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更新于：2025-04-14
Chlorhexidine Gluconate/Isopropyl Alcohol
葡萄糖氯己定/异丙醇
更新于：2025-04-14
概要
基本信息
非在研机构 |
最高研发阶段批准上市 |
首次获批日期 美国 (2000-07-14), |
最高研发阶段(中国)- |
特殊审评- |
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结构/序列
分子式C3H8O |
InChIKeyKFZMGEQAYNKOFK-UHFFFAOYSA-N |
CAS号67-63-0 |
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关联
25
项与 葡萄糖氯己定/异丙醇 相关的临床试验NCT04756154
Assessment of the Antimicrobial Efficacy of 3M™ SoluPrep™ Preoperative Skin Preparation Against Resident Human Skin Flora on the Inguinal Region
NCT04218110
Preoperative Skin Preparation Study Following ASTM E1173 Methods to Evaluate the Antimicrobial Capabilities of Four Test Substances
NCT03861780
Pilot Evaluation of Two Test Materials With a Positive Control When Used as a Patient Preoperative Skin Preparation
100 项与 葡萄糖氯己定/异丙醇 相关的临床结果
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100 项与 葡萄糖氯己定/异丙醇 相关的转化医学
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100 项与 葡萄糖氯己定/异丙醇 相关的专利（医药）
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10
项与 葡萄糖氯己定/异丙醇 相关的文献（医药）2024-06-01Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
BD Chloraprep™ (“2 % chlorhexidine with 70 % isopropyl alcohol”) versus povidone iodine plus alcohol, for prevention of blood culture contamination at children: An investigator-initiated, open-label, single centre, randomized controlled trial
Article
作者: Şahinkaya, Şahika ; Devrim, İlker ; Sözen, Ceren ; Yaman, Yakup ; Kaçar, Pelin ; Ayhan, Fahri Yüce ; Yılmaz Çelebi, Miray ; Bayram, Süleyman Nuri ; Cem, Ela
INTRODUCTION:
One of the important problems that lower the diagnostic value of blood culture is contamination with skin organisms. The povidone-iodine, alcohol, and chlorhexidine gluconate alcohol are used for disinfection prior to blood sampling for culture.
METHODS:
The investigator-initiated, open label, single centre, randomised trial compared blood culture contamination rates between two groups of patients in which using a povidone iodine skin-preparation process with the contamination rate for using "2 % chlorhexidine with 70 % isopropyl alcohol" skin-disinfection. The patients who required sampling for blood cultures were included in the study and study period was from 15 March 2023 to 15 July 2023.
RESULTS:
A total of 400 blood cultures were obtained during the study, including 133 in the study group and 267 in the control group. In the total blood cultures, 11.75 % (n = 47) had microorganism isolation. Among them 39 (9.75 %) were contaminants and 8 (2 %) of them were true pathogens. The contaminant microorganisms were as following; 34 coagulase-negative Staphylococci, 3 Micrococcus spp, and 2 Streptococci viridans. The blood culture contamination rate in the study group was 5.3 % (n = 7) and 12.0 % (n = 32) in the control group, and significantly lower in the study group (p = 0.033). There is no significant difference regarding skin related side effects between two groups.
CONCLUSIONS:
This study, showed that 2 % chlorhexidine gluconate in 70 % isopropyl alcohol is more efficacious in children than 10 % povidone-iodine preparations for disinfecting the skin prior to blood specimen collection for prevention of blood culture contamination.
2023-06-01International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
Reduction of adverse outcomes from cesarean section by surgical‐site infection prevention care bundles in maternity
Article
作者: Rees, Jacqui ; Thomas, James ; Fluck, David ; Wright, Ria ; Williams, Lisa ; Fry, Christopher H. ; Low, Anna ; Irukulla, Shashi ; Thompson, Anna ; Hale, Joann ; George, Richard ; Dumitrescu, Alexandra ; Erritty, Matthew ; Carr, Megan ; Han, Thang S.
Abstract:
Objective:
To reduce average surgical‐site infection (SSI) rates to less than 7.5%, as well as other complications by incrementally implementing an SSI prevention care bundle in maternity: (1) ChloraPrep; (2) PICO dressings, performing elective cesarean sections in a main theater rather than a labor ward and warming blankets; (3) vaginal cleansing; and (4) Hibiscrub.
Methods:
In this prospective cohort study, the association between categorical variables was assessed by χ2 tests, temporal trends in the monthly percentage change of SSI were measured using the Joinpoint Regression Program v4.7.0.0.
Results:
In all, 1682 women (mean age 33.1 ± 5.2 years) underwent either elective (53.9%) or emergency (46.1%) cesarean section. After a small initial increase (10.0%–11.8%), SSI progressively declined to 4.4% (χ2 = 22.1, P < 0.001), as did sepsis, reoperation or readmission for SSI: from 12.5% to 0.5% (χ2 = 90.1, P < 0.001). The rates of SSI fell progressively with the cumulative introduction care bundle components. The average monthly percentage change was −14.0% (95% confidence interval −21.8% to −5.4%, P = 0.004), and the average SSI rate was kept below 7.5% for the last 12 months of the study.
Conclusion:
The maternal SSI prevention care bundle is simple and inexpensive; it effectively reduces SSI after a cesarean section and should be offered routinely to women undergoing cesarean section.
2022-10-01Orthopaedics & traumatology, surgery & research : OTSR
Surgical solutions for preoperative skin preparation in total hip arthroplasty: A cost-effectiveness analysis of Betadine® and Chloraprep™
Article
作者: Ollat, Didier ; Zadegan, Frédéric ; Terracher, Richard ; Chatelain, Léonard ; Rougereau, Grégoire
OBJECTIVE:
The purpose of our study was to compare the cost of surgical site skin preparation using ChloraPrep™ (2% chlorhexidine gluconate [CHG] and 70% isopropyl alcohol [IPA]) with skin cleansing using Betadine® Surgical Scrub and Betadine® 5% solution (povidone-iodine [PVI]) in total hip arthroplasty (THA).
HYPOTHESIS:
The hypothesis was that the ChloraPrep™ skin disinfection protocol reduces the cost of perioperative antisepsis.
METHODS:
A prospective database was created for all THAs performed at our university hospital between November 1st, 2020, and December 31st, 2020. Each surgeon was randomly assigned one type of antiseptic prior to the start of the study: one surgeon to the ChloraPrep™ group and one to the Betadine® group. In both groups, the enrollment stopped at the 15th patient. The costs related to consumables, waste disposal, and operating room occupancy time of each protocol were then assessed for each patient.
RESULTS:
The mean duration of the ChloraPrep™ protocol was 3.5±0.3minutes compared to 13.5±0.9minutes for the Betadine® protocol. The overall cost of a surgical site skin preparation involving all three steps was on average €46.8±4.2 for the ChloraPrep™ group compared to €155±10.9 for the Betadine® group (p<0.0001).
DISCUSSION:
Not only is the effectiveness of ChloraPrep™ already recognized but it also appears to have health economic benefits. However, further studies are needed to confirm this finding.
LEVEL OF EVIDENCE:
III, case control study.
100 项与 葡萄糖氯己定/异丙醇 相关的药物交易
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外链
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| - | - | - |
研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 消毒剂 | 澳大利亚 | 2007-02-26 | |
| 细菌性皮肤疾病 | 美国 | 2000-07-14 |
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临床结果
临床结果
适应症
分期
评价
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临床3期 | - | 154 | (CHG/IPA Surgical Skin Preparation) | 廠製網淵網蓋網鑰膚製(鬱衊積鏇餘膚夢餘範鏇) = 顧顧憲鏇憲選衊艱選簾 遞簾網選窪遞襯獵夢醖 (顧觸壓鹽選積夢顧繭獵, 0.816) 更多 | - | 2023-08-01 | |
(Normal Saline) | 廠製網淵網蓋網鑰膚製(鬱衊積鏇餘膚夢餘範鏇) = 壓願網選衊膚鏇顧壓齋 遞簾網選窪遞襯獵夢醖 (顧觸壓鹽選積夢顧繭獵, 0.411) 更多 | ||||||
临床2期 | - | 28 | (3M CHG/IPA Prep / Center) | 網願鹽夢簾窪構範齋襯(構淵襯憲糧築壓襯醖淵) = 簾餘選醖簾膚壓鏇鹽鬱 積窪膚觸網願鹹築積鏇 (齋構範壓窪壓襯鹹觸夢, 1.31) 更多 | - | 2023-06-27 | |
(3M CHG/IPA Prep / Mid-peripheral) | 範膚醖憲鑰鹹選窪憲衊 = 簾艱糧鏇糧構鑰構遞淵 繭選壓獵鹽糧壓壓糧襯 (鹽夢醖艱構構餘願糧衊, 觸憲膚願壓築蓋鏇網襯 ~ 衊鑰膚遞遞選夢壓鹽鹹) 更多 | ||||||
临床3期 | 329 | (Project X 26ml) | 窪艱壓壓觸積鬱襯積構(夢製獵顧製鹹蓋選鏇鹽) = 鏇顧蓋夢築壓襯鑰膚鬱 鑰顧衊繭襯齋鹽觸觸鬱 (膚願積鹽憲淵遞願廠醖, 1.58) 更多 | - | 2021-10-22 | ||
(Project X 10.5ml) | 窪艱壓壓觸積鬱襯積構(夢製獵顧製鹹蓋選鏇鹽) = 積憲蓋廠窪獵網衊製選 鑰顧衊繭襯齋鹽觸觸鬱 (膚願積鹽憲淵遞願廠醖, 1.48) 更多 | ||||||
临床3期 | - | 170 | (Project X 26ml) | 餘窪廠構製獵鏇築願齋(製網淵遞積夢廠壓窪願) = 夢膚壓廠醖繭獵窪蓋蓋 顧鹹衊醖遞艱顧範築憲 (膚鬱餘願製窪鹹齋網窪, 1.42) 更多 | - | 2021-10-22 | |
(Project X 5.1ml) | 餘窪廠構製獵鏇築願齋(製網淵遞積夢廠壓窪願) = 築餘鑰獵鬱鑰鏇鏇憲壓 顧鹹衊醖遞艱顧範築憲 (膚鬱餘願製窪鹹齋網窪, 1.56) 更多 | ||||||
临床3期 | - | 152 | (Project X 26ml) | 膚簾憲蓋糧遞夢獵憲淵(膚淵醖糧構鬱範鹹觸鏇) = 鹽淵糧鏇網積蓋範醖餘 選鑰壓鑰鹹構觸網醖範 (膚蓋醖衊願網窪廠遞餘, 1.4) 更多 | - | 2021-10-22 | |
(Project X 5.1ml) | 膚簾憲蓋糧遞夢獵憲淵(膚淵醖糧構鬱範鹹觸鏇) = 選襯糧夢獵窪艱艱壓壓 選鑰壓鑰鹹構觸網醖範 (膚蓋醖衊願網窪廠遞餘, 1.3) 更多 | ||||||
临床4期 | - | 20 | Chlorhexidine (Chlorhexidine Group) | 願構鏇齋壓繭範簾糧觸 = 窪廠鏇繭遞簾鏇製壓積 憲簾廠糧網醖膚顧廠鑰 (糧醖選鑰範窪壓糧膚觸, 廠醖選構顧簾衊製憲壓 ~ 夢鏇襯鹽繭願淵淵積獵) 更多 | - | 2013-07-10 | |
Iodophor+Iodine+IPA (Iodine Group) | 願構鏇齋壓繭範簾糧觸 = 膚鹽鑰築膚製繭淵窪壓 憲簾廠糧網醖膚顧廠鑰 (糧醖選鑰範窪壓糧膚觸, 壓鏇窪壓窪繭醖鏇餘夢 ~ 鑰積觸鏇艱簾顧窪壓窪) 更多 |
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