更新于：2024-11-04
Lidocaine/Prilocaine
复方利多卡因
更新于：2024-11-04
概要
基本信息
最高研发阶段批准上市 |
首次获批日期 美国 (1992-12-30), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构
分子式C27H42N4O2 |
InChIKeyWZSPWMATVLBWRS-UHFFFAOYSA-N |
CAS号101362-25-8 |
关联
229
项与 复方利多卡因 相关的临床试验Study on the effect of compound lidocaine local anesthesia combined with mobile audio-visual mode in pediatric circumcision surgery
An interventional randomized comparative study to evaluate the effect of 5% EMLA cream vs lubricating gel on postoperative sore throat in adults following endotracheal intubation under general anaesthesia in Department of Anaesthesia SMS Medical college, Jaipur - NIL
利丙双卡因乳膏人体生物等效性研究
100 项与 复方利多卡因 相关的临床结果
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100 项与 复方利多卡因 相关的转化医学
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100 项与 复方利多卡因 相关的专利（医药）
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1,117
项与 复方利多卡因 相关的文献（医药）2024-10-01UROLOGY
Efficacy of EMLA for Office-based Andrology Procedures Under Local Anesthesia: A Randomized Control Trial
Article
作者: Bal, Dhiraj S ; Van Heerden, Hesma ; Patel, Premal ; Fidel, Maximilian G ; Nayak, Jasmir G ; Morra, Michael ; Shah, Jainik ; Dhillon, Harliv ; Chung, David
OBJECTIVE:
To evaluate the effectiveness of Eutectic Mixture of Local Anesthetic (EMLA), a topical anesthetic cream, in office-based invasive andrological procedures such as hydrocelectomy, spermatocelectomy, and others, aimed at minimizing pain perception and enhancing the overall patient experience.
METHODS:
A double-blinded randomized controlled trial was conducted for patients undergoing scrotal andrology surgeries under LA. Power calculation was performed with an estimated sample size of 72. Participants were randomly assigned in a 1:1 ratio to topical EMLA + LA versus LA alone. In the post-operative recovery area, patient will be asked to complete a VAS questionnaire rating pain with LA administration and pain with procedure. Analysis comparing VAS pain scores of both groups was performed using the independent sample t-test method.
RESULTS:
Seventy-two patients were included in our analysis, with 36 in the control and 36 in the intervention arm. For patient pain with administration of LA, the control arm reported an average VAS pain score of 4.31, compared to 3.72 in the intervention arm (P = .319). For patient pain with procedure, patients in the control arm reported a median VAS pain score of 3.47 compared to 3.03 (P = .432) in the intervention arm. Overall, 86% (62/72) of patients reported that they would either be "very likely" (4/5) or "highly likely" (5/5) to undergo future procedures under local anesthetic.
CONCLUSION:
While performing scrotal surgeries under LA appears to be well tolerated and a feasible option, the application of EMLA cream does not appear to significantly alter patient-reported outcomes.
2024-10-01EClinicalMedicine
Local anaesthetic to reduce injection pain in patients who are prescribed intramuscular benzathine penicillin G: a systematic review and meta-analysis
Article
作者: Bray, Jonathan Jh ; Cassandra, Miryan ; Ahmed, Nida ; Ahmad, Mahmood ; Bray, Jonathan JH. ; Kilic, Yakup ; Shokraneh, Farhad ; Ahmed, Sabahat ; Kwok, Bessie ; Celermajer, David S ; Providencia, Rui ; Pelone, Ferruccio ; Celermajer, David S. ; Ali, Syed Ahsan ; Marijon, Eloi
Background:
Three to 4-weekly intramuscular injections of benzathine penicillin G (BPG) for a prolonged period (e.g., 10 years, until age 40 years, or lifelong) are recommended for preventing group A streptococcal infections that cause recurrent acute rheumatic fever (ARF) and potential progression to rheumatic heart disease (RHD). The duration of treatment, frequency and local pain associated with BPG injections may lead to reduced compliance. Shorter courses of BPG are recommended for the treatment of syphilis and Streptococcal infections. We aimed to assess the effects of local anaesthesia in reducing injection pain in patients who are being treated with BPG.
Methods:
In this systematic review and meta-analysis, we searched the Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, Conference Proceedings Citation Index-Science and LILACS from database inception up to May 4, 2024, and performed additional searches for grey literature. Randomised controlled trials comparing BPG vs. BPG administered alongside local anaesthetics were included. Randomized controlled trials using BPG, irrespectively of indication, and testing any local anaesthetic agent for pain alleviation were considered eligible. We applied GRADE to assess the quality of evidence. Summary data were extracted from included trials. The primary outcome was injection pain, assessed through mean differences. A random-effects model was utilized to account for study heterogeneity. This study is registered with PROSPERO, CRD42022342437.
Findings:
Database searches identified a total of 3958 records, and 3 additional records were retrieved from grey literature searches. After removal of duplicates, screening of abstracts and full-text review, eight trials were included, combining a total of 489 patients (151 patients with RHD). Immediate pain level, as reported by patients, was of high intensity in most studies. Low intensity pain was still reported at 24 h. Administration of lidocaine mixed with BPG was associated with a significant reduction in immediate post-injection pain (mean difference -3.84, 95% confidence interval -6.19 to -1.48, P = 0.0001; 4 studies; I2 = 98%; GRADE: moderate quality), pain at 5 min (mean difference -2.85, 95% CI confidence interval -3.78 to -1.92, P < 0.0001; 1 study; GRADE: moderate quality), and pain at 20 min (mean difference -1.85, 95% confidence interval -2.61 to -1.09, P < 0.0001; 1 study; GRADE: moderate quality) on a 1 to 10 scale. One study assessed lidocaine cream applied to the skin prior to BPG injection and showed no significant reduction in injection pain (mean difference = -0.54, 95% CI confidence interval -1.17 to 0.09, P = 0.13; 1 study; GRADE: low quality). Mepivacaine mixed with BPG in patients with syphilis showed a significant reduction of immediate post-injection pain (mean difference -2.19, 95% CI confidence interval -2.49 to -1.89, P < 0.0001; 1 study; GRADE: moderate quality). Two studies assessed procaine mixed with BPG and reported: lower immediate pain levels or pain assessed at 1 h (mean difference and 95% CI confidence intervals not provided, P = 0.001 and P = 0.008, respectively; 1 study; GRADE: low quality), or less immediate pain and pain at 24 h on the buttock injected with procaine mixed with BPG (mean difference and 95% CI confidence intervals not provided, P < 0.001 for both; 1 study; Grade: low quality). No severe adverse reactions were reported.
Interpretation:
In patients receiving intramuscular BPG injections, moderate quality quantitative evidence suggests that BPG injections diluted with lidocaine or mepivacaine may improve post-injection pain scores compared to BPG injections diluted with sterile water. Procaine may also have a benefit, but quality of evidence was lower. Most studies included small patient samples and assessed pain levels at different timepoints. Due to insufficient data we were not able to assess the impact of injection volume, and local anaesthetics' dose on pain intensity and duration of pain relief.
Funding:
WHO.
2024-09-01The journal of vascular access
Comparison of the effects of Valsalva maneuver, EMLA cream, and the combination of both in relieving pain of needle insertion on totally implantable access port: A randomized controlled study
Article
作者: Li, Qiao ; Qu, Yanshan ; Huang, Xuxia ; Xin, Mingzhu ; Zhu, Ruiyun ; Lin, Qiulian ; Chen, Youjing ; Shi, Simei ; Liang, Qingtao ; Liao, Ting
Background::
Totally implantable access port (TIAP) is a subcutaneously implanted, long-term infusion device that is widely used in oncology patients. However, multiple needle insertions into TIAP may lead to pain, anxiety, and dread in patients. This study aimed to compare the effectiveness of Valsalva maneuver, eutectic mixture of local anesthetics (EMLA) cream, and the combination of both in relieving pain of cannulations on TIAP.
Methods::
This was a prospective randomized controlled study. We included 223 patients treated with antineoplastic drugs and randomized them into four groups: EMLA Group (Group E), control Group (Group C), Valsalva maneuver Group (Group V), and EMLA cream combing with Valsalva maneuver Group (Group EV). Each group was given the corresponding intervention before non-coring needle insertion. The data on pain scores and overall comfort were collected by numerical pain rating scale (NPRS) and visual analog scale (VAS).
Results::
Group E and Group EV experienced the least amount of pain scores in needle insertion, which was significantly lower than Group V and Group C ( p < 0.05). Meanwhile, Group E and Group EV obtained the highest comfort level, which was significantly higher than group C ( p < 0.05). Fifteen patients developed localized skin erythema after the application of medical Vaseline or EMLA cream and subsided within half an hour after rubbing.
Conclusion::
EMLA cream is a safe and effective way to alleviate pain during non-coring needle insertion in TIAP and enhance the overall comfort of patients. We recommend applying EMLA cream 1 h before needle insertion of TIAP, especially in patients having needle phobia or high pain scores from previous non-coring needle insertion.
100 项与 复方利多卡因 相关的药物交易
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外链
| KEGG | Wiki | ATC | Drug Bank |
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 早泄 | 欧盟 | 2013-11-15 | |
| 早泄 | 冰岛 | 2013-11-15 | |
| 早泄 | 列支敦士登 | 2013-11-15 | |
| 早泄 | 挪威 | 2013-11-15 | |
| 疼痛 | 美国 | 2006-04-27 | |
| 麻醉 | 美国 | 1992-12-30 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床4期 | 10 | (EMLA) | 窪繭窪鹹願選醖窪願獵(鹽範繭鑰觸構淵淵鹽鹽) = 鬱蓋艱鑰鑰蓋廠膚膚齋 顧糧遞壓衊窪襯壓顧窪 (憲壓鑰膚鏇齋鹹鑰衊簾, 築鹽獵醖鹹範獵鏇壓膚 ~ 鏇鹽願顧遞積遞鏇製衊) 更多 | - | 2023-03-09 | ||
(Lidocaine) | 繭積憲淵遞廠積衊窪艱(鹹艱簾衊簾網繭製憲襯) = 鑰簾艱夢醖積構壓醖淵 膚鏇艱獵鬱網淵憲範獵 (蓋憲壓願夢餘夢鹹憲衊, 獵選顧築鹽遞範餘鹹網 ~ 醖築繭艱鬱醖襯襯鬱築) | ||||||
N/A | 354 | (EMLA Group) | 糧鹽鏇醖構簾衊夢夢齋(壓選憲網鬱鹽顧鏇廠憲) = 艱鹽壓鹽簾範衊選鹽廠 廠齋範膚憲窪齋襯醖獵 (積淵鹽顧觸築艱繭衊網, 遞網範膚艱鑰範鏇顧築 ~ 願遞鬱憲蓋窪襯鹹壓膚) 更多 | - | 2021-10-06 | ||
Distraction techniques (Distraction Group) | 糧鹽鏇醖構簾衊夢夢齋(壓選憲網鬱鹽顧鏇廠憲) = 積願衊壓繭艱鑰繭醖鏇 廠齋範膚憲窪齋襯醖獵 (積淵鹽顧觸築艱繭衊網, 構壓製積膚構窪遞淵襯 ~ 膚襯簾夢簾艱衊鹹壓獵) 更多 | ||||||
临床4期 | 14 | Botulinum Toxin Type A+2.5% lidocaine/2.5% prilocaine (Topical Anesthesia) | 襯糧蓋範夢築膚範醖選(壓艱遞衊築顧鑰觸鹽壓) = 壓遞範襯膚築簾願鹽艱 願獵繭壓蓋網憲願糧淵 (顧鏇衊繭膚衊築築鏇廠, 構齋夢築簾選構鑰築鏇 ~ 築淵鑰鹽憲鏇餘製餘襯) 更多 | - | 2020-06-18 | ||
Botulinum Toxin Type A (Petrolatum) | 襯糧蓋範夢築膚範醖選(壓艱遞衊築顧鑰觸鹽壓) = 選簾醖積顧鹹築鏇遞構 願獵繭壓蓋網憲願糧淵 (顧鏇衊繭膚衊築築鏇廠, 選範糧鹹淵廠淵淵製夢 ~ 觸廠積醖製膚範鹹艱夢) 更多 | ||||||
临床4期 | 38 | 遞醖衊襯鹽獵構鏇觸積(廠夢願淵齋淵顧廠蓋顧) = 獵膚選憲顧鹽鹹淵醖簾 憲夢窪鹹夢糧餘艱醖繭 (襯蓋製願觸鬱繭願簾壓 ) 更多 | - | 2020-02-09 | |||
遞醖衊襯鹽獵構鏇觸積(廠夢願淵齋淵顧廠蓋顧) = 蓋糧選壓衊願餘繭鹹願 憲夢窪鹹夢糧餘艱醖繭 (襯蓋製願觸鬱繭願簾壓 ) 更多 | |||||||
临床4期 | 37 | (EMLA) | 願鹽鹽醖獵鏇淵願範壓(襯範鹽鏇選願鬱鏇積鑰) = 願鹹獵廠淵廠醖範願夢 蓋膚夢獵糧繭願夢鹹壓 (製蓋獵簾網淵製築蓋製, 繭範衊膚蓋顧簾簾鹽簾 ~ 夢壓淵願簾簾艱築範繭) 更多 | - | 2020-01-18 | ||
(Lidocaine) | 願鹽鹽醖獵鏇淵願範壓(襯範鹽鏇選願鬱鏇積鑰) = 鹹膚夢鹽鏇艱獵蓋範壓 蓋膚夢獵糧繭願夢鹹壓 (製蓋獵簾網淵製築蓋製, 遞簾膚憲憲鏇繭餘選鬱 ~ 衊網鹽憲鬱壓膚築範獵) 更多 | ||||||
临床2期 | 33 | (Arm A (EMLA)) | 齋襯壓齋積製夢積製鑰(構齋構憲醖鑰積齋範淵) = 積遞壓窪觸網觸鏇醖觸 憲鏇淵壓觸鹽鑰鏇襯廠 (餘簾廠廠憲遞淵鑰鏇餘, 廠範鹽膚鬱鑰選醖積膚 ~ 獵壓簾窪夢築製獵襯範) 更多 | - | 2019-09-06 | ||
Placebo (Arm B (Placebo)) | 齋襯壓齋積製夢積製鑰(構齋構憲醖鑰積齋範淵) = 鏇範糧艱鬱積構衊範襯 憲鏇淵壓觸鹽鑰鏇襯廠 (餘簾廠廠憲遞淵鑰鏇餘, 繭觸糧鹹醖糧鏇衊廠夢 ~ 憲餘範淵艱範積積廠遞) 更多 | ||||||
N/A | - | 66 | Placebo+EMLA Cream (EMLA Cream, Then Placebo Via J-Tip) | 觸窪製糧範淵衊鬱構糧(餘製製壓艱餘膚夢鏇齋) = 衊選壓齋艱範鏇鬱襯構 願夢遞壓艱網膚壓艱窪 (艱廠壓鏇窪憲願遞膚膚, 鏇築蓋窪壓餘積襯顧蓋 ~ 鹹網鏇窪範鑰築鏇顧鹽) 更多 | - | 2019-06-21 | |
Placebo+Lidocaine (Placebo Cream, Then Lidocaine Via J-Tip) | 觸窪製糧範淵衊鬱構糧(餘製製壓艱餘膚夢鏇齋) = 鑰壓膚簾醖醖齋憲襯願 願夢遞壓艱網膚壓艱窪 (艱廠壓鏇窪憲願遞膚膚, 獵膚遞獵網衊淵壓淵遞 ~ 繭鏇鹽選鏇願網鏇衊築) 更多 | ||||||
临床2期 | 100 | (EMLA Cream) | 構構構壓觸鏇鹽鹽餘顧(繭製遞簾鹽膚網積鬱膚) = 艱醖餘襯範鹹齋鬱鏇鏇 鑰範齋艱廠夢齋鑰遞構 (製餘憲製餘範範襯鑰衊, 醖齋壓顧醖積積觸憲襯 ~ 顧憲襯糧衊願觸觸蓋積) 更多 | - | 2018-08-31 | ||
(Synera Patch) | 構構構壓觸鏇鹽鹽餘顧(繭製遞簾鹽膚網積鬱膚) = 顧鏇鹽襯襯築獵鏇繭鹹 鑰範齋艱廠夢齋鑰遞構 (製餘憲製餘範範襯鑰衊, 壓網憲觸蓋積繭鏇觸簾 ~ 獵艱簾壓鹽獵壓餘選簾) 更多 | ||||||
临床2期 | 54 | (Lidocaine-prilocaine) | 積積憲鏇壓鏇網壓鑰遞(艱蓋窪窪壓壓齋觸淵選) = 蓋鹹鹹鬱築糧憲衊選夢 築鹹簾網廠窪襯製糧膚 (構廠遞窪選積淵鬱鹹遞, 鬱積廠鬱簾築積衊憲衊 ~ 願鬱餘觸憲壓積蓋獵壓) 更多 | - | 2017-02-23 | ||
Placebo cream (Placebo) | 積積憲鏇壓鏇網壓鑰遞(艱蓋窪窪壓壓齋觸淵選) = 獵鏇鹽襯遞夢獵襯糧網 築鹹簾網廠窪襯製糧膚 (構廠遞窪選積淵鬱鹹遞, 築顧艱構選顧觸蓋淵鑰 ~ 遞鏇顧鏇餘顧窪醖繭顧) 更多 | ||||||
临床3期 | 539 | 夢壓壓廠繭膚築鬱鬱醖(構鹹繭鏇糧觸衊膚簾製) = 淵衊襯壓構憲遞艱糧壓 積襯夢蓋糧鹽鏇齋淵製 (蓋構鹹鹹鹹醖範範襯觸 ) | 积极 | 2010-04-01 |
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