别名 MENINGITIS TUBERCULOUS、MENINGITIS, TUBERCULOUS、Meningeal Tuberculoses + [54] |
简介 A form of bacterial meningitis caused by MYCOBACTERIUM TUBERCULOSIS or rarely MYCOBACTERIUM BOVIS. The organism seeds the meninges and forms microtuberculomas which subsequently rupture. The clinical course tends to be subacute, with progressions occurring over a period of several days or longer. Headache and meningeal irritation may be followed by SEIZURES, cranial neuropathies, focal neurologic deficits, somnolence, and eventually COMA. The illness may occur in immunocompetent individuals or as an OPPORTUNISTIC INFECTION in the ACQUIRED IMMUNODEFICIENCY SYNDROME and other immunodeficiency syndromes. (From Adams et al., Principles of Neurology, 6th ed, pp717-9) |
靶点 |
作用机制 GR拮抗剂 |
最高研发阶段批准上市 |
首次获批国家/地区 美国 |
首次获批日期1955-02-21 |
靶点 |
作用机制 GR激动剂 |
非在研适应症 |
最高研发阶段批准上市 |
首次获批国家/地区 美国 |
首次获批日期1952-08-05 |
开始日期2024-03-01 |
申办/合作机构 |
开始日期2024-01-13 |
申办/合作机构- |
开始日期2023-12-18 |
申办/合作机构- |