susceptible to bacterial infection, which can lead to the formation of bacterial biofilms, making diabetic wound healing a major challenge. In this study, a composited microneedle that incorporated drug-loaded conjugated polymer nanoparticles and basic fibroblast growth factor was prepared to eliminate biofilms and promote vascular regeneration. This microneedle released minocycline under near-infrared (NIR) light, effectively penetrating bacterial biofilms. The photothermal properties of the conjugated polymers, combined with the antibacterial action of minocycline, contribute to the eradication of biofilms and the elimination of drug-resistant bacteria. Moreover, it regulated the wound microenvironment by reducing the level of oxidative stress, as well as the production of inflammatory factors at the wound site. Meanwhile, it effectively boosted cell migration and promoted angiogenesis to accelerate diabetic wound healing. This composited microneedle for biofilm elimination represents a promising approach for promoting diabetic wound healing.

2024-09-01·Blood transfusion = Trasfusione del sangue

Platelet rich plasma for facial rejuvenation: an overview of systematic reviews.

Review

作者: Pupella, Simonetta ; Pati, Ilaria ; De Angelis, Vincenzo ; Cruciani, Mario ; Masiello, Francesca

BACKGROUNDPlatelet-rich plasma (PRP) as a non-surgical therapy for facial rejuvenation is increasingly adopted. This article aims to review the literature and critically appraise the available evidence regarding the efficacy and safety of PRP for facial rejuvenation.MATERIAL AND METHODSAn overview of systematic reviews (SRs) of PRP use for facial rejuvenation. The methodological quality of the SRs was assessed using the AMSTAR-2 checklist; quality of the evidence from the trials included in each SR was appraised following the GRADE approach.RESULTSThirteen SRs published between 2015 and 2023, reporting data from 114 overlapping reports, based on 28 individual primary studies (18 uncontrolled reports), were included in this umbrella review. Eight primary studies evaluated PRP in combination with other treatments (laser therapy, fat grafting, hyaluronic acid, basic fibroblast growth factor), and 20 PRP monotherapy. Most of the included primary studies were uncontrolled, and meta-analysis for outcomes related to facial rejuvenation was conducted in only 1 of the 13 SRs, showing that patients treated with PRP as an adjunct treatment have increased satisfaction over controls without PRP (mean difference, 0.63; 95% confidence intervals (CIs) 0.25/1; p=0-001; low certainty of evidence due to risk of bias (ROB) and inconsistency). No other quantitative data were available from the SRs, although 4 SRs concluded in a descriptive way reveal that PRP combined with laser therapy increased subject satisfaction and skin elasticity, and decreased the erythema index (very low certainty of evidence due to imprecision, unsystematic clinical observations, and ROB). The occurrence of adverse events was a predefined outcome in only 2 SRs (15%). Almost all the SRs demonstrated poor compliance with the AMSTAR 2 items, and the confidence in the results of SRs was graded as low or critically low in 12 of the 13 SRs.DISCUSSIONThe available evidence is insufficient to suggest firm conclusions about the use of PRP, alone or in combination with other treatments, in promoting facial rejuvenation.

100 项与 Basic fibroblast growth factor(Kyoto University) 相关的药物交易

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研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
外周动脉疾病	临床1期	-	Kyoto University	-

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


REBIOS (ISC2014)	N/A	缺血性卒中 basic fibroblast growth factor (bFGF) \| HbA1c \| causal plasma glucose ... 更多	171	Basic Fibroblast Growth Factor (Diabetic patients)	鏇襯鹹餘獵鹹鹹願壓鬱(顧糧網顧鑰齋鹽積餘壓) = 淵獵艱鏇繭齋選積壓築艱鏇觸膚衊窪顧選鏇顧 (選簾選醖鬱網鏇夢觸簾 )	-	2014-02-01
				Basic Fibroblast Growth Factor (Non-diabetic patients)	鏇襯鹹餘獵鹹鹹願壓鬱(顧糧網顧鑰齋鹽積餘壓) = 衊蓋窪鹽積壓網糧鬱願艱鏇觸膚衊窪顧選鏇顧 (選簾選醖鬱網鏇夢觸簾 )
ASGCT2009	N/A	-	-	Basic Fibroblast Growth Factor Gene (BMSC transfected with cationic polymers)	鏇廠鹽蓋衊簾襯齋鏇繭(鹹顧餘鑰憲廠繭簾膚廠) = 鹹蓋構顧艱積蓋壓餘鏇淵蓋顧積構衊鹽獵網網 (襯製窪積糧廠簾製艱範 )	-	2009-05-01
ARVO2002	N/A	病理性新生血管	18	Medpor(R) soaked with bFGF	糧觸餘積構構選艱製願(壓窪鹽觸衊簾餘淵醖鏇) = 襯鹽糧繭選壓觸積膚鹹獵鹽觸壓艱齋鏇築艱鬱 (艱製願鬱鑰壓顧襯獵糧 )	积极	2002-12-01
				Basic Fibroblast Growth Factor (Unsoaked Medpor(R))	糧觸餘積構構選艱製願(壓窪鹽觸衊簾餘淵醖鏇) = 顧齋積憲憲醖觸蓋淵襯獵鹽觸壓艱齋鏇築艱鬱 (艱製願鬱鑰壓顧襯獵糧 )