Etanercept

WELLESLEY, Mass., Nov. 11, 2024 (GLOBE NEWSWIRE) -- Climb Bio, Inc. (Nasdaq: CLYM) today announced the appointment of Douglas E. Williams, Ph.D., as Climb Bio’s Chair of its Board of Directors. Dr. Williams will assume the role of Chair of the Board, succeeding Andrew Levin, who will remain on the Board as a director, while Liam Ratcliffe will step down from his position as a director. Dr. Williams has over 30 years of executive leadership experience in the biotechnology sector. Throughout his career, Dr. Williams has held leadership roles in research and development, contributing significantly to the creation of drugs such as Leukine®, Enbrel®, Adcetris®, Tecfidera®, Alprolix®, Eloctate® and Spinraza®. As a CEO, he has successfully guided both private and public companies from development to commercialization and has overseen multiple successful mergers. “I am thrilled to welcome Dr. Doug Williams to Climb Bio. As our incoming Chair of the Board, Doug’s experiences over his 30 plus year career building and leading a range of biotechnology and pharmaceutical companies will offer critical perspective as we grow Climb Bio,” said Aoife Brennan, President and CEO of Climb Bio. “In particular, Doug’s expertise in immunology drug development will be very valuable as we pursue our mission to develop better treatments for the approximately 50 million patients in the U.S. and many more globally living with immune-mediated diseases.” Dr. Williams previously served as the President of Research and Development at Sana Biotechnology and was CEO of Codiak BioSciences. He has also served as Executive Vice President of Research and Development at Biogen. Prior to Biogen he was CEO at ZymoGenetics and led its acquisition by Bristol Myers Squibb. He has also held a variety of leadership positions, including Chief Scientific Officer and Executive Vice President of Research and Development at Seattle Genetics (acquired by Pfizer in 2023), Senior Vice President and Washington Site Leader at Amgen and Executive Vice President and Chief Technology Officer and a member of the Board of Directors at Immunex (acquired by Amgen in 2021). Dr. Williams has served as a board member of more than a dozen public and private biotechnology companies and is currently Chair of the Board of AC Immune SA and a Director of Stablix. He holds a Ph.D. from the State University of New York at Buffalo, Roswell Park Division and completed a postdoctoral fellowship at Indiana University School of Medicine. Dr. Williams added: “I am honored to be joining Climb Bio’s Board at this exciting time as they work to advance budoprutug and build a leading immune-mediated disease focused company. I believe budoprutug has potential across a broad range of B-cell mediated diseases and provides a cornerstone for the company to expand. I look forward to working with the talented Climb Bio team and the board to help them advance their mission to develop therapeutics for patients with immune-mediated diseases.” “I look forward to continuing to work with Aoife, the Climb Bio team, and other board members,” stated Andrew Levin, a member of Climb Bio’s Board and former Chair of the Board. “In the short time since acquiring Tenet Medicines, we have achieved a great deal. With the tremendous opportunity ahead, I am excited to transition the Chair role to Doug while remaining on the Board. Doug has incredible experience and a proven track record in building successful biotechnology companies and will be invaluable in guiding Climb Bio going forward. In addition, on behalf of the Board, I would also like to thank Liam for his valuable contributions and commitment to the Company through its transition.” About Climb Bio, Inc. Climb Bio, Inc. is a clinical-stage biotechnology company developing therapeutics for patients with immune-mediated diseases. The Company’s lead product candidate, budoprutug, is an anti-CD19 monoclonal antibody that has demonstrated B-cell depletion and has potential to treat a broad range of B-cell mediated diseases. For more information, please visit climbbio.com. Forward-Looking Statements This press release contains “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995, including without limitation statements regarding: future expectations, plans and prospects for Climb Bio; the anticipated benefits of the acquisition of Tenet Medicines, Inc.; expectations regarding budoprutug’s therapeutic benefits, clinical potential and clinical development; plans to optimize the administration of budoprutug; and other statements containing the words “anticipate,” “believe,” “continue,” “could,” “estimate,” “expect,” “intend,” “may,” “plan,” “potential,” “predict,” “project,” “should,” “target,” “would,” “will,” “working” and similar expressions. Forward-looking statements are based on management’s current expectations of future events and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those set forth in, or implied by, such forward-looking statements. Climb Bio may not actually achieve the plans, intentions or expectations disclosed in these forward-looking statements, and you should not place undue reliance on these forward-looking statements. These risks and uncertainties include, but are not limited to, important risks and uncertainties associated with: the ability of Climb Bio to timely and successfully achieve or recognize the anticipated benefits of its acquisition of Tenet Medicines, Inc.; changes in applicable laws or regulation; the possibility that Climb Bio may be adversely affected by other economic, business and/or competitive factors; Climb Bio’s ability to advance budoprutug on the timelines expected or at all and to obtain and maintain necessary approvals from the U.S. Food and Drug Administration and other regulatory authorities; obtaining and maintaining the necessary approvals from investigational review boards at clinical trial sites and independent data safety monitoring boards; replicating in clinical trials positive results found in early-stage clinical trials of budoprutug; competing successfully with other companies that are seeking to develop treatments for primary membranous nephropathy, immune thrombocytopenia and systemic lupus erythematosus and other immune-mediated diseases; maintaining or protecting intellectual property rights related to budoprutug and/or its other product candidates; managing expenses; and raising the substantial additional capital needed, on the timeline necessary, to continue development of budoprutug and any other product candidates Climb Bio may develop. For a discussion of other risks and uncertainties, and other important factors, any of which could cause Climb Bio’s actual results to differ materially from those contained in the forward-looking statements, see the “Risk Factors” section, as well as discussions of potential risks, uncertainties and other important factors, in Climb Bio’s most recent filings with the U.S. Securities and Exchange Commission. In addition, the forward-looking statements included in this press release represent Climb Bio’s views as of the date hereof and should not be relied upon as representing Climb Bio’s views as of any date subsequent to the date hereof. Climb Bio anticipates that subsequent events and developments will cause Climb Bio’s views to change. However, while Climb Bio may elect to update these forward-looking statements at some point in the future, Climb Bio specifically disclaims any obligation to do so, except as required by law. InvestorsChris Brinzey ICR Healthcarechris.brinzey@icrhealthcare.com 339-970-2843 MediaJon YuICR Healthcarejon.yu@icrhealthcare.com475-395-5375

作者｜momo 近年来，自身免疫药物研发呈现出迅猛的发展态势。全球销售额前十的药品中，3款为自身免疫性疾病药物。沙利文数据预测，到2030年，全球自身免疫性疾病药物市场规模有望达到1760亿美元，2022—2030年复合年增长率为3.6%。这一数据充分彰显了该领域的巨大潜力。 在国内，众多药企积极投身于自免药物研发，其中恒瑞医药表现突出，已有超过 10 款自免药物处于研发阶段。从药物靶点的角度而言，以 JAK、CTLA - 4、IL 等为靶点的药物如雨后春笋般不断涌现...... 在这里，我们将根据2024年上半年自身免疫药物销售统计数据，预测2024年下半年最值得关注的15种自身免疫药物。经整理，排名如下： 表1：2024H1自免药物销售额TOP15 注1：由于货币汇率波动，销售额换算统一货币时略有差异。 注2：表格数据为笔者手动统计，如有错误及纰漏，还请文末留言指正。 1、TOP1: Dupixent（度普利尤单抗） 作为赛诺菲和再生元合作开发的核心自免药物，自上市以来一直是医药领域的焦点。这款针对自身免疫疾病的重磅药物在中重度特应性皮炎、中重度哮喘、慢性鼻炎等多种适应证中表现出卓越疗效，成为了这些领域治疗的重要选择。它是全球首个获批治疗中重度特应性皮炎的生物制剂，适应证拓展能力极强。 2024年上半年，Dupixent销售额高达66美元，其在自身免疫疾病市场占据重要地位。据赛诺菲发布的第三季度最新财报显示，Dupixent第三季度的销售收入超过37.5亿美元，同比增长23.8%。，其销售额保持稳定增长趋势，为赛诺菲和再生元带来了可观的收入。并且随着适应证进一步拓展和市场渗透率的提高，Dupixent在未来无疑将持续巩固其在自免药物领域的领先地位，销售额有望持续攀升。 2、TOP2: Stelara（乌司奴单抗） Stelara（乌司奴单抗）是治疗自身免疫性疾病的药物，对银屑病、克罗恩病等病症有着出色的疗效，通过精准调节免疫系统来减轻炎症反应。它主要是通过靶向特定的免疫相关通路发挥作用。2009年，Stelara获FDA批准上市。在欧洲，它也被广泛用于相关疾病的治疗。 在全球市场，Stelara已成为众多自身免疫病患者的重要治疗选择之一。根据强生公司公告，2024年上半年Stelara在全球实现了63.36亿美元高额销售额，为强生公司在自免药物领域的营收做出了重要贡献。强生公司发布的2024年第三季度报告显示，该制药公司的销售额接近225亿美元，同比增长5.2%。其中，Stelara（乌司奴单抗）的销售额接近27亿美元，显示出其在市场上的强大竞争力。 3、TOP3: Humira（阿达木单抗） Humira（阿达木单抗）是一种全人源化抗肿瘤坏死因子 - α（TNF - α）单克隆抗体，用于治疗多种自身免疫性疾病，像类风湿关节炎、强直性脊柱炎、银屑病、克罗恩病等。它能特异性地与 TNF - α结合，从而抑制炎症反应。1998年，Humira在美国获批上市，之后在全球众多国家和地区广泛应用，极大地改善了患者的病情和生活质量。 近年来，阿达木单抗多年来一直是全球销售额领先的药物之一，为艾伯维公司创造了巨大的收益，据艾伯维发布的财报显示，在2023年，Humira销售额达到144.04亿美元，在2024年前三季度，Humira的销售额超过70亿美元。 4、TOP4: Skyrizi（利生奇珠单抗） Skyrizi（利生奇珠单抗）是一种白细胞介素 - 23（IL - 23）抑制剂，主要用于治疗中重度斑块状银屑病、银屑病关节炎等自身免疫性疾病。它通过精准作用于特定靶点，有效减轻皮肤炎症和关节症状。Skyrizi已在全球多个国家和地区获批上市，包括美国、欧洲等地。在临床应用中，为众多自身免疫疾病患者带来了新的治疗选择。 2023年Skyrizi全球销售额合计77.63亿美元，2024年上半年销售额接近50亿美元，同比增长46%。Skyrizi 2024年第三季度销售额为32.05亿美元，同比增长50.8%，预计全年收入可超过110亿美元。 5、TOP5:Ocrevus（奥瑞利珠单抗） Ocrevus (奥瑞利珠单抗)是一种人源化单克隆抗体，主要用于治疗多发性硬化症（MS），包括复发型多发性硬化症和原发进展型多发性硬化症。它通过靶向作用于 CD20 阳性的 B 细胞，调节免疫系统对神经组织的攻击，从而减缓疾病的进展。Ocrevus已在多个国家和地区获批上市，为大量多发性硬化症患者提供了重要的治疗选择。在临床实践中，其疗效和安全性得到了广泛验证。 根据罗氏公司公告显示，Ocrevus是罗氏制药业务前三季度销售额最高的药物，达到50.6亿瑞士法郎。 6、TOP6: Entyvio （维德力珠单抗） Entyvio（维德力珠单抗）是一种治疗炎症性肠病（包括溃疡性结肠炎和克罗恩病）的生物制剂，由武田制药研发。它通过特异性地结合肠道血管内皮细胞上的α4β7整合素，阻止白细胞向肠道炎症部位迁移，从而减轻肠道炎症。Entyvio用于对传统治疗或肿瘤坏死因子拮抗剂应答不足、失应答或不耐受的中重度活动性溃疡性结肠炎或克罗恩病成年患者。 它在炎症性肠病治疗领域占据重要地位，2024年上半年，Entyvio销售额在武田制药自身免疫疾病业务收入中占比显著，销售额达到28.7亿美元，同比增长20%。 7、TOP7: Cosentyx（司库奇尤单抗） Cosentyx（司库奇尤单抗）被广泛用于治疗多种自身免疫性疾病，包括中重度斑块状银屑病、银屑病关节炎和强直性脊柱炎等。它通过特异性地阻断白细胞介素 - 17A（IL - 17A）信号通路，抑制炎症反应，从而减轻疾病症状。 2024年上半年销售额为28.52亿美元，同比增长21%；第三季度销售额增长了28%，达到17亿美元，超出共识预期7%。 8、TOP8: Rinvoq（乌帕替尼） Rinvoq（乌帕替尼）是一种口服的选择性 Janus 激酶（JAK）抑制剂，用于治疗多种自身免疫性疾病，包括类风湿关节炎、银屑病关节炎、特应性皮炎、溃疡性结肠炎等。它通过抑制 JAK 信号通路，从而减少炎症反应，缓解患者症状。 据艾伯维2024年第三季度的业绩报告显示，Rinvoq第三季度销售额为16.14亿美元，同比增长45.3%，预计全年收入将超50亿美元。 9、TOP9: Jakafi（芦可替尼） Jakafi（芦可替尼）是一种口服JAK抑制剂，由Incyte公司开发，用于治疗中危或高危骨髓纤维化（MF），包括原发性骨髓纤维化、真性红细胞增多症骨髓纤维化和原发性血小板增多症骨髓纤维化。Jakafi的作用机制是通过抑制JAK1和JAK2，中断JAK-STAT信号通路，从而抑制细胞增殖和炎症反应。 2024上半年，Incyte最重要的产品JAK1/2抑制剂芦可替尼占所有产品总销售额的90%以上，总销售额达24.34亿美元，同比增长8%。 10、TOP10: Xolair（奥马珠单抗） Xolair（奥马珠单抗）是一种重组的人源化单克隆抗体，用于治疗哮喘和慢性特发性荨麻疹等过敏性疾病。其活性成分omalizumab通过特异性地结合游离IgE（免疫球蛋白E），降低游离IgE水平，从而减少IgE与肥大细胞和嗜碱性粒细胞表面的高亲和力IgE受体（FcεRI）结合，抑制炎症介质的释放，发挥抗过敏作用。 2024年上半年销售额为21亿美元，同比增长11%。 11、TOP11: Enbrel（依那西普） Enbrel（依那西普）是一种肿瘤坏死因子（TNF）抑制剂，主要用于治疗类风湿关节炎、强直性脊柱炎、银屑病关节炎和斑块状银屑病等自身免疫性疾病。它通过与TNF - α和TNF - β结合，阻断它们与细胞表面TNF受体的相互作用，从而减轻炎症反应。 2024年上半年 Enbrel 销售额为18.14亿美元，据安进最新发布的第三季度收益报告显示，Enbrel 第三季度季度销售额为 8.25 亿美元。 12、TOP12: Orencia（阿巴西普） Orencia（阿巴西普）是一种选择性T细胞共刺激调节剂，用于治疗类风湿关节炎（RA）和幼年特发性关节炎（JIA）等。它通过与抗原递呈细胞表面的CD80/CD86结合，阻断其与T细胞表面CD28的相互作用，抑制T细胞激活，从而减少炎症反应。 2024年上半年Orencia销售额为17.46亿美元，同比增长3%。 13、TOP13: Tremfya（古塞奇尤单抗） Tremfya（古塞奇尤单抗）是一种人源化单克隆抗体，用于治疗中重度斑块状银屑病。其活性成分guselkumab可特异性地结合白细胞介素 - 23（IL - 23）的p19亚基，抑制IL - 23信号传导，减轻皮肤炎症。 2024年10月16日，强生公布2024年第三季度财报。其中Tremfya销售增长13.0%至10.07亿美元。 14、TOP14: Actemra（托珠单抗） Actemra（托珠单抗）是一种人源化抗白细胞介素 - 6（IL - 6）受体单克隆抗体，主要用于治疗类风湿关节炎、全身型幼年特发性关节炎等炎症性疾病。Actemra已在全球广泛获批使用，为众多患者改善了病情，其2024年上半年在全球销售额达到14.62亿美元，在自身免疫疾病治疗领域地位显著。 15、TOP15: Simponi（戈利木单抗） Simponi（戈利木单抗）是一种全人源化抗肿瘤坏死因子 - α（TNF - α）单克隆抗体，用于治疗类风湿关节炎、强直性脊柱炎和银屑病关节炎等自身免疫性疾病。它能特异性地与TNF - α结合，抑制TNF - α的活性，减少炎症反应。 2024年上半年 Simponi销售额为14.47亿美元，同比增长2%。 参考资料 [1]药智数据 [2]各公司官网、企业公开数据 共建Biomedical创新生态圈！ 如何加入BiG会员？