贯叶连翘提取物(Hypericum perforatum Extract)

概要

基本信息

药物类型

中药

别名

Jarsin、SJW、St. John's Wort extract

+ [4]

靶点-

作用方式-

作用机制-

治疗领域

心血管疾病泌尿生殖系统疾病其他疾病

在研适应症-

非在研适应症

经前综合征子宫出血血管舒缩症

原研机构

Herbarium Laboratório Botânico Ltda

在研机构-

非在研机构

Herbarium Laboratório Botânico Ltda

权益机构-

最高研发阶段无进展临床3期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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结构/序列

分子式C30H16O8

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CAS号548-04-9

关联

22

项与贯叶连翘提取物相关的临床试验

IRCT20241118063767N1

/ Suspended早期临床1期IIT

Investigating the Effect of Hypericum perforatum (Perforan) Tablets on Neurological Pain, Functional Independence and Severity of Depression in Patients with Spinal Cord Injuries

开始日期2025-01-19

申办/合作机构

Islamic Azad University

NCT04558697

/ Completed临床4期

Use of Vagitories Based on St. John's Wort, Tea Tree Oil and Shepherd's Purse in the Treatment of Vaginal Inflammation

There are more and more herbal preparations that are used for the purpose of treatment and improvement of the clinical picture of vaginitis by patients themselves, but also by healthcare professionals. Plant species, St. John's wort, chamomile, calendula, yarrow, shepherd's purse and tea tree oil are well known for there anti-inflammatory, antimicrobial and wound healing activity. This paper presents the results of a clinical study in which three herbal formulations/vagitories, based on extracts of above mentioned plant species, were investigated for their effectiveness on non-specific vaginitis.
This was randomized controlled clinical study that included 210 women with diagnosed non-specific vaginitis. Patients were divided into two basic groups, women in reproductive stage and postmenopausal stage. Three subgroups, containing approximately 30 patients each, received one of three vagitorie formulations for 5 days during which the effects on subjective and objective symptoms were monitored.

开始日期2019-03-21

申办/合作机构

University of Sarajevo

[+1]

NCT03796377

/ Completed临床1期

Effects of Hypericum Perforatum (St. John's Wort) on the Pharmacokinetics and Pharmacodynamics of Rivaroxaban in Humans

Single-center, open-label, sequential treatment study to investigate the influence of the combined P-glycoprotein and CYP3A4 inducer hypericum perforatum on the pharmacokinetics and pharmacodynamics of rivaroxaban in healthy volunteers.

开始日期2019-02-13

申办/合作机构

Insel Gruppe AG

[+1]

100 项与贯叶连翘提取物相关的临床结果

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100 项与贯叶连翘提取物相关的转化医学

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100 项与贯叶连翘提取物相关的专利（医药）

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2,773

项与贯叶连翘提取物相关的文献（医药）

2025-04-15·Chemistry – A European Journal

Proton Pachinko: Probing Excited‐State Intramolecular Proton Transfer of St. John's Wort‐Derived Fluorescent Photosensitizer Hypericin with Ultrafast Spectroscopy**

Article

作者: Chen, Cheng ; Johnson, Seth L. ; Krueger, Taylor D. ; Solaris, Janak ; Fang, Chong

AbstractHypericin from St. John's wort has been used as a potent photosensitizer, but its working mechanism remains elusive which hinders its rational design for improved functionality. We implement ultrafast spectroscopy and quantum calculations to track the excited‐state dynamics in an intricate hydrogen‐bonding network of hypericin in solution. Using femtosecond transient absorption (fs‐TA), we track excited state intramolecular proton transfer (ESIPT) via a previously unreported blueshift of a long‐wavelength stimulated emission (SE) band with excitation‐dependent dynamics in various solvents, owing to the dominant Q7,14 tautomer that undergoes bidirectional ESIPT. This finding is corroborated by ground‐state femtosecond stimulated Raman spectroscopy (GS‐FSRS) and density functional theory (DFT) calculations. Moreover, contrasting the neutral and anionic forms of hypericin enables us to reveal an intramolecular charge transfer step underlying ESIPT. We demonstrate UV and visible excitations as an integral platform to provide direct insights into the photophysics and origin for phototoxicity of hypericin. Such mechanistic insights into the excited state of hypericin will power its future development and use.

2025-04-10·Journal of Applied Polymer Science

Thermoplastic Polyurethane/Polylactic Acid Blend Foams Loaded With Curcuma longa L. and Hypericum perforatum Extracts Towards Wound Dressing Applications

作者: Popa, Andreea Daniela ; Bužarovska, Aleksandra ; Stanoeva, Jasmina Petreska ; Karamanolevski, Predrag ; Avérous, Luc ; Dinescu, Sorina

ABSTRACTThis study aimed to fabricate and evaluate TPU/polylactic acid foams loaded with natural extracts of Curcuma longa L. (C) and Hypericum perforatum (H) for WD application. In the frame of the structure/properties relationships study, different and complementary analyzes for WD materials, such as water contact angles measurements, water vapor transmission rate, water absorption, and extracts release studies were performed, in connection with the structural and thermal characterizations performed using scanning electron microscopy, differential scanning calorimetry and Fourier transform spectroscopy. The water absorption capacity of the blank blend foam and foams loaded with extracts (C and H) was found to be in the range of 8.31% ± 0.27, 90.7% ± 4.1 and 164% ± 4.0%, respectively. The loaded foams presented cumulative extracts release of 45.5% ± 2% (C) and 100% ± 1.1% (H) within 96 h and acceptable water vapor transmission rate in the range of 2088 ± 66 and 3520 ± 991 g·m−2·24 h−1, respectively. Summary, the investigated foams, enriched with both extracts, showed excellent performances in agreement with WD materials requirements, higher cell viability and proliferation compared to the reference foams, as well as non‐cytotoxic effects on human fibroblasts in experimental conditions.

2025-04-01·Journal of Chromatography B

Evaluation of binding interaction between compounds targeting peroxisome proliferator-activated receptor γ in Nelumbinis folium using receptor chromatography and molecular dynamic simulation

Article

作者: Gao, Yifan ; Lu, Dan ; Yao, Qingqing ; Li, Qian ; Ji, Xiuli ; Li, Xue ; Yin, Jiatai ; Zhi, Dalong ; Chen, Ying

Despite considerable efforts invested in clinical trials aimed at treating obesity and enhancing the metabolic profiles of Nelumbinis Folium, the precise phytochemicals involved and their mechanisms of action remain unclear due to the absence of an efficient screening technique. Herein, Nelumbinis Folium serves as the focal point to elucidate the bioactive compounds that specifically bind to peroxisome proliferator-activated receptor γ using immobilized receptor chromatography. Following identification through liquid chromatography-mass spectrometry, the compounds were further evaluated using chromatographic techniques and molecular dynamics simulations. The results unveiled catechin and hypericin as the receptor-binding compounds present in Nelumbinis Folium, with hypericin exhibiting a stronger affinity and a faster dissociation rate constant compared to catechin. Molecular dynamics studies highlighted the crucial role of cysteine located at position of 285 in the receptor ligand binding domain during the initial ligand capture phase. Subsequently, Van Der Waals forces and electrostatic interactions facilitated the binding process. The calculated standard binding free energies were - 61.75 ± 2.61 kcal/mol for hypericin and - 43.19 ± 0.63 kcal/mol for catechin. Collectively, these findings provide valuable insights into receptor-drug interactions and confirm the effectiveness of immobilized receptor chromatography in screening potential lead compounds from complex systems.

100 项与贯叶连翘提取物相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	贯叶连翘提取物	-	DB13014

研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
经前综合征	临床3期	巴西	Herbarium Laboratório Botânico Ltda	2012-03-01
子宫出血	临床3期	巴西	Herbarium Laboratório Botânico Ltda	2012-03-01
血管舒缩症	临床3期	巴西	Herbarium Laboratório Botânico Ltda	2012-03-01

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT00048815 (CTgov)	N/A	抑郁症	73	Citalopram (Citalopram)	膚選鹹壓膚憲糧簾繭壓(淵壓網範選鏇構鹹構範) = 構鏇範觸膚顧蓋獵糧艱糧遞糧範蓋觸艱獵窪繭 (鏇窪醖餘網襯願壓醖憲, 顧鏇選淵鏇憲餘廠醖製 ~ 簾衊醖選艱艱範壓淵艱) 更多	-	2018-05-11
				St. John's Wort (St. John's Wort)	膚選鹹壓膚憲糧簾繭壓(淵壓網範選鏇構鹹構範) = 獵餘築選簾鹽願糧餘衊糧遞糧範蓋觸艱獵窪繭 (鏇窪醖餘網襯願壓醖憲, 襯製鹽壓繭鹹顧夢窪觸 ~ 窪餘窪齋襯網觸糧壓簾) 更多
NCT00110136 (CTgov)	临床2期	潮热 \| 乳腺癌	9	St. John's Wort	鹽繭鏇衊鬱築醖醖鬱顧(願艱淵築壓餘製衊築鏇) = 醖鹽顧製糧餘餘網築簾鹽壓餘醖齋淵築醖膚製 (憲獵觸網淵鹽齋衊顧鏇, 憲積蓋衊淵範範鑰獵壓 ~ 膚膚艱願製鏇廠窪膚憲) 更多	-	2014-12-29
EASD2012	N/A	-	-	St. John's Wort extract	廠積鏇獵窪窪遞鹽憲鑰(醖顧觸遞獵淵簾觸醖繭) = partially corrected the cytokine-induced unbalance between anti- and pro-apoptotic factors 衊構窪鏇廠範選襯獵築 (選艱鹽網窪繭願廠遞衊 ) 更多	积极	2012-10-04
				Hyperforin
NCT00587860 (CTgov)	临床2期	肠易激综合征	70	St. John's wort (St. John's Wort)	獵膚築憲餘齋齋鬱淵鹽(衊襯鑰築鏇蓋觸衊繭窪) = 齋範網範製觸壓膚窪糧築製構襯淵壓選選簾蓋 (網鏇醖糧獵築願壓築襯, 製餘構範淵顧選遞鏇範 ~ 糧範憲範醖襯艱鬱鹹鹽) 更多	-	2010-03-01
				Placebo (Placebo)	獵膚築憲餘齋齋鬱淵鹽(衊襯鑰築鏇蓋觸衊繭窪) = 製膚鹹獵網選艱選淵鏇築製構襯淵壓選選簾蓋 (網鏇醖糧獵築願壓築襯, 選鹹糧夢築觸鏇艱醖簾 ~ 願壓願鏇選壓蓋鏇醖鹹) 更多