A Phase III Randomized, Double-blind, Placebo-controlled, Parallel-group, Group-sequential Study to Evaluate Efficacy, Safety and Tolerability of BI 767551 for Post-exposure Prevention of SARS-CoV-2 Infection in Household Contacts to a Confirmed SARS-CoV-2 Infected Individual

This study is open to adults living with a person who has tested positive for the coronavirus SARS-CoV-2. People who do not have symptoms of COVID-19 can take part in this study. The study is done to find out whether a medicine called BI 767551 can prevent COVID-19. BI 767551 is an antibody against the coronavirus SARS-CoV-2.
Participants are put into 3 groups randomly, which means by chance.
1 group gets BI 767551 via an inhaler and placebo as an infusion
1 group gets BI 767551 as an infusion and placebo via an inhaler
1 group gets placebo both via an inhaler and as an infusion
All participants get study medicine once at study start and after 1 week. Placebo inhaler and infusion look like BI 767551 inhaler and infusion but do not contain any medicine.
Participants are in the study for about 3 months. During this time, they visit the study site about 10 times. About 7 of the 10 visits can be done at the participant's home. Participants are regularly tested for the coronavirus SARS-CoV-2. The doctors check whether the participants have been infected with the coronavirus and whether they have symptoms. The results are compared between the treatment groups. The doctors check the health of the participants and note any health problems that could have been caused by BI 767551.

开始日期2021-06-17

申办/合作机构

Boehringer Ingelheim GmbH

NCT04822701 / Terminated临床2/3期

A Phase II/III Seamless, Randomized, Double-blind, Placebo-controlled, Parallel-group, Group-sequential Study to Evaluate Efficacy, Safety and Tolerability of BI 767551 for the Treatment of Symptomatic, Non-hospitalized Adults With Mild to Moderate COVID-19.

This study is open to adults with mild to moderate symptoms of COVID-19 (coronavirus disease). The purpose of this study is to find out whether a medicine called BI 767551 helps people with COVID-19. BI 767551 is an antibody against the coronavirus.
The study has 2 parts.
Part 1 wants to find out the best dose of BI 767551 given as infusion into a vein. It also tests how BI 767551 is taken up by the body when taken via an inhaler. Participants are put into 4 groups by chance. Participants get BI 767551 or placebo once.
1 group gets a high dose of BI 767551 as an infusion into a vein
1 group gets a low dose of BI 767551 as an infusion into a vein
1 group gets BI 767551 via an inhaler
1 group gets placebo both as an infusion into a vein and via an inhaler
The placebo infusion and inhaler look like the BI 767551 infusion and inhaler but do not contain any medicine.
Doctors check how BI 767551 reduces the amount of coronavirus. Once the best dose of BI 767551 is found, part 2 of the study tests BI 767551 in a larger group of people. Also, in part 2, the participants get BI 767551 or placebo as an infusion into a vein once. In this part, doctors will check how many people need to be treated in a hospital or die. The results will be compared between the groups.
For each part, participants are in the study for about 13 weeks. During this time, they visit the study site about 8 times and get about 3 remote visits.
The doctors also regularly check participants' health and take note of any unwanted effects of BI 767551.

开始日期2021-04-21

申办/合作机构

Boehringer Ingelheim GmbH

NCT04631705 / Completed临床1/2期IIT

A Phase 1/2a Trial of the Inhaled Administration of the SARS-CoV-2-Neutralizing Monoclonal Antibody DZIF-10c in SARS-CoV-2-Infected and -Uninfected Individuals

This is the first-in-human phase 1/2a trial of the inhaled administration of the SARS-CoV-2-neutralizing monoclonal antibody DZIF-10c in healthy volunteers and SARS-CoV-2-infected individuals. It will evaluate the safety, pharmacokinetic profile, immunogenicity, and antiviral activity of DZIF-10c.

开始日期2020-12-14

申办/合作机构

University of Cologne Executive School GmbH

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100 项与 Lomtegovimab 相关的临床结果

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100 项与 Lomtegovimab 相关的转化医学

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100 项与 Lomtegovimab 相关的专利（医药）

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项与 Lomtegovimab 相关的文献（医药）

2024-02-01·Journal of the American Medical Directors Association

Underuse of SARS-CoV-2–Neutralizing Monoclonal Antibodies in Skilled Nursing Facilities

Article

作者: Kong, Lan ; Heilbrunn, Emily S ; Paules, Catharine I ; Kraschnewski, Jennifer L ; Osevala, Nicole ; Lehman, Erik ; Hogentogler, R Ellen ; Francis, Erica

OBJECTIVE:

Little is known about deployment of SARS-CoV-2-neutralizing monoclonal antibodies (mab) in skilled nursing facilities (SNFs), a high-risk population for COVID-19-related complications. We assessed the utilization of mabs in SNFs and identified facility characteristics associated with effective use.

DESIGN:

Retrospective cohort study assessing the correlation of SNF characteristics with increasing mab use.

SETTING AND PARTICIPANTS:

United States SNFs participating in Project ECHO (Extensions for Community Health Outcomes).

METHODS:

The primary outcome was percentage of total mabs per COVID-19 cases in SNFs. Facilities were divided into 3 groups based on the percentage of the administration of mabs per number of cases: 0%, >0% to 20%, >20%. Ordinal logistic regression was applied to assess whether facility characteristics-study group, state, location, type, size, rating at baseline, weekly average of residents vaccinated, weekly average of staff vaccinated, and total weeks short staffed-correlated with the primary outcome. A multivariable model was used to evaluate the independent effect of predictors.

RESULTS:

A total of 130 facilities were included. Between the weeks ending on May 30, 2021, and on May 29, 2022, mean mab use when accounting for the number of COVID-19 cases was 12.96% (±26.71%) and >50% of facilities administered 0 doses of mabs. Facility location was associated with mab use (P value .030), with micropolitan facilities having the highest percentage of facilities administering mabs (30.4% in >0% to 20%, and 39.1% in >20%, respectively). There was a nonsignificant trend toward increased mab use in facilities reporting fewer staffing shortages. When the multivariable ordinal logistic regression model was applied, location in a micropolitan vs metropolitan area was associated with higher odds [3.29 (1.30, 8.32), P value .012] of increasing percentage total mabs per cases.

CONCLUSIONS AND IMPLICATIONS:

COVID-19 mabs were underutilized in a high-risk population for COVID-19 hospitalization and death. Understanding the barriers to effective distribution is critical in shaping pandemic preparedness efforts for the future.

2023-10-01·Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi

Clinical efficacy and safety of SARS-CoV-2-neutralizing monoclonal antibody in patients with COVID-19: A living systematic review and meta-analysis

Article

作者: Yoon, Young Kyung ; Cheong, Chelim ; Yu, Su-Yeon ; Choi, Miyoung ; Huh, Kyungmin ; Choi, Jungwoo ; Ryoo, Seungeun ; Kim, Sun Bean

This study evaluated the efficacy and safety of neutralizing monoclonal antibodies (mAbs) with usual care in patients with coronavirus disease 2019 (COVID-19). Randomized controlled trials comparing the efficacy and safety of neutralizing mAb treatment in patients with COVID-19 were identified using electronic database searches through March 10, 2023. This systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Overall, 13 trials (23 articles) involving 25,646 patients were included in this systematic review. Compared with usual care, neutralizing mAbs were associated with significantly reduced all-cause mortality in outpatients with COVID-19 (pooled risk ratios [RR], 0.41; 95% confidence interval (CI), 0.20-0.83; 12 studies), but not in inpatients. In the subgroup analysis, only outpatients infected prior to the emergence of Delta variant or those with mAb-VOC match had significantly reduced mortality, while no significant benefit was observed in patients infected with Delta and post-Delta variants or mAb-VOC mismatch. Moreover, the rate of hospitalization and number of hospital visits had significantly reduced only in outpatients infected prior to the emergence of the Delta variant and those with mAb-VOC match. Our systematic review used majority of the high-certainty evidence. Our study found neutralizing mAbs were beneficial for outpatients infected prior to Delta variant or mAb-VOC match. In the face of the continuous emergence of new COVID-19 variants, additional clinical data are needed to determine whether neutralizing mAb treatment will be effective for the newly emerging variants.

2023-02-01·Transplant infectious disease : an official journal of the Transplantation Society

Early administration of SARS‐CoV‐2 monoclonal antibody reduces the risk of mortality in hematologic malignancy and hematopoietic cell transplant patients with COVID‐19

Article

作者: Raja, Mohammed ; Khatri, Akshay ; Natori, Yoichiro ; Viotti, Julia Bini ; Camargo, Jose F. ; Garcia, Leopoldo Cordova ; Anderson, Anthony D. ; Morris, Michele I. ; Jabr, Ra'ed

Abstract:

Background:

Data on severe acute respiratory distress syndrome coronavirus 2 monoclonal antibody (SARS‐CoV‐2‐specific mAb) use in hematologic malignancy and hematopoietic cell transplantation (HM/HCT) patients are limited. Here, we describe our experience with the use of casirivimab–imdevimab or bamlanivimab for the treatment of coronavirus disease 2019 (COVID‐19) in HM/HCT patients.

Methods:

This was a retrospective chart review at the University of Miami Hospital and Sylvester Comprehensive Cancer Center for HM/HCT patients with COVID‐19 who received casirivimab–imdevimab or bamlanivimab from November 21, 2020, to September 30, 2021. Outcomes measured were mortality, hospital admission, and infusion reaction to SARS‐CoV‐2‐specific mAbs.

Results:

We identified 59 HM/HCT patients with mild to moderate COVID‐19 who received casirivimab–imdevimab or bamlanivimab. Median age was 57 years (interquartile range [IQR]: 45–65). Among the 59 patients, 25 (42%) received cellular therapy: 14 (24%) had undergone allogeneic HCT, nine (15%) autologous HCT, and two (3%) received chimeric antigen receptor T‐cell therapy. The median time from COVID‐19 symptom onset to SARS‐CoV‐2‐specific mAb administration was 4 (IQR: 3–6) days. Forty‐six (78%) patients received SARS‐CoV‐2‐specific mAbs as outpatients and 13 (22%) patients received SARS‐CoV‐2‐specific mAbs during hospitalization. Among patients who received SARS‐CoV‐2‐specific mAbs as outpatients, only four (9%) visited the emergency department at days 10, 11, 15, and 35 after SARS‐CoV‐2‐specific mAb administration. None of these four patients required hospital admission. Among the hospitalized patients, five (38%) were admitted to the hospital with neutropenic fever, four (31%) were already hospitalized for transplantation and cellular therapy, three (23%) were admitted for monitoring of COVID‐19 symptoms, and one (8%) was admitted with acute kidney injury. Three hospitalized patients (23%) died at 14, 35, and 59 days after SARS‐CoV‐2‐specific mAb administration; two of these three deaths were attributed to COVID‐19 infection. One patient developed an immediate infusion reaction to bamlanivimab, and no infusion reactions were reported to casirivimab–imdevimab use.

Conclusion:

During the alpha and delta variant surges, early administration of bamlanivimab or casirivimab–imdevimab prevented hospitalization and death when given in the outpatient setting. Among patients who received mAbs at or after hospital admission, the risk of COVID‐19 disease progression and death remains significant. Larger studies of the use of mAb therapy to treat COVID‐19 in this population are needed. image

项与 Lomtegovimab 相关的新闻（医药）

2021-03-28

·Pharmaceutical Technology

Boehringer Ingelheim sees business growth in 2020

Boehringer Ingelheim has seen positive business momentum in 2020, according to an annual report published by the biopharmaceutical company on Wednesday. Despite the global impact of the coronavirus pandemic, Boehringer Ingelheim reported net sales of €19.57bn, an increase of 3% compared to the year before. Overall investments in R&D totalled €3.7bn, a year-on-year increase of 7%. The figure represents the highest annual investment in R&D in Boehringer Ingelheim’s 136-year history. The company added that it has shown a strong commitment to develop treatments against Covid-19 over the past year, with research efforts particularly accelerated in this area. In December 2020, the company – in collaboration with Cologne University Hospital, the University of Marburg, and the German Center for Infection Research – initiated a Phase I/IIa clinical investigation of BI 767551, the first coronavirus-neutralising antibody administrated via inhalation as a potential new therapeutic and prophylactic option to block the virus at the site of infection. The company is also undertaking research into Covid-19 antibodies that can be combined with BI 767551, small molecules to inhibit its replication, and therapies to prevent blood clots. Boehringer Ingelheim completed several acquisitions in 2020, including the purchase of Belgian veterinary biotech company Global Stem cell Technology, and the acquisition of all shares of NBE-Therapeutics, a Swiss clinical-stage biotechnology company. Boehringer also bought an equity stake in the China-based, pet medical care company New Ruipeng Group last September. Boehringer Ingelheim board of managing directors member with responsibility for finance and group functions Michael Schmelmer said: “We are pleased with the results we achieved in 2020, considering the challenging conditions we faced. We met our ambitious targets, both in terms of our contribution to the wellbeing of humans, pets and livestock, and our business performance. “This allows us to continue to invest even more in R&D, as well as in the long-term opportunities we have identified, most notably in the fields of oncology as well as digital and data technologies.” Thematic Reports Are you worried about the pace of innovation in your industry? GlobalData's TMT Themes 2021 Report tells you everything you need to know about disruptive tech themes and which companies are best placed to help you digitally transform your business. Find out more The ongoing pandemic and a more challenging industry environment, with increasing price pressure in several key markets, is expected to have an impact on Boehringer Ingelheim’s 2021 results. Provided the approved vaccines and other medicines currently undergoing the approval process help combat coronavirus, the company expects strong general market growth for prescription pharmaceuticals next year. It also expects to achieve a slight year-on-year increase in net sales on a comparable basis.

抗体疫苗小分子药物并购

2021-03-24

·BioSpace

Boehringer Ingelheim sees positive business momentum in 2020 despite impact of COVID-19

March 24, 2021 09:00 UTC Strong R&D commitment to developing therapeutics against SARS-CoV-2 virus Overall R&D investment up 7% to 3.7 billion EUR in 2020 (18.9% of net sales) Outlook 2021: slight year-on-year increase in net sales on a comparable basis INGELHEIM, Germany--(BUSINESS WIRE)-- Boehringer Ingelheim stepped up its investments in R&D significantly in 2020 in pursuit of innovative medicines and therapies for diseases for which no satisfactory treatments are available. In particular, efforts to research potential COVID-19 related therapies were accelerated. The company spent 3.7 billion EUR on R&D, 7% more than in the previous year. This represents the highest annual investment in R&D in the 136-year history of the research-driven biopharmaceutical company. “We started our R&D for potential COVID-19 therapies early in the first quarter of 2020, recognizing the urgent need,” said Hubertus von Baumbach, Chairman of the Board of Managing Directors. “Together with many partners worldwide, this work is ongoing. Our employees have done remarkable work to fight COVID-19, ensure our medicines continued to reach patients and animals, and physicians continued to be supported. Our achievements in 2020 are the result of their effort.” Building on its vast knowledge in various therapeutic areas, such as respiratory diseases and virology, Boehringer Ingelheim is engaged in several projects aimed at finding medical solutions to treat COVID-19. In December 2020, the company announced together with Cologne University Hospital, the University of Marburg, and the German Center for Infection Research the initiation of Phase I/IIa clinical investigation of BI 767551, the first SARS-CoV-2 neutralizing antibody administrated via inhalation as a potential new therapeutic and prophylactic option to block the virus at the site of infection. Other COVID-19 initiatives include the research and development of SARS-CoV-2 antibodies that can be combined with BI 767551, small molecules to inhibit its replication, and therapy development to prevent microcoagulation (blood clots). Solid performance despite COVID-19 pandemic 2020 was a good year for Boehringer Ingelheim, although the effects of the COVID-19 pandemic were omnipresent. All of its businesses contributed positively to net sales and operating income. The company recorded net sales of 19.57 billion EUR, a 3% increase compared to the previous year. Foreign currency headwinds had a considerable impact; adjusted for currency effects, net sales rose by 5.6% year on year. Emphasis on profitable growth and protecting liquidity Operating income at Group level rose to 4.62 billion EUR (2019: 3.78 billion EUR). One-time gains from divestitures supported the operating income. Income after taxes saw a 12.5% year-on-year increase to 3.06 billion EUR (2019: 2.72 billion EUR). Cash flow from operating activities increased by 619 million EUR to 3.96 billion EUR (2019: 3.34 billion EUR). At the end of 2020, the equity ratio stood at 47% (2019: 44%). “We are pleased with the results we achieved in 2020, considering the challenging conditions we faced,” said Michael Schmelmer, the Member of the Board of Managing Directors responsible for Finance and Group Functions. “We met our ambitious targets, both in terms of our contribution to the wellbeing of humans, pets and livestock, and our business performance. This allows us to continue to invest even more in R&D, as well as in the long-term opportunities we have identified, most notably in the fields of oncology as well as digital and data technologies.” Continued high investments in tangible assets The company invested 1.05 billion EUR (2019: 1.07 billion EUR) in tangible assets in 2020, including the large-scale production facility for biopharmaceutical products (LSCC) in Vienna, Austria, and the new development center for biopharmaceutical medicines (BDC) in Biberach, Germany. Expenditures in tangible assets decreased slightly compared to the all-time high in 2019, due to the partial delay of construction work caused by COVID-19. Targeted M&A activities round off the portfolio Boehringer Ingelheim completed several acquisitions in 2020 to selectively expand its portfolio. In July, the company announced the acquisition of Global Stem cell Technology (GST), a Belgian veterinary biotech company. Boehringer Ingelheim acquired GST to develop and produce state-of-the art stem cell products for horses and pets. In September, an equity stake in the China-based New Ruipeng Group, a company that specializes in providing medical care services for pets, was acquired. In December, the company announced the acquisition of all shares of NBE-Therapeutics, a clinical-stage Swiss biotechnology company focused on antibody-drug conjugates and advancing targeted cancer therapies derived from its immune stimulatory iADC™ platform. This acquisition adds another key dimension to Boehringer Ingelheim’s focus on patients with difficult-to-treat solid tumors as part of the company’s comprehensive oncology development portfolio. Human Pharma – Strong growth across all regions At 14.42 billion EUR, net sales of human pharmaceuticals grew strongly by 5.8% (year on year and adjusted for currency effects) and accounted for 74% of total net sales. All regions contributed to the strong results in Human Pharma. The United States remains the largest market for Boehringer Ingelheim with the highest regional net sales in the Human Pharma business. Boehringer Ingelheim generated net sales of 5.66 billion EUR in the US, up 3.4% (year on year and adjusted for currency effects). In the EUCAN region (Europe, Canada, Australia, and New Zealand), net sales rose by 6.0% (year on year and adjusted for currency effects) to 4.59 billion EUR. In Emerging Markets, including the People’s Republic of China, Boehringer Ingelheim registered net sales of 2.84 billion EUR, a 10.4% increase (year on year and adjusted for currency effects). In Japan, net sales increased by 6.2% (year on year and adjusted for currency effects) to 1.33 billion EUR. Medicines for the treatment of cardiovascular and metabolic diseases, as well as respiratory diseases, remain the most important contributors to net sales. JARDIANCE®, a medicine used along with diet and exercise to lower blood sugar in adults with type 2 diabetes, remains the biggest revenue contributor in Human Pharma, generating net sales of 2.48 billion EUR (2019: 2.15 billion EUR). JARDIANCE® reduces the risk of cardiovascular death in adults with type 2 diabetes who have known cardiovascular disease. OFEV® was the company’s second-strongest revenue contributor for the first time, with net sales of 2.06 billion EUR and growth of 41% (year on year and adjusted for currency effects) (2019: 1.49 billion EUR). OFEV® is a medicine for the treatment of patients with idiopathic pulmonary fibrosis (IPF), systemic sclerosis-associated interstitial lung disease (SSc-ILD) and, in some countries, other chronic fibrosing interstitial lung diseases with a progressive phenotype. High R&D investment in Human Pharma R&D investments in the Human Pharma business amounted to 3.28 billion EUR or 22.8% of net sales. There are around 100 projects across all phases of the research process. The goal is for 75% of these projects to be either the first molecule in their active ingredient class or in a new therapeutic area. Over 50% of them have breakthrough potential. The focus of R&D in Human Pharma lies on cardiovascular and metabolic diseases, oncology, respiratory, immunology, diseases of the central nervous system and retinal health. Animal Health – Strong performance in a highly competitive market The Animal Health business of Boehringer Ingelheim is one of the largest providers of veterinary vaccines and medicines and has a strong presence in the livestock and companion animal segments. In 2020, the Animal Health business delivered a strong performance in a highly competitive market and grew by 5% (year on year and adjusted for currency effects), with net sales of 4.12 billion EUR. The swine and pet antiparasitics segments in particular developed successfully and outperformed expectations. In 2020, the decrease in the incidence of African swine fever in China had a rebound effect on the swine segment. As a result, the swine vaccine INGELVAC CIRCOFLEX® registered a strong 14.9% increase in net sales (year on year and adjusted for currency effects) to 264 million EUR (2019: 238 million EUR). The parasiticide NEXGARD® for dogs remained the best-selling product, with growth of 12% (year on year and adjusted for currency effects) and net sales of 804 million EUR. Biopharmaceutical Contract Manufacturing – One of the leading providers in the industry Boehringer Ingelheim is one of the leading manufacturers of biopharmaceuticals, both for its own portfolio and for partners in the industry. 60% of the top 20 pharmaceutical companies and innovative biotech firms are clients of Boehringer Ingelheim’s Biopharmaceutical Contract Manufacturing business, known under the brand name Boehringer Ingelheim BioXcellenceTM. The biopharmaceuticals business achieved net sales of 837 million EUR in 2020, up 6.6% (year on year and adjusted for currency effects). Outlook 2021: Boehringer Ingelheim expects a slight year on year increase in net sales on a comparable basis The ongoing COVID-19 pandemic and a more challenging industry environment with increasing price pressure in several key markets is expected to have an impact on Boehringer Ingelheim’s results in 2021. Assuming that the approved vaccines and other medicines currently undergoing the approval process help curb the COVID-19 pandemic, the company expects strong general market growth for prescription pharmaceuticals. For 2021, Boehringer Ingelheim expects to achieve a slight year-on-year increase in net sales on a comparable basis. The 2020 Annual Report can be found here: Boehringer Ingelheim Boehringer Ingelheim is working on breakthrough therapies that improve the lives of humans and animals. As a leading research-driven biopharmaceutical company, the company creates value through innovation in areas of high unmet medical need. Founded in 1885 and family-owned ever since, Boehringer Ingelheim takes a long-term perspective. Around 52,000 employees serve more than 130 markets in the three business areas, Human Pharma, Animal Health, and Biopharmaceutical Contract Manufacturing. Learn more at . Please click on the link for ‘Notes to Editors’: View source version on businesswire.com: Contacts Boehringer Ingelheim Corporate Communications and Public Affairs Mattias Reinig 55216 Ingelheim/Germany Phone: +49 6132 - 77 18 48 55 Fax: +49 6132 - 77 6601 Email: press@boehringer-ingelheim.com Source: Boehringer Ingelheim View this news release online at:

抗体疫苗小分子药物抗体药物偶联物并购

100 项与 Lomtegovimab 相关的药物交易

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研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
新型冠状病毒感染	临床3期	美国	Boehringer Ingelheim GmbH	2021-04-21
新型冠状病毒感染	临床3期	西班牙	Boehringer Ingelheim GmbH	2021-04-21
严重急性呼吸综合征	临床2期	德国	University of Cologne Executive School GmbH	2020-12-08
严重急性呼吸综合征	临床2期	德国	Boehringer Ingelheim GmbH	2020-12-08

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT04822701 (CTgov)	临床2/3期	新型冠状病毒感染	5	Placebo (Placebo Intravenous (i.v.) + Placebo Inhaled)	膚顧淵範衊襯遞鏇獵衊(鹽製鬱廠糧艱鹹夢鹽鑰) = 淵夢觸齋糧糧獵鑰壓壓鹽醖願襯夢範鬱夢壓製 (壓夢艱製齋淵遞觸窪齋, 淵遞鹹顧餘廠簾鹹鑰繭 ~ 醖夢簾願選選製艱壓鬱) 更多	-	2022-07-21
				Placebo+BI 767551 (Placebo Intravenous (i.v.) + BI 767551 250 mg Inhaled)	膚顧淵範衊襯遞鏇獵衊(鹽製鬱廠糧艱鹹夢鹽鑰) = 齋積壓齋鑰醖選壓築窪鹽醖願襯夢範鬱夢壓製 (壓夢艱製齋淵遞觸窪齋, 醖鏇鹽餘窪鏇膚襯淵觸 ~ 壓夢糧夢夢鑰憲蓋觸淵) 更多