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更新于：2025-05-16
Eperisone Hydrochloride
盐酸乙哌立松
更新于：2025-05-16
概要
基本信息
原研机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C17H26ClNO |
InChIKeyGTAXGNCCEYZRII-UHFFFAOYSA-N |
CAS号56839-43-1 |
关联
37
项与 盐酸乙哌立松 相关的临床试验CTR20250266
盐酸乙哌立松片在空腹及餐后条件下的人体生物等效性试验
CTR20244465
盐酸乙哌立松片餐后生物等效性试验
CTR20244466
盐酸乙哌立松片空腹生物等效性试验
100 项与 盐酸乙哌立松 相关的临床结果
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100 项与 盐酸乙哌立松 相关的转化医学
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100 项与 盐酸乙哌立松 相关的专利（医药）
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259
项与 盐酸乙哌立松 相关的文献（医药）2025-04-01SYNLETT
Comparison of the Effects of Stirring and Standing on Chemical Reactions
作者: Fang, Pengkai ; Han, Hongliang ; Liu, Zhong-Quan ; Zhao, Jianyou ; Zhang, Lanlan ; Zhang, Lanlan ; Huang, Xianting ; Han, Hongliang ; Chen, Meng ; Fang, Pengkai ; Chen, Meng ; Wang, Fan ; Xie, Wei ; Wang, Qingxu ; Xie, Wei ; Zhang, Jiatai ; Liu, Zhong-Quan ; Zhang, Jiatai ; Wang, Fan
Abstract:
For hundreds of years, it seems that people have needed stirring to conduct chemical experiments. This operation can be seen everywhere in chemical, pharmaceutical, and materials laboratories and factories. People generally believe that stirring helps with processes such as material dispersion, dissolution, and collision, thereby enabling more-efficient reactions. However, why do chemical reactions that occur in Nature not require stirring? What are the facts? For this purpose, we investigated a total of 329 organic chemical reactions in eight categories and 25 types, including 26 chemical reactions magnified to gram or even kilogram levels. Under the same conditions of temperature, humidity, pressure, and reaction time, we compared the reaction yields under stirring and standing conditions. More than 600 results showed that stirring or not stirring had almost no effect on the efficiency of chemical reactions in solution. If most chemists performing reactions turned off the agitator, it would not be difficult to imagine how much electricity could be saved!
2025-02-19POSTGRADUATE MEDICAL JOURNAL
Comparative effect of oral drugs in improving spasticity of different etiology: a network meta-analysis
Article
作者: López-López, Samuel ; Cavero-Redondo, Iván ; Saz-Lara, Alicia ; Martínez-Rodrigo, Arturo ; Moreno-Herráiz, Nerea ; Otero-Luis, Iris
Abstract:
Introduction:
Spasticity, a prevalent manifestation of various neurological conditions, significantly impacts the quality of life of patients. Research on the effects of oral drugs on spasticity has produced controversial results. Thus, the aim of this network meta-analysis was to compare the efficacy of oral drugs for improving spasticity in patients with different etiologies.
Methods:
We searched four different databases from their inception to 30 November 2023. A network meta-analysis using a frequentist perspective was conducted to assess the effects of different oral drugs on spasticity, evaluated by the modified Ashworth scale.
Results:
Our findings showed that, in a frequentist network meta-analysis, eperisone, diazepam, and baclofen had significantly greater spasticity, as measured by the modified Ashworth scale, than did the placebo (MD: −0.80; 95% CIs: −1.42, −0.18; MD: −0.68; 95% CIs: −1.28, −0.09; MD: −0.58; 95% CIs: −1.11, −0.06, respectively).
Conclusion:
In summary, our study confirmed that eperisone, diazepam, and baclofen could be effective approaches for reducing spasticity of different etiologies and could be useful approaches for improving patient quality of life.Key messages What is already known on this topic: The impact of oral drugs, such as baclofen, gabapentin, tizanidine, and dantrolene, in the treatment of spasticity has been documented. What this study adds: This study determines which of the oral drugs aimed at treating spasticity is the most effective across different etiologies. How this study might affect research, practice, or policy: This study suggests tailored treatment strategies for spasticity based on its etiology.
2025-02-13ACS Medicinal Chemistry Letters
Eperisone Analogs, Rescuers of MiaB Defects As a Prokaryotic Homologue of CDKAL1, Suppress Blood Glucose Elevation in Rats
Article
作者: Taniguchi, Shintaro ; Wei, Fan-Yan ; Tejima, Manabu ; Hashimoto, Tomoko ; Tomizawa, Kazuhito ; Hoshina, Tomoyuki ; Matsuno, Kenji ; Takasaki, Kotaro ; Ohno, Osamu ; Nakamura, Kanako
Cdk5 regulatory associated protein 1-like 1 (CDKAL1) is one of the most reliable risk genes for type 2 diabetes mellitus (T2DM). Because CDKAL1 controls glucose-induced insulin secretion by KATP channel responsiveness and faithful decoding of Lys codons to prevent mistranslation in pancreatic β-cells, a rescuer of CDKAL1 defects is expected as a new antidiabetes drug. We found that eperisone analogs effectively rescued mistranslation in a MiaB-deficient Escherichia coli dual-luciferase reporter gene system (MiaB is a prokaryotic homologue of eukaryotic CDKAL1). Among them, compounds 1f and 1t demonstrated significant antihyperglycemic efficacy in an oral glucose tolerance test by subcutaneous administration in Wister rats, along with a significant enhancement of insulin secretion in the MIN6 insulinoma cell line without cytotoxicity. These results indicate that CDKAL1 could be a viable molecular target for a new anti-T2DM medication.
100 项与 盐酸乙哌立松 相关的药物交易
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研发状态
批准上市
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 腰痛 | 日本 | 2014-05-16 | |
| 肌张力亢进 | 日本 | 2014-05-16 | |
| 颈、肩、臂综合征 | 日本 | 2014-05-16 | |
| 肩周炎 | 日本 | 2014-05-16 | |
| 痉挛性麻痹 | 日本 | 2014-05-16 |
未上市
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 急性腰痛 | 临床3期 | - | 2014-03-01 | |
| 椎间盘疾病 | 临床3期 | - | 2014-03-01 | |
| 痉挛 | 临床3期 | 印度 | 2006-04-01 |
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