预约演示

更新于：2025-05-07

Calcium chloride/Magnesium chloride/Potassium chloride/Sodium acetate/Sodium chloride/Sodium citrate

氯化钙/氯化镁/氯化钾/醋酸钠/氯化钠/柠檬酸钠

更新于：2025-05-07

概要

基本信息

药物类型

小分子化药

别名

BSS、ISOLYTE E

靶点-

作用方式-

作用机制

钙补充剂、镁补充剂、钠补充剂

治疗领域

其他疾病

在研适应症

眼科外科手术

非在研适应症-

原研机构

B. Braun Medical, Inc.

在研机构

Alcon Laboratories, Inc.

非在研机构

B. Braun Medical, Inc.

权益机构-

最高研发阶段批准上市

首次获批日期

美国 (1983-10-31),

眼科外科手术

最高研发阶段(中国)-

特殊审评-

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结构/序列

分子式ClNa

InChIKeyFAPWRFPIFSIZLT-UHFFFAOYSA-M

CAS号7647-14-5

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关联

100 项与氯化钙/氯化镁/氯化钾/醋酸钠/氯化钠/柠檬酸钠相关的临床结果

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100 项与氯化钙/氯化镁/氯化钾/醋酸钠/氯化钠/柠檬酸钠相关的转化医学

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100 项与氯化钙/氯化镁/氯化钾/醋酸钠/氯化钠/柠檬酸钠相关的专利（医药）

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250

项与氯化钙/氯化镁/氯化钾/醋酸钠/氯化钠/柠檬酸钠相关的文献（医药）

2025-04-01·Eye & Contact Lens: Science & Clinical Practice

Evaluating the Protective Effects of a Dispersive Ophthalmic Viscosurgical Device Versus Balanced Salt Solution on the Cornea During Cataract Surgery

Article

作者: Kanamoto, Kellie ; Strawbridge, Jason ; Lin, Shawn R ; Khorrami, Roxana ; Hanson, Justin ; Miller, Kevin M

Objectives:To compare intraoperative and postoperative effects of applying a viscosurgical device versus balanced salt solution (BSS) during cataract surgery.Methods:Single-center retrospective case–control pilot study. Reviewed 27 patients who received Viscoat (Alcon Laboratories, Inc. Fort Worth, TX) or BSS on the cornea during uncomplicated cataract surgery. Surgeries were analyzed for time when the microscope light reflection was indistinct on the cornea while instruments were in the eye. Postoperative data included patient pain ratings, National Eye Institute score, and Ocular Surface Disease Index (OSDI) scores.Results:Compared with BSS, Viscoat application resulted in a significant increase in time with a clear light reflex during surgery (P<0.001). With BSS, average time without a clear light reflex while instruments were in the eye was 82.69±50.14 sec, or 17.56%±12.00% of the surgery, compared with 0% with Viscoat. There was no significant difference in postoperative pain and National Eye Institute score between groups. However, OSDI score two about grittiness was significantly lower with Viscoat application (P=0.01) and approaching significance for OSDI score three, about painful or sore eyes (P=0.09).Conclusions:Viscoat provided greater optical clarity during surgery with a single application and was associated with less sensation of grittiness compared with BSS.

2024-10-01·Heliyon

Untargeted metabolomics combined with pseudotargeted lipidomics revealed the metabolite profiles of blood-stasis syndrome in type 2 diabetes mellitus

Article

作者: Chen, Bao-Xin ; Zhou, Qing-Bing ; Liu, Li ; Zhang, Ying ; Tong, Wen-Xin ; Liang, Yuan-bin ; Liu, Xiao-Lin ; Wang, Min ; Wang, Hong-Qin ; Tong, Wen-xin ; Liang, Yuan-Bin ; Liu, Xiao-lin ; Zhou, Qing-bing ; Qi, Yi-Fei ; Chen, Bao-xin ; Wang, Hong-qin ; Qi, Yi-fei

ObjectiveBlood-stasis syndrome (BSS), an important syndrome in Type 2 diabetes mellitus(T2DM), is associated with the pathophysiological mechanisms underlying diabetic vascular complications. However, BSS has not been fully characterized as of yet. Due to the strong correlation between BSS and vasculopathy, we hypothesized that the metabolic characteristics of BSS in T2DM (T2DM BSS) are highly specific. By combining untargeted metabolomics and pseudotargeted lipidomics approaches, this study aimed to comprehensively elucidate the metabolic traits of T2DM BSS, thereby providing novel insights into the vascular complications of diabetes and establishing a foundation for precision medicine.MethodsThe survey was conducted in Haidian District of Beijing from October 2021 to November 2021, and data collection was completed in January 2022. Liquid chromatography-mass spectrometry (LC-MS) based untargeted metabolomics and liquid chromatography-tandem mass spectrometry (LC-MS/MS) based pseudotargeted lipidomics were performed to detect metabolites and lipids. Multivariate, univariate, and pathway analyses were utilized to investigate metabolic changes. The unique metabolites of BSS were obtained by inter-group comparisons and screening. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the diagnostic accuracy of metabolites.ResultsA total of 1189 participants completed the survey, of which 120 participants were recruited in this study and further divided into a discovery cohort (n = 90) and a validation cohort (n = 30). Among these, 21 participants were selected for psuedotargeted lipidomics analysis. 81 metabolites, mainly involving glycerophospholipids, were identified as unique metabolites of T2DM BSS, while fatty acyls (FAs) were identified as unique lipids. T2DM BSS was associated with significant dysregulation in glycerophospholipid metabolism and choline metabolism within cancer pathways as major metabolic disturbances. Furthermore, analyses of both the discovery and validation cohorts, indicated that LysoPC (20:5(5Z,8Z,11Z,14Z,17Z)/0:0) and LysoPC (15:0) had the greatest impact on distinguishing BSS.ConclusionAltered levels of glycerophospholipids and FAs have been associated with T2DM BSS. These results provide valuable mechanistic insights linked with the development of BSS in T2DM subjects.

2024-09-23·Current Pharmaceutical Biotechnology

Aspects of β-sitosterol's Pharmacology, Nutrition and Analysis

Article

作者: Dwivedi, Jyotsana ; Dwivedi, Monika ; Wal, Pranay ; Wasnik, Ujwala ; Gunjal, Sachinkumar Dnyaneshwar ; Singhai, Ashish ; Sachan, Pranjal

Phytosterols are bioactive substances found naturally in the cell membranes of plants and have an arrangement of molecules similar to that of fat, which is produced by mammalian cells. They are widely distributed as dietary sources of lipids in plants, such as nuts, seeds, olive oil, and legumes. This review provides a summary of the efficacy of BS in treating lifestyle problems, as well as an appraisal of previous research. Data was collected from PubMed, ScienceDirect, Scopus, and Google scholar (1968 -2024) using standard keywords “β-sitosterol,” “Classification,” “Biosynthesis,” “Pharmacokinetics,” “Herbal nutraceutical,” “Analytical,” “Structure,” “Pharmacological effect.” A total of 222 studies were included in this review. Numerous in vitro and in vivo investigations have shown that BSs exhibit several biological properties such as calming and anxiolytic effects; narcotic and immune-stimulating effects; antibacterial, antineoplastic, inflammation-causing, lipid-lowering, and hepatoprotective effects; and antioxidant, anti-diabetic, and wound-healing effects in contrast to respiratory and non-alcoholic fatty liver disease illnesses. β-sitosterol is a promising natural substance for the management of cholesterol and inflammation. However, further studies are needed to understand its pharmacological consequences and determine its best use in clinical applications. β-Sitosterol, also known as "plant sterol ester," is often present in plants and has several applications, notably in medicine and the food industry. Experimental research on β-sitosterol provides unequivocal evidence that phytosterol can be supplemented with other methods to combat serious illnesses. Such a high potential identifies this substance as a noteworthy medication for the future based on its composition. Although β-sitosterol has anticancer and anti-inflammatory properties and is useful in human clinical trials for enlarged prostates, its mechanism of action remains unclear

100 项与氯化钙/氯化镁/氯化钾/醋酸钠/氯化钠/柠檬酸钠相关的药物交易

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研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
眼科外科手术	美国	Alcon Laboratories, Inc.	1997-12-10

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


ARVO2010	N/A	角膜上皮缺损	-	BSS	(襯膚鏇構廠鏇簾鏇壓築) = 網製淵艱艱襯齋繭憲構壓鏇壓憲鹹選鏇鏇淵繭 (衊窪餘鏇廠顧製觸襯鬱, 4.9)	不佳	2010-04-01
				Vigamox	(襯膚鏇構廠鏇簾鏇壓築) = 膚淵醖醖窪廠簾窪夢積壓鏇壓憲鹹選鏇鏇淵繭 (衊窪餘鏇廠顧製觸襯鬱, 4.1)
Pubmed	N/A	幽门螺杆菌感染	50	Omeprazole 40 mg	艱齋鏇壓餘願鏇膚餘膚(獵夢範遞夢齋蓋遞觸遞) = 膚蓋築艱製選築淵壓簾艱齋遞襯鏇鹽構獵獵願 (積糧蓋廠糧夢鬱窪構繭 )	不佳	1991-11-01
				Bismuth subsalicylate (BSS)	(蓋糧構築鏇鑰襯餘觸繭) = 鹹壓憲糧淵淵鏇鹽淵糧簾齋繭繭蓋製膚簾願鬱 (齋衊獵範鹹構製鬱顧窪 ) 更多