更新于：2024-11-01

Epilepsia Partialis Continua

部分性癫痫持续状态

更新于：2024-11-01

基本信息

别名

Chronic Progressive Epilepsia Partialis Continua、Chronic progressive epilepsia partialis continua、Chronic progressive epilepsia partialis continua (disorder)

+ [43]

简介

A variant of EPILEPSY characterized by continuous focal jerking of a body part over a period of hours, days, or even years without spreading to other body regions. Contractions may be aggravated by movement and are reduced, but not abolished during sleep. ELECTROENCEPHALOGRAPHY demonstrates epileptiform (spike and wave) discharges over the hemisphere opposite to the affected limb in most instances. The repetitive movements may originate from the CEREBRAL CORTEX or from subcortical structures (e.g., BRAIN STEM; BASAL GANGLIA). This condition is associated with Russian Spring and Summer encephalitis (see ENCEPHALITIS, TICK BORNE); Rasmussen syndrome (see ENCEPHALITIS); MULTIPLE SCLEROSIS; DIABETES MELLITUS; BRAIN NEOPLASMS; and CEREBROVASCULAR DISORDERS. (From Brain, 1996 April;119(pt2):393-407; Epilepsia 1993;34;Suppl 1:S29-S36; and Adams et al., Principles of Neurology, 6th ed, p319)

关联

项与部分性癫痫持续状态相关的药物

Levetiracetam

左乙拉西坦

靶点

SV2A

作用机制

SV2A调节剂

在研机构

Ratiopharm GmbH [+21]

原研机构

UCB SA

在研适应症

部分性癫痫持续状态 [+10]

非在研适应症

急性反复发作 [+28]

最高研发阶段批准上市

首次获批国家/地区

美国

首次获批日期1999-11-30

项与部分性癫痫持续状态相关的临床试验

NCT04309721 / Terminated临床3期IIT

Efficacy of add-on PEramPanel in Focal Motor Status Epilepticus

Randomized controlled trial on focal motor status epilepticus (SE), studying the add-on efficacy of the enteral administration of perampanel (PER) to a conventional intravenous antiepileptic drug.

开始日期2022-11-02

申办/合作机构

Assistance Publique des Hôpitaux de Paris SA

IRCT2016050212452N3 / CompletedN/AIIT

The effect of family-centered care on the family caregivers' burden, stress, anxiety and depression of epilepsy patients .

开始日期2016-07-02

申办/合作机构-

NCT03154307 / TerminatedN/AIIT

Repeated TMS at Low Frequencies to Reduce Seizure Occurrence

Perform non-invasive neuro-navigated repeated Transcranial Magnetic Stimulation (rTMS) at low frequencies (LF) with the intent to reduce the occurrence of seizures over time (long-term protocol). Seizure reduction and improvements in the quality of life in patients with epilepsy will be associated with increased cortical inhibition resulting from the LF-rTMS sessions over time. This procedure using rTMS at low frequencies (LF-rTMS) between 0.5 and 1 Hz is a safe and painless method for noninvasive focal cortical brain stimulation, which will be evaluated in its efficacy at reducing/suppressing seizures. Accordingly, we propose a clinical trial in patients with epilepsy to test whether LF-rTMS can improve seizure suppression. The location of the presumed 3D source in the brain will be stimulated for few minutes (10 to 15 min.). With the same rTMS modality, we will also perform motor threshold mapping in conjunction with its fully integrated and compatible electroencephalography (EEG) module. Up to 100 individuals 18 to 80 years with epilepsy will be enrolled.
In addition, a short-term protocol has been added to test whether LF-rTMS can reduce or suppress status epilepticus in medically refractory participants.

开始日期2016-02-19

申办/合作机构

Baptist Health South Florida, Inc.

[+1]

100 项与部分性癫痫持续状态相关的临床结果

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100 项与部分性癫痫持续状态相关的转化医学

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0 项与部分性癫痫持续状态相关的专利（医药）

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889

项与部分性癫痫持续状态相关的文献（医药）

2024-11-26·Neurology

Epilepsia Partialis Continua in an Adolescent With GAD65 Antibody–Associated Encephalitis

Article

作者: Zhang, Yuying ; Ni, Guanzhong ; Zhang, Heyu ; Chen, Jingjing

2024-10-21·Zhonghua er ke za zhi = Chinese journal of pediatrics

[Clinical features of KCNB1 gene variation related developmental and epileptic encephalopathy].

Article

作者: Liao, J X ; Tan, Q Z ; Yang, X L ; Cheng, M M ; Liu, C H ; Wang, T ; Zhang, Y H ; Zeng, Q ; Yang, Y

目的： 总结KCNB1基因变异相关癫痫和（或）发育落后患儿的临床特点。 方法： 病例系列研究，选取2015年7月至2024年6月在北京大学第一医院儿童医学中心和深圳市儿童医院神经内科诊治的24例KCNB1基因变异相关癫痫和（或）发育落后的患儿，对患儿的癫痫发作表现、脑电图和基因检测结果等进行分析。 结果： 24例患儿KCNB1基因变异均为新生变异，包括20个不同的变异位点，其中错义变异15个、移码变异3个、无义变异2个，7个变异尚未见报道。24例发育性癫痫性脑病患儿中男14例、女10例，末次随访年龄9月龄至13岁9月龄。21例（88%）患儿有癫痫发作，癫痫起病年龄为1月龄至7岁，其中76%（16/21）在2岁前发病。癫痫发作类型包括局灶性发作15例（71%），癫痫性痉挛发作、肌阵挛发作和全面强直阵挛发作各6例，不典型失神发作4例，肌阵挛失张力发作1例，17例（81%）发作有丛集性特点。5例有局灶性发作伴意识障碍持续状态史。24例患儿均有不同程度发育落后，其中3例仅表现为发育落后。21例有癫痫发作的患儿脑电图均存在异常，其中发作间期局灶性或多灶性放电20例，广泛性放电10例，高峰失律2例，睡眠中癫痫性电持续状态3例。24例患儿中，5例颅脑磁共振成像显示有异常。21例有癫痫发作的患儿中，12例（57%）发作已控制。 结论： KCNB1基因变异以新生错义变异为主，多数患儿有癫痫发作，少数可仅表现为发育落后。癫痫多数在2岁前起病，以局灶性发作最常见，约80%的患儿发作有丛集性特点。虽然多数患儿癫痫发作可控制，但仍有不同程度的发育落后，符合发育性癫痫性脑病的特点。.

2024-10-01·Neurological Sciences

The role of EEG and neuroimaging in the diagnosis of non-convulsive status epilepticus in Subacute Encephalopathy with Seizures in Alcoholics (SESA syndrome): a case report and overview of the literature

Review

作者: Biassoni, Erica ; Ferrari, Alessandra ; Miggino, Marco ; Roccatagliata, Luca ; Andorno, Enzo ; Bellucci, Margherita ; Resaz, Martina ; Micalizzi, Elisa ; Villani, Flavio ; Castellan, Lucio ; Porcile, Elisa

Epileptic seizures are frequently associated with liver dysfunction and alcoholism. Subacute encephalopathy with seizures in chronic alcoholics (SESA) is an underrecognized condition with peculiar clinical, EEG and neuroradiological features.We report the case of a 58-year-old man with previous alcohol use disorder (AUD) and acute-on chronic liver failure on alcohol-related cirrhosis, referred for urgent Orthotopic Liver Transplantation evaluation. The patient presented with delirium, aphasia and progressive deterioration of consciousness leading to intensive care unit admission. EEG showed slow activity with superimposed lateralized periodic discharges (LPDs) over the left temporo-occipital regions and ictal discharges with focal motor phenomena, consistent with focal status epilepticus. Antiseizure treatment with lacosamide and levetiracetam was administered with progressive improvement of consciousness.Brain MRI disclosed T2/FLAIR areas of hyperintensity in the left pulvinar and T2/FLAIR hyperintensity with corresponding DWI hyperintensity in the left hippocampal cortex, suggestive of post/peri-ictal excitotoxic changes with anatomical correspondence to focal LPDs distribution. SWI demonstrated decreased prominence of cortical veins in the left temporo-occipital region consistent with increased venous blood oxygenation in compensatory hyperperfusion.In conclusion, SESA should be suspected in the differential diagnosis of patients with AUD presenting with focal neurological deficits, seizures and focal EEG abnormalities. In this context, EEG and brain MRI represent useful tools with both diagnostic and prognostic value.