Adalimumab biosimilar (Merck Serono Sa)

技术日新月异的更替对生物医药行业的发展产生了重要推动作用，也使得这个行业成为了变化尤为快速、竞争越发激烈的赛道之一。身处浪潮中的制药企业也在根据行业发展趋势不断地调整自身的业务方向。世界上唯一不变的就是变。当强生、罗氏、默沙东、辉瑞等制药巨头在力求业绩增长而不断进行业务调整、分拆、重组、重构时，仿制药巨头们也在市场变化中不断优化着各自的业务布局。本文将以梯瓦（Teva）、晖致（Viatris）、山德士（Sandoz）、太阳制药（Sun Pharma）、费森尤斯卡比（Fresenius Kabi）、阿拉宾度制药（Aurobindo）、瑞迪博士实验室（Dr. Reddy’s）、西普拉（Cipla）、Amneal、鲁宾（Lupin）这10家全球领先的仿制药巨头为样本，分析他们未来的业务走向。从仿制药切入创新药赛道相较于低投入、低风险的仿制药，创新药研发风险高，投入大，不过利润也非常可观。新晋药王宝座的PD-1抑制剂Keytruda仅2023年就为默沙东带来了250.11亿美元的收入，而2023年全球第一大仿制药企业Teva的年总收入为158.46亿美元。纵使创新药开发难度非常大，但是这诱人的利润也吸引有了一定积累的仿制药企业开始加入这一赛道。在这10家仿制药巨头中，已有梯瓦、晖致、太阳制药、瑞迪博士实验室4家企业走上了创新药开发道路，并且他们之中，有的创新药业务已经初具规模，有的初尝成功的果实，也有企业正在加速入场。梯瓦是创新药的坚定拥护者，并且已经尝到了创新药带来的甜头。根据2023年披露的财报信息，Teva实现158.46亿美元营收，同比增长7%，但基本盘的仿制药业务仅实现1.53%的增长；创新药收入反而成为这家仿制药巨头的增长驱动力，品牌药Austedo（氘代丁苯那嗪）和Ajovy（瑞玛奈珠单抗）全年收入高达12.25亿美元（+28%）和4.34亿美元（+15%），均实现双位数增长。2023年5月，该公司新上任的总裁兼首席执行官Richard Francis提出了“Pivot to Growth”战略，明确提出扩大创新管线并专注于具有first-in-class 和best-in-class机会的核心治疗领域，通过加速强大的创新药物组合恢复增长。前两日（5月8日），Teva创新药业务迎来了新进展，其皮下注射奥氮平（olanzapine）缓释注射剂TEV-‘749在治疗精神分裂症成年患者的III期临床试验SOLARIS中达到主要终点，患者只需每月注射一针，极大提高了用药依从性。今年下半年，其潜在best-in-class TL1A单抗TEV-‘574将会有治疗溃疡性结肠炎和克罗恩病这两种炎症性肠病的IIb期数据读出。晖致虽然成立时间较晚（2020年），不过作为仿制药巨头迈蓝（Mylan）与辉瑞旗下辉瑞普强（Pfizer Upjohn）的强强联合，也可谓出道即巅峰。辉瑞普强的品牌药基础也为晖致种下了创新基因。这也使得晖致越来越重视利润率更高的创新产品。在剥离了生物类似药，非处方药（OTC）、女性健康、印度仿制药等业务后，其将目标聚焦在了品牌药（创新药和改良创新）和仿制药。去年2月，晖致以3.5亿美元的首付款以及后续的里程碑付款与Idorsia达成全球研发合作达成协议，获得后者两项极具潜力III期资产selatogrel和cenerimod的全球独家开发和商业化权。前者被开发用于治疗急性心肌梗死，后者则用于治疗系统性红斑狼疮。晖致还以总计7-7.5亿美元现金收购了眼科公司Oyster Point Pharma和family Life Sciences，并成立新的眼科护理部门，如今已经搭建了拥有数款产品的创新药管线。印度仿制药巨头太阳制药和瑞迪博士实验室也已经着力于创新药的开发。太阳制药已有包括Ilumya（替瑞奇珠单抗）、Odomzo（索立德吉）、Cequa（0.09%环孢素滴眼液）在内的多款创新药/改良新药获批上市，2023年，其IL-23p19单抗Ilumya获得了1.82亿美元收入；目前太阳制药管线中还有数款在研创新药，包括口服JAK抑制剂氘代芦可替尼、免疫细胞因子疗法Nidlegy（daromun）等。瑞迪博士实验室的核心业务比较多元，包括仿制药、生物类似药、品牌仿制药、OTC以及API。不过在2023年6月举行的投资者会议上，该公司明确提出了向肿瘤免疫新分子实体（NCEs）药物转型，进军生物药和细胞基因疗法（CGT）等业务的发展战略。在2023年新出炉的仿制药巨头排名中，Teva和晖致分别位居第一和第二名，太阳制药排名第四，瑞迪博士实验室暂居第七名。他们纷纷转战创新药，似乎也预示着仿制药企业未来的主流发展方向。从仿制药切入生物类似药赛道当有人转向创新药的同时，也有人奔向了另一个蓝海市场。排名前5的仿制药巨头中，除了晖致和太阳制药外，山德士和费森尤斯卡比坚定拥抱生物类似药赛道，Teva也低调跟进。今年3月，山德士独立运营后发布的第一份全年业绩报告显示，其仿制药收入仅实现低个位数（4%）增长，而生物类似药板块则交出了亮眼成绩单，以15%的增幅达到22.15亿美元。前几日公布的第一季度报中，生物类似药业务更是增长了21%。Omnitrope（重组人生长激素生物类似物）保持着强劲的市场需求，已取代原研Ipsen成为市场领导者；2023年在美国推出的 Hyrimoz（阿达木单抗）如今已经获得美国阿达木单抗生物类似药市场的82%，未来将继续蚕食原研修美乐的市场份额。山德士从三星生物获得的Pyzchiva（乌司奴单抗）已于上个月在欧盟获批；那他珠单抗作为唯一一款获批治疗多发性硬化的生物类似药，也已成功在欧洲多国上市。此外，今年1月，山德士还与Coherus达成合作，收购后者雷珠单抗生物类似药CIMERLI，目前，山德士管线中共有24款生物类似药，可以说是目前生物类似药领域当之无愧的王者。自2017年收购Akorn及默克集团的生物类似药业务后，费森尤斯卡比将生物类似药作为基本盘，同时聚焦在自免疾病和肿瘤领域，并于2019年在欧洲推出了首个生物类似药Idacio（阿达木单抗）；2022年，费森尤斯卡比收购了mAbxience的大部分股份，进一步扩大其生物类似药业务，囊获的利妥昔单抗、曲妥珠单抗、英夫利西单抗、贝伐珠单抗生物类似药均已获批上市。2023年，其还通过与Formycon AG达成合作，获得了乌司奴单抗生物类似药（FYB202，III期）上市后的全球商业化权益。经过7年的布局，费森尤斯卡比的生物药逐渐进入开花结果阶段。2023年，生物药业务收入达到3.63亿欧元，在年度财报中，费森尤斯卡比提出了“3+1战略”，将进一步扩大生物药业务作为了首要战略目标；今年3月，其生物类似药Tyenne（托珠单抗）成功在美国获批，成为了FDA批准的第一个同时具备静脉注射和皮下注射剂型的托珠单抗生物类似药。Teva的主要目标是进军创新药，对于生物类似药的布局相对佛系：力争在以外部合作为主导结合少量自研的开发模式下将产品管线数量提升至20个。目前Teva研发费用的20%用于生物类似药，计划在未来三年中逐步将这一比例降至接近10%，从而将更多的投入用于创新药的研发。Teva当前处于审评和在研阶段的生物类似药产品共有15个，其中7个为自研，另外8个来自于合作伙伴们，其与Alvotech于2020年建立了针对美国市场的生物类似药合作联盟，合作产品从最初的5个逐步扩展至如今的9个，虽然双方合作的Selarsdi（乌司奴单抗）和Simlandi（阿达木单抗）生物类似药产品上市之路坎坷，好在苦尽甘来，两款药物今年上半年都成功获FDA批准。此外，印度企业阿拉宾度、鲁宾以及美国企业Amneal均有生物类似药业务布局。自2017年收购瑞士TL Biopharmaceutical后，阿拉宾度正式切入生物类似药赛道，主要聚焦在自免和肿瘤领域。目前，其子公司CuraTeQ拥有14款生物类似药，与BioFactura合作开发的一款乌司奴单抗生物类似药有望在2026/2027年上市。Amneal在去年成功完成了聚乙二醇化非格司亭（PEG-GCSF）生物类似药Fylnetra的上市，将美国市场在售生物类似药产品数量增加至3个，此前已有贝伐珠单抗、G-CSF上市，不过目前均面临多个竞争对手的局面，在最晚入市的情况下当前份额均比较惨淡。过去的12个月，3款产品收入为9000万美元。在研管线中新增加了与mAbxience合作的地舒单抗，目前处于III期阶段。不过Amneal仍对生物类似药赛道充满信心，未来希望将更多的生物类似药纳入管线。鲁宾正处于生物类似药业务的初步探索阶段，在最新的财报里，提出了将研发转向复杂仿制药和生物类似药的战略目标。并计划在2028年之前在监管市场完成3个生物类似药申报。今年5月3日，其在加拿大推出了首款生物类似药Rymti（依那西普），此前该药物已在欧盟获批。总结除了创新药和生物类似药业务外，包括晖致、西普拉、Amneal、鲁宾在内的仿制药巨头们还将高端复杂制剂，比如吸入制剂（MDIs, DPI，鼻喷雾剂）、肽类、脂质体、铁剂等作为公司重点业务布局，此处不一一展开叙述。可以肯定的是，他们所做的调整也都是基于自身业务发展情况，或是精简业绩表现不佳的传统业务，或是开拓新的领域寻求增量。在此希望他们的业务开发策略能够给国内仿制药企业一些启发。推荐阅读 星条旗下的宝藏：美国生物类似药市场2023概览2023年全球仿制药巨头TOP10Copyright © 2024 PHARMCUBE. All Rights Reserved.欢迎转发分享及合理引用，引用时请在显要位置标明文章来源；如需转载，请给微信公众号后台留言或发送消息，并注明公众号名称及ID。免责申明：本微信文章中的信息仅供一般参考之用，不可直接作为决策内容，医药魔方不对任何主体因使用本文内容而导致的任何损失承担责任。精彩预告线下活动↑长按扫码，填表报名↑

Tyenne® is the first tocilizumab biosimilar by Fresenius Kabi, an operating company of Fresenius SE, with an intravenous and subcutaneous formulation approved by the FDA. The tocilizumab biosimilar provides increased access and an affordable, high-quality, and safe treatment option for U.S. patients. Excellent performance of the (Bio)Pharma business in 2024 so far, also driven by Tyenne® which became the first tocilizumab biosimilar available in Europe in November 2023. The launch of the tocilizumab biosimilar contributes directly to growing Fresenius’ (Bio)Pharma platform, a substantial cornerstone of the #FutureFresenius strategy. BAD HOMBURG, Germany--(BUSINESS WIRE)-- Fresenius, via its operating company Fresenius Kabi, announced today the immediate U.S. availability of Tyenne® (tocilizumab-aazg), a biosimilar of Actemra® (tocilizumab). Tyenne®, for use in the treatment of chronic autoimmune diseases, is available in an intravenous (IV) formulation. This press release features multimedia. View the full release here: Fresenius Kabi announced that Tyenne® (tocilizumab-aazg), a biosimilar of Actemra® (tocilizumab) is now available in the U.S. in an IV presentation. Tyenne tocilizumab-aazg) is for use in the treatment of chronic autoimmune diseases. (Photo: Business Wire) Michael Sen, CEO of Fresenius: “With the launch of Tyenne® in the U.S., we have reached another important milestone in accelerating our strong (Bio)Pharma momentum. Growing this platform is a substantial cornerstone of our #FutureFresenius journey. Overall, we have seen an excellent performance of our (Bio)Pharma business in 2024 so far. We are particularly happy with the good progress of our majority-owned biotechnology company mAbxience and the traction of Tyenne®, the first tocilizumab biosimilar available in Europe since November 2023.” Tyenne® is the first tocilizumab biosimilar with an intravenous and subcutaneous formulation approved by the FDA. The biosimilar received FDA approval on March 5, 2024. Tyenne® is Fresenius’ third approved biosimilar available in the U.S. and the second within its immunology portfolio. The biologic medicine is indicated for the treatment of several autoimmune diseases, including rheumatoid arthritis, giant cell arteritis, polyarticular juvenile idiopathic arthritis, and systemic juvenile idiopathic arthritis. Pierluigi Antonelli, CEO of Fresenius Kabi: “Tyenne® will impact the treatment landscape for inflammatory and immune diseases in the U.S. Reaching ever more patients with our state-of-the-art biopharma portfolio signals a clear growth path in a highly promising market segment. We will continue to roll out our comprehensive pipeline of autoimmune and oncology biosimilars with several molecules in late-stage development.” Supported by Fresenius Kabi’s support program for health care professionals and patients, the company’s biologic medicine provides wider access to more treatment options and contributes to the viability of health care systems. Next to its two available biosimilars, Idacio® (adalimumab) and Stimufend® (pegfilgrastim), Fresenius Kabi has a growing pipeline of autoimmune and oncology biosimilars with several molecules in late-stage development. To learn more about how Fresenius Kabi provides comprehensive patient support for Tyenne® in the U.S. please click here. With #FutureFresenius, Fresenius successfully set the course last year to become a leading therapy-focused company. In line with the strategy, Fresenius has simplified its structure, is sharpening its focus by concentrating on its operating companies Fresenius Kabi and Fresenius Helios and is continuously enhancing its performance. About Tyenne®, a Tocilizumab Biosimilar Tyenne® (tocilizumab-aazg), a biosimilar to Actemra® (tocilizumab), is a prescription medicine called an Interleukin-6 (IL-6) receptor antagonist. It was developed by Fresenius Kabi using advanced analytical and manufacturing technologies for use in the treatment of several autoimmune diseases, including rheumatoid arthritis, giant cell arteritis, polyarticular juvenile idiopathic arthritis, and systemic juvenile idiopathic arthritis. Serious infections leading to hospitalization or death including tuberculosis (TB), bacterial, invasive fungal, viral, and other opportunistic infections have occurred in patients receiving the product. Tyenne is contraindicated in patients with known hypersensitivity to tocilizumab products. For more information about Tyenne, please see the full prescribing information for the U.S. here. IMPORTANT SAFETY INFORMATION RISK OF SERIOUS INFECTIONS Patients treated with TYENNE® (tocilizumab-aazg) are at increased risk for developing serious infections that may lead to hospitalization or death, including tuberculosis (TB), bacterial, invasive fungal, viral, or other opportunistic infections. If a serious infection develops, interrupt TYENNE until the infection is controlled. Reported infections include: Active tuberculosis, which may present with pulmonary or extrapulmonary disease. Patients should be tested for latent tuberculosis before TYENNE use and during therapy. Treatment for latent infection should be initiated prior to TYENNE use. Invasive fungal infections, including candidiasis, aspergillosis, and pneumocystis. Patients with invasive fungal infections may present with disseminated, rather than localized, disease. Bacterial, viral and other infections due to opportunistic pathogens. The risks and benefits of treatment with TYENNE should be carefully considered prior to initiating therapy in patients with chronic or recurrent infection. Patients should be closely monitored for the development of signs and symptoms of infection during and after treatment with TYENNE, including the possible development of tuberculosis in patients who tested negative for latent tuberculosis infection prior to initiating therapy. CONTRAINDICATION TYENNE is contraindicated in patients with known hypersensitivity to tocilizumab products. WARNINGS AND PRECAUTIONS Gastrointestinal Perforations Events of gastrointestinal (GI) perforation have been reported in clinical trials, primarily as complications of diverticulitis in patients treated with tocilizumab. Use TYENNE with caution in patients who may be at increased risk for GI perforation. Promptly evaluate patients presenting with new-onset abdominal symptoms for early identification of GI perforation. Hepatotoxicity Serious cases of hepatic injury have been observed in patients taking intravenous or subcutaneous tocilizumab products. Some of these cases have resulted in liver transplant or death. Time to onset for cases ranged from months to years after treatment initiation. Most cases presented with marked elevations of transaminases (> 5 times ULN), and some cases presented with signs or symptoms of liver dysfunction and only mildly elevated transaminases. Treatment with tocilizumab was associated with a higher incidence of transaminase elevations; increased frequency and magnitude of these elevations were observed when tocilizumab was used in combination with potentially hepatotoxic drugs (e.g., methotrexate). It is not recommended to initiate TYENNE treatment in RA, GCA, PJIA, and SJIA patients with elevated transaminases ALT or AST greater than 1.5x ULN. In patients who develop elevated ALT or AST greater than 5x ULN discontinue TYENNE. Measure liver tests promptly in patients who report symptoms that may indicate liver injury. If the patient is found to have abnormal liver tests, TYENNE treatment should be interrupted. TYENNE should only be restarted in patients with another explanation for the liver test abnormalities after normalization of the liver tests. Laboratory Parameters Laboratory monitoring is recommended due to potential consequences of treatment-related laboratory abnormalities in neutrophils, platelets, lipids, and liver function tests. Dosage modifications may be required. Neutropenia: Treatment with tocilizumab products was associated with a higher incidence of neutropenia. It is not recommended to initiate TYENNE treatment in RA, GCA, PJIA, and SJIA patients with a low neutrophil count i.e., absolute neutrophil count (ANC) less than 2000 per mm3. In patients who develop an ANC less than 500 per mm3 treatment is not recommended. Thrombocytopenia: Treatment with tocilizumab products was associated with a reduction in platelet counts. It is not recommended to initiate TYENNE in RA, GCA, PJIA, and SJIA patients with a platelet count below 100,000 per mm3. In patients who develop a platelet count less than 50,000 per mm3, treatment is not recommended. Elevated Liver Enzymes: It is not recommended to initiate TYENNE treatment in patients with elevated transaminases ALT or AST >1.5x ULN. In patients who develop elevated ALT or AST >5x ULN, treatment is not recommended. Lipid Abnormalities: Treatment with tocilizumab products was associated with increases in lipid parameters such as total cholesterol, triglycerides, LDL cholesterols, and/or HDL cholesterol. Immunosuppression The impact of treatment with tocilizumab products on the development of malignancies is not known, but malignancies were observed in clinical studies with tocilizumab. TYENNE is an immunosuppressant, and treatment with immunosuppressants may result in an increased risk of malignancies. Hypersensitivity Reactions Hypersensitivity reactions, including anaphylaxis, have been reported in association with tocilizumab products and anaphylactic events with a fatal outcome have been reported with intravenous infusion of tocilizumab products. TYENNE for intravenous use should only be infused by a healthcare professional with appropriate medical support to manage anaphylaxis. For TYENNE subcutaneous injection, advise patients to seek immediate medical attention if they experience any symptoms of a hypersensitivity reaction. If anaphylaxis or other hypersensitivity reaction occurs, stop administration of TYENNE immediately and discontinue TYENNE permanently. Do not administer TYENNE to patients with known hypersensitivity to tocilizumab products. Demyelinating Disorders The impact of treatment with tocilizumab products on demyelinating disorders is not known, but multiple sclerosis and chronic inflammatory demyelinating polyneuropathy were reported rarely in clinical studies. Monitor patients for signs and symptoms of demyelinating disorders. Prescribers should exercise caution in considering the use of TYENNE in patients with preexisting or recent onset demyelinating disorders. Active Hepatic Disease and Hepatic Impairment Treatment with TYENNE is not recommended in patients with active hepatic disease or hepatic impairment. Vaccinations Avoid use of live vaccines concurrently with TYENNE. No data are available on the secondary transmission of infection from persons receiving live vaccines to patients receiving TYENNE or on the effectiveness of vaccination in patients receiving TYENNE. Patients should be brought up to date on all recommended vaccinations prior to initiation of TYENNE therapy, if possible. ADVERSE REACTIONS Most common adverse reactions (incidence of at least 5%): upper respiratory tract infections, nasopharyngitis, headache, hypertension, increased ALT, injection site reactions. DRUG INTERACTIONS In GCA patients, no effect of concomitant corticosteroid on tocilizumab exposure was observed. Cytochrome P450s in the liver are down-regulated by infection and inflammation stimuli including cytokines such as IL-6. Inhibition of IL-6 signaling in RA patients treated with tocilizumab products may restore CYP450 activities to higher levels than those in the absence of tocilizumab products leading to increased metabolism of drugs that are CYP450 substrates. Exercise caution when coadministering TYENNE with CYP3A4 substrate drugs where decrease in effectiveness is undesirable, e.g., oral contraceptives, lovastatin, atorvastatin, etc. USE IN PREGNANCY The limited available data with tocilizumab products in pregnant women are not sufficient to determine whether there is a drug-associated risk for major birth defects and miscarriage. You may report side effects to the FDA at (800) FDA-1088 or . You may also report side effects to Fresenius Kabi at (800) 551-7176. Please see additional Important Safety Information in full Prescribing Information, including Boxed Warning. INDICATIONS TYENNE is indicated for the treatment of adult patients with moderately to severely active rheumatoid arthritis (RA) who have had an inadequate response to one or more Disease-Modifying Anti-Rheumatic Drugs (DMARDs). TYENNE is indicated for the treatment of giant cell arteritis (GCA) in adult patients. TYENNE is indicated for the treatment of active polyarticular juvenile idiopathic arthritis (PJIA) in patients 2 years of age and older. TYENNE is indicated for the treatment of active systemic juvenile idiopathic arthritis (SJIA) in patients 2 years of age and older. Tyenne® demonstrates Fresenius Kabi’s commitment to providing access to affordable and cost-effective biosimilars to more patients living with autoimmune diseases around the world while enabling savings for health care systems. KabiCare, Fresenius Kabi’s comprehensive patient support program, will be available to patients and health care providers in the U.S. from launch. About Fresenius SE Fresenius SE & Co. KGaA (Frankfurt/Xetra: FRE) is a global healthcare company headquartered in Bad Homburg v. d. Höhe, Germany. In the 2023 fiscal year, Fresenius generated €22.3 billion in annual revenue with its more than 190,000 employees. Fresenius offers solutions to the social challenges posed by a growing and ageing population and the resulting need for affordable, high-quality healthcare. The Fresenius Group comprises the operating companies Fresenius Kabi and Fresenius Helios as well as the investment companies Fresenius Vamed and Fresenius Medical Care. With 140 hospitals and countless outpatient facilities, Fresenius Helios is the leading private hospital operator in Germany and Spain, treating around 26 million patients every year. Fresenius Kabi’s product portfolio includes a range of highly complex biopharmaceuticals, clinical nutrition, medical technology, and generic intravenous drugs. Fresenius was established in 1912 by the Frankfurt pharmacist Dr. Eduard Fresenius. After his death, Else Kröner took over management of the company in 1952. She laid the foundations for a global enterprise that today pursues the goal of improving people’s health. The largest shareholder is the non-profit Else Kröner-Fresenius Foundation, which is dedicated to advancing medical research and supporting humanitarian projects. For more information visit the company website at . Follow us on social media: . About Fresenius Kabi Fresenius Kabi is a global healthcare company that specializes in lifesaving medicines and technologies for infusion, transfusion and clinical nutrition. The company’s products and services are used for the therapy and care of critically and chronically ill patients. Its product portfolio comprises a range of highly complex biopharmaceuticals, clinical nutrition, medical technologies, and I.V. generic drugs. Within biopharmaceuticals, Fresenius Kabi offers, among others, biosimilar drugs with a focus on autoimmune diseases and oncology. The company’s clinical nutrition offering includes a wide selection of enteral and parenteral nutrition products. In the segment of medical technologies, its offering includes vital disposables, infusions pumps, apheresis machines, cell therapy devices, and more. Fresenius Kabi puts essential medicines and technologies in the hands of people who help patients and finds the best answers to the challenges they face. Following its strategy “Vision 2026”, which is a key part of the #FutureFresenius program of the Fresenius healthcare group, the company is furthermore committed to increase efficiencies in the therapy and care of patients and improve access to high-quality healthcare around the globe. Fresenius Kabi aspires to be leading globally in its product segments – all for the benefit of patients, its customers, and its stakeholders. Actemra® is a registered trademark of Chugai Seiyaku Kabushiki Kaisha Corp., a member of the Roche Group. Tyenne® is a registered trademark of Fresenius Kabi Deutschland GmbH. Idacio® and Stimufend® are registered trademarks of Fresenius Kabi Deutschland GmbH in selected countries. View source version on businesswire.com: Contacts Matt Kuhn (847) 220-3033 matt.kuhn@fresenius-kabi.com Source: Fresenius Kabi Smart Multimedia Gallery Photo Fresenius Kabi announced that Tyenne® (tocilizumab-aazg), a biosimilar of Actemra® (tocilizumab) is now available in the U.S. in an IV presentation. Tyenne tocilizumab-aazg) is for use in the treatment of chronic autoimmune diseases. (Photo: Business Wire) Logo View this news release and multimedia online at: