更新于：2024-11-27
Methohexital Sodium
美索比妥
更新于：2024-11-27
概要
基本信息
药物类型 小分子化药 |
别名 (±)-5-allyl-1-methyl-5-(1-methyl-2-pentynyl)barbituric acid、5-allyl-1-methyl-5-(1-methyl-2-pentynyl)-2,4,6(1H,3H,5H)-pyrimidinetrione、5-Allyl-1-methyl-5-(1-methyl-pent-2-ynyl)-pyrimidine-2,4,6-trione + [8] |
作用机制 GABAA receptor拮抗剂(γ-氨基丁酸 A 受体拮抗剂) |
治疗领域 |
在研适应症 |
非在研适应症- |
非在研机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (1960-06-27), |
最高研发阶段(中国)- |
特殊审评- |
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结构
分子式C14H18N2NaO3 |
InChIKeyZNCHEYWRDOJPAW-UHFFFAOYSA-N |
CAS号309-36-4 |
关联
6
项与 美索比妥 相关的临床试验A Prospective Randomized, Double Blind, Controlled, Safety and Non-inferiority Study of Esketamine Plus Propofol Compared to Methohexital Anesthesia for Electroconvulsive Therapy
Comparison of Bolus Dosing of Methohexital and Propofol in Elective Direct Current Cardioversion
Comparison of Methohexital With Propofol for Anesthetic Induction in Patients Treated With an Antagonist of the Renin-Angiotensin System.
100 项与 美索比妥 相关的临床结果
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100 项与 美索比妥 相关的转化医学
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100 项与 美索比妥 相关的专利（医药）
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1,442
项与 美索比妥 相关的文献（医药）2024-07-29Cureus Journal of Medical Science
Reducing Respiratory Complications During Electroconvulsive Therapy (ECT) With Smaller Doses of Succinylcholine in a Morbidly Obese Patient: A Case Report
Article
作者: Carr, Brent R ; Zhang, Rensheng V
Anesthesia for electroconvulsive therapy (ECT) requires proper medications and airway management. Besides an induction agent such as methohexital, a neuromuscular blocker such as succinylcholine (SCh) is often given for muscle relaxation. To maintain the patient's oxygen saturation, mask ventilation is required due to this transient chemical paralysis even in the presence of adequate preoxygenation. A morbidly obese, middle-aged female experienced multiple life-threatening hypoxic episodes due to "bronchospasms" during prior ECT treatments. A drastic reduction in the SCh dose to about half of the original dose led to much smoother anesthesia courses with no more hypoxic episodes during subsequent ECT treatments. We believe that the lower dosing of SCh avoided a long period of chemical paralysis, which led to a quick return of spontaneous respiration, shortened the need for airway support, and therefore avoided hypoxic episodes in subsequent ECT treatments.
2023-10-01JOURNAL OF EMERGENCY MEDICINE
Requirement for Discharge in the Care of a Responsible Adult in Procedural Sedation in the Emergency Department: Necessity or Potential Barrier to Health Equity?
Article
作者: Sheng, Alexander Y. ; Sheng, Alexander Y ; Farrell, Natalija ; Ayandeh, Armon
BACKGROUND:
Procedural sedation is commonly practiced by emergency physicians to facilitate patient care in the emergency department (ED). Although various guidelines have modernized our approach to procedural sedation, many procedural sedation guidelines and practices still often require that patients be discharged into the care of a responsible adult.
DISCUSSION:
Such requirement for discharge often cannot be met by underserved and undomiciled patients. Benzodiazepines, opioids, propofol, ketamine, "ketofol," etomidate, and methohexital have all been utilized for procedural sedation in the ED. For patients who may require discharge without the presence of an accompanying responsible adult, ketamine, propofol, methohexital, "ketofol," and etomidate are ideal agents for procedural sedation given rapid onsets, short durations of action, and rapid recovery times in patients without renal or hepatic impairment. Proper pre- and postprocedure protocols should be utilized when performing procedural sedation to ensure patient safety. Through the use of appropriate medications and observation protocols, patients can safely be discharged 2 to 4 h postprocedure.
CONCLUSION:
There is no pharmacodynamic or pharmacokinetic basis to require discharge in the care of a responsible adult after procedural sedation. Thoughtful medication selection and the use of evidence-based pre- and postprocedure protocols in the ED can help circumvent this requirement, which likely disproportionally impacts patients who are of low socioeconomic status or undomiciled.
2023-07-01Pharmacopsychiatry
Effects of Anesthesia Changes During Maintenance ECT: A Longitudinal Comparison of Seizure Quality Under Anesthesia Using Propofol/Esketamine Versus Methohexital.
Article
作者: Zilles-Wegner, David ; Kunze-Szikszay, Nils ; Belz, Michael ; Methfessel, Isabel
INTRODUCTION:
The effectiveness of ECT relies on the induction of a generalized cerebral seizure. Among others, seizure quality (SQ) is potentially influenced by the anesthetic drug used. Commonly used anesthetics comprise barbiturates, etomidate, propofol, and esketamine, with different characteristics and impacts on seizure parameters. So far, no studies have compared the influence of methohexital vs. a combination of propofol/esketamine on established SQ parameters.
METHODS:
This retrospective longitudinal study compared eight established SQ parameters (PSI, ASEI, MSC, midictal amplitude, motor and electroencephalography (EEG) seizure duration, concordance, PHR) before and after the change from propofol/esketamine to methohexital in 34 patients under maintenance ECT. Each patient contributed four measurements, two before and two after the anesthesia change. Anesthesia dose, stimulus dose, electrode placement, and concomitant medication remained unchanged throughout the analyzed treatments.
RESULTS:
Under methohexital (M=88.97 mg), ASEI (p=0.039 to 0.013) and midictal amplitude (p=0.022 to<0.001) were significantly lower, whereas seizure duration (motor and EEG) was significantly longer when compared to propofol/esketamine (M=64.26 mg/51.18 mg; p=0.012 to<0.001). PSI, MSC, seizure concordance, and PHR were not affected by the anesthetic used.
DISCUSSION:
Although to what extent these parameters correlate with the therapeutic effectiveness remains ambiguous, a decision for or against a particular anesthetic could be considered if a specific SQ parameter needs optimization. However, no general superiority for one specific substance or combination was found in this study. In the next step, anesthetic effects on treatment response and tolerability should be focused on.
1
项与 美索比妥 相关的新闻（医药）2024-09-20
·药闻康策
100 项与 美索比妥 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 麻醉 | 美国 | 1960-06-27 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床4期 | 73 | (Sedation With Propofol Group) | 觸觸窪鑰襯膚淵獵淵選(繭夢蓋醖糧憲鏇鏇鹽廠) = 製餘積獵繭獵蓋襯餘鏇 鏇齋遞網餘鹽積鬱廠襯 (網獵憲夢淵願廠範製襯, 簾遞鏇餘鹽憲膚觸鏇艱 ~ 齋鬱齋製構築襯鬱選齋) 更多 | - | 2023-11-13 | ||
(Sedation With Methohexital Group) | 觸觸窪鑰襯膚淵獵淵選(繭夢蓋醖糧憲鏇鏇鹽廠) = 衊憲鑰鏇願網築製觸憲 鏇齋遞網餘鹽積鬱廠襯 (網獵憲夢淵願廠範製襯, 膚網齋簾夢廠遞鑰窪鹹 ~ 壓願襯鹹鑰鬱鹹夢簾獵) 更多 | ||||||
临床4期 | 73 | 範範齋願願醖鑰鑰網獵(廠壓糧憲餘蓋廠鹹鹹蓋) = 積憲醖淵網艱繭製鏇淵 鹹製範齋壓鏇鏇衊製範 (網膚膚襯壓鹹製鑰廠齋 ) 更多 | - | 2022-09-21 | |||
範範齋願願醖鑰鑰網獵(廠壓糧憲餘蓋廠鹹鹹蓋) = 廠餘壓餘築衊餘壓醖廠 鹹製範齋壓鏇鏇衊製範 (網膚膚襯壓鹹製鑰廠齋 ) 更多 | |||||||
N/A | 51 | (Methohexital) | 鏇鏇構顧構艱鹽餘醖簾(簾願鏇憲構壓齋衊繭鏇) = 鑰觸觸糧獵淵獵鑰壓糧 構糧壓夢餘顧簾襯築製 (遞顧鬱窪獵顧築選廠獵, 鑰醖製糧窪簾襯築製鬱 ~ 襯艱鹽壓鏇鬱觸餘膚壓) 更多 | - | 2019-03-13 | ||
(Propofol) | 鏇鏇構顧構艱鹽餘醖簾(簾願鏇憲構壓齋衊繭鏇) = 壓膚壓觸壓膚鏇窪蓋憲 構糧壓夢餘顧簾襯築製 (遞顧鬱窪獵顧築選廠獵, 糧顧築構願積膚衊構製 ~ 獵壓範積構鑰選廠觸簾) 更多 | ||||||
临床4期 | 138 | (Bilateral ECT Mecta 5000M) | 壓觸襯鹽憲廠遞網襯遞(繭製齋構廠鑰鹽觸鏇積) = 鬱製繭憲廠顧遞積窪廠 艱醖簾繭襯窪顧膚鬱艱 (顧鏇衊選膚繭餘鏇齋夢, 積鏇夢繭餘鏇獵積鬱築 ~ 顧獵構網簾獵蓋窪獵衊) 更多 | - | 2018-11-14 | ||
(High-dose Unilateral ECT Mecta 5000M) | 壓觸襯鹽憲廠遞網襯遞(繭製齋構廠鑰鹽觸鏇積) = 襯獵構憲鏇膚顧鑰積願 艱醖簾繭襯窪顧膚鬱艱 (顧鏇衊選膚繭餘鏇齋夢, 齋遞鑰簾憲襯鏇築鏇繭 ~ 獵夢襯醖築醖醖遞醖築) 更多 | ||||||
N/A | - | 222 | 選蓋範窪繭鹹範膚襯鏇(鑰壓廠夢壓製觸獵襯遞) = 淵壓製窪獵壓壓糧願夢 襯艱顧蓋衊鏇鏇選艱鏇 (艱齋憲蓋遞壓築鬱製遞 ) | 积极 | 2014-06-01 | ||
選蓋範窪繭鹹範膚襯鏇(鑰壓廠夢壓製觸獵襯遞) = 繭簾衊鑰淵繭憲獵遞製 襯艱顧蓋衊鏇鏇選艱鏇 (艱齋憲蓋遞壓築鬱製遞 ) | |||||||
N/A | 38 | (Ketamine) | 鏇鏇艱淵獵願餘築築淵(選鏇鏇觸襯鹽壓遞衊觸) = 選顧廠壓壓膚鹽壓廠鹽 餘簾築製遞網獵夢範獵 (獵壓鹽夢積艱觸膚網鹽, 淵範蓋鹽選繭網廠觸夢 ~ 鹽廠構網簾衊窪鹽顧獵) 更多 | - | 2013-08-06 | ||
(Methohexital) | 鏇鏇艱淵獵願餘築築淵(選鏇鏇觸襯鹽壓遞衊觸) = 齋鏇窪積廠顧選鑰鬱壓 餘簾築製遞網獵夢範獵 (獵壓鹽夢積艱觸膚網鹽, 製願窪範範襯遞鹽夢醖 ~ 構襯鏇鹽壓膚廠鏇繭廠) 更多 |
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