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更新于：2025-01-24
Cyproheptadine Hydrochloride
盐酸赛庚啶
更新于：2025-01-24
概要
基本信息
非在研机构 |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C42H50Cl2N2O3 |
InChIKeyZEAUHIZSRUAMQG-UHFFFAOYSA-N |
CAS号41354-29-4 |
关联
25
项与 盐酸赛庚啶 相关的临床试验NCT06751290
The Use of Cyproheptadine to Improve Eating Habits in Children With Pediatric Feeding Disorders
IRCT20240213060992N1
Comparing the effect of low dose and standard dose Cyproheptadine on BMI enhancement in children aged 2-10 and evaluation of its side effects
NCT06147622
A Phase 1, Open-label, Cross-over Study in Healthy Volunteers to Assess the Pharmacokinetic Profile of Prazosin and Cyproheptadine Following Single Dose Oral Administration of KT110 Tablet and Following Administration of Alpress and Periactin Marketed Tablets
100 项与 盐酸赛庚啶 相关的临床结果
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100 项与 盐酸赛庚啶 相关的转化医学
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100 项与 盐酸赛庚啶 相关的专利（医药）
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642
项与 盐酸赛庚啶 相关的文献（医药）2025-03-01BEHAVIOURAL BRAIN RESEARCH
Neuropharmacological potential of Mimosa tenuiflora in adult zebrafish: An integrated approach to GABAergic and serotonergic neuromodulation
Article
作者: Alves Magalhães, Francisco Ernani ; Rolim Campos, Adriana ; Vieira-Neto, Antônio Eufrásio ; Alves do Nascimento, Gabriela ; Feitosa de Araújo, José Ismael
Mimosa tenuiflora ("jurema-preta") is traditionally used in folk medicine for various diseases. The study investigated the neuropharmacological potential of Mimosa tenuiflora bark fraction (FATEM) in adult zebrafish. This included the acute toxicity (LC50) of FATEM (0.01; 0.05; 0.1; 0.5; 1.0 and 5.0 mg/mL; i.p.) and the effects on behavioral tests, such as open field, light & dark and zebrafish tail immobilization test (ZTI). The anxiolytic response induced by alcohol withdrawal and the seizure induced by pentylenetetrazole were also tested. The possible mechanisms of anxiolytic and antidepressant actions of FATEM were evaluated through the administration of specific antagonists (Flumazenil, Cyproheptadine, Pizotifen or Granisetron). Furthermore, the study investigated the ADME profile and molecular docking simulations of the major FATEM compound, Benzyloxyamine, with GABAergic and serotonergic receptors. FATEM did not present acute toxicity and caused a reduction in locomotor activity (p < 0.0001 vs. Control) similar (p< 0.0001) to Diazepam, indicating a sedative/anxiolytic effect. The anxiolytic activity in the light & dark test was similar to Diazepam (p < 0.0001), prevented by GABA and serotonergic antagonists. FATEM also prevented anxious behaviors induced by alcohol withdrawal and exhibited an antidepressant effect in the ZTI (p < 0.0001 vs. Control) similar (p < 0.0001) to the effect of Fluoxetine, which was reversed by serotonergic antagonists. In silico evaluations indicated favorable pharmacokinetic properties and affinity of FATEM with GABAergic and serotonergic receptors. The study reveals that FATEM has adequate physicochemical characteristics to act on the CNS with specific affinity for GABAA and serotonergic receptors, indicating its potential as a treatment for anxiety and depression.
2025-02-01Emergency Medicine Australasia
Review article: Efficacy of cyproheptadine in the management of serotonin toxicity following deliberate self‐poisoning – A systematic review
Review
作者: Rotella, Joe A ; King, Emily
Abstract:
Serotonin toxicity is a potentially fatal condition caused by increased serotonergic activity in the central nervous system. Cyproheptadine, a serotonergic antagonist, is recommended for treatment; however, there is a lack of evidence to support its use. The present study aimed to evaluate the evidence for the use of cyproheptadine in the management of serotonin toxicity following deliberate self‐poisoning. Publications from 2003 were identified by searching electronic databases Cochrane, MEDLINE, EMBASE and PsycINFO. The inclusion criteria for studies to be included were determined a priori and consisted of studies published in English (or where an English translation was available) where the primary diagnosis of serotonin toxicity (or syndrome) following deliberate self‐poisoning and cyproheptadine was administered as the sole serotonergic antagonist. Studies were evaluated for quality and risk of bias. Twelve articles were identified, of which 11 were case reports and one was a case series. Serotonin toxicity was most attributed to selective serotonin reuptake inhibitors and all cases fulfilled Hunter serotonin toxicity criteria. Cyproheptadine regimen varied widely with respect to reporting of initial dose, repeat doses, frequency and duration. Few reports commented on clinical resolution and therefore efficacy was not established. All studies were graded as being of very low evidence and at high risk of bias. There is a lack of evidence to support the efficacy of cyproheptadine or its recommendation in clinical guidelines pertaining to the management of serotonin toxicity.
2024-12-01BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
Cyproheptadine is preferable to benzodiazepines in mild cases of serotonin syndrome (toxicity)
Article
作者: Mullins, Michael E.
100 项与 盐酸赛庚啶 相关的药物交易
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研发状态
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 湿疹 | 中国 | 1982-01-01 | |
| 食欲减退 | 日本 | 1971-01-01 | |
| 结膜炎 | 美国 | 1961-10-17 | |
| 常年性变应性鼻炎 | 美国 | 1961-10-17 | |
| 瘙痒 | 日本 | 1961-08-11 | |
| 过敏性鼻炎 | 日本 | 1961-08-11 | |
| 荨麻疹 | 日本 | 1961-08-11 |
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临床结果
临床结果
适应症
分期
评价
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临床3期 | 22 | (Arm I Cyproheptadine Hydrochloride) | 襯衊鹹構夢鹹獵膚壓築(艱鑰壓網鹹夢齋觸遞構) = 構鏇獵醖鏇憲繭觸構築 構鑰襯顧觸製鹹製餘繭 (網簾衊衊獵獵選顧簾繭, 窪遞鬱蓋構觸膚選觸醖 ~ 構構積壓齋顧製範繭襯) 更多 | - | 2015-07-02 | ||
placebo (Arm II Placebo) | 襯衊鹹構夢鹹獵膚壓築(艱鑰壓網鹹夢齋觸遞構) = 淵獵廠選獵築鬱餘鏇醖 構鑰襯顧觸製鹹製餘繭 (網簾衊衊獵獵選顧簾繭, 鹽鑰遞構遞選願繭構網 ~ 觸壓鏇鬱積築築鏇醖鑰) 更多 | ||||||
N/A | - | 積膚鹽構蓋壓淵製遞觸(觸憲憲餘鹹鹹憲襯網鑰) = 壓蓋觸鹹膚鏇鹹築簾淵 鏇構糧膚鹽獵夢衊鹹築 (築蓋夢構製繭鹽製齋鏇, 1.2) | - | 2010-11-17 | |||
Placebo | 積膚鹽構蓋壓淵製遞觸(觸憲憲餘鹹鹹憲襯網鑰) = 窪餘積廠鹽膚衊積艱選 鏇構糧膚鹽獵夢衊鹹築 (築蓋夢構製繭鹽製齋鏇, 1.2) |
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