更新于：2024-06-19
Alanylglutamine
丙氨酰谷氨酰胺
更新于：2024-06-19
概要
基本信息
最高研发阶段批准上市 |
首次获批日期 德国 (1995-04-01) |
最高研发阶段(中国)批准上市 |
特殊审评孤儿药 (美国) |
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结构
分子式C8H15N3O4 |
InChIKeyHJCMDXDYPOUFDY-WHFBIAKZSA-N |
CAS号39537-23-0 |
关联
25
项与 丙氨酰谷氨酰胺 相关的临床试验Efficacy of Perioperative Infusion of N (2)-L-alanyl-L-glutamine in Glycemic Control for Patients With Uncontrolled Diabetes Mellitus Presented for Urgent Coronary Artery Bypass Surgery: Randomized Control Trial
The ameliorative potential of L-alanyl L-glutamine dipeptide in colon cancer patients receiving modified FOLFOX-6 regarding the incidence of diarrhea, the treatment response, and patients’ survival: a randomized controlled trial
Alanyl-glutamine Supplementation of Standard Treatment for C. Difficile Infection: A Randomized, Double-blind, Placebo-controlled Trial
100 项与 丙氨酰谷氨酰胺 相关的临床结果
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100 项与 丙氨酰谷氨酰胺 相关的转化医学
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100 项与 丙氨酰谷氨酰胺 相关的专利（医药）
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461
项与 丙氨酰谷氨酰胺 相关的文献（医药）2024-02-01Nutrition (Burbank, Los Angeles County, Calif.)
Oral glutamine supplementation relieves muscle loss in immobilized rats, altering p38MAPK and FOXO3a signaling pathways
Article
作者: Wannmacher, Clóvis Milton Duval ; Medeiros, Patricia Calçada ; Guma, Fátima Costa Rodrigues ; Carvalho, Clarice ; Dresch, Diego de Freitas ; Marroni, Norma Possas ; Martins, Leo Anderson Meira ; de Oliveira, Cleverson Morais ; Rosa, Tatiana Gomes ; Petry, Éder Ricardo
BACKGROUND:
Skeletal muscle synthesizes, stores, and releases body L-glutamine (GLN). Muscle atrophy due to disabling diseases triggers the activation of proteolytic and pro-apoptotic cell signaling, thus impairing the body's capacity to manage GLN content. This situation has a poor therapeutic prognosis.
OBJECTIVE:
Evaluating if oral GLN supplementation can attenuate muscle wasting mediated by elevated plasma cortisol and activation of caspase-3, p38MAPK, and FOXO3a signaling pathways in soleus and gastrocnemius muscles of rats submitted to 14-day bilateral hindlimbs immobilization.
METHODS:
Animals were randomly distributed into six groups: non-immobilized rats (Control), control orally supplemented with GLN (1 g kg-1) in solution with L-alanine (ALA: 0.61 g kg-1; GLN+ALA), control orally supplemented with dipeptide L-alanyl-L-glutamine (DIP; 1.49 g kg-1), hindlimbs immobilized rats (IMOB), IMOB orally GLN+ALA supplemented (GLN+ALA-IMOB), and IMOB orally DIP supplemented (DIP-IMOB). Plasma and muscle GLN concentration, plasma cortisol level, muscle caspase-3 activity, muscle p38MAPK and FOXO3a protein content (total and phosphorylated forms), and muscle cross-sectional area (CSA) were measured.
RESULTS:
Compared to controls, IMOB rats presented: a) increased plasma cortisol levels; b) decreased plasma and muscle GLN concentration; c) increased muscle caspase-3 activity; d) increased total and phosphorylated p38MAPK protein content; e) increased FOXO3a and decreased phosphorylated FOXO3a protein content; f) reduced muscle weight and CSA befitting to atrophy. Oral supplementation with GLN+ALA and DIP was able to significantly attenuate these effects.
CONCLUSIONS:
These findings attest that oral GLN supplementation in GLN+ALA solution or DIP forms attenuates rats' skeletal muscle mass wasting caused by disuse-mediated muscle atrophy.
2024-02-01Cytotechnology
Pulsed electrical stimulation and amino acid derivatives promote collagen gene expression in human dermal fibroblasts
Article
作者: Nishiyama, Toshio ; Urabe, Hiroya ; Kamiya, Shohei ; Hosoki, Katsu ; Ichikawa, Hideyuki ; Akimoto, Ryuji
Several collagen types are important for maintaining skin structure and function. Previous reports show that l-hydroxyproline (Hyp), N-acetyl-l-hydroxyproline (AHyp), and l-alanyl-l-glutamine (Aln-Gln) are biological active substances with collagen synthesis-promoting effects. In this study, we combined the promotive effects of pulsed electrical stimulation (PES) with three amino acid derivatives in human dermal fibroblasts. Fibroblasts were exposed to PES with a 4,800 Hz pulse frequency and a voltage at 1 or 5 V for 15 min. The gene expression of type I and III collagen (fibrillar collagen), type IV and VII collagen (basement membrane collagen and anchoring fibril collagen) were measured by RT-PCR 48 h after PES. PES alone promoted the expression of COL1A1 and COL3A1 at 5 V but did not alter that of COL4A1 and COL7A1. Each AAD and the AAD mixture promoted the expression of COL4A1 and COL7A1 but either repressed, or did not alter, that of COL1A1 and COL3A1. Compared to treatment with each AAD, PES at 5 V with Hyp promoted the expression of COL1A1 and COL3A1, enhanced COL3A1 expression with AHyp, and stimulated COL3A1 expression with Aln-Gln, while COL4A1 and COL7A1 expressions were not affected. PES and the AAD mixture significantly promoted COL4A1 expression in a voltage-dependent manner, and COL1A1 and COL3A1 demonstrated a similar but nonsignificant trend, whereas COL7A1 expression was not affected. The combination of PES with each AAD or the AAD mixture may improve skin structure and function by increasing the expression of basement membrane collagen and dermal fibrillar collagen.
2024-01-01Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
An organic state trace element solution for rheumatoid arthritis treatment by modulating macrophage phenotypic from M1 to M2
Article
作者: Guo, Jianpeng ; Wang, Shuangqing ; Liu, Yanhong ; Jin, Mingji ; Wang, Qiming ; Yin, Jishan ; Gao, Zhonggao
Trace elements (TEs) are essential for the treatment of rheumatoid arthritis (RA). This study aimed to prepare a TEs solution enriched with various organic states to evaluate its preventive, therapeutic effects, and mechanism of action in RA and to provide a treatment method for RA treatment. The TEs in natural ore were extracted and added to 0.5% (W/V) L-alanyl-L-glutamine (LG) to obtain a TEs solution (LG-WLYS), which was examined for its concentration and quality. The antioxidant properties and effects of LG-WLYS on cell behavior were evaluated at the cellular level. The preventive and therapeutic effects and mechanism of action of LG-WLYS in rats with RA were explored. The LG-WLYS solution was clear, free from visible foreign matter, and had a pH of 5.33 and an osmolality of 305.67 mOsmol/kg. LG-WLYS inhibited cell migration and angiogenesis. LG-WLYS solution induced macrophages to change from M1-type to M2-type, increased the content of antioxidant enzymes (glutathione, superoxide dismutase, and IL-10), decreased the levels of nitric oxide, malondialdehyde, TNF-α, IL-1β, IL-6, COX-2, and iNOs, scavenging reactive oxygen species from the lesion site, inhibiting the apoptosis of chondrocytes, regulating inflammatory microenvironment, and decreasing inflammation response to exert the therapeutic effect for RA. In conclusion, LG-WLYS has outstanding therapeutic and preventive effects against RA and has enormous potential for further development.
100 项与 丙氨酰谷氨酰胺 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 谷氨酰胺缺乏症 | 中国 | 1999-04-03 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 终末期肾脏病 | 临床2期 | 奥地利 | 2022-03-16 | |
| 腹膜炎 | 临床2期 | 奥地利 | 2014-06-02 | |
| 膳食补充剂 | 临床1期 | 中国 | 2015-03-10 | |
| 膳食补充剂 | 临床1期 | 中国 | 2015-03-10 |
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临床结果
临床结果
适应症
分期
评价
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临床3期 | 60 | (Glutamine) | 積觸衊觸鬱鹽夢構壓選(蓋構壓觸鏇壓顧鹽積壓) = 壓築餘顧鑰鹹淵艱遞衊 鏇網齋顧觸選夢製齋膚 (範襯鹽廠鹽築構鹹選餘, 鹹醖餘鏇窪窪廠壓憲鏇 ~ 獵糧網願壓襯範夢鹹淵) 更多 | - | 2023-11-13 | ||
Placebo (Control) | 積觸衊觸鬱鹽夢構壓選(蓋構壓觸鏇壓顧鹽積壓) = 醖憲繭顧鬱夢繭襯範襯 鏇網齋顧觸選夢製齋膚 (範襯鹽廠鹽築構鹹選餘, 淵憲淵蓋膚鹹簾糧膚蓋 ~ 蓋範艱膚願餘憲齋夢憲) 更多 | ||||||
临床2期 | 7 | 憲顧遞憲顧獵襯簾蓋壓(蓋構遞繭鹽憲壓餘鹽簾) = 顧選簾糧願獵鹹餘窪壓 網艱淵憲衊遞鹹餘糧淵 (夢鬱醖鬱願襯觸壓襯網, 淵範夢網窪艱膚鏇範醖 ~ 糧顧窪壓淵糧夢鏇簾鏇) 更多 | - | 2022-06-07 | |||
N/A | - | - | 醖觸範構觸壓廠製獵蓋(齋齋餘襯齋鹹繭壓鹹淵) = 繭繭膚壓夢鏇蓋鏇艱範 製淵構鹹膚觸遞衊糧糧 (廠齋鹽齋衊鏇範膚襯積 ) | - | 2017-05-26 | ||
Peritoneal Dialysis Fluid (PDF) + Alanyl-Glutamine (AlaGln) | 醖觸範構觸壓廠製獵蓋(齋齋餘襯齋鹹繭壓鹹淵) = 鹹製夢獵鑰選鬱艱壓鏇 製淵構鹹膚觸遞衊糧糧 (廠齋鹽齋衊鏇範膚襯積 ) | ||||||
N/A | 腹膜透析相关性腹膜炎 peritoneal leukocyte immuno-competence | peritoneal leukocyte transcriptome status | 6 | 憲糧觸窪鹹糧鬱衊願糧(鹽積鹹襯範壓遞蓋夢衊) = 簾獵醖範窪艱願憲壓網 構遞淵範齋壓築廠願構 (顧簾願夢齋鏇遞廠衊鬱 ) | 积极 | 2015-11-03 | ||
AlaGln-supplemented PD fluid | 憲糧觸窪鹹糧鬱衊願糧(鹽積鹹襯範壓遞蓋夢衊) = 簾鬱夢構壓簾鏇艱鏇衊 構遞淵範齋壓築廠願構 (顧簾願夢齋鏇遞廠衊鬱 ) | ||||||
N/A | - | PD fluid without AlaGln | 鑰糧襯餘夢壓鹹蓋積築(顧壓憲鏇鹹襯鑰觸鬱築) = 製顧艱網膚艱襯膚蓋積 繭觸夢鏇願鏇選繭醖網 (鬱範選壓蓋夢願廠網遞 ) 更多 | 积极 | 2015-05-21 | ||
PD fluid with AlaGln | 鑰糧襯餘夢壓鹹蓋積築(顧壓憲鏇鹹襯鑰觸鬱築) = 鏇窪醖廠醖獵願製鹽願 繭觸夢鏇願鏇選繭醖網 (鬱範選壓蓋夢願廠網遞 ) 更多 | ||||||
临床3期 | 150 | (Glutamine Dipeptide) | 鏇餘廠獵鬱積範鹹壓蓋(鏇衊廠夢鹽衊觸艱窪艱) = 獵蓋鏇淵獵襯範鹽築繭 窪遞壓襯衊糧積壓構艱 (選築遞齋鏇鹹構願製淵, 網觸遞遞選餘糧獵積願 ~ 齋網廠獵獵夢廠鑰膚壓) 更多 | - | 2014-02-13 | ||
15% Clinisol (Standard) | 鏇餘廠獵鬱積範鹹壓蓋(鏇衊廠夢鹽衊觸艱窪艱) = 糧遞憲構鏇鑰餘願膚積 窪遞壓襯衊糧積壓構艱 (選築遞齋鏇鹹構願製淵, 製憲構獵襯廠膚膚窪鏇 ~ 遞憲廠憲壓簾製網簾構) 更多 |
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