Tenecteplase

5 月 27 日，石药集团发布 2024 年一季度财报。截至 2024 年 3 月 31 日止三个月的季度业绩，取得收入总额 89.83 亿元（人民币，下同），同比增加 11.5%；其中，成药业务收入于本期增加 17.7% 至 75.61 亿元。除呼吸系统外，各个治疗领域的产品收入均较去年同期有所增长，来自近年推出的新产品的贡献亦持续增加。来自：石药集团年报（下文如无特殊标注，为同一来源）从各领域产品销售情况来看，神经和肿瘤仍是石药集团成药业务中最关键的两大领域。神经系统领域销售收入继续增长 27.4% 达到 27.07 亿元，肿瘤领域以 11.6% 增长幅度，实现 16.11 亿元的收入。此外，值得一提的是，消化代谢疾病领域 60% 的高增长，而这都得益于近年相应领域新产品的加持。不过，呼吸系统疾病领域有下降趋势，营业收入同比减少 6.2%。2024 年 Q1 各领域产品销售额情况数据来自石药财报，Insight 整理研发费用为 11.69 亿元，较去年同期增加 16.0%，约占成药业务收入 15.5%。目前石药已有超 60 个重点在研药物已进入临床或申报阶段，其中 7 个已递交上市申请，20 个处于注册临床阶段。石药在各技术平台的布局上相当广泛，目前建成的研发技术平台包括纳米制剂、长效注射剂、单抗、双抗、ADC、mRNA、siRNA、PROTAC 及人工智能（AI）药物设计在内。大分子药物方面，重点开发多功能化的蛋白及抗体药物，如双抗、三抗、新型 ADC。小分子药物研发平台则重点打造 PROTAC、LYTAC 及基于 AI 技术的筛选平台，开发具有抗肿瘤、免疫调整等多重功能的小分子靶向药物，及基于表观遗传学的小分子药物。其中，针对 ADC 新药，据 Insight 数据库显示，当前石药已有 7 款在研。其中，HER3 ADC 以及 Nectin-4 ADC 在今年都有积极临床进展。HER3 ADC 新药 SYS6023 今年 3 月获批临床（受理号：CXSL2400013）；其二，Nectin-4 ADC 新药 SYS6002 今年 2 月在 ClinicalTrials.gov 上登记启动了 I/II 期临床试验（登记号：NCT06265727），并在上个月完成首例受试者的给药工作。除 ADC 外，对于改良新药司美格鲁肽，也在今年 3 月获批了减重适应症临床试验（受理号：CXHL2400032）。此外，2024 年至今，国内有 1 款生物类似药获批新适应症，替奈普酶（明复乐）（注射用重组人TNK组织型纤溶酶原激活剂，rhTNK-tPA）用于急性缺血性卒中患者的溶栓治疗于 2 月获批上市，该适应症为同类产品在中国首家获批，也是该产品获批的第二个适应症。附：7 项在研药物首发适应症和 9 项新增适应症国内获批临床封面来源：企业 Logo免责声明：本文仅作信息分享，不代表 Insight 立场和观点，也不作治疗方案推荐和介绍。如有需求，请咨询和联系正规医疗机构。编辑：HebePR 稿对接：微信 insightxb投稿：微信 insightxb；邮箱 insight@dxy.cn多样化功能、可溯源数据……Insight 数据库网页版等你体验点击阅读原文，立刻解锁！

ADA, Okla., May 20, 2024 /PRNewswire/ -- Dillion Kirkland is a 31-year-old Mercy emergency medical technician who works with life-threatening injuries and illnesses every day. Last October, he found himself on the receiving end of care when he was taken to the emergency department by his own co-workers after he experienced a stroke. May is American Stroke Month and this week is National EMS Week, making Kirkland's story important and reinforcing stroke awareness and treatment through in-person and virtual care. For his complete story and video, click here. Continue Reading "I'm 31, I can't be having a stroke. Even with all my training and experience, I couldn't process what was happening." Post this Kirkland was in the driver's seat of an ambulance after a routine patient transfer when he started feeling strange. He asked his partner, Brian Ridgway, to take the wheel. But after arriving back in Ada, Oklahoma, his symptoms continued to worsen. Kirkland's paramedic partner recognized something was seriously wrong and loaded him up in his own ambulance and took him straight to the ER. "Brian told me, 'I think you're having a stroke,' but I thought, 'I'm 31, I can't be having a stroke,'" said Kirkland. "Even with all my training and experience, I couldn't process what was happening. It progressed to where I couldn't speak, I couldn't formulate a sentence, everything was garbled and delayed. What I wanted to say in my brain just wouldn't come out of my mouth." According to the Centers for Disease Control and Prevention, someone experiences a stroke every 40 seconds in the United States, and stroke remains one of the leading causes of death and long-term disability. While stroke risk increases with age, a stroke can occur at any age. After Kirkland arrived in the Mercy Hospital Ada emergency department, he was evaluated and connected with a Mercy Virtual neurologist. Sensing the urgency of the situation, the virtual neurologist rushed the local team to administer a beta-blocker to lower blood pressure and a clot-dissolving stroke medication called Tenecteplase (TNK). "Our team quickly evaluated Dillion and gave him the medication he needed," said Dr. Advait Mahulikar, a member of Kirkland's virtual neurology team. "The quick actions and assessment of our team combined with clot-busting medication helped prevent the worsening of symptoms that could have potentially become disabling, especially at such a young age." Mercy Virtual has a team of neurologists who provide care 24/7 to 31 Mercy facilities across four states. Depending on a hospital's needs, Mercy Virtual supplements in-person neurology care or provides full neurology coverage for many rural hospitals unable to staff full-time physicians. This allows the local team to work collaboratively at a patient's bedside without spending extra time transporting them to larger trauma centers. "Virtual care has literally changed the lives of thousands of patients by providing access to a neurologist when it matters most during a time-sensitive diagnosis like stroke," said Dr. Meghan Rodden, physician lead of Mercy Virtual stroke care. "Time is brain, and a typical patient can lose 1.9 million neurons each minute a stroke is untreated. That is why it's essential that our virtual neurologists do a combination of bedside and virtual work so some of our smaller facilities can get access to the specialized care they need faster." With the help of his in-person and virtual care team, Kirkland's story has a happy ending. "After the TNK medication was administered, my symptoms were resolved within 30 minutes, and I've fully recovered with no deficits to this day," he said. "TNK was actually a relatively new standard of stroke care. It was something we had recently discussed as an EMS team, but I had yet to see it in action, so it was scary to try it myself firsthand. I'm a firm believer in TNK now." While Kirkland didn't have the typical stroke symptoms of one-sided weakness, he had overall coordination loss, garbled speech and an extremely elevated blood pressure. Mercy recommends the acronym B.E.F.A.S.T. if someone is believed to be having a stroke. B – Balance: Does the person complain of sudden dizziness or difficulty walking? E – Eyes: Does the person complain of blurred vision, seeing dark or bright spots? F – Face: Ask the person to smile. Is the smile even or lop-sided? A – Arms: Ask the person to raise both arms. Does one arm drift downward? S – Speech: Ask the person to repeat a simple phrase. Is the speech slurred or strange? T – Time: If you see any of these signs, call 9-1-1 right away and note the time. Observers should record the time when any symptoms first appear to help health professionals plan the best treatment and minimize long-term stroke damage. Kirkland is back at work saving lives, but he hopes sharing his story will help spread awareness. "Knowing the signs is important for everyone and can make a big difference in recovery or even between life and death," Kirkland said. "When in doubt, call 9-1-1 and seek medical attention." About Mercy Mercy, one of the 20 largest U.S. health systems and named the top large system in the U.S. for excellent patient experience by NRC Health, serves millions annually with nationally recognized care and one of the nation's largest and highest performing Accountable Care Organizations in quality and cost. Mercy is a highly integrated, multi-state health care system including more than 50 acute care and specialty (heart, children's, orthopedic and rehab) hospitals, convenient and urgent care locations, imaging centers and pharmacies. Mercy has over 900 physician practice locations and outpatient facilities, more than 4,500 physicians and advanced practitioners and 50,000 co-workers serving patients and families across Arkansas, Kansas, Missouri and Oklahoma. Mercy also has clinics, outpatient services and outreach ministries in Arkansas, Louisiana, Mississippi and Texas. In fiscal year 2023 alone, Mercy provided more than half a billion dollars of free care and other community benefits, including traditional charity care and unreimbursed Medicaid. SOURCE Mercy