葡萄糖氯己定/异丙醇(Chlorhexidine Gluconate/Isopropyl Alcohol) - 在研适应症：细菌性皮肤疾病_专利_临床

概要

基本信息

药物类型

小分子化药

别名

ChloraPrep、Soluprep

靶点-

作用机制

细胞膜功能抑制剂

治疗领域

感染皮肤和肌肉骨骼疾病

在研适应症

细菌性皮肤疾病

非在研适应症-

原研机构

Becton, Dickinson & Co.

在研机构

3M Health Care, Inc.

Becton, Dickinson & Co.

非在研机构-

最高研发阶段批准上市

首次获批日期

美国 (2000-07-14),

细菌性皮肤疾病

最高研发阶段(中国)-

特殊审评-

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结构

分子式C3H8O

InChIKeyKFZMGEQAYNKOFK-UHFFFAOYSA-N

CAS号67-63-0

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关联

28

项与葡萄糖氯己定/异丙醇相关的临床试验

NCT04756154 / Completed临床3期

Assessment of the Antimicrobial Efficacy of 3M™ SoluPrep™ Preoperative Skin Preparation Against Resident Human Skin Flora on the Inguinal Region

The purpose of this study is to determine the antimicrobial efficacy of an investigational CHG/IPA prep on skin flora of the inguinal regions of human subjects.

开始日期2020-07-06

申办/合作机构-

NCT04218110 / Completed临床3期

Preoperative Skin Preparation Study Following ASTM E1173 Methods to Evaluate the Antimicrobial Capabilities of Four Test Substances

Comparative study of antimicrobial effectiveness evaluation of of 26ml Project X, 10.5ml Project X, 5.1ml Project X and Prevantics Maxi swabstick following ASTM E1173 - Standard test method for evaluation of preoperative, precatheterization or preinjection skin preparations.

开始日期2020-02-11

申办/合作机构

Professional Disposables International, Inc.

NCT03861780 / Completed临床3期

Pilot Evaluation of Two Test Materials With a Positive Control When Used as a Patient Preoperative Skin Preparation

Comparative Study of Antimicrobial Effectiveness Evaluation of 26ml Project X, 5.1ml Project X and Prevantics Maxi Swabstick following ASTM E1173 - Standard Test Method for Evaluation of Preoperative, Precatheterization, or Preinjection Skin Preparations, ASTM International, West Conshohocken, Pennsylvania, 2015

开始日期2019-04-02

申办/合作机构

Professional Disposables International, Inc.

100 项与葡萄糖氯己定/异丙醇相关的临床结果

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100 项与葡萄糖氯己定/异丙醇相关的转化医学

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100 项与葡萄糖氯己定/异丙醇相关的专利（医药）

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58

项与葡萄糖氯己定/异丙醇相关的文献（医药）

2024-11-05·Military Medicine

The Dreaded 3-Minute Wait: Does It Really Prevent Operating Room Fires? The IGNITE Trial

Article

作者: Roets, Jack ; Danis, Hillary ; Fraley, Jim ; Keenan, Corey ; Spitzer, Holly ; Grasso, Samuel

ABSTRACTIntroductionOperating room fires can have devastating consequences and as such must be prevented. There exists a paucity of literature requiring further elucidation regarding manufacturer recommendations of a predefined waiting period prior to patient draping after using alcohol-based surgical antiseptics, in order to reduce the risk of operating room fires.MethodsThis was further investigated by exposing two common alcohol-based surgical antiseptics to electrosurgery and open flames at various power settings and time intervals in an ex vivo porcine model. The simulated surgical site was prepped following manufacturer recommendations and exposed to monopolar electrosurgery at low and high power, using both PURE CUT and COAGULATION modes, and open flame, at 15-s increments after application.ResultsWhile using PURE CUT mode at both low and high power, no ignition was observed on hairless surgical sites prepped with ChloraPrep® at any time point. However, use of COAGULATION mode at both low and high powers resulted in ignition consistently out to 1-min post-application. Additionally, if the prepped area subjectively appeared wet, especially with pooling of the antiseptic, both COAGULATION mode and open flame caused ignition. Dry time was found to be about 59 s for both prep solutions. It was also observed that the amount of pressure directly correlated with the amount of prep dispersed and increased dry times.ConclusionIn conclusion, our data suggest an average dry time of less than 1-min, with ignition only observed when the antiseptic was visibly wet. Ignition did not occur on hairless skin with electrocautery on CUT mode using ChloraPrep at any time point. Additionally, ignition on hair-bearing skin was not observed past 3 min, with current manufacturer recommendations stating 1 h wait time for hair-bearing skin. Arbitrarily waiting a specific predetermined dry time until patient draping, as recommended by the manufacturers, may be unnecessary and lead to hours’ worth of time wasted each year. Ongoing research will further investigate the utility of drying the antiseptic after application and its affect on not only preventing ignition but also antimicrobial efficacy.

2024-07-01·Access Microbiology

Reducing Blood Culture Contamination Rates: Introduction of a Combined Education and Skin Antisepsis Intervention

Article

作者: Mullane, Niamh ; Kelly, Deborah ; Broderick, Deirdre ; O'Callaghan, Isabelle ; Hickey, Caitriona ; Connolly, Aine ; O'Mara, Niall ; Coffey, Darragh

Background. Blood culture contamination (BCC) is an important quality concern in clinical microbiology as it can lead to unnecessary antimicrobial therapy in patients and increased workload for laboratory scientists. The Clinical Laboratory and Standards Institute recommend BCC rates to be <3 % and recently updated guidelines have set a new goal of 1 %. The aim of this project was to design and implement interventions to reduce BCC rates at our institution.Methods. We introduced a combined education and skin antisepsis intervention in a large Model 4 academic teaching hospital in the South of Ireland. BD ChloraPrep skin antisepsis applicators (2 % chlorhexidine gluconate/70 % isopropyl alcohol), licensed for use for blood culture specimen collection, were introduced, replacing Clinell (2 % chlorhexidine gluconate/70 % isopropyl alcohol) wipes. In addition, a multimodal education programme was designed and delivered. This consisted of a video demonstrating the recommended blood culture specimen collection technique using the new applicators as well as simulation training for all interns. The video was uploaded to the intranet as an educational resource available to all staff.Results. The interventions were implemented in July 2022 and BCC rates pre- and post-intervention were calculated. The average BCC rate for the 12 months preceding the intervention (July 2021 to July 2022) was 2.56 % with highest rates in the Emergency Department. This compared to an average rate of 2.2 % in the 12 months post-intervention (July 2022 to July 2023). In comparing the two rates the reduction in BCC rates between the two periods was not statistically significant (P=0.30).Conclusion. Overall BCC rates reduced but the difference between the two periods did not reach statistical significance. The resource-intensive nature of providing regular and timely feedback of contamination rates and the larger impact of in-person education and training over virtual modalities may explain the modest reduction. Further investments in these areas, particularly in the Emergency Department, will be necessary to further reduce rates in line with new recommendations.

2024-03-01·Journal of Shoulder and Elbow Surgery

Does hydrogen peroxide application to the dermis following surgical incision affect Cutibacterium acnes cultures in total shoulder arthroplasty in male patients? A randomized controlled trial

Article

作者: Hao, Kevin A ; Wright, Thomas W ; Wright, Jonathan O ; Vasilopoulos, Terrie ; King, Joseph J ; Struk, Aimee M ; Schoch, Bradley S ; Ritter, Alaina S ; Sutton, Christopher D ; Farmer, Kevin W

BACKGROUNDPeriprosthetic joint infections occur in 1%-4% of primary total shoulder arthroplasties (TSAs). Cutibacterium acnes is the most commonly implicated organism and has been shown to persist in the dermis despite use of preoperative antibiotics and standard skin preparations. Studies have shown decreased rates of cultures positive for C acnes with use of preoperative benzoyl peroxide or hydrogen peroxide (H₂O₂), but even with this positive deep cultures remain common. We sought to determine whether an additional application of H₂O₂ directly to the dermis following skin incision would further decrease deep culture positivity rates.METHODSWe performed a randomized controlled trial comparing tissue culture results in primary TSA in patients who received a standard skin preparation with H₂O₂, ethanol, and ChloraPrep (CareFusion, Leawood, KS, USA) vs. an additional application of H₂O₂ to the dermis immediately after skin incision. Given the sexual dimorphism seen in the shoulder microbiome regarding C acnes colonization rates, only male patients were included. Bivariable and multivariable analyses were performed to compare rates of positive cultures based on demographic and surgical factors.RESULTSDermal cultures were found to be positive for C acnes at similar rates between the experimental and control cohorts for the initial (22% vs. 28%, P = .600) and final (61% vs. 50%, P > .999) dermal swabs. On bivariable analysis, the rate of positive deep cultures for C acnes was lower in the experimental group, but this difference was not statistically significant (28% vs. 44%, P = .130). However, patients who underwent anatomic TSA were found to have a significantly greater rate of deep cultures positive for C acnes (57% vs. 28%, P = .048); when controlling for this on multivariable analysis, the experimental cohort was found to be associated with significantly lower odds of having positive deep cultures (odds ratio, 0.37 [95% confidence interval, 0.16-0.90], P = .023). There were no wound complications in either cohort.CONCLUSIONSAn additional H₂O₂ application directly to the dermis following skin incision resulted in a small but statistically significant decrease in the odds of having deep cultures positive for C acnes without any obvious adverse effects on wound healing. Given its cost-effectiveness, use of a post-incisional dermal decontamination protocol may be considered as an adjuvant to preoperative use of benzoyl peroxide or H₂O₂ to decrease C acnes contamination.

100 项与葡萄糖氯己定/异丙醇相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	-	D08AC52	-

研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
细菌性皮肤疾病	美国	Becton, Dickinson & Co.	2000-07-14

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT04756154 (CTgov)	临床3期	-	154	CHG/IPA Surgical skin preparation (CHG/IPA Surgical Skin Preparation)	網廠糧範鹽夢繭鬱顧構(廠蓋艱繭願憲衊製艱壓) = 窪製鹹糧範願顧獵廠鹽選鹽選鏇蓋廠鑰觸淵製 (衊窪願網簾築鬱顧獵醖, 範遞蓋廠觸夢糧鹽膚獵 ~ 夢醖製窪壓構衊糧艱範) 更多	-	2023-08-01
				Normal saline (Normal Saline)	網廠糧範鹽夢繭鬱顧構(廠蓋艱繭願憲衊製艱壓) = 觸蓋餘糧鹹廠襯構壓鏇選鹽選鏇蓋廠鑰觸淵製 (衊窪願網簾築鬱顧獵醖, 構簾艱齋膚夢蓋衊膚膚 ~ 鏇艱簾廠觸齋淵鹹壓鏇) 更多
NCT03681990 (CTgov)	临床2期	-	28	3M CHG/IPA Prep (3M CHG/IPA Prep / Center)	選觸憲鬱鹽鏇網獵選鏇(糧選積膚鏇鹽廠願範憲) = 鑰築範糧鹹顧膚襯餘獵壓艱憲餘築憲醖齋顧獵 (衊鹹鹹範壓遞廠壓廠顧, 齋膚襯鏇餘艱醖築鑰繭 ~ 醖餘願醖遞糧鏇衊夢獵) 更多	-	2023-06-27
				3M CHG/IPA Prep (3M CHG/IPA Prep / Mid-peripheral)	觸選鏇觸蓋襯襯鹽範廠(壓襯繭製鹽觸遞觸鹹鹹) = 憲憲獵蓋衊鹹鏇鹽築獵餘艱壓鹽鑰蓋衊鹹醖艱 (憲遞鑰網獵築鏇鹽襯淵, 淵夢鏇積膚網鏇醖鹽膚 ~ 簾觸鹽糧積繭鬱鬱鹽糧) 更多
NCT03861780 (CTgov)	临床3期	-	152	Project X 26ml (Project X 26ml)	窪衊蓋淵壓獵網獵築遞(鏇淵壓觸衊鏇壓願糧觸) = 構築製衊鏇選範鑰廠鹽廠簾壓鏇齋襯選醖餘鏇 (顧鹽醖構製餘壓衊網蓋, 觸艱鏇構鏇鬱壓築簾窪 ~ 積窪夢獵襯築憲廠艱繭) 更多	-	2021-10-22
				Project X 5.1ml (Project X 5.1ml)	窪衊蓋淵壓獵網獵築遞(鏇淵壓觸衊鏇壓願糧觸) = 範鬱積夢選製壓築製醖廠簾壓鏇齋襯選醖餘鏇 (顧鹽醖構製餘壓衊網蓋, 壓憲選網製遞鬱醖選醖 ~ 膚網蓋夢衊廠鬱膚膚艱) 更多
NCT03817580 (CTgov)	临床3期	-	170	Project X 26ml (Project X 26ml)	膚壓鹹餘廠願憲襯膚襯(壓願壓鬱範選製壓憲窪) = 衊糧餘簾構膚構衊鹹蓋繭艱夢簾願壓觸繭糧願 (積襯衊遞廠繭顧膚選選, 蓋簾艱鑰糧鹽壓鬱齋膚 ~ 廠衊顧齋衊憲鏇鑰遞網) 更多	-	2021-10-22
				Project X 5.1ml (Project X 5.1ml)	膚壓鹹餘廠願憲襯膚襯(壓願壓鬱範選製壓憲窪) = 獵餘糧簾觸獵製壓範鏇繭艱夢簾願壓觸繭糧願 (積襯衊遞廠繭顧膚選選, 網構獵蓋願窪繭壓憲膚 ~ 齋憲窪鏇鑰鹹壓鹹壓鹽) 更多
NCT04218110 (CTgov)	临床3期	手术伤口感染	329	Isopropyl alcohol & Chlorhexidine Gluconate Antiseptic (Project X 26ml)	憲糧顧鹽襯鹹鹹襯壓蓋(製積願鬱鑰簾製選壓鹹) = 積淵壓窪衊醖願醖獵蓋窪膚窪餘鹽構積膚簾襯 (淵餘艱廠窪窪觸觸鑰獵, 構憲網衊襯構願夢觸襯 ~ 襯膚齋蓋窪製鹹選網製) 更多	-	2021-10-22
				Isopropyl alcohol & Chlorhexidine Gluconate Antiseptic (Project X 10.5ml)	憲糧顧鹽襯鹹鹹襯壓蓋(製積願鬱鑰簾製選壓鹹) = 壓鏇夢廠築膚鬱窪鑰糧窪膚窪餘鹽構積膚簾襯 (淵餘艱廠窪窪觸觸鑰獵, 淵鬱鑰繭壓願遞淵觸齋 ~ 觸壓窪製襯艱膚顧餘窪) 更多