贯叶连翘提取物(Hypericum perforatum Extract)

概要

基本信息

药物类型

中药

别名

Jarsin、SJW、St. John's Wort extract

+ [4]

靶点-

作用机制-

治疗领域

心血管疾病泌尿生殖系统疾病其他疾病

在研适应症-

非在研适应症

经前综合征子宫出血血管舒缩症

原研机构

Herbarium Laboratório Botânico Ltda

在研机构-

非在研机构

Herbarium Laboratório Botânico Ltda

最高研发阶段无进展临床3期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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结构/序列

分子式C30H16O8

InChIKeyBTXNYTINYBABQR-UHFFFAOYSA-N

CAS号548-04-9

关联

22

项与贯叶连翘提取物相关的临床试验

IRCT20241118063767N1

/ Suspended早期临床1期IIT

Investigating the Effect of Hypericum perforatum (Perforan) Tablets on Neurological Pain, Functional Independence and Severity of Depression in Patients with Spinal Cord Injuries

开始日期2025-01-19

申办/合作机构

Islamic Azad University

NCT04558697

/ Completed临床4期IIT

Use of Vagitories Based on St. John's Wort, Tea Tree Oil and Shepherd's Purse in the Treatment of Vaginal Inflammation

There are more and more herbal preparations that are used for the purpose of treatment and improvement of the clinical picture of vaginitis by patients themselves, but also by healthcare professionals. Plant species, St. John's wort, chamomile, calendula, yarrow, shepherd's purse and tea tree oil are well known for there anti-inflammatory, antimicrobial and wound healing activity. This paper presents the results of a clinical study in which three herbal formulations/vagitories, based on extracts of above mentioned plant species, were investigated for their effectiveness on non-specific vaginitis.
This was randomized controlled clinical study that included 210 women with diagnosed non-specific vaginitis. Patients were divided into two basic groups, women in reproductive stage and postmenopausal stage. Three subgroups, containing approximately 30 patients each, received one of three vagitorie formulations for 5 days during which the effects on subjective and objective symptoms were monitored.

开始日期2019-03-21

申办/合作机构

University of Sarajevo

[+1]

NCT03796377

/ Completed临床1期

Effects of Hypericum Perforatum (St. John's Wort) on the Pharmacokinetics and Pharmacodynamics of Rivaroxaban in Humans

Single-center, open-label, sequential treatment study to investigate the influence of the combined P-glycoprotein and CYP3A4 inducer hypericum perforatum on the pharmacokinetics and pharmacodynamics of rivaroxaban in healthy volunteers.

开始日期2019-02-13

申办/合作机构

Insel Gruppe AG

[+1]

100 项与贯叶连翘提取物相关的临床结果

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100 项与贯叶连翘提取物相关的转化医学

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100 项与贯叶连翘提取物相关的专利（医药）

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234

项与贯叶连翘提取物相关的文献（医药）

2024-11-01·Nursing

The perils of St. John's wort in cancer care

Article

作者: Boyle, Deborah A

Abstract:Approximately one-third of Americans use healthcare approaches including herbs and botanicals, such as St. John's wort (SJW), to improve overall well-being, gain control over their health, and manage the adverse reactions of conventional therapies. This article examines the use of SJW in cancer care, discussing its pharmacokinetics, toxicity, and potential interactions with cancer treatments while emphasizing the importance of patient education and collaboration between oncology nurses and pharmacists to ensure safe and effective care.

2024-08-01·Clinical and Translational Science

Dose‐dependent induction of CYP3A activity by St. John's wort alone and in combination with rifampin

Article

作者: Hohmann, Nicolas ; Blank, Antje ; Mikus, Gerd ; Haefeli, Walter E. ; Friedrichs, Anna S. ; Burhenne, Jürgen

AbstractThe dose dependence of the effect of enzyme inducers and the effect of the combined administration of two inducers that exert their effect via the same induction pathway (pregnane X receptor) have not been well studied. Using oral midazolam microdoses (30 μg), we have investigated CYP3A4 induction by St. John's wort (SJW) in 11 healthy volunteers using low (300 mg/day containing 7.48 mg hyperforin), therapeutic (900 mg/day), and supratherapeutic doses of SJW (1800 mg/day) for 14 days. SJW was then co‐administered with rifampin (600 mg/day) for a further 7 days to evaluate the effect of the combined administration of two inducers. In addition, intravenous midazolam microdoses (10 μg) were administered before SJW, at SJW 1800 mg/day, and during administration of the two inducers to assess the hepatic contribution to total induction (semi‐simultaneous administration). Administration of SJW increased oral midazolam clearance 1.96‐fold (300 mg/day), 3.86‐fold (900 mg/day), and 5.62‐fold (1800 mg/day), and 17.5‐fold after the addition of rifampin. Concurrently, the clearance of intravenous midazolam increased 2.05‐fold (1800 mg/day) and 2.93‐fold (SJW + rifampin). These results show that rifampin significantly enhances the induction of the highest SJW doses both hepatically and overall and suggest that these metabolic effects occur predominantly in the gut. These findings also suggest that in drug interactions involving strong and moderate enzyme inducers, the perpetrator effects of the strong inducer are decisive for the interaction.

2024-05-01·Clinical and Translational Science

St. John's wort extract with a high hyperforin content does not induce P‐glycoprotein activity at the human blood–brain barrier

Article

作者: Bamminger, Karsten ; Bauer, Martin ; Jackwerth, Matthias ; Lozano, Irene Hernández ; Mairinger, Severin ; Weber, Maria ; Schindler, Natalie ; Wölfl‐Duchek, Michael ; Jäger, Walter ; Poschner, Stefan ; Tournier, Nicolas ; Zeitlinger, Markus ; Rausch, Ivo ; Langer, Oliver ; Nics, Lukas ; El Biali, Myriam ; Hacker, Marcus

AbstractSt. John's wort (SJW) extract, a herbal medicine with antidepressant effects, is a potent inducer of intestinal and/or hepatic cytochrome P450 (CYP) enzymes and P‐glycoprotein (P‐gp), which can cause clinically relevant drug interactions. It is currently not known whether SJW can also induce P‐gp activity at the human blood–brain barrier (BBB), which may potentially lead to decreased brain exposure and efficacy of certain central nervous system (CNS)‐targeted P‐gp substrate drugs. In this study, we used a combination of positron emission tomography (PET) imaging and cocktail phenotyping to gain a comprehensive picture on the effect of SJW on central and peripheral P‐gp and CYP activities. Before and after treatment of healthy volunteers (n = 10) with SJW extract with a high hyperforin content (3–6%) for 12–19 days (1800 mg/day), the activity of P‐gp at the BBB was assessed by means of PET imaging with the P‐gp substrate [11C]metoclopramide and the activity of peripheral P‐gp and CYPs was assessed by administering a low‐dose phenotyping cocktail (caffeine, omeprazole, dextromethorphan, and midazolam or fexofenadine). SJW significantly increased peripheral P‐gp, CYP3A, and CYP2C19 activity. Conversely, no significant changes in the peripheral metabolism, brain distribution, and P‐gp‐mediated efflux of [11C]metoclopramide across the BBB were observed following the treatment with SJW extract. Our data suggest that SJW does not lead to significant P‐gp induction at the human BBB despite its ability to induce peripheral P‐gp and CYPs. Simultaneous intake of SJW with CNS‐targeted P‐gp substrate drugs is not expected to lead to P‐gp‐mediated drug interactions at the BBB.

100 项与贯叶连翘提取物相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	贯叶连翘提取物	-	DB13014

研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
经前综合征	临床3期	巴西	Herbarium Laboratório Botânico Ltda	2012-03-01
子宫出血	临床3期	巴西	Herbarium Laboratório Botânico Ltda	2012-03-01
血管舒缩症	临床3期	巴西	Herbarium Laboratório Botânico Ltda	2012-03-01

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT00048815 (CTgov)	N/A	抑郁症	73	Citalopram (Citalopram)	觸願遞夢鏇壓鬱製夢糧(觸齋淵簾憲獵構構網繭) = 窪窪觸齋齋膚餘積鹽簾繭鑰簾顧憲鑰衊鬱衊壓 (淵繭構鬱齋選膚鑰獵襯, 糧製鏇廠廠範衊構衊繭 ~ 膚顧獵構願鹹醖築築襯) 更多	-	2018-05-11
				St. John's Wort (St. John's Wort)	觸願遞夢鏇壓鬱製夢糧(觸齋淵簾憲獵構構網繭) = 鹽鬱衊衊襯壓簾鏇壓壓繭鑰簾顧憲鑰衊鬱衊壓 (淵繭構鬱齋選膚鑰獵襯, 顧製醖繭選鹽簾積衊積 ~ 窪鹽餘繭襯製窪蓋襯夢) 更多
NCT00110136 (CTgov)	临床2期	潮热 \| 乳腺癌	9	St. John's Wort	艱醖齋襯艱製觸積糧艱(鏇選憲鑰製積築選築餘) = 網廠衊齋顧襯製醖鑰鏇醖願製觸齋願觸餘願蓋 (構鏇製選襯範積鹹醖鹹, 製醖膚鑰憲鏇遞網鏇願 ~ 襯願顧鑰醖獵簾淵鬱糧) 更多	-	2014-12-29
EASD2012	N/A	-	-	St. John's Wort extract	淵選網壓壓夢鏇鬱膚廠(繭獵蓋醖繭築夢網壓築) = partially corrected the cytokine-induced unbalance between anti- and pro-apoptotic factors 廠鏇鹽遞簾壓範積鹽顧 (積範醖製淵膚觸蓋襯鏇 ) 更多	积极	2012-10-04
				Hyperforin
NCT00587860 (CTgov)	临床2期	肠易激综合征	70	St. John's wort (St. John's Wort)	顧遞遞鬱構憲構膚製糧(遞窪鏇鏇築蓋衊鏇選鹹) = 築鏇餘積鏇範襯蓋醖襯範觸觸製膚膚願壓齋簾 (窪獵構餘淵鏇觸艱簾齋, 鑰構範餘繭憲壓繭繭蓋 ~ 鬱糧鹽簾夢廠襯襯鏇鹹) 更多	-	2010-03-01
				Placebo (Placebo)	顧遞遞鬱構憲構膚製糧(遞窪鏇鏇築蓋衊鏇選鹹) = 蓋鏇繭艱窪構餘憲糧衊範觸觸製膚膚願壓齋簾 (窪獵構餘淵鏇觸艱簾齋, 遞鏇簾構膚壓鹹範願夢 ~ 簾襯範網廠構襯窪願鏇) 更多