更新于：2024-12-17
Penehyclidine hydrochloride
盐酸戊乙奎醚
更新于：2024-12-17
概要
基本信息
原研机构 |
非在研机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构
分子式C20H30ClNO2 |
InChIKeyDDTVVMRZNVIVQM-UHFFFAOYSA-N |
CAS号151937-76-7 |
关联
37
项与 盐酸戊乙奎醚 相关的临床试验Inhaling Penehyclidine to Prevent Perioperative Respiratory Adverse Events in Children at Risk Undergoing Minor Elective Surgery
Penehyclidine for prevention of postoperative nausea and vomiting following temporomandibular joint surgery
Effect of penehyclidine hydrochloride on postoperative nausea and vomiting in preoperative anxiety patients undergoing gynecologic outpatient surgery
100 项与 盐酸戊乙奎醚 相关的临床结果
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100 项与 盐酸戊乙奎醚 相关的转化医学
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100 项与 盐酸戊乙奎醚 相关的专利（医药）
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1,238
项与 盐酸戊乙奎醚 相关的文献（医药）2024-12-01RESUSCITATION
Drug therapy versus placebo or usual care for comatose survivors of cardiac arrest; a systematic review with meta-analysis
Article
作者: McAuley, Daniel F ; Skrifvars, Markus B. ; Nichol, Alistair D. ; Nielsen, Niklas ; Pauley, Ellen ; McGuigan, Peter J. ; Jakobsen, Janus C. ; Blackwood, Bronagh ; Nichol, Alistair D ; Moseby-Knappe, Marion ; Hays, Leanne M.C. ; McGuigan, Peter J ; Hays, Leanne M C ; Jakobsen, Janus C ; Eastwood, Glenn ; Skrifvars, Markus B ; McAuley, Daniel F.
BACKGROUND:
In Europe, approximately 291,000 cardiac arrests occur annually. Despite critical care therapy, hospital mortality remains high. This systematic review assessed whether, in comatose survivors of cardiac arrest, any drug therapy, compared to placebo or usual care, improves outcomes.
METHODS:
We searched Medline, EMBASE, the Cochrane Central Register of Controlled Trials, and The International Clinical Trials Registry Platform for randomized controlled trials of drug therapy in comatose survivors of cardiac arrest (last searched 20th October 2024). The primary outcome was mortality at 30 days/hospital discharge. Other outcomes reflected those of the Core Outcome Set for Cardiac Arrest. Risk of bias was assessed using Cochrane Risk-Of-Bias Version 1. Studies of steroids, coenzyme Q10 and thiamine were meta-analysed.
RESULTS:
From 2562 records, 207 full texts were screened and 45 studies (5800 patients) investigating 30 therapies were included. Studies were grouped thematically as supportive drug therapies (n = 10), neuroprotective agents (n = 19), and anti-inflammatory/antioxidants (n = 16). Four studies reported reduced mortality at 30 days/hospital discharge: one of the anticholinergic penehyclidine hydrochloride, two of intra-arrest vasopressin and methylprednisolone plus hydrocortisone for post resuscitation shock, and one of the traditional Chinese medicine, shenfu. Studies of steroids, coenzyme Q10 and thiamine were meta-analysed. We could not detect an effect on mortality with steroids (n = 739, risk ratio (RR), 0.93; 95 % CI 0.83-1.04, p = 0.21; I2 = 60 %, low certainty), coenzyme Q10 (n = 107, RR, 0.91; 95 % CI 0.61-1.37, p = 0.65; I2 = 0 %, low certainty), or thiamine (n = 149, RR, 1.11; 95 % CI 0.88-1.40, p = 0.39; I2 = 0 %, very low certainty).
CONCLUSION:
In comatose survivors of cardiac arrest, the majority of trials of drug therapy reported no effect on mortality. Meta-analyses of steroids, coenzyme Q10 and thiamine demonstrated no evidence of an effect on mortality. However, the low certainty of evidence warrants further research.
2024-11-01Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Prevalence, Dynamics, and Prognostic Role of Clonal Hematopoiesis of Indeterminate Potential in Patients With Breast Cancer
Article
作者: Stover, Daniel G. ; Patel, Ashka ; Mittendorf, Elizabeth A. ; King, Tari A. ; Jin, Qingchun ; Miller, Peter G. ; Stokes, Samantha ; Tayob, Nabihah ; Vincuilla, Julie ; Lin, Nancy U. ; Merrill, Margaret ; Weeks, Lachelle D. ; Wilson, Alex ; Parsons, Heather A. ; Hughes, Melissa E. ; Lipsyc-Sharf, Marla ; Morganti, Stefania ; Curigliano, Giuseppe ; Santos, Katheryn ; Garber, Judy E. ; Tolaney, Sara M. ; Gibson, Christopher J. ; Parker, Tonia
PURPOSE:
Clonal hematopoiesis of indeterminate potential (CHIP) is frequent in patients with solid tumors. Prospective data about CHIP prevalence at breast cancer diagnosis and its dynamic evolution under treatment selective pressure are limited.
PATIENTS AND METHODS:
We performed targeted error-corrected sequencing on 614 samples from 380 patients with breast cancer. We investigated the dynamics of CHIP on prospectively collected paired samples from patients with early breast cancer (eBC) receiving chemotherapy (CT) or endocrine therapy (ET). We assessed the correlation of CHIP with survival in patients with metastatic triple-negative breast cancer (mTNBC). We estimated the risk of progression to treatment-related myeloid neoplasms (t-MN) according to the clonal hematopoiesis risk score (CHRS). In exploratory analyses, we considered clonal hematopoiesis (CH) with variant allele fraction (VAF) ≥0.005.
RESULTS:
CHIP was identified in 15% of patients before treatment. Few CHIP emerged after treatment, and the risk of developing new mutations was similar for patients receiving CT versus ET (odds ratio [OR], 1.16;
P
= .820). However, CT increased the risk of developing new CH with VAF ≥0.005 (OR, 3.45;
P
= .002). Five
TP53-
mutant CH with VAF ≥0.005 emerged among patients receiving CT. Most patients had low risk of t-MN according to the CHRS score. CHIP did not correlate with survival in mTNBC.
CONCLUSION:
CHIP is frequent in patients with breast cancer. In this study, CT did not lead to emergence of new CHIP, and most patients had low risk of developing t-MN. This finding is reassuring, given long life expectancy of patients with eBC and the association of CHIP with morbidity and mortality. However,
TP53
-mutant CH with VAF ≥0.005 emerged with CT, which carries high risk of t-MN. Evolution of these small clones and their clinical significance warrant further investigation.
2024-08-01INTERNATIONAL IMMUNOPHARMACOLOGY
ZBP1-mediated PANoptosis: A possible novel mechanism underlying the therapeutic effects of penehyclidine hydrochloride on myocardial ischemia–reperfusion injury
Article
作者: Zhang, Guanzheng ; Cui, Boqun ; Lin, Duomao ; Liu, Wenjun ; Qi, Zeyou
Although penehyclidine hydrochloride (PHC) has been identified to alleviate myocardial injury induced by ischemia/reperfusion (I/R), the regulatory molecules and related mechanisms are unknown. In this study, bioinformatics, molecular biology, and biochemistry methods were used to explore the molecular mechanisms and targets of PHC. In the myocardial ischemia-reperfusion injury (MIRI)-induced rat model, PHC pretreatment significantly improved cardiac function (p < 0.01). Multiple differentially expressed genes, including Z-DNA binding protein 1 (ZBP1), were identified through mRNA sequencing analysis of myocardial ischemic penumbra tissue in MIRI rats. The transduction of the ZBP1 adenovirus vector (Ad-Zbp1) in PHC-pretreated rats exhibited a reversible augmentation in myocardial infarct size (p < 0.01), pronounced pathological damage to the myocardial tissue, as well as a significant elevation of serum myocardial enzymes (p < 0.05). The interaction among ZBP1, fas-associating via death domain (FADD), and receptor-interacting serine/threonine-protein kinase 3 (RIPK3) leads to a remarkable up-regulation of cleaved-Caspase-1 (Cl-Casp-1), N-terminal gasdermin D (N-GSDMD), phospho-mixed lineage kinase domain-like Ser358 (p-MLKLS358), and other regulatory proteins, thereby triggering pyroptosis, apoptosis, and necroptosis (PANoptosis) in cardiomyocytes of MIRI rats. Moreover, the transduction of Ad-Zbp1 in the oxygen-glucose deprivation/re-oxygenation (OGD/R)-induced H9c2 cell model also dramatically augmented the number of cell deaths. However, the intervention of PHC considerably enhanced cell viability (p < 0.01), effectively mitigated the release of myocardial enzymes (p < 0.05), and markedly attenuated the expression levels of PANoptosis regulatory proteins through restraint of ZBP1 expression. Therefore, the therapeutic efficacy of PHC in improving MIRI might be attributed to targeting ZBP1-mediated PANoptosis.
100 项与 盐酸戊乙奎醚 相关的药物交易
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研发状态
批准上市
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 麻醉 | 中国 | 2002-10-24 | |
| 药物中毒 | 中国 | 2002-10-24 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 胆道痛 | 临床2期 | 中国 | 2017-05-19 | |
| 胆道痉挛 | 临床2期 | 中国 | 2017-05-19 | |
| 慢性阻塞性肺疾病 | 临床2期 | 中国 | 2008-07-21 | |
| 脓毒性休克 | 临床1期 | 中国 | 2012-06-11 | |
| 帕金森病 | 临床1期 | 中国 | 2012-03-15 | |
| 休克 | 临床1期 | 中国 | 2012-03-15 | |
| 平滑肌痉挛 | 临床1期 | 中国 | 2012-03-15 |
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临床结果
临床结果
适应症
分期
评价
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临床4期 | - | 100 | 觸憲醖憲襯繭衊獵壓範(網網構獵鹹製壓鬱鬱顧) = 積糧衊鏇鹽鏇艱選製繭 簾選繭憲鏇齋艱壓襯憲 (糧築網壓醖鬱膚糧遞簾 ) | - | 2022-10-14 | ||
TIVA group | 觸憲醖憲襯繭衊獵壓範(網網構獵鹹製壓鬱鬱顧) = 鬱齋顧鹽顧艱製淵鬱餘 簾選繭憲鏇齋艱壓襯憲 (糧築網壓醖鬱膚糧遞簾 ) | ||||||
临床3期 | - | 864 | 夢製繭淵壓構窪蓋顧積(鏇鑰蓋艱遞衊壓糧繭觸) = dry mouth and delirium 廠繭網簾淵顧鑰範築網 (鑰壓築鏇壓積糧衊壓遞 ) | 积极 | 2022-04-01 | ||
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