作者: Sieving, Paul A ; Hartnett, M Elizabeth ; Harper, Clio Armitage ; Wood, Edward H ; Moshfeghi, Darius M ; Capone, Antonio ; Williams, George A ; Drenser, Kimberly A ; Blumenkranz, Mark S

Michael T. Trese, MD (1946–2022), a vitreoretinal surgeon, made significant contributions to the field of retina. Although most known for his work in pediatric retina surgery, he was a pioneer in areas such as medical retina, translational research, and telemedicine. This article reviews his major contributions to spread his knowledge more widely to vitreoretinal trainees and specialists. We discuss six areas where Trese made a lasting impact: lens-sparing vitrectomy, familial exudative vitreoretinopathy, congenital X-linked retinoschisis, autologous plasmin enzyme, regenerative medicine, and telemedicine. [ Ophthalmic Surg Lasers Imaging Retina 2023;54:701–712.]

2013-02-01·Retina2区 · 医学

Update and Review

2区 · 医学

Review

作者: Wong, S Chien ; Capone, Antonio

PURPOSETo discuss the potential role of microplasmin (ocriplasmin) as a surgical adjunct to vitrectomy in pediatric vitreoretinopathies.METHODSLiterature review of the laboratory and clinical evidence to date for the use of both autologous plasmin enzyme as an adjunct to vitrectomy and more recently recombinant microplasmin (ocriplasmin) as monotherapy for focal vitreomacular traction in adults.RESULTSAutologous plasmin enzyme is currently being used as a surgical adjunct to vitrectomy, with supporting Levels 2 and 3 published evidence in a range of pediatric vitreoretinopathies including Stage 5 retinopathy of prematurity and congenital X-linked retinoschisis. The availability of autologous plasmin enzyme is limited. In recent Phase 3 clinical trials, intravitreal ocriplasmin versus sham injection resulted in resolution of focal vitreomacular traction in 27% versus 10% (P < 0.001, n = 652).CONCLUSIONOcriplasmin may potentially be used as a surgical adjunct to vitrectomy in place of autologous plasmin enzyme. A Phase 2, randomized, placebo-controlled surgical trial is under way to assess this.

2011-08-01·American Journal of Ophthalmology

Intravitreal Injection of Autologous Plasmin Enzyme for Macular Edema Associated With Branch Retinal Vein Occlusion

Letter

作者: Patricia Udaondo ; David Salom ; Manuel Díaz-Llopis ; Salvador Garcia-Delpech ; Maria Garcia-Pous

100 项与纤溶酶相关的药物交易

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研发状态

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适应症	国家/地区	公司	日期
脑梗塞	中国	吉林津升制药有限公司	2003-05-22
血栓闭塞性血管炎	中国	北京赛升药业股份有限公司	1999-01-01
血栓性脑梗塞	中国	北京赛升药业股份有限公司	1999-01-01

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


PA022 (AAO2008)	N/A	糖尿病性黄斑水肿	-	Intravitreal Plasmin	(廠築鏇廠簾窪衊遞獵鹽) = 膚範餘壓繭艱觸範壓鹹窪顧淵鏇鹹夢選餘淵製 (窪願衊範鏇繭窪膚鹹繭, 0.24) 更多	积极	2008-11-09
ARVO2002	N/A	-	16	Plasmin 1U combined with hyaluronidase 20U	網艱顧衊醖範鹹繭願膚(淵鏇構齋觸積鹽淵鏇鏇) = 衊艱製選觸遞夢獵膚鑰獵夢艱齋鹹積鏇窪糧憲 (廠觸製衊製選選顧鑰願 )	积极	2002-12-01
				Plasmin 1U alone	網艱顧衊醖範鹹繭願膚(淵鏇構齋觸積鹽淵鏇鏇) = 膚鑰淵獵鑰簾繭鏇廠選獵夢艱齋鹹積鏇窪糧憲 (廠觸製衊製選選顧鑰願 )
AAO2000	N/A	糖尿病性视网膜病变	-	Autologous Plasmin Enzyme (APE)	(繭鑰願餘觸鹹網衊窪鹽) = 繭夢餘簾獵衊膚鹽構構醖獵廠獵遞顧鹹廠廠艱 (壓築蓋夢築夢繭築範築 )	积极	2000-10-23
				Autologous Plasmin Enzyme	(繭鑰願餘觸鹹網衊窪鹽) = 簾蓋鏇顧窪築蓋夢憲鏇醖獵廠獵遞顧鹹廠廠艱 (壓築蓋夢築夢繭築範築 )