Sodium fluoride/triclosan(Sodium fluoride/triclosan)

概要

基本信息

药物类型

小分子化药

别名

Colgate Total

靶点-

作用机制

骨生成刺激剂

治疗领域

感染口颌疾病

在研适应症-

非在研适应症

龋齿牙菌斑牙龈炎

原研机构

Colgate Palmolive

在研机构-

非在研机构

Colgate Palmolive

最高研发阶段撤市

首次获批日期

美国 (1997-07-11),

龋齿牙菌斑牙龈炎

最高研发阶段(中国)-

特殊审评-

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结构

分子式FNa

InChIKeyPUZPDOWCWNUUKD-ULWFUOSBSA-M

CAS号22554-99-0

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关联

20

项与 Sodium fluoride/triclosan 相关的临床试验

NCT05138978 / Completed临床2期

Metagenomic and Metatranscriptomic Analysis of Clinical Plaque Samples

The objective of this study is to determine the metagenomic and metatranscriptomic analysis of clinical samples.

开始日期2017-10-06

申办/合作机构

Colgate-Palmolive Co.

NCT02193165 / Completed临床3期

The Comparative Efficacy of Three Oral Hygiene Multi-component Regimens Encompassing the Use of a Manual Toothbrush, Toothpaste and a Mouthwash in Controlling Established Dental Plaque and Gingivitis.

The objective of this clinical research study is to assess the efficacy of three oral hygiene multi-component regimens encompassing the use of a manual toothbrush, toothpaste and a mouthwash in controlling established dental plaque and gingivitis.

开始日期2014-07-01

申办/合作机构

Colgate-Palmolive Co.

NCT02988349 / CompletedN/AIIT

Ecological Effect of 8% Arginine Dentifrice on Oral Microbiota of Caries-Free and Caries-active Populations

caries-free (CF) individuals caries-active (CA) individuals (DMFT ≥ 6) will be recruited. Subjects will be instructed to brush their teeth twice daily for 3 min using Colgate® Sensitive Pro-Relief® toothpaste (containing 8% arginine and 1450 ppm NaF) for 2 weeks. Supra- and subgingival plaque, saliva, and in situ plaque samples will be collected before and after the treatment for laboratory analyses.

开始日期2013-10-01

申办/合作机构

四川大学

100 项与 Sodium fluoride/triclosan 相关的临床结果

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100 项与 Sodium fluoride/triclosan 相关的转化医学

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100 项与 Sodium fluoride/triclosan 相关的专利（医药）

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109

项与 Sodium fluoride/triclosan 相关的文献（医药）

2024-06-01·Journal of Esthetic and Restorative Dentistry

Development of toothpaste formulations containing mineral clays as abrasive agents and their effects on the physical properties of dental enamel

Article

作者: Lima, Débora Alves Nunes Leite ; Gonçalves, Iana Maria Costa ; Aguiar, Flávio Henrique Baggio ; da Silva, Julliana Andrade

AbstractTo assess the physical properties and topographical aspect of dental enamel's surface microhardness (KHN), surface roughness (Ra), and color parameters CIELAB (∆Eab*), CIEDE 2000 (∆E00), and whiteness index for dentistry (∆WID) after toothbrushing with experimental toothpaste formulations with the following mineral clay types: kaolin, Sparclay SGY, and Tersil CGY used as abrasive component. Scanning electron microscopy (SEM) was performed for topographical analyses purposes. A total of 96 bovine incisors were used in the experiment. They were divided into eight experimental groups (n = 12), namely: NC—negative control (no treatment), CT12—Colgate Total 12®, CMP—Colgate® Máxima Proteção Anticáries, K—kaolin experimental toothpaste, SGY—Sparclay SGY experimental toothpaste; CGY—Tersil CGY experimental toothpaste, SD—SiO2 experimental toothpaste, and CC—CaCO3 experimental toothpaste. All samples were subjected to mechanical brushing protocol with 5000 cycles and kept in artificial saliva with daily exchanges. KHN was analyzed through the mixed linear model for repeated measures over time. Ra was analyzed through nonparametric Kruskal Wallis and Dunn tests to compare the groups. Paired Wilcoxon test was run to compare experimental times. ∆WID, ∆Eab*, and ∆E00 were analyzed through Kruskal Wallis and Dunn tests. All analyses were performed in R* software, at 5% significance level. EXP_SGY recorded higher KHN than EXP_SiO2 and EXP_CaCO3, whereas EXP_K showed increased Ra in comparison to CMP (p = 0.0229). ∆Eab and ∆E00 were significantly higher in the CT12, EXP_SiO2, and EXP_CaCO3 groups than in the NC and EXP_K (p < 0.0001). There were no significant changes in ∆WID (p = 0.0852). According to SEM results, toothbrushing with experimental toothpastes added with mineral clay types did not have significant impact on enamel's polishing and smoothness.Clinical RelevanceMineral clays have a broad application in the cosmetic industry, and recently, they have been used in the formulation of vegan toothpaste.

2024-06-01·American journal of dentistry

Effects of natural products-based dentifrices on acrylic resin for denture bases: A simulated period of 4 years.

Article

作者: Dos Reis, Andréa C ; de Castro, Denise T ; Oliveira, Viviane D C ; Lovato da Silva, Clकudia H ; Fernandes, Marcela S ; Lepri, César P ; Costa, Marcela S ; Watanabe, Evandro

PURPOSETo evaluate the antimicrobial activity of dentifrices based on Malva sylvestris and propolis and the effect on the acrylic resin.METHODSThe inhibitory effect against Candida albicans, Enterococcus faecalis and Streptococcus mutans was determined. The specimens of resin were divided into groups: Control (brushing with distilled water); brushing with Colgate; brushing with Protex; brushing with Malvatricin, brushing with Proporalcare Dental Gel and brushing with Green Propolis Dental Gel. Brushing was carried out in a brushing machine. Roughness and color were assessed. The data were analyzed by ANOVA, followed by the Bonferroni post test (α= 0.05).RESULTSThe products evaluated showed antimicrobial activity against all microorganisms (P< 0.05), except Proporalcare Dental Gel, which was not effective against E. faecalis. Greater roughness (P< 0.05) was observed in the samples treated with Colgate. The samples from control and Protex groups showed the lowest color variation and the highest luminosity, with a difference in relation to the others (P< 0.05), which showed higher values, although clinically acceptable.CLINICAL SIGNIFICANCEThe dentifrices based on natural products can be indicated for cleaning prostheses, since they showed antimicrobial activity and did not cause perceptible color changes of the resin tested. The dentifrices did not produce adverse effects on the surface of the resin or did so less than the conventional dentifrice.

2024-04-15·Cureus

Influence of Five Different Commercially Available Mouthwashes on the Growth of Candida albicans Adhered to Customized Prefabricated Heat-Cured Denture Base Acrylic Resin Sheets: An In Vitro Study

Article

作者: Poyil, Neethu ; Abdul Razak, Pattathil ; Krishna K, Athira ; Venugopalan, Deepthi ; Mohamed Ali Kp, Aysha ; Jassim, Amal

Background The purpose of this in vitro investigation was to evaluate the impact of five distinct commercial mouthwashes on the development of Candida albicans that had been adhered to heat-cured acrylic resin sheets. Methods This in vitro investigation was carried out at the MES Medical College's Microbiology Department in Perinthalmanna, Kerala, India. A total of 72 heat-cured acrylic resin sheets, size 10 × 10 × 2 mm, were fabricated. After disinfection, all 72 acrylic sheets were placed in a flask containing a suspension of the standard strain of Candida species (American Type Culture Collection) and incubated at 37ºC for 24 hours. Then, the acrylic sheets were randomly divided into six groups, with each group containing 12 acrylic sheets. Group 1 was the control group to which no mouthwash was added. In group 2, Colgate Plax was added. In group 3, Hiora Himalaya was added. In group 4, Oral B was added. In group 5, Listerine was added. In group 6, Pepsodent was added. Colony-forming units (CFUs) were assessed using a colony counter every six, 24, 48, and 120 hours. After obtaining the pH and CFU of all 72 specimens, software known as the Statistical Package for Social Sciences (SPSS) (IBM Corp., Armonk, NY) was used to analyze the data. Results Candida albicans adhered to heat-cured denture base acrylic resin sheets differed significantly in response to commercially available mouthwashes (Oral B, Colgate Plax, and Pepsodent) and non-commercial mouthwashes (Hiora Himalaya and Listerine) that contained cetylpyridinium chloride. Conclusions Compared to other mouthwashes that do not contain cetylpyridinium chloride (Listerine and Hiora Himalaya), mouthwashes with cetylpyridinium chloride as the active ingredient (Oral B, Pepsodent, and Colgate Plax) have shown good antifungal properties against the adhering Candida albicans on denture base resin.

100 项与 Sodium fluoride/triclosan 相关的药物交易

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研发状态

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT02193165 (CTgov)	临床3期	牙菌斑 \| 牙龈炎	120	cetylpyridinium chloride+triclosan/fluoride (Regimen 1)	齋窪蓋鹹遞壓廠構窪觸(膚積鑰淵觸憲顧衊襯餘) = 範淵築獵範遞鹹廠網築構積鹽積壓糧窪製觸鏇 (簾壓簾簾製壓壓選憲憲, 繭簾鑰醖衊製構鬱齋襯 ~ 鹽構衊鹹範製蓋鏇製顧) 更多	-	2015-02-06
				stannous fluoride toothpaste+cetylpyridinium chloride (Regimen 2)	齋窪蓋鹹遞壓廠構窪觸(膚積鑰淵觸憲顧衊襯餘) = 觸遞鹽繭築網襯襯築窪構積鹽積壓糧窪製觸鏇 (簾壓簾簾製壓壓選憲憲, 獵築艱顧鏇糧範鹹鏇襯 ~ 窪構窪糧衊糧醖糧糧鹹) 更多
NCT00762528 (CTgov)	临床4期	牙龈炎	49	Triclosan/Copolymer/fluoride toothpaste (Total Toothpaste)	鑰構構觸糧蓋齋鑰顧簾(艱選鏇膚網襯膚憲選簾) = 遞壓構鹹簾淵夢製襯憲繭選構選築築鏇築憲艱 (構鑰鏇簾廠衊淵鹹鬱艱, 願築鬱糧衊製鑰憲鑰鹹 ~ 鬱窪築襯齋廠鑰獵鬱夢) 更多	-	2012-04-03
				Sodium monofluorophosphate toothpaste (Fluoride Toothpaste)	鑰構構觸糧蓋齋鑰顧簾(艱選鏇膚網襯膚憲選簾) = 築網鹹鑰襯鬱鬱淵築鏇繭選構選築築鏇築憲艱 (構鑰鏇簾廠衊淵鹹鬱艱, 艱遞衊鬱夢構夢醖夢淵 ~ 願蓋遞願齋鏇鏇構範範) 更多