更新于：2024-11-04
Alanylglutamine
丙氨酰谷氨酰胺
更新于：2024-11-04
概要
基本信息
最高研发阶段批准上市 |
首次获批日期 德国 (1995-04-01) |
最高研发阶段(中国)批准上市 |
特殊审评孤儿药 (美国) |
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结构
分子式C8H15N3O4 |
InChIKeyHJCMDXDYPOUFDY-WHFBIAKZSA-N |
CAS号39537-23-0 |
关联
20
项与 丙氨酰谷氨酰胺 相关的临床试验Efficacy of Perioperative Infusion of N (2)-L-alanyl-L-glutamine in Glycemic Control for Patients With Uncontrolled Diabetes Mellitus Presented for Urgent Coronary Artery Bypass Surgery: Randomized Control Trial
The ameliorative potential of L-alanyl L-glutamine dipeptide in colon cancer patients receiving modified FOLFOX-6 regarding the incidence of diarrhea, the treatment response, and patients’ survival: a randomized controlled trial
Alanyl-glutamine Supplementation of Standard Treatment for C. Difficile Infection: a Randomized, Double-blind, Placebo-controlled Trial
100 项与 丙氨酰谷氨酰胺 相关的临床结果
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100 项与 丙氨酰谷氨酰胺 相关的转化医学
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100 项与 丙氨酰谷氨酰胺 相关的专利（医药）
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491
项与 丙氨酰谷氨酰胺 相关的文献（医药）2024-12-01EXPERIMENTAL EYE RESEARCH
Hyperglycemia-depleted glutamine contributes to the pathogenesis of diabetic corneal endothelial dysfunction
Article
作者: Chen, Huilin ; Chen, Chen ; Zhou, Qingjun ; Zhao, Can ; Yu, Mengmeng ; Wang, Ting ; Xie, Lixin
Diabetic mellitus (DM) causes various complications, including the corneal endothelial dysfunction that leads to corneal edema and vision loss, especially in the DM patients with intraocular surgeries. However, the pathogenic mechanism of hyperglycemia-caused corneal endothelial dysfunction remains incomplete understood. Here we firstly screened and identified the glutamine contents of aqueous humor (AH) were significantly reduced in the type 2 diabetic patients and type 1 and type 2 diabetic mice. To explore the potential therapeutic effects of glutamine (Gln) supplement on the protection of diabetic corneal endothelial dysfunction, we performed the anterior chamber perfusion with the addition of L-alanyl-L-glutamine (Ala-Gln), and confirmed that Ala-Gln supplement not only accelerated the resolution of corneal edema and recovery of corneal thickness, but also preserved the regular arrangement and barrier-pump function of cornea. Mechanistically, we revealed that the supplements of Ala-Gln protect corneal endothelial cells (CECs) from the deleterious effects of high glucose-induced oxidative stress, mitochondrial dysfunction, and cell apoptosis. Overall, these results indicate the Gln depletion plays an important role in the diabetic corneal endothelial dysfunction, while the Ala-Gln supplement during intraocular surgery provide an effective prevention strategy through regulating the redox homeostasis and mitochondrial function of corneal endothelium.
2024-11-01INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Fabrication of versatile and durable superhydrophobic cotton fabrics using PTA-Ala adhesive
Article
作者: Xing, Tieling ; Xing, Lili ; Li, Wenji ; Chen, Guoqiang ; Cheng, Jin ; Yang, Haiwei
In recent years, the preparation of functional textiles based on polyphenols adhesion has received extensive attention and research. However, polyphenols are prone to peroxidation during oxidative polymerization, which can compromise the interfacial adhesion of their monomers. Reintroducing reactive functional groups after oxidative polymerization of polyphenols may potentially compensate for the lost interfacial adhesion while increasing cohesion. In this paper, L-alanine (Ala) is introduced into poly (tannic acid) (PTA) solution to generate the PTA-Ala via Michael addition and Schiff base reaction. Original cotton fabrics are modified with PTA-Ala solution to enhance adhesion strength between the fabrics and subsequent functional modifiers. A silver nanowire network is then incorporated to increase the surface roughness through tannic acid reduction. Finally, polydimethylsiloxane is applied to reduce fabric surface energy, resulting in superhydrophobic multifunctional OH-PDMS/Ag/PTA-Ala/cotton fabrics. The finished cotton fabric exhibits a water contact angle of 166.7 ± 1.9° and a rolling angle of 5 ± 0.5°. Moreover, the fabric features diverse functionalities such as oil-water separation, photothermal conversion, antimicrobial properties, water collection, and anti-icing capabilities, alongside excellent durability and self-healing properties that extend its service life. This finished cotton fabric demonstrates promising applications in oil pollution control, outdoor clothing and medical protection, highlighting its broad across various industries.
2024-10-31JOURNAL OF PHYSICAL CHEMISTRY B
Deciphering Spectroscopic Signatures of Competing Ca2+ - Peptide Interactions
Article
作者: Schneider, Paul ; Sutter, Johannes ; Hunger, Johannes ; Meyer, Raphael ; Krevert, Carola S. ; Gunkel, Lucas ; Nagata, Yuki
Calcium-protein interactions are of paramount importance in biochemistry. They are a key element in a number of biological processes, such as neuronal signaling. Therefore, an understanding of the interaction at the molecular level is highly desirable. Here, we study the zwitterionic model peptide l-alanyl-l-alanine (2Ala), which has two distinct and competing binding sites for Ca2+: The carbonyl of the peptide bond and the C-terminus, the carboxylate group. We perform linear and two-dimensional IR spectroscopy experiments and find that the spectroscopic signatures of both moieties in the IR spectra change in amplitude and peak position upon the addition of CaCl2: A blueshift of the asymmetric carboxylate band and a redshift for the amide I mode. Ab initio molecular dynamics simulations confirm the direct interaction of the Ca2+ ion at both the carboxylate and the amide CO site leading to different spectral responses. The blueshift of the asymmetric carboxylate band is caused by a localization of the charge, leading to a decoupling of the CO stretching modes of the carboxylate group. The slight redshift of the amide I mode of 2Ala upon the addition of CaCl2 contrasts the blueshift that has been observed for isolated amide motifs, such as N-methylacetamide (NMA). This difference is caused by the smaller number of water molecules being replaced by the Ca2+ ion for 2Ala's amide compared to less sterically hindered, isolated amide carbonyls, in conjunction with vibrational Stark effects. Our results highlight the importance of considering potential competing binding sites, such as the amide CO backbone, the termini and residues, as well as the nature of the hydration of both peptide and ion, when exploring ions' interacting with small peptides and larger proteins.
100 项与 丙氨酰谷氨酰胺 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 谷氨酰胺缺乏症 | 中国 | 1999-04-03 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 终末期肾脏病 | 临床2期 | 奥地利 | 2022-03-16 | |
| 腹膜炎 | 临床2期 | 奥地利 | 2014-06-02 | |
| 膳食补充剂 | 临床1期 | 中国 | - | |
| 膳食补充剂 | 临床1期 | 中国 | - | |
| 腹膜纤维变性 | 临床前 | 荷兰 | 2015-11-03 |
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临床结果
临床结果
适应症
分期
评价
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临床3期 | 60 | (Glutamine) | 膚遞獵製願廠襯範淵鏇(範齋觸鑰製夢蓋蓋膚蓋) = 憲廠鬱衊鏇餘製窪餘餘 選襯膚網範蓋齋範鹽積 (夢壓窪顧願選製願糧艱, 製艱顧壓遞遞積憲襯壓 ~ 廠膚鏇蓋艱鬱艱鹽鹽艱) 更多 | - | 2023-11-13 | ||
Placebo (Control) | 膚遞獵製願廠襯範淵鏇(範齋觸鑰製夢蓋蓋膚蓋) = 襯鏇網襯蓋積積積顧網 選襯膚網範蓋齋範鹽積 (夢壓窪顧願選製願糧艱, 夢網齋觸願鏇襯觸壓遞 ~ 衊繭憲選艱鏇鏇觸積鹽) 更多 | ||||||
临床2期 | 7 | 夢襯齋蓋醖鹽範夢襯選(醖壓簾鹽襯範願襯餘糧) = 繭廠鏇鏇淵淵窪簾蓋餘 鹽鏇鬱鏇繭築蓋膚製鏇 (繭鏇淵構衊鏇選蓋願艱, 觸艱壓製蓋範構製壓顧 ~ 願衊製鹽衊願淵鬱鏇衊) 更多 | - | 2022-06-07 | |||
N/A | - | - | 壓餘鏇顧糧衊構鏇積窪(選製獵醖鑰獵餘糧窪鏇) = 壓觸窪鹹顧網繭範願襯 醖築構餘憲獵積糧築築 (簾壓淵鑰壓積膚齋製醖 ) | - | 2017-05-26 | ||
Peritoneal Dialysis Fluid (PDF) + Alanyl-Glutamine (AlaGln) | 壓餘鏇顧糧衊構鏇積窪(選製獵醖鑰獵餘糧窪鏇) = 壓觸廠繭繭鹹鹹鏇壓觸 醖築構餘憲獵積糧築築 (簾壓淵鑰壓積膚齋製醖 ) | ||||||
N/A | 腹膜透析相关性腹膜炎 peritoneal leukocyte immuno-competence | peritoneal leukocyte transcriptome status | 6 | 鏇夢獵襯鹹鑰膚築糧膚(築壓衊鹽顧顧餘鬱繭艱) = 齋淵觸夢簾夢選網顧廠 襯鏇製淵鑰網醖膚積淵 (獵鏇糧願艱醖壓鏇齋願 ) | 积极 | 2015-11-03 | ||
AlaGln-supplemented PD fluid | 鏇夢獵襯鹹鑰膚築糧膚(築壓衊鹽顧顧餘鬱繭艱) = 繭淵艱鹹蓋積製積簾鹹 襯鏇製淵鑰網醖膚積淵 (獵鏇糧願艱醖壓鏇齋願 ) | ||||||
临床3期 | 150 | (Glutamine Dipeptide) | 餘築壓網築憲夢觸簾範(糧顧鹹齋蓋觸糧願壓窪) = 顧糧餘顧窪觸襯鏇淵醖 觸淵積蓋鬱築製壓繭鏇 (積壓網積鬱蓋築鑰廠網, 鑰構願願構餘網醖鏇範 ~ 獵衊齋顧鏇鏇積夢網餘) 更多 | - | 2014-02-13 | ||
15% Clinisol (Standard) | 餘築壓網築憲夢觸簾範(糧顧鹹齋蓋觸糧願壓窪) = 遞糧襯糧積艱鹹窪憲願 觸淵積蓋鬱築製壓繭鏇 (積壓網積鬱蓋築鑰廠網, 壓壓築艱鹽憲鑰襯夢範 ~ 積夢醖範構廠鏇蓋壓鹽) 更多 |
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