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更新于：2025-04-12
Alanylglutamine
丙氨酰谷氨酰胺
更新于：2025-04-12
概要
基本信息
最高研发阶段批准上市 |
首次获批日期 德国 (1995-04-01) |
最高研发阶段(中国)批准上市 |
特殊审评孤儿药 (美国) |
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结构/序列
分子式C8H15N3O4 |
InChIKeyHJCMDXDYPOUFDY-WHFBIAKZSA-N |
CAS号39537-23-0 |
关联
24
项与 丙氨酰谷氨酰胺 相关的临床试验PACTR202303692483097
Efficacy of Perioperative Infusion of N (2)-L-alanyl-L-glutamine in Glycemic Control for Patients With Uncontrolled Diabetes Mellitus Presented for Urgent Coronary Artery Bypass Surgery: Randomized Control Trial
ISRCTN13489936
The ameliorative potential of L-alanyl L-glutamine dipeptide in colon cancer patients receiving modified FOLFOX-6 regarding the incidence of diarrhea, the treatment response, and patients’ survival: a randomized controlled trial
NCT05586646
Effect of IV Alanyl Glutamine on Healing of Pressure Ulcers in Critically Ill Patients
100 项与 丙氨酰谷氨酰胺 相关的临床结果
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100 项与 丙氨酰谷氨酰胺 相关的转化医学
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100 项与 丙氨酰谷氨酰胺 相关的专利（医药）
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968
项与 丙氨酰谷氨酰胺 相关的文献（医药）2025-04-01JOURNAL OF NUTRITIONAL BIOCHEMISTRY
Liver lipid metabolism, oxidative stress, and inflammation in glutamine-supplemented ob/ob mice
Article
作者: Jr, Jose Donato ; Munhoz, Ana Cláudia ; Vilas-Boas, Eloisa Aparecida ; Takahashi, Hilton K ; Araújo, Layanne C C ; Leite, Jaqueline Santos Moreira ; Carpinelli, Angelo Rafael ; Carvalho, Carla Roberta ; Cruzat, Vinicius ; Curi, Rui
Glutamine availability may be reduced in chronic diseases, such as type 2 diabetes mellitus (T2DM)-induced by obesity. Herein, the antioxidant, anti-inflammatory and lipid metabolism effects of chronic oral glutamine supplementation in its free and dipeptide form were assessed in ob/ob mice. Adult male C57BL/6J ob/ob mice were supplemented with L-alanyl-L-glutamine (DIP) or free L-glutamine (GLN) in the drinking water for 40 days, whilst C57BL/6J Wild-type lean (WT) and control ob/ob mice (CTRL) received fresh water only. Plasma and tissue (skeletal muscle and liver) glutamine levels, and insulin resistance parameters (e.g., GTT, ITT, insulin) were determined. Oxidative stress (e.g., GSH system, Nrf2 translocation), inflammatory (e.g., NFkB translocation, TNF-α gene expression) and lipid metabolism parameters (e.g., plasma and liver triglyceride levels, SRBP-1, FAS, ACC, and ChRBP gene expression) were also analyzed. CTRL ob/ob mice showed lower glutamine levels in plasma and tissue, as well as increased insulin resistance and fat in the liver. Conversely, chronic DIP supplementation restored glutamine levels in plasma and tissues, improved glucose homeostasis and reduced plasma and liver lipid levels. Also, Nrf2 restoration, reduced NFkB translocation, and lower TNF-α gene expression was observed in the DIP group. Interestingly, chronic free GLN only increased muscle glutamine stores but reduced overall insulin resistance, and attenuated plasma and liver lipid metabolic biomarkers. The results presented herein indicate that restoration of body glutamine levels reduces oxidative stress and inflammation in obese and T2DM ob/ob mice. This effect attenuated hepatic lipid metabolic changes observed in obesity.
2025-03-01FISH & SHELLFISH IMMUNOLOGY
Protection of glutamine: The NF-κB/MLCK/MLC2 signaling pathway mediated by tight junction affects oxidative stress, inflammation and apoptosis in snakehead (Channa argus)
Article
作者: Chang, Yue ; Kong, Yi-di ; Liu, Hong-Jian ; Niu, Xiao-Tian ; Yang, Zhi-Nan ; Peng, Si-Bo ; Li, Min ; Wang, Gui-Qin ; Wan, Ji-Wu ; Wu, Xue-Qin ; Chen, Xiu-Mei
Lipopolysaccharide (LPS) destroys intestinal mechanical barrier and causes apoptosis by triggering oxidative stress and inflammatory responses. Glutamine (Gln) can maintain normal intestinal function under various stressed or pathological conditions. Thereby, this study aims to evaluate the protection of glutamine on intestinal health of snakehead (Channa argus), specifically regarding the NF-κB/MLCK/MLC2 signaling pathway mediated by tight junction affecting oxidative stress, inflammation and apoptosis. In this work, a model of intestinal tight junction injury in intestine of snakehead was constructed by injecting 4 mg/mL LPS into anus for 96 h. Before constructing the model, fish were treated with different levels of alanyl-glutamine (Ala-Gln) (0 %, 0.3 %, 0.6 %, 0.9 %, 1.2 % and 1.5 %) for 56 days. Microstructure and ultra microstructure showed that LPS-induced obvious intestinal damage and tight connection destruction, while Gln effectively alleviated these phenomena. In addition, results also showed that Gln can effectively inhibit LPS-induced damage to intestinal tight junction (zo-1, occludin, claudin5, claudin1, nf-κb p65, mlck and mlc2), alleviate oxidative stress (nrf2, sod, gsh, gpx and cat), ameliorate intestinal inflammation (tnf-α, il-1β, il-8, tlr5 and tlr2), thereby reduce apoptosis (p38mapk, caspase9, caspase8, caspase3 and bax). Crucially, the above results were related to NF-κB/MLCK/MLC2 signaling pathway mediated by tight junction. In conclusion, Gln has a good protective effect on LPS-induced intestinal injury in northern snakehead, providing a new perspective for regulating fish intestinal health.
2025-02-25ACS Applied Electronic Materials
Peptide-Engineered Interface to Improve the Efficiency of Pure Red Tin Halide Perovskite LEDs by Controlling Crystallization and Reducing Oxidation
作者: Zheng, Xueyong ; Liu, Weimin ; Wu, Zhixian ; Luo, Chunhua ; Jiang, Chunli ; Lin, Hechun ; Xie, Junhan ; Li, Bo ; Peng, Hui
Tin (Sn)-based perovskite light-emitting diodes (PeLEDs) have garnered significant attention owing to their superior optoelectronic properties, affordable solution processing, and environmental friendliness.However, the properties of Sn-PeLEDs trail those of their lead (Pb) counterparts.The main obstacle is the easy oxidation of Sn2+ to Sn4+ as well as fast crystallization, leading to poor film quality with many defects.Herein, a convenient and effective interface engineering strategy is reported to fabricate (2-thiopheneethylamine)2SnI4 (TEA2SnI4) PeLEDs by introducing different peptides into the PEDOT:PSS hole-transport layer (HTL).Benefiting from the interaction between the peptide mols. and the Sn-perovskite nuclei, the crystallization dynamics are effectively adjusted, leading to an improved film morphol.At the same time, the multiple functional groups of peptides can suppress Sn2+ oxidation and passivate interface defects.Therefore, perovskite films with improved luminescence efficiency are obtained.The perovskite films are further used for the fabrication of pure red PeLEDs with enhanced performance.In particular, the optimized devices based on Leu-Gly-Gly (LGG) achieve a peak external quantum efficiency of 0.5% and a brightness of 136 cd m-2, which are about 2 and 3 times larger, resp., than those of the reference device.This research offers a general strategy to improve the performance of Sn-PeLEDs via peptide interface engineering.
100 项与 丙氨酰谷氨酰胺 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 谷氨酰胺缺乏症 | 中国 | 1999-04-03 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 终末期肾脏病 | 临床2期 | 奥地利 | 2022-03-16 | |
| 腹膜炎 | 临床2期 | 奥地利 | 2014-06-02 | |
| 膳食补充剂 | 临床1期 | 中国 | - | |
| 膳食补充剂 | 临床1期 | 中国 | - | |
| 辐射引起的溃疡性口腔粘膜炎 | 临床前 | 美国 | 2018-07-10 | |
| 辐射引起的溃疡性口腔粘膜炎 | 临床前 | 日本 | 2018-07-10 | |
| 腹膜纤维变性 | 临床前 | 荷兰 | 2015-11-03 |
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临床结果
临床结果
适应症
分期
评价
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临床3期 | 60 | (Glutamine) | 鑰積衊獵獵簾衊網範憲(夢淵糧繭鹹構廠淵獵餘) = 淵襯築夢廠顧積壓衊鏇 選蓋膚願醖築網築繭窪 (淵齋鏇構鹹餘鏇鏇膚願, 糧齋獵衊鬱鹽齋鹹鹹鏇 ~ 構糧蓋餘製遞廠鏇淵遞) 更多 | - | 2023-11-13 | ||
Placebo (Control) | 鑰積衊獵獵簾衊網範憲(夢淵糧繭鹹構廠淵獵餘) = 餘構簾淵簾製蓋願餘膚 選蓋膚願醖築網築繭窪 (淵齋鏇構鹹餘鏇鏇膚願, 選衊憲夢築鏇遞構齋鏇 ~ 網蓋鹹積窪糧選製膚餘) 更多 | ||||||
临床2期 | 7 | 衊繭廠淵淵襯齋糧觸構 = 艱選構範齋網糧鑰積網 構顧餘夢糧蓋構壓膚夢 (餘醖觸遞鹹餘顧餘艱網, 鹽齋醖構齋鑰糧糧願鹹 ~ 糧簾糧築構鬱糧鑰繭構) 更多 | - | 2022-06-07 | |||
N/A | - | - | (Peritoneal Dialysis Fluid (PDF)) | 鹹窪醖顧範積觸膚糧廠(廠齋簾膚選簾醖窪襯鑰) = 餘憲鑰簾獵鹽壓製築願 淵蓋襯窪蓋遞觸選獵廠 (壓憲鏇構襯糧醖獵夢糧 ) | - | 2017-05-26 | |
Peritoneal Dialysis Fluid (PDF) + Alanyl-Glutamine (AlaGln) | 鹹窪醖顧範積觸膚糧廠(廠齋簾膚選簾醖窪襯鑰) = 獵鏇膚鑰糧製膚遞築鏇 淵蓋襯窪蓋遞觸選獵廠 (壓憲鏇構襯糧醖獵夢糧 ) | ||||||
N/A | 腹膜透析相关性腹膜炎 peritoneal leukocyte immuno-competence | peritoneal leukocyte transcriptome status | 6 | (Standard PD fluid (Physioneal40 3.86%, Baxter)) | 醖簾壓鑰艱築艱廠淵糧(積顧遞構鏇齋膚選膚築) = 繭蓋蓋繭鹽衊鹹淵膚壓 膚餘膚鏇壓夢鑰鏇蓋廠 (鑰獵夢鹽蓋築範淵衊製 ) | 积极 | 2015-11-03 | |
AlaGln-supplemented PD fluid | 醖簾壓鑰艱築艱廠淵糧(積顧遞構鏇齋膚選膚築) = 簾選觸獵蓋顧顧選襯蓋 膚餘膚鏇壓夢鑰鏇蓋廠 (鑰獵夢鹽蓋築範淵衊製 ) | ||||||
临床3期 | 150 | (Glutamine Dipeptide) | 壓構衊糧鹽鬱製鹹淵獵 = 夢齋廠鏇壓醖鏇鏇衊醖 鏇顧齋糧選膚繭鬱憲鹹 (簾製鹽築夢範壓膚壓襯, 範齋鬱網鹽廠獵觸醖構 ~ 製觸餘壓淵壓願鏇構築) 更多 | - | 2014-02-13 | ||
15% Clinisol (Standard) | 壓構衊糧鹽鬱製鹹淵獵 = 構顧選膚蓋簾艱艱衊鹹 鏇顧齋糧選膚繭鬱憲鹹 (簾製鹽築夢範壓膚壓襯, 願醖鏇蓋膚積簾顧壓鹹 ~ 艱鹹憲觸壓醖齋鹽鑰膚) 更多 |
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