This study is an examination of the influence of cooling components of WS-3, WS-23, and menthol on the appeal and addiction potential of nicotine-containing e-liquids among adults.

开始日期2024-11-01

申办/合作机构

Yale University

[+1]

NCT05932693 / Not yet recruitingN/AIIT

Examine the Effects of Novel E-cigarette Constituents and Determining Appropriate Concentrations Among Adults

This pilot sensory experiment will examine cooling from comparable concentrations of WS-3 and menthol to determine appropriate concentrations to use in the main study.

开始日期2024-09-01

申办/合作机构

Yale University

[+1]

NCT06444594 / Not yet recruiting早期临床1期IIT

Transient Receptor Potential Channels in Human Skin

Neurovascular signaling in the skin associated with stimulation of the transient receptor potential (TRP) channels. These channels are stimulated by both temperature and naturally occurring bioactive agents found in mint, chili peppers, garlic, etc. The aim of the study is to examine how topically applied TRP channel agonists including menthol, capsaicin and camphor impact neurovascular responses in the skin.

开始日期2024-06-15

申办/合作机构

The Pennsylvania State University

100 项与薄荷脑相关的临床结果

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100 项与薄荷脑相关的转化医学

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100 项与薄荷脑相关的专利（医药）

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项与薄荷脑相关的文献（医药）

2024-12-01·MOLECULAR BIOLOGY REPORTS

Menthol as an effective inhibitor of quorum sensing and biofilm formation in Candida albicans and Candida glabrata by targeting the transcriptional repressor TUP1

Article

作者: Soogh, Maryam Miri ; Khodavandi, Alireza ; Nouripour-Sisakht, Sadegh ; Khodavandi, Pouria ; Alizadeh, Fahimeh

BACKGROUND:

Menthol, a natural quorum sensing molecule, is derived from the Mentha species. Combating pathogenicity by inactivating quorum sensing is an emerging approach. Therefore, our objective was to investigate anti-quorum sensing and anti-biofilm potentials of menthol in Candida albicans and Candida glabrata.

METHODS:

The antifungal properties of menthol were evaluated using a broth microdilution assay and a time-kill assay, and its effects on quorum sensing-mediated virulence factors, cellular reactive oxygen species (ROS), and biofilm formation were tested by evaluating TUP1 expression levels in both C. albicans and C. glabrata.

RESULTS:

Quorum sensing-mediated virulence factors and biofilm formation were inhibited by menthol in both C. albicans and C. glabrata. Furthermore, coinciding with elevated ROS levels, mRNAs of the quorum sensing-related gene TUP1 were upregulated in both C. albicans and C. glabrata.

CONCLUSIONS:

This study highlights the anti-quorum sensing potential of menthol through the inhibition of quorum sensing-mediated virulence factors, ROS generation, and biofilm development by targeting TUP1, which could have potential in the treatment of Candida infections.

2024-12-01·CURRENT MOLECULAR MEDICINE

Preparation of Menthyl 3-amino-4-(2,4,5-trifluorophenyl) Butyrate and Investigation of its Hypoglycemic Activity

Article

作者: Liu, Zhonghua ; Cai, Huan ; Su, Minru ; Sheng, Xiaolan ; Xie, Shuilin ; Li, Hao ; Kuang, Xinmou

Background::

3-Amino-4-(2,4,5-trifluorophenyl) butyric acid has potential pharmacological effects in promoting insulin secretion. Menthol promotes drug transdermal absorption and hypoglycemic effects.

Objective::

The objective of the study was to combine the 3-amino-4-(2,4,5- trifluorophenyl) butyric acid and menthol to develop a new candidate drug molecule that can be used as a hypoglycemic drug in type II diabetes.

Methods::

In this study, the molecular structure of 3-amino-4-(2,4,5-trifluorophenyl) butyric acid in sitagliptin was modified by replacing pyrazine imidazole with menthol. The structure of the target compound was characterized by nuclear magnetic resonance (NMR). The anti-diabetic activity of BHF in N000180 BKS.Cg-Dock7m+/ +Leprdb/Nju mice with spontaneous diabetes was preliminarily studied.

Results::

A potential multi-target drug molecule, 3-amino-4-(2,4,5-trifluorophenyl) butyrate (BHF), was synthesized by combining 3-amino-4-(2,4,5-trifluorophenyl) butyric acid and menthol. BHF is suitable for hyperglycemic mice and has a significant hypoglycemic effect; the low dose of 10 mg/kg-1 started to be effective, and the high dose of 40 mg/kg-1 was more effective than the positive drug metformin.

Conclusion::

In this study, BHF has been synthesized and presented significant antidiabetic activities.

2024-12-01·POULTRY SCIENCE

Characterization and antibacterial application of peppermint essential oil nanoemulsions in broiler

Article

作者: Jabbar, Muhammad ; Baboo, Irfan ; Farooq, Zahid ; Palangi, Valiollah ; Majeed, Hamid

In order to mitigate the risk of antibiotic resistance in poultry, scientists nowadays consider plant secondary metabolites to be a major organic antibacterial substitute. This study aimed to characterize and investigate the in silico, in vitro, and in vivo antibacterial effects of peppermint essential oil (PEO) in the form of a nanoemulsion (NE), termed PEONE. Menthol as a major compound of PEO has been identified by gas chromatography and mass spectroscopy (GCMS) analysis as 32.3 %, while lower droplet size, polydispersity Index (PDI), and optimum zeta potential values depicted the stability of PEONE have been observed and validated by transmission electron microscopy (TEM) micrograph image. In silico antibacterial activity was studied by molecular docking of menthol and enrofloxacin with Topoisomerase IV protein (PDB: 1s16;) of Escherichia coli K12 MG1655 and this effect was validated by in vitro and in vivo analysis. In vitro analysis, sustained release of PEONE has been observed against Escherichia coli and Staphylococcus aureus. In this study for in vivo experiments (n = 90) day-old broiler chicks were distributed into 6 dietary treatments with 5 replicates of 3 birds per replication. Dietary treatments included 1) Negative control (basal diet), 2) Positive control (basal diet + 200 µl enrofloxacin), 3) 25 µl PEONE + basal diet, 4) 50 µl PEONE + basal diet, 5) 75 µl PEONE + basal diet, and 6) 100 µl PEONE + basal diet. Analyzed data by different statistical tools confirmed that PEONE significantly affected body weight gain (BWG) with an improved feed conversion ratio (FCR) compared to the control group. A significant increase in cecal Lactobacillus count and a decrease in total coliform was observed. Positive effects on physiological parameters, visceral organs, and meat quality characteristics have been observed. In conclusion, our experiments suggest that PEONE can be used in the broiler industry as a substitute for antibiotics to minimize bacterial resistance.

项与薄荷脑相关的新闻（医药）

2024-11-05

·drugs

Banning Menthol Cigarettes Might Drive Smokers to Quit-Smoking Therapies

TUESDAY, Nov. 5, 2024 -- Banning menthol cigarettes could help convince smokers quit the habit, a new study finds. People who prefer menthol cigarettes would rather buy nicotine gum or other nicotine replacement therapies than switch to traditional tobacco cigarettes, researchers reported recently in the journal Drug and Alcohol Dependence . In addition, menthol cigarette smokers were less likely to use e-cigarettes as a substitute if menthol vaping products are also restricted, researchers found. “I think the most important conclusion from this study is that we can improve health outcomes by emphasizing policies that reduce sales of flavored products and increase accessibility of nicotine replacement therapies,” said researcher Roberta Freitas-Lemos , an assistant professor at the Virginia Tech Fralin Biomedical Research Institute. More than 9 million adults -- about 32% of all smokers -- use menthol cigarettes, researchers said in background notes. Menthol makes smoking easier by reducing the harshness of cigarette smoke and cooling the throat. The Biden Administration has come under fire for delaying a proposed U.S. Food and Drug Administration ban on menthol cigarettes. In a September hearing before Congress, FDA leaders said a menthol ban is still in the works. "It's a priority for us. We followed through rule-making processes and it's presently with the White House and it continues to be a priority for us," Brian King, director of the FDA's Center for Tobacco Products, told a House Energy and Commerce Committee hearing. For the new study, researchers analyzed data from 172 people who smoke cigarettes, including 76 who only smoke menthol cigarettes and 96 who smoke non-menthol cigarettes. They also looked at 91 who use multiple types of tobacco products. The smokers were asked to use an online account to buy tobacco and nicotine products, which included replacement therapies. When menthol cigarettes weren’t available, smokers who prefer menthol were less willing to buy other types of cigarettes. Instead, they turned to nicotine replacement products like patches or gum. The study also found higher demand for high-ventilation cigarettes, which feature filter holes for airflow that make the smoke less harsh. “Cigarettes with ventilation are milder and people think they are less harmful, but it is a false perception,” Freitas-Lemos said in a Virginia Tech news release. Bans of these products could help smokers choose to quit, the researchers concluded. “It could be that people who smoke ventilated cigarettes are more responsive to one ban than another,” Freitas-Lemos said. Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.

2024-09-24

·PRNewswire

Stop Itchy Skin in its Tracks

5 tips for relief from a board-certified dermatologist ROSEMONT, Ill., Sept. 24, 2024 /PRNewswire/ -- Itchy skin can be irritating, especially an itch that doesn't go away. There are many potential causes for itchy skin like common skin conditions such as eczema, shingles, hives, psoriasis, or bug bites, or it could be a sign of a contagious disease, like scabies or ringworm. While these causes could mean a visit to a board-certified dermatologist, there are options for self-care at home to provide itch relief. "Our first instinct is to scratch that pesky itch, but in reality, that could be making things worse by irritating your skin further," said Susan Massick, MD, FAAD, clinical associate professor of dermatology at The Ohio State University. "Everyone experiences itchy skin from time to time, but relief can be possible by following a few easy steps at home." To help soothe itchy skin, Dr. Massick and the American Academy of Dermatology recommend following these tips: Apply a cool, damp washcloth to itchy skin for about 5-10 minutes, or until the itch goes away. Take a warm colloidal oatmeal bath. This can soothe your skin, especially if the cause of your itch is chickenpox, hives, poison ivy, or sunburn. Apply a "fragrance-free" moisturizer when your skin is still damp after bathing or whenever it itches. Soaps, detergents, and other products should also be "fragrance-free" as fragrance can irritate the skin. If your moisturizer doesn't relieve the itch, apply a cooling agent, like menthol or calamine. You can also try an over-the-counter cream or gel that contains pramoxine, a topical pain reliever. Sometimes keeping these in the refrigerator also helps. Wear loose-fitting, cotton clothes. These help you stay cool and won't irritate your skin, like wool and other rough-feeling fabrics can. Avoid extreme temperature changes, as these can make itch worse. Keep your house cool during the summer and use a humidifier and avoid high heat in the winter. "If you do not find relief after trying these at-home tips, or if you notice changes to your skin, such as redness, swelling, rash, bumps, or sores, a board-certified dermatologist can diagnose the underlying condition," said Dr. Massick. "Often, itching can have more than one cause, and together we can work toward a treatment plan that offers the best results, healthier skin, and, ultimately, symptom relief." These tips are demonstrated in "How to relieve itchy skin," a video posted to the AAD website and YouTube channel. This video is part of the AAD's "Your Dermatologist Knows" series, which offers tips people can use to properly care for their skin, hair, and nails. To manage itchy skin and learn more tips, partner with a board-certified dermatologist. To find a board-certified dermatologist in your area, visit aad.org/findaderm. More Information Itchy Skin Resource Center 10 Reasons Your Skin Itches and How to Get Relief AAD B-Roll Library About the AAD Headquartered in Rosemont, Ill., the American Academy of Dermatology, founded in 1938, is the largest, most influential and most representative of all dermatologic associations. With a membership of more than 21,000 physicians worldwide, the AAD is committed to advancing the diagnosis and medical, surgical, and cosmetic treatment of the skin, hair, and nails; advocating high standards in clinical practice, education and research in dermatology; and supporting and enhancing patient care because skin, hair, and nail conditions can have a serious impact on your health and well-being. For more information, contact the AAD at (888) 462-DERM (3376) or aad.org. Follow @AADskin on Facebook, TikTok, Pinterest and YouTube and @AADskin1 on Instagram. SOURCE American Academy of Dermatology WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

2024-09-17

·PRNewswire

IVIEW Therapeutics Inc. Completes Patient Recruitment for Phase 1/2 Trial of IVW-1001 Ophthalmic Eyelid Wipe in Dry Eye Disease Patients

CRANBURY, N.J., Sept. 17, 2024 /PRNewswire/ -- IVIEW Therapeutics Inc., a clinical-stage biotechnology company dedicated to advancing innovative treatments for ocular diseases, today announced the completion of patient recruitment for its Phase 1/2 clinical trial evaluating IVW-1001, a novel TRPM8 agonist delivered via ophthalmic eyelid wipe, for the treatment of signs and symptoms of dry eye disease. The company anticipates reporting topline data in the first quarter of 2025. Advancing Toward Promising Results "We are thrilled to have reached this significant milestone in our clinical development program for IVW-1001," said Houman Hemmati, MD, PhD, Chief Medical Advisor at IVIEW Therapeutics Inc. "Completing patient enrollment brings us one step closer to potentially offering a new therapeutic option for individuals suffering from dry eye disease. We are eagerly awaiting the trial results and remain optimistic about the potential impact on patient care." A Step Forward in Innovative Ophthalmic Treatments Bo Liang, PhD, MBA, Co-founder, Chairman, and CEO of IVIEW Therapeutics Inc., commented, "The completion of patient recruitment ahead of schedule is a testament to the dedication of our clinical team and the interest from the ophthalmic community. IVW-1001's novel mechanism of TRPM8 activation and its innovative delivery through an ophthalmic eyelid wipe could offer a differentiated treatment for dry eye disease worldwide. We look forward to sharing our findings as soon as they are available." About IVIEW Therapeutics Inc. IVIEW Therapeutics Inc. is a clinical-stage biotechnology company focusing on innovative ophthalmic therapeutics. Driven by the pursuit of cutting-edge science, we aim to develop differentiated products that fulfill unmet medical needs. We invest in novel mechanisms of action and advanced drug delivery technology platforms to bring forward assets with potentially superior target product profiles. Our innovative portfolio of small molecules and gene therapy assets covers dry eye, myopia, conjunctivitis, glaucoma, and presbyopia. Located in Cranbury, New Jersey, IVIEW operates a state-of-the-art 11,045 sq. ft. laboratory and office space in the Princeton area. For additional information, please visit our website at . SOURCE IVIEW Therapeutics Inc. WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

临床研究

100 项与薄荷脑相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D04918	薄荷脑	R05X	DB14123

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适应症	国家/地区	公司	日期
支气管炎	-	-	-
鼻窦炎	-	-	-

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适应症	最高研发状态	国家/地区	公司	日期
咽炎	临床3期	俄罗斯	Sandoz International GmbH	2017-02-22
腺瘤性结肠息肉病	临床3期	日本	Nihon Pharmaceutical Co., Ltd.	2011-09-01
去势抵抗性前列腺癌	临床3期	日本	Nihon Pharmaceutical Co., Ltd.	2011-09-01
胃腺瘤	临床3期	日本	Nihon Pharmaceutical Co., Ltd.	2011-09-01
胃癌	临床3期	日本	Nihon Pharmaceutical Co., Ltd.	2011-09-01
诊断试剂	临床1期	中国	-	2018-12-26
诊断试剂	临床1期	中国	山东百诺医药股份有限公司	2018-12-26

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT01855607 (CTgov)	临床2期	结肠癌 \| 乳腺癌 \| 周围神经系统疾病 ... 更多	12	placebo+menthol	繭膚憲餘糧淵構積簾醖(淵願顧鹽憲網廠鹹積簾) = 繭艱築繭鹹醖鹹鹽衊膚窪鬱壓顧鹹築蓋齋醖網 (遞鑰鏇選觸願憲構鑰網, 醖遞鏇範簾餘製顧壓艱 ~ 艱獵衊範艱獵築蓋膚觸) 更多	-	2024-07-11
NCT03095508 (CTgov)	临床3期	咽炎	229	Angal S, topical spray [Menthol] (Angal S (Arm A))	遞醖顧襯鬱製鹹鹹鹽鹹(製鹽遞壓鑰簾齋憲簾艱) = 遞鹹願鏇夢構選淵齋襯襯窪蓋壓廠襯衊鑰願願 (淵衊齋築鏇淵憲餘範蓋, 壓顧膚淵齋製鑰選憲餘 ~ 範膚憲範膚醖鑰壓鏇憲) 更多	-	2019-03-21
				ANTI-ANGIN® FORMULA, topical metered spray (ANTI-ANGIN® FORMULA (Arm B))	遞醖顧襯鬱製鹹鹹鹽鹹(製鹽遞壓鑰簾齋憲簾艱) = 艱醖獵膚築鹹繭鹽壓衊襯窪蓋壓廠襯衊鑰願願 (淵衊齋築鏇淵憲餘範蓋, 獵廠簾鹽鹽淵艱構積積 ~ 顧積顧選夢窪壓膚壓積) 更多
NCT02102100 (CTgov)	N/A	尼古丁依赖	57	nicotine+menthol (Menthol-Preferring Smokers)	鏇艱廠壓繭範製繭淵築(鑰選獵獵鏇襯蓋鏇製襯) = 壓壓遞襯築蓋醖願鹽糧選憲遞鬱鑰糧齋鹹顧鹽 (餘網製醖襯選構夢製鬱, 蓋鹹廠鏇糧構餘製鏇廠 ~ 憲窪窪壓膚齋鬱夢繭遞) 更多	-	2019-02-20
				nicotine+menthol (Non-Menthol Preferring Smokers)	鏇艱廠壓繭範製繭淵築(鑰選獵獵鏇襯蓋鏇製襯) = 餘範齋蓋齋窪築壓範膚選憲遞鬱鑰糧齋鹹顧鹽 (餘網製醖襯選構夢製鬱, 膚醖蓋憲夢獵鹽艱顧鬱 ~ 願艱糧淵網醖獵廠憲繭) 更多